BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.4485.p (1062 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSp1597 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia s... 1504 0.0 SMa0875 [V] COG0841 Cation/multidrug efflux pump Sme Sinorhizobi... 394 e-109 aq_786 [V] COG0841 Cation/multidrug efflux pump Aae Aquifex aeol... 368 e-101 BH3816 [V] COG0841 Cation/multidrug efflux pump Bha Bacillus hal... 353 1e-96 AGl494 [V] COG0841 Cation/multidrug efflux pump Atu Agrobacteriu... 353 2e-96 >RSp1597 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia solanacearum Length = 1064 Score = 1504 bits (3895), Expect = 0.0, Method: Compositional matrix adjust. Identities = 758/1054 (71%), Positives = 880/1054 (83%), Gaps = 5/1054 (0%) Query: 1 MNMVALALRRPYTFIVMALLIVLATPLTLKNMATDIFPEINIPVVSIIWNYNGLSAQEMG 60 M +V LALRRP TFIV+ALLI+LATP L MATDIFPEI+IPV SIIWNYNGL A+EM Sbjct: 1 MWIVQLALRRPLTFIVLALLILLATPFVLMRMATDIFPEIDIPVCSIIWNYNGLPAKEMA 60 Query: 61 QRIAAQNERGLTTVVSDIEHIESQSLAGVAVIKVFFQPKANIQTAIAQVVASVQSQLRQL 120 RI + ER LTT V+DIEHIESQSL GV++IKVFFQP ANIQTA+AQ+V+ Q+QLRQL Sbjct: 61 DRIVSVTERSLTTTVNDIEHIESQSLGGVSIIKVFFQPTANIQTALAQIVSVSQAQLRQL 120 Query: 121 PPGITPPLVIKYSASSIPVMQLALSSPTLPEQAVFDNAVQTLRPQLVTIPGVAVPYPYGG 180 PPGITPPLVIKYSASSIP++QL LSS TL EQ + D A+ LRP+L+T+PG+AVP+PYGG Sbjct: 121 PPGITPPLVIKYSASSIPILQLGLSSNTLSEQELNDAALNFLRPRLITVPGIAVPFPYGG 180 Query: 181 KSRLISVDLDTQALQARGLAPIDVVNAINTQNLILPSGTAKFGGAEYSVKINGSPEAVAG 240 KSR I+VDLDTQ L A+GL P D+VNA++ QNLILP+GT K +EY+V +NG+P +A Sbjct: 181 KSRQITVDLDTQKLLAQGLTPTDIVNAVSAQNLILPAGTQKIDASEYAVALNGTPGTIAQ 240 Query: 241 LNELPVRTTNGATIYLKDVANVRDGFSPQTNVVRQDGARGVLLSILKNGGASTLDIVDNL 300 LN +PVRT NGAT+ L DVANVRDGFSPQTNVVRQDG RGVLLSILKNGGASTLDIV N+ Sbjct: 241 LNAMPVRTRNGATLVLGDVANVRDGFSPQTNVVRQDGQRGVLLSILKNGGASTLDIVSNI 300 Query: 301 RKLLPAAAQTLPEDLKITPLFDQSLFVKAAVTGVISEALIAAGLTAAMVLLFLGNWRSTL 360 KLLP AA LP+D+KITPLFDQSLFVKAA+ GVI EALIAA LTAAM+LLFLGNWRST Sbjct: 301 YKLLPVAATALPQDIKITPLFDQSLFVKAAIEGVIREALIAACLTAAMILLFLGNWRSTA 360 Query: 361 IIGLTIPLSIMAAILMLAALGETLNLMTLGGLALSVGILVDQAIVTIENIERHLHLGKPL 420 II ++IPLSI+++I++L LGET+NLMTLGGLAL+VGILVD A VTIENIERHLH GK Sbjct: 361 IIAVSIPLSILSSIIVLHLLGETINLMTLGGLALAVGILVDDATVTIENIERHLHEGKAP 420 Query: 421 HEAIIVGAGEIGVPAFVATLCICIVFVPMFFLSGVARFLFVPLAEAVVFAMAASYLLSRT 480 AI+ GA EI VPAFV+TLCICIVFVPMFFL+GVAR+LFVP+AEAV+FAM ASY+LSRT Sbjct: 421 ITAILDGAAEIAVPAFVSTLCICIVFVPMFFLTGVARYLFVPMAEAVIFAMLASYVLSRT 480 Query: 481 LVPTLVMLLMGSHGQVDHAKQSLLQRLYRAFDSRFERVRHGYTLVLSSLLAHRRRFALSF 540 LVPTLVM+LM H + D K ++ +Y+AF++RFE +R Y +L LL HRR FALSF Sbjct: 481 LVPTLVMMLMTGHTE-DAKKPGPMRYIYQAFNARFEHMRGNYAAILGGLLEHRRVFALSF 539 Query: 541 LGFCLLSCLLYPFLGRDFFPNVDGGQIRLHMRMPTGTRIEETARAADEVERVIRSLIPAS 600 LGFC+ SC LY LGRDFFP+VD GQIRLHMR P+G RIEETAR ADEVE IR++IP + Sbjct: 540 LGFCVASCALYLALGRDFFPDVDAGQIRLHMRAPSGLRIEETARLADEVEAAIRTIIPRN 599 Query: 601 ELETILDNLGVPNSGINLSYSNAGTIGTLDGEILMALKPGHR-PSEELVAMLREQLPHRF 659 EL T+LDNLGVPNSGINLSYSNAGTIGTLDGEIL+AL+ G R PS E V LRE+LP RF Sbjct: 600 ELATLLDNLGVPNSGINLSYSNAGTIGTLDGEILIALREGERKPSAEYVRRLREELPKRF 659 Query: 660 PGIEFFFQPADIVTQILNFGLPAAIDVQFTGANMEANARLAAELTKQIRQIPGAVDAHVH 719 PG+EF FQPADIV+QILNFGLP+AIDVQF+GA++ AN +LA L +IR+IPGAVD HVH Sbjct: 660 PGVEFAFQPADIVSQILNFGLPSAIDVQFSGADVAANQQLAGILANRIRRIPGAVDTHVH 719 Query: 720 QRLDGPSLDLRMDRTRLQQFGLSASNVGQNLLIALSGSSQTQPAFWLNPNNGVVYSIAVQ 779 QR D P+L + MDRTR+QQ GL +V QNLL++LS S QT P FWLNP NGVVY +AVQ Sbjct: 720 QRFDQPTLAVNMDRTRIQQVGLQGRDVAQNLLVSLSSSFQTSPTFWLNPVNGVVYQVAVQ 779 Query: 780 SPQYQVDSLDALLNIPV-GAGANAATP--PQLLGNLVDVHAGRQMAVASRYNISPAIDVY 836 SPQY+VDSLDALL PV GAG A P PQLLGNLV V Q V S Y+I+P +DVY Sbjct: 780 SPQYRVDSLDALLRTPVAGAGGGATQPGGPQLLGNLVQVGPAVQPQVVSHYDITPVVDVY 839 Query: 837 VSVQGTDLASVAGKVSELVEQIKPKLARGSQVVIRGQVETMQSSFIGLGVGLAMAIVLVY 896 +VQG DL +VA +V + V++I+PKL RG+Q+ +RGQV TM+SSF+GLGVGL MAIVLVY Sbjct: 840 AAVQGRDLGAVAKEVQKAVDEIRPKLPRGAQITVRGQVRTMESSFVGLGVGLVMAIVLVY 899 Query: 897 LLVVVNFQSWIDAAIIIAALPAALAGIAWMLFITGTTLSVPALTGAIMTMGVATANSILI 956 LL+VVNFQSWID II+ ALPAALAGIAWMLF+TGTTLSVP+LTGAIMTMGVATANSIL+ Sbjct: 900 LLIVVNFQSWIDPLIIVTALPAALAGIAWMLFVTGTTLSVPSLTGAIMTMGVATANSILL 959 Query: 957 VAFARQRREDGATPLAAALEAGSTRIRPVLMTALAMIIGMIPMALGLGEGAEQNAPLGRA 1016 ++FAR+R +G P+ AALEAG+TR+RPVLMTALAMIIGM+PMALGLGEGAEQNAPLGRA Sbjct: 960 ISFARERLHEGIAPMQAALEAGATRLRPVLMTALAMIIGMVPMALGLGEGAEQNAPLGRA 1019 Query: 1017 VIGGLLLATVSTLFFVPVVFAGVHQRLARRAEQR 1050 VIGGLL ATVSTLFFVPVVFA VH RL RRA +R Sbjct: 1020 VIGGLLFATVSTLFFVPVVFASVHGRLQRRAGRR 1053 >SMa0875 [V] COG0841 Cation/multidrug efflux pump Sme Sinorhizobium meliloti Length = 1065 Score = 394 bits (1011), Expect = e-109, Method: Compositional matrix adjust. Identities = 310/1061 (29%), Positives = 513/1061 (48%), Gaps = 53/1061 (4%) Query: 1 MNMVALALRRPYTFIVMALLIVLATPLTLKNMATDIFPEINIPVVSIIWNYNGLSAQEMG 60 M + +++ P +M ++I++ + + D +PE ++PVV + Y G S + + Sbjct: 1 MFLTRISINHPVFATMMMVMILVLGLFSYGRLGVDHYPETDLPVVVVATTYTGASPESVE 60 Query: 61 QRIAAQNERGLTTVVSDIEHIESQSLAGVAVIKVFFQPKANIQTAIAQVVASVQSQLRQL 120 I+ E L T+ I+ I S+S G +++ V F+ + Q A +V V + Sbjct: 61 SEISRPIEAALNTI-GGIDTITSESYEGRSIVVVQFEVDVDSQDAAQEVRDRVARLETKF 119 Query: 121 PPGITPPLVIKYSASSIPVMQLALSSP--TLPEQAVFDNAVQTLRPQLVTIPGVAVPYPY 178 P G+ P V +Y ++ +A+SS TLPE A + + +L I GV Sbjct: 120 PDGVATPQVTRYKPEGQAILSVAVSSTSRTLPEITTL--ATRVINNRLSVISGVGQVSLI 177 Query: 179 GGKSRLISVDLDTQALQARGLAPIDVVNAINTQNLILPSGTAKFGGAEYSVKINGSPEAV 238 G R + V +D L A GLA V+ AI +N +GT G + V + G Sbjct: 178 GSSERQVLVVVDPDRLGAYGLAVSTVIEAIRGENQDRAAGTLISGINQRIVTVEGRIANT 237 Query: 239 AGLNELPVRTTNGATIYLKDVANVRDGFSPQTNVVRQDGARGVLLSILKNGGASTLDIVD 298 +G N + V NG +YL +VA + D + T++ G + L I+K GA+T+++ Sbjct: 238 SGFNRIIVAQRNGYPVYLSEVATILDTGAEVTSLANYQGQTTLGLHIVKVQGANTVEVAS 297 Query: 299 NLRKLLPAAAQTLPED-LKITPLFDQSLFVKAAVTGVISEALIAAG-LTAAMVLLFLGNW 356 +R+ + A L +D +++T D S + + V+ V L+ G L+ +V +FL +W Sbjct: 298 AVRREVSALNAELTKDNVQLTITRDNSRPIASQVSQV-QRTLVEGGVLSVLIVFIFLNSW 356 Query: 357 RSTLIIGLTIPLSIMAAILMLAALGETLNLMTLGGLALSVGILVDQAIVTIENIERHLHL 416 RST+I GLT+P+S++ + ALG TLN+MTL L+LS+GIL+D AIV ENI RHL + Sbjct: 357 RSTVITGLTLPISVIGTFAAIYALGFTLNIMTLMALSLSIGILIDDAIVVRENITRHLQM 416 Query: 417 GKPLHEAIIVGAGEIGVPAFVATLCICIVFVPMFFLSGVARFLFVPLAEAVVFAMAASYL 476 GK A + G EIG+ TLCI VF+P+ F+ G+ F+ V A+ S Sbjct: 417 GKDPVRAALDGTNEIGLAVLSTTLCIVAVFLPVAFMGGLIGRFFLQFGVTVAVAVVISLF 476 Query: 477 LSRTLVPTLVMLLMGSHGQVDHAKQSLLQRLYRAFDSRFERVRHGYTLVLSSLLAHRRRF 536 +S TL P L + Q AK+ +L FD FE + Y V+ +R+ Sbjct: 477 VSFTLDPMLSSVWCDPQSQ-KTAKRGFFGQLIERFDQWFEGLASRYRSVIYFTFDYRKTT 535 Query: 537 ALSFLGFCLLSCLLYPFLGRDFFPNVDGGQIRLHMRMPTGTRIEETARAADEVERVIRSL 596 LG ++S LL P +G +F P D G++ + + G ++ A ++ER +R Sbjct: 536 IAIVLGMFVVSLLLVPRIGTEFLPPPDQGEVSISLEANEGASLDYMAAKVGQIERALR-- 593 Query: 597 IPASELETILDNLGVPNSGINLSYSNAGTIGTLDGEILMALKPGHR-----PSEELVAML 651 E + NSG ++ A L+A++ H + E + + Sbjct: 594 ----EFNYVSSTYSTINSGEMRGFNKA----------LVAVQLVHSSQRRLKTAETLGPI 639 Query: 652 REQLPHRFPGIEFFF-QPADIVTQILNFGLPAAIDVQFTGANMEANARLAAELTKQIRQI 710 R +L R G+E Q +++V I + + G E R++ +T + I Sbjct: 640 RRRL-SRIAGLEISVGQRSEVVGSI------KPLQLSILGDGDEELRRISDHITSVLAAI 692 Query: 711 PGAVDAHVHQRLDGPSLDLRMDRTRLQQFGLSASNVGQNLLIALSGSSQTQPAFWLNPNN 770 PGA + P+L +R+ R G+S + +G L ++G + + W +P+ Sbjct: 693 PGATEIESSIEKLRPTLAVRVRREAASDLGVSIATIGDTLRSLVAGDA---ISVWNSPD- 748 Query: 771 GVVYSIAVQSPQYQVDSLDALLNIPVGAG---ANAATPPQLLGNLVDVHAGRQMAVASRY 827 G + + V+ P ++ L N+P+ N LL + DV A +R Sbjct: 749 GETHDVVVRLPAAGRENAAQLRNLPIATARMDDNGKPIMVLLDQVADVVESTAPAQITRK 808 Query: 828 NISPAIDVYVSVQGTDLASVAGKVSELVEQIKPKLARGSQVVIRGQVETMQSSFIGLGVG 887 ++S I + +++G L V + K + G ++ G E + S Sbjct: 809 DLSRDIRISSNIEGRTLGDVVADLK--AAMTKMDIPVGFRISFGGDAENLTESTAYALQS 866 Query: 888 LAMAIVLVYLLVVVNFQSWIDAAIIIAALPAALAGIAWMLFITGTTLSVPALTGAIMTMG 947 LAMA++ +Y+++ F S+I II +P +L G+ L TG+TL++ ++ G +M MG Sbjct: 867 LAMAVIFIYIILASQFGSFIQPIAIIMTMPLSLMGVLLGLLFTGSTLNMFSMIGIMMLMG 926 Query: 948 VATANSILIVAFARQRREDGATPLAAALEAGSTRIRPVLMTALAMIIGMIPMALGLGEGA 1007 + T N+IL+V ++ +G + + +AG+ R+RP++MT LAMI GM+P ALGLGEG Sbjct: 927 LVTKNAILLVDYSNLGVREGKSLRQSLADAGAVRLRPIVMTTLAMIFGMLPTALGLGEGG 986 Query: 1008 EQNAPLGRAVIGGLLLATVSTLFFVPVV------FAGVHQR 1042 Q AP+ A+IGGL+ +T+ +L FVPVV FAG +R Sbjct: 987 AQRAPMAHAIIGGLISSTLLSLVFVPVVLTYLDAFAGRVRR 1027 >aq_786 [V] COG0841 Cation/multidrug efflux pump Aae Aquifex aeolicus Length = 1000 Score = 368 bits (945), Expect = e-101, Method: Compositional matrix adjust. Identities = 283/1047 (27%), Positives = 493/1047 (47%), Gaps = 68/1047 (6%) Query: 3 MVALALRRPYTFIVMALLIVLATPLTLKNMATDIFPEINIPVVSIIWNYNGLSAQEMGQR 62 M + RP T ++ L V +LK + D P++ PVV I +Y G + Sbjct: 1 MQKFFIERPVTAFMLMLSFVFLGLYSLKLVPIDRLPDVEFPVVRISADYPGADPYVVDTN 60 Query: 63 IAAQNERGLTTVVSDIEHIESQSLAGVAVIKVFFQPKANIQTAIAQVVASVQSQLRQLPP 122 + E ++TV S IE I S+S G A + V F +I A +V ++Q +R+ P Sbjct: 61 VTRIIEEAVSTV-SGIESIISRSYPGFASVVVTFTLDKDIDVATQEVSNAIQRAMRRFPK 119 Query: 123 GITPPLVIKYSASSIPVMQLALSSPTLPEQAVFDNAVQTLRPQLVTIPGVAVPYPYGGKS 182 G+ PP V+K S P+M L L S T Q + A + ++ +L + GV G + Sbjct: 120 GVEPPTVVKVDTSVAPIMVLLLYSDTADYQRLTYYADKVIKRELEKLYGVGSVSLGGFRD 179 Query: 183 RLISVDLDTQALQARGLAPIDVVNAINTQNLILPSGTAKFGGAEYSVKINGSPEAVAGLN 242 ++ V L L L P+DV+ I+ + +P+G EY +++ G + L+ Sbjct: 180 NVLWVRLKVSELYGYELTPLDVLREIDKNHQDIPAGNVYGKRREYILRLYGKFKTPEELS 239 Query: 243 ELPVRTTNGATIYLKDVANVRDGFSPQTNVVRQDGARGVLLSILKNGGASTLDIVDNLRK 302 L ++ + L DVA V G + ++ R +G R V L + K +T+ ++D ++ Sbjct: 240 NLYIK----ENLRLGDVARVYFGEDEERSLARFNGNRAVALLVFKQAKVNTVRVIDEIKS 295 Query: 303 LLPAAAQTLPEDLKITPLFDQSLFVKAAVTGVISEALIAAGLTAAMVLLFLGNWRSTLII 362 + + LP D+K+ FD S++VK ++ E +I LTA V LFLGN R TL+ Sbjct: 296 RMEFFRELLPPDIKLDYTFDASVYVKESIRAAFEEIIIGVFLTAFTVYLFLGNLRLTLVP 355 Query: 363 GLTIPLSIMAAILMLAALGETLNLMTLGGLALSVGILVDQAIVTIENIERHLHLGKPLHE 422 IP++I+ I L LG +LN +TL LA++VGI++D AIV +E+I R G P E Sbjct: 356 VFAIPVTILGTIFFLYQLGYSLNTITLLALAVAVGIVIDDAIVVMESIHRRREEGLPPFE 415 Query: 423 AIIVGAGEIGVPAFVATLCICIVFVPMFFLSGVARFLFVPLAEAVVFAMAASYLLSRTLV 482 A + G + +T + +VF+P+ FL GV A ++ A+ SYL++ T Sbjct: 416 AGVKGTRVVMFALLASTSVLIVVFLPVVFLKGVLGTFLKNFALTLIIAIGLSYLVAITFT 475 Query: 483 PTLVMLLMGSHGQVDHAKQSLLQRLYRAFDSRFER-----VRHGYTLVLSSLLAHRRRFA 537 P+ + L+ +++ +LY+ F+ F++ + H + ++L Sbjct: 476 PSATVRLI-----TQRPRENFFMKLYKRFEGSFDKALRFSLDHKFIVLL----------- 519 Query: 538 LSFLGFCLLSCLLYPFLGRDFFPNVDGGQIRLHMRMPTGTRIEETARAADEVERVIRSLI 597 LSF F LS L+P + ++F P+VD G+ + MRMP GT E A EVER+ Sbjct: 520 LSFF-FVGLSVYLFPKVKKEFVPHVDEGRFMVRMRMPVGTSFERVKEKAKEVERI----- 573 Query: 598 PASELETILDNLGVPNSGINLSYSNAGTIGTLDGEILMALKPGHRPSEELVAM--LREQL 655 +L N + G+ + G G + LK + ++V M +R +L Sbjct: 574 -------LLKNPHIAKVGMVVGEGVGGAGVH-SGLFFVYLKERSQRPHQMVVMSEVRREL 625 Query: 656 PHRFPGIEFFFQPADIVTQILNFGLPAA----IDVQFT--GANMEANARLAAELTKQIRQ 709 ++ +P G+ A+ D+Q+ G +E ++A + + Sbjct: 626 SE-LKNVKVSVEPPH--------GIGASAGRTTDLQYIVRGERIEVLKKIAKSMEEHFSN 676 Query: 710 IPGAVDAHVHQRLDGPSLDLRMDRTRLQQFGLSASNVGQNLLIALSGSSQTQPAFWLNPN 769 + G D L P + + + R +L G+S ++G L ++L + L Sbjct: 677 VEGFRDVDTSLELSAPYVKISVKREKLSHLGVSVEDLG--LTLSLLFGKYRVGTYELGSE 734 Query: 770 NGVVYSIAVQSPQYQVDSLDALLNIPVGAGANAATPPQLLGNLVDVHAGRQMAVASRYNI 829 + Y +++ + V + L + + A P + L+D +RYN Sbjct: 735 S---YDFYIKAEEDFVKEIHNLNRVYIRARNGELIP---ITELIDFSIEAGPFSLTRYNR 788 Query: 830 SPAIDVYVSVQGTDLASVAGKVSELVEQIKPKLARGSQVVIRGQVETMQSSFIGLGVGLA 889 + Y +++G DLA+ V + +K L G G+V+ + +F G + LA Sbjct: 789 QYSFVFYANLEGIDLATARSLVE---DWLKKNLPFGYTYDTAGRVKEFKKAFSGFVLSLA 845 Query: 890 MAIVLVYLLVVVNFQSWIDAAIIIAALPAALAGIAWMLFITGTTLSVPALTGAIMTMGVA 949 M+++ VY+++ F+S ++ +P + G+ +++T T+L+V + G I+ +G+ Sbjct: 846 MSLIGVYMILASLFESLKHPFTVLLMVPLSALGVFGFMYLTDTSLNVSSYFGIILLVGII 905 Query: 950 TANSILIVAFARQRREDGATPLAAALEAGSTRIRPVLMTALAMIIGMIPMALGLGEGAEQ 1009 +++L + Q R++G A LEA R+RP+LMT + ++ ++P+ALGL G+EQ Sbjct: 906 VRDAVLFIERIIQLRKEGYAVREAILEARRERLRPILMTTITVVSALLPVALGLTAGSEQ 965 Query: 1010 NAPLGRAVIGGLLLATVSTLFFVPVVF 1036 PL AVIGG+ +LF +PV++ Sbjct: 966 RKPLAIAVIGGIASGLPLSLFLLPVLY 992 Score = 45.8 bits (107), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 69/284 (24%), Positives = 114/284 (40%), Gaps = 27/284 (9%) Query: 218 GTAKFGGAEYSVKINGSPEAVA---GLNELPVRTTNGATIYLKDVANVRDGFSPQTNVVR 274 GT + G Y I + V LN + +R NG I + ++ + P Sbjct: 727 GTYELGSESYDFYIKAEEDFVKEIHNLNRVYIRARNGELIPITELIDFSIEAGP------ 780 Query: 275 QDGARGVLLSILKNGGASTLDIVDNLRKLLPAAAQTLPED-LKITPLFDQSL-------- 325 S+ + + NL + A A++L ED LK F + Sbjct: 781 --------FSLTRYNRQYSFVFYANLEGIDLATARSLVEDWLKKNLPFGYTYDTAGRVKE 832 Query: 326 FVKAAVTGVISEALIAAGLTAAMVLLFLGNWRSTLIIGLTIPLSIMAAILMLAALGETLN 385 F KA V+S A+ G+ + LF + + + L +PLS + + +LN Sbjct: 833 FKKAFSGFVLSLAMSLIGVYMILASLF-ESLKHPFTVLLMVPLSALGVFGFMYLTDTSLN 891 Query: 386 LMTLGGLALSVGILVDQAIVTIENIERHLHLGKPLHEAIIVGAGEIGVPAFVATLCICIV 445 + + G+ L VGI+V A++ IE I + G + EAI+ E P + T+ + Sbjct: 892 VSSYFGIILLVGIIVRDAVLFIERIIQLRKEGYAVREAILEARRERLRPILMTTITVVSA 951 Query: 446 FVPMFFLSGVARFLFVPLAEAVVFAMAASYLLSRTLVPTLVMLL 489 +P+ PLA AV+ +A+ LS L+P L L+ Sbjct: 952 LLPVALGLTAGSEQRKPLAIAVIGGIASGLPLSLFLLPVLYELM 995 >BH3816 [V] COG0841 Cation/multidrug efflux pump Bha Bacillus halodurans Length = 1093 Score = 353 bits (906), Expect = 1e-96, Method: Compositional matrix adjust. Identities = 296/1066 (27%), Positives = 509/1066 (47%), Gaps = 77/1066 (7%) Query: 3 MVALALRRPYTFIVMALLIVLATPLTLKNMATDIFPEINIPVVSIIWNYNGLSAQEMGQR 62 M ++RRP IV ++ +L ++ N+ + P++N P+ ++ +Y G SA+E+ + Sbjct: 1 MTQFSIRRPVFTIVGMIIFLLVGGISYVNLPLQLTPDLNPPIGAVTASYPGASAEEVSEN 60 Query: 63 IAAQNERGLTTVVSDIEHIESQSLAGVAVIKVFFQPKANIQTAIAQVVASVQSQLRQLPP 122 + E L+T S + I SQS+ G A+I + F NI +++++ LP Sbjct: 61 VTRILEDELSTT-SGLNKITSQSMEGSAIIILEFGWTTNIDDVENDIISTINRA--DLPD 117 Query: 123 GITPPLVIKYSASSIPVMQLALSSPTLPEQAVFD--NAVQTLRPQLVTIPGVAVPYPYGG 180 G + P +K+ S+ P+M+L ++S T +A+ D A+ L ++ + GVA +G Sbjct: 118 GASNPSFLKFDPSAFPIMELVVTSDT---EAISDISEALDELEREIGRVEGVASVSSHGR 174 Query: 181 KSRLISVDLDTQALQARGLAPIDVVNAINTQNLILPSGTAKFGGAEYSVKINGSPEAVAG 240 + V +D +AL+ L DVV+ I ++ LP GT G + + + +AV Sbjct: 175 LMERVEVTIDDEALEEANLTQQDVVDVIEANDISLPGGTISDGDRSLTTRTIRTLDAVET 234 Query: 241 LNEL--PVRTTNGATIYLKDVANVRDGFSPQTNVVRQDGARGVLLSILKNGGASTLD--- 295 + +L + T G + L DVA+V +T + R + V SI+K A+++D Sbjct: 235 IEDLVLTIDTQTGDDVLLSDVADVSISLEDETVITRANNDPAVQFSIMKEDAANSVDVSV 294 Query: 296 -IVDNLRKLLPAAAQTLPEDLKITPLFDQSLFVKAAVTGVISEALIAAGLTAAMV--LLF 352 I + L +LL Q +D+ L+D+ F+ A+ V+ ALIA G T AMV LF Sbjct: 295 AITERLDELLE---QDRFDDVSAFVLYDEGDFILEAINNVLV-ALIA-GATMAMVVLFLF 349 Query: 353 LGNWRSTLIIGLTIPLSIMAAILMLAALGETLNLMTLGGLALSVGILVDQAIVTIENIER 412 L N+++ LIIG+ IP S++ L +LN+++LGGLAL +G+LVD +IV IENI R Sbjct: 350 LRNFKTPLIIGIAIPFSVIVTFAFLYFTNVSLNILSLGGLALGIGMLVDNSIVVIENIYR 409 Query: 413 HLHLGKPLHEAIIVGAGEIGVPAFVATLCICIVFVPMFFLSGVARFLFVPLAEAVVFAMA 472 HL +GK +A + G E+ +TL VFVP+ FL+G+ LF+ A V ++ Sbjct: 410 HLSMGKEPKQAALEGTREVRGAITASTLTTISVFVPILFLTGLVGELFIQFALTVSLSLF 469 Query: 473 ASYLLSRTLVPTLVMLLMGSHGQVDHAKQSLLQRLYRAFDSRFERVRHGYTLVLSSLLAH 532 AS L++ TLVP LM S RL R F E R +L+ + Sbjct: 470 ASLLVAITLVP-----LMAS-------------RLLRKFQQNEEAKRQQSRFILT--IER 509 Query: 533 RRRFALSFLGFCLLSCLLY--------PFLGRDFFPNVDGGQIRLHMRMPTGTRIEETAR 584 ++AL L++ LL +G DF ++D G + + + GT +E R Sbjct: 510 SIKWALRHRAMVLIATLLLFVGGLYGLSTVGVDFLEDMDEGLMVVEIEHEPGTSLE---R 566 Query: 585 AADEVERVIRSLIPASELETILDNLGVPNSGINLSYSNAGTIGTLDGEILMALKPGHR-- 642 + VE + + L SE+E + G + + N+ +G++ L P Sbjct: 567 TRETVEAIEQKLEDYSEIENFVSTSGARGTNVGRRDGNS-----YEGQVQATLVPSSDRD 621 Query: 643 -PSEELVAMLREQLPHRFPGIEFFFQPADIVTQILNFGLPAAIDVQFTGANMEANARLAA 701 + E V ++ + E P L P + + ++ + Sbjct: 622 LTTLEFVESIKRDVERVDSDAEINVSPLS-----LQGSEPNTLTFYLSDSDPDRLEEATE 676 Query: 702 ELTKQIRQIPGAVDAHVHQRLDGPSLDLRMDRTRLQQFGLSASNVGQNLLIALSGSSQTQ 761 L +++ + + + + P L +D ++ GL + V Q + G + T Sbjct: 677 ALEEELLERNEVTNLELSIDVTTPEYQLLIDEEAARENGLVPAQVAQFVYDVTLGQTVTT 736 Query: 762 PAFWLNPNNGVVYSIAVQSPQYQVDSLDALLNIPVGAGANAATPPQLLGNLVDVHAGRQM 821 L +N + Y + V+ +DSL+ + + + P LG++V + G Sbjct: 737 ----LEIDNDL-YDLFVRYHPDVLDSLETMEELTIRNNEGVYVP---LGDVVTIEEGEGP 788 Query: 822 AVASRYNISPAIDVYVSVQGT-DLASVAGKVSELVEQIKPKLARGSQVVIRGQVETMQSS 880 A +R A++ V+ + L ++ V ++V++ ++ G E ++++ Sbjct: 789 ATINRIEQRDAVEFTVTYDSSLSLGDISSIVLDIVDE--QNFEDTTEFAFTGDQEALETA 846 Query: 881 FIGLGVGLAMAIVLVYLLVVVNFQSWIDAAIIIAALPAALAGIAWMLFITGTTLSVPALT 940 L +A+V V+L++ F+S+ +++ +LP + G++ L +TGT+ SV A Sbjct: 847 MADLTGAFMLAVVFVFLVMAAQFESFRFPFVVMFSLPLVMIGVSLALLVTGTSFSVMAGI 906 Query: 941 GAIMTMGVATANSILIVAFARQRREDGATPLAAALEAGSTRIRPVLMTALAMIIGMIPMA 1000 G I+ G+ N+I+IV + Q + GAT A +EA R RPVLMTAL I+G++P+A Sbjct: 907 GMIILAGIVVNNAIVIVDYMNQLKASGATSYEAIVEAVKQRTRPVLMTALTTILGVLPLA 966 Query: 1001 LGLGEGAEQNAPLGRAVIGGLLLATVSTLFFVPVVFAGVHQRLARR 1046 L LGEG E P+G VIGGL+ T TLF +PV+++ + + RR Sbjct: 967 LALGEGTEMQRPIGLTVIGGLISGTFLTLFVIPVIYS-LFDKDTRR 1011 Score = 48.1 bits (113), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 75/364 (20%), Positives = 159/364 (43%), Gaps = 28/364 (7%) Query: 702 ELTKQIRQIPGAVDAHVHQRLDGPSLDLRMDRTRLQQFGLSASNVGQNLLIALSGSSQTQ 761 EL ++I ++ G H RL +++ +D L++ L+ Q+++ + + + Sbjct: 155 ELEREIGRVEGVASVSSHGRL-MERVEVTIDDEALEEANLTQ----QDVVDVIEANDISL 209 Query: 762 PAFWLNPNNGVVYSIAVQSPQYQVDSLDALLNIPVGAGANAATPPQLLGNLVDVHAG-RQ 820 P ++ + + + +++ D +L I G + LL ++ DV Sbjct: 210 PGGTISDGDRSLTTRTIRTLDAVETIEDLVLTIDTQTGDDV-----LLSDVADVSISLED 264 Query: 821 MAVASRYNISPAIDVYVSVQGTDLAS-------VAGKVSELVEQIKPKLARGSQVVIRGQ 873 V +R N PA V S+ D A+ + ++ EL+EQ + + G Sbjct: 265 ETVITRANNDPA--VQFSIMKEDAANSVDVSVAITERLDELLEQDRFDDVSAFVLYDEGD 322 Query: 874 --VETMQSSFIGLGVGLAMAIVLVYLLVVVNFQSWIDAAIIIAALPAALAGIAWMLFITG 931 +E + + + L G MA+V+++L + NF++ + II A+P ++ L+ T Sbjct: 323 FILEAINNVLVALIAGATMAMVVLFLFLR-NFKTPL---IIGIAIPFSVIVTFAFLYFTN 378 Query: 932 TTLSVPALTGAIMTMGVATANSILIVAFARQRREDGATPLAAALEAGSTRIR-PVLMTAL 990 +L++ +L G + +G+ NSI+++ + G P AALE G+ +R + + L Sbjct: 379 VSLNILSLGGLALGIGMLVDNSIVVIENIYRHLSMGKEPKQAALE-GTREVRGAITASTL 437 Query: 991 AMIIGMIPMALGLGEGAEQNAPLGRAVIGGLLLATVSTLFFVPVVFAGVHQRLARRAEQR 1050 I +P+ G E V L + + + VP++ + + ++ + E + Sbjct: 438 TTISVFVPILFLTGLVGELFIQFALTVSLSLFASLLVAITLVPLMASRLLRKFQQNEEAK 497 Query: 1051 RARA 1054 R ++ Sbjct: 498 RQQS 501 >AGl494 [V] COG0841 Cation/multidrug efflux pump Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 1048 Score = 353 bits (905), Expect = 2e-96, Method: Compositional matrix adjust. Identities = 306/1048 (29%), Positives = 521/1048 (49%), Gaps = 51/1048 (4%) Query: 13 TFIVMALLIVLATPLTLKNMATDIFPEINIPVVSIIWNYNGLSAQEMGQRIAAQNERGLT 72 T +++ALL++ A +L+ + D +P +++PVV ++ +Y G + + + + E L Sbjct: 15 TMMMVALLVMGA--FSLQRLGLDQYPNVDVPVVVVVTSYPGATPETVEMEVTRPVEDALN 72 Query: 73 TVVSDIEHIESQSLAGVAVIKVFFQPKANIQTAIAQVVASVQSQLRQLPPGITPPLVIKY 132 + ++ + S S G +V+ F+ + A +V + + P P++ ++ Sbjct: 73 AI-GGLDEVTSTSYEGRSVVVAKFKLEVQSSAAAQEVRDKIAAIEANFPEDTKKPVISRF 131 Query: 133 SASSIPVMQLALSSPTLPEQAVFDNAVQTLRPQLVTIPGVAVPYPYGGKSRLISVDLDTQ 192 ++ P++ LA+SS +L A+ A Q + QL T+ G+ GG+ R I V +D Sbjct: 132 DPAAEPILSLAISSTSLDVPALATLAEQKVVRQLTTVAGIGQATLVGGRKRQIDVTIDET 191 Query: 193 ALQARGLAPIDVVNAINTQNLILPSGTAKFGGAEYSVKINGSPEAVAGLNELPVRTTNGA 252 ++A G+ +VV A+ N P+G+ +E +++I E L ++ V G Sbjct: 192 RMRALGIGVNEVVTALRAGNSNSPAGSVVDPVSERTIQIQSRIEEPEALLDMVVARRGGV 251 Query: 253 TIYLKDVANVRDGFSPQTNVVRQDGARGVLLSILKNGGASTLDIVDNLRKLLPA-AAQTL 311 I L+DVA + +G + N +G + + I+K A+T+ +V ++RK L A A+ Sbjct: 252 AILLRDVATLSEGAADAENRAIYNGQTALAIDIVKVQDANTVQVVSDVRKRLDALNAELS 311 Query: 312 PEDLKITPLFDQSLFVKAAVTGVISEALIAAGLTAAMVLLFLGNWRSTLIIGLTIPLSIM 371 P+++++ + D S+ ++ +VT V + + A L A+V LFL +WRST+I GLT+P++I+ Sbjct: 312 PQNIQLRIVTDSSIPIQESVTQVQTTLIEGAALAVAIVFLFLNSWRSTVITGLTLPIAII 371 Query: 372 AAILMLAALGETLNLMTLGGLALSVGILVDQAIVTIENIERHLHLGKPLHEAIIVGAGEI 431 + ++ LG TLN ++L L LS+GILVD AIV ENI RHLH+GK A + G GEI Sbjct: 372 GTLTVVDFLGFTLNTLSLLALTLSIGILVDDAIVVRENITRHLHMGKSHLRAALDGTGEI 431 Query: 432 GVPAFVATLCICIVFVPMFFLSGVARFLFVPLAEAVVFAMAASYLLSRTLVPTLVMLLMG 491 G+ T I VF+P+ F+ G+ F V A+ S ++ TL P L + Sbjct: 432 GLAVIATTATIVAVFLPVAFMDGIVGRFFYQFGVTVSAAVLISLFVAFTLDPMLSSVWYD 491 Query: 492 SHGQVDHAKQSLLQRLYRAFDSRFERVRHGYTLVLSSLLAHRRRFALSFLGFCLLSCLLY 551 Q D AK+ + RL FD FE + Y + L HR L G + S + Sbjct: 492 PDAQAD-AKRGPIGRLIARFDHGFEWMAGQYRHAIDWTLRHRLVTLLVTAGIFIGSLFMV 550 Query: 552 PFLGRDFFPNVDGGQIRLHMRMPTGTRIEETARAADEVERVIRSLIPASELETILDNLGV 611 P +G +F P+ D G+ ++++ P G+ ++ T +V++ +R E+E + + Sbjct: 551 PLVGTEFVPDADEGRFQINLTAPVGSSLDYTTAKLQQVKKALREF---PEVEMLYSTI-- 605 Query: 612 PNSGINLSYSNAGTIGTLDGEILMALKPGHRPSEELVAMLREQLPHRF---PGIEFFFQP 668 N+G G G IL+ L P E+ L E + R PGIE Sbjct: 606 -NTG--------GAAGKHRAAILVGLVP-LSAREQTPLSLAEPVRKRLSAIPGIEI---- 651 Query: 669 ADIVTQILNFGL---PAAIDVQFTGANMEANARLAAELTKQIRQIPGAVDAHVHQRLDGP 725 IL GL + + + G + ++A L + +++IPG V+ + Sbjct: 652 -----NILQNGLGGGESPVQLSILGDDRAVLEKIANGLVEDMKKIPGLVEVTSSTKDVTS 706 Query: 726 SLDLRMDRTRLQQFGLSASNVGQNLLIALSGSSQTQPAFWLNPNNGVVYSIAVQSP-QYQ 784 L +R+ G++ +++ L + G ++ W + + G Y I V+ P + + Sbjct: 707 ILSVRLKPAAASDLGIARADLAAALSALIGGEDVSK---WTDAH-GNSYDIVVRLPVERR 762 Query: 785 VDS--LDALLNIPVGAGANAATPPQLLGNLVDVHAGRQMAVASRYNISPAIDVYVSVQGT 842 D+ L L+ GAN A L + D+ A R++ I V ++ G Sbjct: 763 SDAARLGELMITTGRTGANGAPLMVRLDQVADIGTVAAPAEIRRFDNRREILVSANITGR 822 Query: 843 DLASVAGKVSELVEQIKP--KLARGSQVVIRGQVETMQSSFIGLGVGLAMAIVLVYLLVV 900 L G V+E ++ + L G ++ G+ ETMQ + +G L+MAI+ +Y+++ Sbjct: 823 TL----GDVTETLQGLTASRDLPAGYRIRFGGEAETMQETVGHMGTALSMAIIFIYIVLA 878 Query: 901 VNFQSWIDAAIIIAALPAALAGIAWMLFITGTTLSVPALTGAIMTMGVATANSILIVAFA 960 F S++ I+ +LP +L G+ L + G+T+++ +L G IM MG+ T N IL+V FA Sbjct: 879 SQFGSFLQPLAIMVSLPLSLIGVLLGLMVAGSTINMFSLIGFIMLMGLVTKNGILLVDFA 938 Query: 961 RQRREDGATPLAAALEAGSTRIRPVLMTALAMIIGMIPMALGLGEGAEQNAPLGRAVIGG 1020 + R G T A AG R RP++MT LAMI GMIP+ L +G G Q AP+ AV+GG Sbjct: 939 NRERRRGLTLNEALANAGVIRFRPIIMTTLAMIFGMIPLGLAVGGGGAQRAPMAHAVVGG 998 Query: 1021 LLLATVSTLFFVPVVFA---GVHQRLAR 1045 L+ +T+ TL VPV+ + + +R AR Sbjct: 999 LISSTLLTLIVVPVILSYIDSITRRFAR 1026