BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.4480.p (484 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value STM2130 [T] COG0642 Signal transduction histidine kinase Sty Sal... 365 e-100 ZbaeS [T] COG0642 Signal transduction histidine kinase EcZ Esche... 365 e-100 ECs2886 [T] COG0642 Signal transduction histidine kinase Ecs Esc... 365 e-100 baeS [T] COG0642 Signal transduction histidine kinase Eco Escher... 364 e-100 RSp1162 [T] COG0642 Signal transduction histidine kinase Rso Ral... 316 6e-86 >STM2130 [T] COG0642 Signal transduction histidine kinase Sty Salmonella typhimurium LT2 Length = 467 Score = 365 bits (938), Expect = e-100, Method: Compositional matrix adjust. Identities = 200/460 (43%), Positives = 286/460 (62%), Gaps = 6/460 (1%) Query: 16 YRANIRLKLFYAMLALIVAVIAAINGAGHYIFNRDFLGYLNEQAQQRMEDMVPRLEQAYR 75 +R I KLF A+ A + ++ +++ A F R F+ Y+ +QR++ + L Y+ Sbjct: 4 WRPGITGKLFLAIFATCIVLLISMHWAVRVSFERGFIDYIKHGNEQRLQMLGDALGDQYQ 63 Query: 76 EHGSWDFIRGNPRLWFELMKPAIVEHIGVTTRPMPPMTASDLTGAALRFSLLDARRQFVI 135 +HG+W F+R N R F++++ EH +P P M G +F ++D + ++ Sbjct: 64 QHGNWRFLRNNDRFVFQILRS--FEHDNDRDKPGPGMPPH---GWRTQFWVVDQNGRVLV 118 Query: 136 GYPNLGP-DARLRPLLQDDVIVGWVAQTPFESVIGAVDLRFQQSQFLAQLIIALVAVMLA 194 G P D RP+L +DV VG + +P E + D+ F Q A +I ++ +LA Sbjct: 119 GPRGPVPHDGTRRPILVNDVEVGAIIASPVERLTRNTDINFDMQQRRASWMIVALSTLLA 178 Query: 195 AFLVVRISGVLTRPLTRVARATHRLAGGDYAIRVEVESGDEVGMLAQDFNQLAMTLERNE 254 A ++ L P+ R+ THRLA GD+ RV S DE+G LAQDFNQLA TLE+N+ Sbjct: 179 ALATFLLARGLLAPVKRLVEGTHRLAAGDFTTRVTPTSADELGKLAQDFNQLASTLEKNQ 238 Query: 255 KLRREFMADVSHELRTPLGILNGQLEALEDGVLQPDAQTLRSLKSEVEHLNKLVGDLYDL 314 ++RR+FMAD+SHELRTPL +L G+LEA++DGV Q +++ SL++EV L KLV DL+ L Sbjct: 239 QMRRDFMADISHELRTPLAVLRGELEAIQDGVRQFTPESVTSLQAEVGTLTKLVDDLHQL 298 Query: 315 SLADAGALTYRHADIDLTPLLQDSAATYAERFNQRGMSLTTALPAAMLVHADGARLQQLF 374 SL+D GAL Y+ +DL PLL+ + + ERF RG++L ALP +M V D RL QLF Sbjct: 299 SLSDEGALAYQKTTVDLVPLLEVAGGAFRERFTSRGLTLHYALPDSMTVFGDPDRLMQLF 358 Query: 375 NNLFENSLRYTDTGGRLQVHAQLQQQQWHLFFDDSEPGVPPEVMARLFERFFRVETSRNR 434 NNL ENSLRYTD+GG L + A+ + + L F DS PGV E + +LF+RF+R E SRNR Sbjct: 359 NNLLENSLRYTDSGGGLHISAEQRDKSLFLTFADSAPGVSDEQLQKLFDRFYRTEVSRNR 418 Query: 435 ASGGAGLGLAICRRIIDAHQGTIGASDSPLGGLRVSVILP 474 ASGG+GLGLAIC I+ AH G + A+ SP GG+ ++V LP Sbjct: 419 ASGGSGLGLAICVNIVHAHNGHLHAAHSPFGGVSITVELP 458 >ZbaeS [T] COG0642 Signal transduction histidine kinase EcZ Escherichia coli O157:H7 EDL933 Length = 467 Score = 365 bits (936), Expect = e-100, Method: Compositional matrix adjust. Identities = 199/465 (42%), Positives = 288/465 (61%), Gaps = 6/465 (1%) Query: 15 FYRANIRLKLFYAMLALIVAVIAAINGAGHYIFNRDFLGYLNEQAQQRMEDMVPRLEQAY 74 F+R I KLF A+ A + ++ +++ A F R F+ Y+ +QR++ + L + Y Sbjct: 3 FWRPGITGKLFLAIFATCIVLLISMHWAVRISFERGFIDYIKHGNEQRLQLLSDALGEQY 62 Query: 75 REHGSWDFIRGNPRLWFELMKPAIVEHIGVTTRPMPPMTASDLTGAALRFSLLDARRQFV 134 +HG+W F+R N R F++++ EH +P P M G +F ++D + + Sbjct: 63 AQHGNWRFLRNNDRFVFQILRS--FEHDNSEDKPGPGMPPH---GWRTQFWVVDQNNKVL 117 Query: 135 IG-YPNLGPDARLRPLLQDDVIVGWVAQTPFESVIGAVDLRFQQSQFLAQLIIALVAVML 193 +G + PD RP+L + VG V +P E + D+ F + Q +I +A +L Sbjct: 118 VGPRAPIPPDGTRRPILVNGAEVGAVIASPVERLTRNTDINFDKQQRQTSWLIVALATLL 177 Query: 194 AAFLVVRISGVLTRPLTRVARATHRLAGGDYAIRVEVESGDEVGMLAQDFNQLAMTLERN 253 AA ++ L P+ R+ TH+LA GD+ RV S DE+G LAQDFNQLA TLE+N Sbjct: 178 AALATFLLARGLLAPVKRLVDGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLASTLEKN 237 Query: 254 EKLRREFMADVSHELRTPLGILNGQLEALEDGVLQPDAQTLRSLKSEVEHLNKLVGDLYD 313 +++RR+FMAD+SHELRTPL +L G+LEA++DGV + +T+ SL++EV L KLV DL+ Sbjct: 238 QQMRRDFMADISHELRTPLAVLRGELEAIQDGVRKFTPETVASLQAEVGTLTKLVDDLHQ 297 Query: 314 LSLADAGALTYRHADIDLTPLLQDSAATYAERFNQRGMSLTTALPAAMLVHADGARLQQL 373 LS++D GAL Y+ A +DL PLL+ + + ERF RG+ L +LP ++ V D RL QL Sbjct: 298 LSMSDEGALAYQKAPVDLIPLLEVAGGAFRERFASRGLKLQFSLPDSITVFGDRDRLMQL 357 Query: 374 FNNLFENSLRYTDTGGRLQVHAQLQQQQWHLFFDDSEPGVPPEVMARLFERFFRVETSRN 433 FNNL ENSLRYTD+GG L++ A+ + L F DS PGV + + +LFERF+R E SRN Sbjct: 358 FNNLLENSLRYTDSGGSLKISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRN 417 Query: 434 RASGGAGLGLAICRRIIDAHQGTIGASDSPLGGLRVSVILPARLD 478 RASGG+GLGLAIC I++AH G I A+ SP GG+ ++V LP D Sbjct: 418 RASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERD 462 >ECs2886 [T] COG0642 Signal transduction histidine kinase Ecs Escherichia coli O157:H7 Length = 467 Score = 365 bits (936), Expect = e-100, Method: Compositional matrix adjust. Identities = 199/465 (42%), Positives = 288/465 (61%), Gaps = 6/465 (1%) Query: 15 FYRANIRLKLFYAMLALIVAVIAAINGAGHYIFNRDFLGYLNEQAQQRMEDMVPRLEQAY 74 F+R I KLF A+ A + ++ +++ A F R F+ Y+ +QR++ + L + Y Sbjct: 3 FWRPGITGKLFLAIFATCIVLLISMHWAVRISFERGFIDYIKHGNEQRLQLLSDALGEQY 62 Query: 75 REHGSWDFIRGNPRLWFELMKPAIVEHIGVTTRPMPPMTASDLTGAALRFSLLDARRQFV 134 +HG+W F+R N R F++++ EH +P P M G +F ++D + + Sbjct: 63 AQHGNWRFLRNNDRFVFQILRS--FEHDNSEDKPGPGMPPH---GWRTQFWVVDQNNKVL 117 Query: 135 IG-YPNLGPDARLRPLLQDDVIVGWVAQTPFESVIGAVDLRFQQSQFLAQLIIALVAVML 193 +G + PD RP+L + VG V +P E + D+ F + Q +I +A +L Sbjct: 118 VGPRAPIPPDGTRRPILVNGAEVGAVIASPVERLTRNTDINFDKQQRQTSWLIVALATLL 177 Query: 194 AAFLVVRISGVLTRPLTRVARATHRLAGGDYAIRVEVESGDEVGMLAQDFNQLAMTLERN 253 AA ++ L P+ R+ TH+LA GD+ RV S DE+G LAQDFNQLA TLE+N Sbjct: 178 AALATFLLARGLLAPVKRLVDGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLASTLEKN 237 Query: 254 EKLRREFMADVSHELRTPLGILNGQLEALEDGVLQPDAQTLRSLKSEVEHLNKLVGDLYD 313 +++RR+FMAD+SHELRTPL +L G+LEA++DGV + +T+ SL++EV L KLV DL+ Sbjct: 238 QQMRRDFMADISHELRTPLAVLRGELEAIQDGVRKFTPETVASLQAEVGTLTKLVDDLHQ 297 Query: 314 LSLADAGALTYRHADIDLTPLLQDSAATYAERFNQRGMSLTTALPAAMLVHADGARLQQL 373 LS++D GAL Y+ A +DL PLL+ + + ERF RG+ L +LP ++ V D RL QL Sbjct: 298 LSMSDEGALAYQKAPVDLIPLLEVAGGAFRERFASRGLKLQFSLPDSITVFGDRDRLMQL 357 Query: 374 FNNLFENSLRYTDTGGRLQVHAQLQQQQWHLFFDDSEPGVPPEVMARLFERFFRVETSRN 433 FNNL ENSLRYTD+GG L++ A+ + L F DS PGV + + +LFERF+R E SRN Sbjct: 358 FNNLLENSLRYTDSGGSLKISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRN 417 Query: 434 RASGGAGLGLAICRRIIDAHQGTIGASDSPLGGLRVSVILPARLD 478 RASGG+GLGLAIC I++AH G I A+ SP GG+ ++V LP D Sbjct: 418 RASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERD 462 >baeS [T] COG0642 Signal transduction histidine kinase Eco Escherichia coli K12 Length = 467 Score = 364 bits (935), Expect = e-100, Method: Compositional matrix adjust. Identities = 200/465 (43%), Positives = 288/465 (61%), Gaps = 6/465 (1%) Query: 15 FYRANIRLKLFYAMLALIVAVIAAINGAGHYIFNRDFLGYLNEQAQQRMEDMVPRLEQAY 74 F+R I KLF A+ A + ++ +++ A F R F+ Y+ +QR++ + L + Y Sbjct: 3 FWRPGITGKLFLAIFATCIVLLISMHWAVRISFERGFIDYIKHGNEQRLQLLSDALGEQY 62 Query: 75 REHGSWDFIRGNPRLWFELMKPAIVEHIGVTTRPMPPMTASDLTGAALRFSLLDARRQFV 134 +HG+W F+R N R F++++ EH +P P M G +F ++D + + Sbjct: 63 AQHGNWRFLRNNDRFVFQILRS--FEHDNSEDKPGPGMPPH---GWRTQFWVVDQNNKVL 117 Query: 135 IG-YPNLGPDARLRPLLQDDVIVGWVAQTPFESVIGAVDLRFQQSQFLAQLIIALVAVML 193 +G + PD RP+L + VG V +P E + D+ F + Q +I +A +L Sbjct: 118 VGPRAPIPPDGTRRPILVNGAEVGAVIASPVERLTRNTDINFDKQQRQTSWLIVALATLL 177 Query: 194 AAFLVVRISGVLTRPLTRVARATHRLAGGDYAIRVEVESGDEVGMLAQDFNQLAMTLERN 253 AA ++ L P+ R+ TH+LA GD+ RV S DE+G LAQDFNQLA TLE+N Sbjct: 178 AALATFLLARGLLAPVKRLVDGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLASTLEKN 237 Query: 254 EKLRREFMADVSHELRTPLGILNGQLEALEDGVLQPDAQTLRSLKSEVEHLNKLVGDLYD 313 +++RR+FMAD+SHELRTPL +L G+LEA++DGV + +T+ SL++EV L KLV DL+ Sbjct: 238 QQMRRDFMADISHELRTPLAVLRGELEAIQDGVRKFTPETVASLQAEVGTLTKLVDDLHQ 297 Query: 314 LSLADAGALTYRHADIDLTPLLQDSAATYAERFNQRGMSLTTALPAAMLVHADGARLQQL 373 LS++D GAL Y+ A +DL PLL+ + + ERF RG+ L +LP ++ V D RL QL Sbjct: 298 LSMSDEGALAYQKAPVDLIPLLEVAGGAFRERFASRGLKLQFSLPDSITVFGDRDRLMQL 357 Query: 374 FNNLFENSLRYTDTGGRLQVHAQLQQQQWHLFFDDSEPGVPPEVMARLFERFFRVETSRN 433 FNNL ENSLRYTD+GG LQ+ A + + L F DS PGV + + +LFERF+R E SRN Sbjct: 358 FNNLLENSLRYTDSGGSLQISAGQRDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRN 417 Query: 434 RASGGAGLGLAICRRIIDAHQGTIGASDSPLGGLRVSVILPARLD 478 RASGG+GLGLAIC I++AH G I A+ SP GG+ ++V LP D Sbjct: 418 RASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERD 462 >RSp1162 [T] COG0642 Signal transduction histidine kinase Rso Ralstonia solanacearum Length = 512 Score = 316 bits (810), Expect = 6e-86, Method: Compositional matrix adjust. Identities = 197/498 (39%), Positives = 269/498 (54%), Gaps = 44/498 (8%) Query: 19 NIRLKLFYAMLALIVAVIAAINGAGHYIFNRDFLGYLNEQAQQRMEDMVPRLEQAYREHG 78 I KLF A+ AL + V A+ A + F+ +FL Y+N + +RM +E Y EHG Sbjct: 6 GITSKLFVALFALSMVVALAMGAAVRWRFDTNFLDYVNAREAERMAVFAQSIESVYAEHG 65 Query: 79 SWDFIRGNPRLWFELMKPAIVE-HIGVTTRP----------------------------- 108 +W +R + + W+ L++ I H G P Sbjct: 66 NWGVLRNDRQAWYRLIRREIGRTHAGPFGGPRGDAEPVPPFAPPPGDVPPPGLPPPPPDA 125 Query: 109 ------MPPMTASDLTGAALRFSLLDARR-QFVIGYPNLGPDARLRPLLQDDVIVGWVAQ 161 PP + G LLDA R V P GP ++ L + VGW+A Sbjct: 126 GDRPPQHPP---GEGPGMHPPIWLLDAGRVPIVGDGPPPGPGSQWHALHHNGQTVGWLAT 182 Query: 162 TPFESVIGAVDLRFQQSQFLAQLIIALVAVMLAAFLVVRISGVLTRPLTRVARATHRLAG 221 V D F Q A IIA ++V+LAA + + ++ + P+ R+A AT R+A Sbjct: 183 PQRMHVPEGADQAFLAQQLRATWIIAALSVLLAAGVAILLARGVLAPMRRLAHATRRMAE 242 Query: 222 GDYAIRVEVESGDEVGMLAQDFNQLAMTLERNEKLRREFMADVSHELRTPLGILNGQLEA 281 GDYA RV+V SGDE+G LA DFN+LA TLE N+K+RR+ AD+SHELRTPL +L G+LEA Sbjct: 243 GDYAARVDVHSGDEIGHLADDFNRLAETLEANQKMRRQLTADISHELRTPLAVLRGELEA 302 Query: 282 LEDGVLQPDAQTLRSLKSEVEHLNKLVGDLYDLSLADAGALTYRHADIDLTPLLQDSAAT 341 LEDGV +L SL++EV L+KL+ DLY+LSLAD GAL + IDL + +A Sbjct: 303 LEDGVRALTPASLTSLQAEVGTLSKLIDDLYELSLADVGALAFHMESIDLADTVCSAAQG 362 Query: 342 YAERFNQRGMSLTTALPAA----MLVHADGARLQQLFNNLFENSLRYTDTGGRLQVHAQL 397 + R + ++L LP + D RL+QL NL EN+LRYTD GG L++H Sbjct: 363 FTPRLMDKRIALQLDLPTGPSRDAAIQGDPQRLRQLMQNLLENTLRYTDAGGTLRIHVHR 422 Query: 398 QQQQWHLFFDDSEPGVPPEVMARLFERFFRVETSRNRASGGAGLGLAICRRIIDAHQGTI 457 W L DS PGVP ++ R+F+R FR + SR RA GGAGLGL++C+ I+ H GTI Sbjct: 423 AGAWWCLDVQDSAPGVPEAMLPRVFDRLFRADPSRGRAQGGAGLGLSLCQTIVQTHGGTI 482 Query: 458 GASDSPLGGLRVSVILPA 475 A SPLGGL +++ LPA Sbjct: 483 DARPSPLGGLWIAIRLPA 500