BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.4478.p (1051 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value CC0807 [V] COG0841 Cation/multidrug efflux pump Ccr Caulobacter ... 1268 0.0 YPO3043 [V] COG0841 Cation/multidrug efflux pump Ype Yersinia pe... 1266 0.0 STM3391 [V] COG0841 Cation/multidrug efflux pump Sty Salmonella ... 1264 0.0 STM2481 [V] COG0841 Cation/multidrug efflux pump Sty Salmonella ... 1262 0.0 acrF [V] COG0841 Cation/multidrug efflux pump Eco Escherichia co... 1260 0.0 >CC0807 [V] COG0841 Cation/multidrug efflux pump Ccr Caulobacter vibrioides Length = 1051 Score = 1268 bits (3282), Expect = 0.0, Method: Compositional matrix adjust. Identities = 635/1018 (62%), Positives = 794/1018 (77%), Gaps = 4/1018 (0%) Query: 1 MARFFIDRPIFAWVMAIIIMLGGMMSIRSLSLEQYPNIAPPQVNIKATYTGASAKTLEDS 60 ++RFFIDRPIFAWV+AI+IML G ++IR+L + QYP IA PQV+I A Y GASAKT+EDS Sbjct: 2 LSRFFIDRPIFAWVIAIVIMLAGALAIRTLPIAQYPEIALPQVSISANYPGASAKTVEDS 61 Query: 61 VTQIIEQQMKGLDNLQYMSASSSSAGSSTVTLTFTAGTNPDVAQMQVQNKLQQVTARLPQ 120 VTQ+IEQ+MKGLD L YMS++S +GS+TVTLTF AGT+ D+AQ+QVQNKLQ TA LPQ Sbjct: 62 VTQVIEQKMKGLDGLDYMSSTSDGSGSATVTLTFKAGTDIDIAQVQVQNKLQTATALLPQ 121 Query: 121 AVQNNGVTVTKASTDILMVLSLSSDDPRITSIDIGDFINSSLTDQISRVPGVGDVTAFGT 180 VQ G+TV K++ + +MV+ L S+DP+ T D+ D++ S+L D +SRV GVGD+ FG+ Sbjct: 122 EVQQQGLTVAKSARNFMMVIGLYSEDPKTTGADLADYMASNLQDPLSRVDGVGDIQLFGS 181 Query: 181 NYAMRIWLDPAKLQKYALMPSDITSALEAQNTEVSAGEIGALPAQPGQQINATITARSKL 240 YAMRIWLDP KL ++L P+D+ +A+ AQN +VSAG+IG P PG +NATITA+S+L Sbjct: 182 QYAMRIWLDPQKLASFSLTPADVAAAIRAQNAQVSAGQIGGTPNLPGTGLNATITAQSRL 241 Query: 241 TTAEEFRNIVVKSSSDGSVVKMSDVARVELGGESYQTASRQDGKPSSALAIQLATGANAL 300 T E+FR I+VK++S G+ V++SDVARVELG ESY + ++ +G ++ +AI+LA GANAL Sbjct: 242 QTPEQFRQIIVKNTSGGATVRLSDVARVELGAESYASIAKFNGYQAAGMAIKLAPGANAL 301 Query: 301 STADAVKKKMAELEPYFPASMKLKTHIAYDTTPFVRVSLEEVVKTLLEAIVLVVLIMYLF 360 TA AV +MA+LE FPA+ K I YD+TPFV++S+EEVVKTL+EAI+LV ++M+LF Sbjct: 302 DTAAAVNARMAQLEKNFPANYKYV--IPYDSTPFVKLSIEEVVKTLVEAIILVFIVMFLF 359 Query: 361 LQNIRATFIPAITVPVVLLGTFGILAMFGYSINTLTMFGMVLAIGLLVDDAIVVVENVER 420 LQN RAT IP I VPVVLLGTFG+LA FGYSINTLTMFG+VLAIGLLVDDAIVVVENVER Sbjct: 360 LQNWRATLIPTIAVPVVLLGTFGVLAAFGYSINTLTMFGLVLAIGLLVDDAIVVVENVER 419 Query: 421 LMSEEKLSPKEATRKSMQEITGALVGIAMVLSAVFIPMAFFGGSTGVIYRQFSITIVSAM 480 +MSEE LSPKEATRKSM EITGAL+GIA+VL+AVF+PMAFFGGS GVIYRQFSITIVSAM Sbjct: 420 VMSEEGLSPKEATRKSMNEITGALIGIALVLAAVFVPMAFFGGSQGVIYRQFSITIVSAM 479 Query: 481 ALSVTVALTLTPALCASLLKPHPGGHVPHGK-FFTWFNRSFDRNATRYRGGVGGLLKRGK 539 ALSV VAL LTPAL A++LKP GH FF WFNRSF+ ++RY+G V +L + Sbjct: 480 ALSVVVALVLTPALTATMLKPVKAGHHEEKTGFFGWFNRSFNDMSSRYQGSVRKILGKRG 539 Query: 540 RGLLMYALIAVAMAVLFMRLPTSFLPEEDQGVLMAQIQLPTGATAEQTATVVKTVQDYFL 599 R + +YA I VAM +LF+RLP++FLPEEDQG + +QLP GAT E+T V+ V+D+FL Sbjct: 540 RWMAIYAAIIVAMGLLFVRLPSAFLPEEDQGTMFTLVQLPAGATEEKTLAVLDQVRDHFL 599 Query: 600 -NKPESVESVLAIVGSGVGGNSQNSARAFIRLKQWDERTAADQSALALVRRANADLSKIR 658 + E+V+SV + G G QN+ AF+RLK ++ R +A+ A A+ RA S+ R Sbjct: 600 VGEKEAVQSVFTVSGFSFAGAGQNAGLAFVRLKDFEHRKSANLKAQAVAGRAMGAFSQFR 659 Query: 659 GARVFLMNPPVVRGLGQSSGFDFELKDVGGVGHDALLKARDQFLRAARSSAVLANVRTTG 718 A VF + PP V+ LG SSGFDF+L+DVGGVGH+AL+ AR+ L A L VR G Sbjct: 660 DAMVFAIVPPAVQELGNSSGFDFQLQDVGGVGHEALMNARNMMLGMASQDPSLVGVRPNG 719 Query: 719 LDDTPQLRVAIDDRKADALSVATSDINSSLATVMGGTYVNDFLSNGRVKKVYVQGDAPFR 778 DDTPQL++ +D KA AL + T+DINS+L+ GG+YVNDF+ GRVKKVY+Q DAPFR Sbjct: 720 QDDTPQLKIEVDQAKAGALGLTTADINSALSAAWGGSYVNDFIDRGRVKKVYMQADAPFR 779 Query: 779 MQAEDLNRWYVRNSASQMVPFSAFMTSKWSYGPSLLERYNGVSSFEIVGEPAAGVSSGTA 838 M EDLNRWYVRN+ QMV F AF T+ W+YG LERYNG+SS I G PA G SSG A Sbjct: 780 MTPEDLNRWYVRNNQGQMVAFPAFATASWTYGSPRLERYNGLSSVNIQGAPAPGKSSGDA 839 Query: 839 MAEVEKLAAQLPAGIGFEWTGSSYQERLSGNQAPMLYAISILFVFLCLAALYESWSVPFA 898 +A +EK+AA+LP G+G+EWTG S QE +GNQAP LYAISIL VFL LAALYESWS+P A Sbjct: 840 IAAMEKIAAKLPPGVGYEWTGLSAQELEAGNQAPALYAISILVVFLLLAALYESWSIPLA 899 Query: 899 VILAVPLGIIGTVLLTGIFGMSNDVYFQVGLLTTVGLSAKNAILIVEFAKQLHESGKSLW 958 VI+ +PLG+IG +L T G+SND+YFQVGLLTT+GL+AKNAILIVEFAK L+E G L Sbjct: 900 VIMVIPLGVIGALLATFARGLSNDIYFQVGLLTTMGLAAKNAILIVEFAKDLYEKGMGLI 959 Query: 959 DATLEAVQLRLRPILMTSLAFVFGVLPLAVATGAGSASRRAIGTGVMGGMLSATMLGI 1016 +ATLEAV+LRLRPI+MTSLAFVFGVLPLA++ GAGS ++ AIGTGV+GGM+SAT+L I Sbjct: 960 EATLEAVRLRLRPIIMTSLAFVFGVLPLAISNGAGSGAQHAIGTGVIGGMISATLLAI 1017 >YPO3043 [V] COG0841 Cation/multidrug efflux pump Ype Yersinia pestis Length = 1043 Score = 1266 bits (3276), Expect = 0.0, Method: Compositional matrix adjust. Identities = 640/1028 (62%), Positives = 794/1028 (77%), Gaps = 4/1028 (0%) Query: 1 MARFFIDRPIFAWVMAIIIMLGGMMSIRSLSLEQYPNIAPPQVNIKATYTGASAKTLEDS 60 MA FFIDRPIFAWV+AII+ L G ++I +L +EQYPN+APP V I A+Y GASA+TLE++ Sbjct: 1 MANFFIDRPIFAWVLAIILCLTGALAISTLPVEQYPNLAPPNVRISASYPGASAQTLENT 60 Query: 61 VTQIIEQQMKGLDNLQYMSASSSSAGSSTVTLTFTAGTNPDVAQMQVQNKLQQVTARLPQ 120 VTQ+IEQ M GLDNL YMS+ SS++GS++VTLTF AGTNP+ A QVQN+LQ RLPQ Sbjct: 61 VTQVIEQSMTGLDNLLYMSSQSSNSGSASVTLTFQAGTNPNEAMQQVQNQLQSAIKRLPQ 120 Query: 121 AVQNNGVTVTKASTDILMVLSLSSDDPRITSIDIGDFINSSLTDQISRVPGVGDVTAFGT 180 VQ GV+V+K+ + LM+++ S D + DI D++ S+L D +SR+ GVG V AFG+ Sbjct: 121 DVQQQGVSVSKSGDNTLMMVAFVSTDGSMDKQDISDYVASNLQDPLSRIEGVGSVDAFGS 180 Query: 181 NYAMRIWLDPAKLQKYALMPSDITSALEAQNTEVSAGEIGALPAQPGQQINATITARSKL 240 YAMRIWLDP KL Y L SDI SA+++QNT+V+ G++G PA Q +NATI A+S+L Sbjct: 181 QYAMRIWLDPNKLTNYQLTTSDIVSAIQSQNTQVAVGQLGGTPAVDNQALNATINAQSQL 240 Query: 241 TTAEEFRNIVVKSSSDGSVVKMSDVARVELGGESYQTASRQDGKPSSALAIQLATGANAL 300 T EEFR I ++ + DGS+V + DVA++ELG E Y SR +G+ +S + I+LA+GAN L Sbjct: 241 QTPEEFREITLRVNQDGSLVTLGDVAKIELGSEKYDYLSRFNGQAASGMGIKLASGANEL 300 Query: 301 STADAVKKKMAELEPYFPASMKLKTHIAYDTTPFVRVSLEEVVKTLLEAIVLVVLIMYLF 360 T VK ++AEL P+FP ++ K IAY+TTPFV+ S+++VVKTLLEAI+LV L+MYLF Sbjct: 301 QTDKRVKARLAELAPFFPHGLEAK--IAYETTPFVQASIKDVVKTLLEAILLVFLVMYLF 358 Query: 361 LQNIRATFIPAITVPVVLLGTFGILAMFGYSINTLTMFGMVLAIGLLVDDAIVVVENVER 420 LQN RAT IP + VPVVLLGTF +L+ FG+SINTLTMF +VLAIGLLVDDAIVVVENVER Sbjct: 359 LQNFRATLIPTVAVPVVLLGTFAVLSAFGFSINTLTMFAIVLAIGLLVDDAIVVVENVER 418 Query: 421 LMSEEKLSPKEATRKSMQEITGALVGIAMVLSAVFIPMAFFGGSTGVIYRQFSITIVSAM 480 +MSEE L P+EATRKSM +I GAL+GIA+VLSAVFIPMAFFGG+TG IYRQFSITIVSAM Sbjct: 419 VMSEEGLDPREATRKSMGQIQGALIGIALVLSAVFIPMAFFGGTTGAIYRQFSITIVSAM 478 Query: 481 ALSVTVALTLTPALCASLLKP-HPGGHVPHGKFFTWFNRSFDRNATRYRGGVGGLLKRGK 539 LSV VAL LTPA+CA+LLKP PG H FF WFNR FDRN+ RY GV +L Sbjct: 479 VLSVLVALILTPAMCATLLKPIAPGHHHAKRGFFGWFNRMFDRNSHRYERGVARVLHHSL 538 Query: 540 RGLLMYALIAVAMAVLFMRLPTSFLPEEDQGVLMAQIQLPTGATAEQTATVVKTVQDYFL 599 R +L+Y L+ +A+LF++LPTSFLP ED+GV MAQ+QLP G+T +QT VV+ V++YFL Sbjct: 539 RYMLLYLLLLGGLALLFLKLPTSFLPLEDRGVFMAQVQLPVGSTQQQTLKVVEKVENYFL 598 Query: 600 NKPES-VESVLAIVGSGVGGNSQNSARAFIRLKQWDERTAADQSALALVRRANADLSKIR 658 + ++ V SV A VGSG GGN QN AR FIRL WD+RTA+ S+ A++ RA +LSKI Sbjct: 599 TEEKNNVLSVFATVGSGPGGNGQNVARLFIRLADWDQRTASTDSSFAIIERATKELSKIV 658 Query: 659 GARVFLMNPPVVRGLGQSSGFDFELKDVGGVGHDALLKARDQFLRAARSSAVLANVRTTG 718 A+V + +PP + GLG SSGFD EL+D GG GHD L+ AR+Q L+ A L VR G Sbjct: 659 EAKVSVSSPPAISGLGGSSGFDMELQDHGGHGHDKLMVARNQLLQMASQEPALTRVRHNG 718 Query: 719 LDDTPQLRVAIDDRKADALSVATSDINSSLATVMGGTYVNDFLSNGRVKKVYVQGDAPFR 778 LDD+PQL++ ID RKA AL V+ +DINS+L T G TYVNDF+ GRVKKVYVQ +A R Sbjct: 719 LDDSPQLQIDIDQRKAQALGVSLNDINSTLKTAWGSTYVNDFVDRGRVKKVYVQSEATAR 778 Query: 779 MQAEDLNRWYVRNSASQMVPFSAFMTSKWSYGPSLLERYNGVSSFEIVGEPAAGVSSGTA 838 M ED+N+WYVRN MVPFSAF T++W YG LERYNG S+ EIVGE A+GVS+GTA Sbjct: 779 MLPEDVNKWYVRNKNGGMVPFSAFSTTRWEYGSPRLERYNGYSALEIVGEAASGVSTGTA 838 Query: 839 MAEVEKLAAQLPAGIGFEWTGSSYQERLSGNQAPMLYAISILFVFLCLAALYESWSVPFA 898 M +EKL +QLP G G EWTG SYQERLSG+QAP LYAIS+L VFLCLAALYESWS+PF+ Sbjct: 839 MDVMEKLVSQLPNGFGLEWTGMSYQERLSGSQAPALYAISLLVVFLCLAALYESWSIPFS 898 Query: 899 VILAVPLGIIGTVLLTGIFGMSNDVYFQVGLLTTVGLSAKNAILIVEFAKQLHESGKSLW 958 V+L VPLG+IG V T + G+ NDVYFQVGLLT +GLSAKNAILIVEFA +L+ GK L Sbjct: 899 VMLVVPLGVIGAVAATWMRGLENDVYFQVGLLTIIGLSAKNAILIVEFANELNNRGKDLV 958 Query: 959 DATLEAVQLRLRPILMTSLAFVFGVLPLAVATGAGSASRRAIGTGVMGGMLSATMLGIFF 1018 +ATLEA + RLRPILMTSLAF+FGVLP+A++ GAGS S+ A+GTGVMGGM+SAT+L IFF Sbjct: 959 EATLEASRQRLRPILMTSLAFIFGVLPMAISQGAGSGSQHAVGTGVMGGMISATVLAIFF 1018 Query: 1019 VPLFYYLI 1026 VPLF+ L+ Sbjct: 1019 VPLFFVLV 1026 Score = 33.1 bits (74), Expect = 3.6, Method: Compositional matrix adjust. Identities = 68/337 (20%), Positives = 136/337 (40%), Gaps = 35/337 (10%) Query: 184 MRIWLDPAKLQKYALMPSDITSALEAQ------NTEVSAGEIGALPAQPGQQINATITAR 237 ++I +D K Q + +DI S L+ N V G + + Q + TAR Sbjct: 725 LQIDIDQRKAQALGVSLNDINSTLKTAWGSTYVNDFVDRGRVKKVYVQ------SEATAR 778 Query: 238 SKLTTAEEFRNIVVKSSSDGSV-VKMSDVARVELGGESYQTASRQDGKPSSALAIQLATG 296 E+ V++ + G V R E G + R +G + + + A+G Sbjct: 779 ---MLPEDVNKWYVRNKNGGMVPFSAFSTTRWEYGSPRLE---RYNGYSALEIVGEAASG 832 Query: 297 ANALSTADAVKKKMAELEPYFPASMKLK-THIAYDTTPFVRVSLEEVVKTLLEAIVLVVL 355 + + D ++K +++L P L+ T ++Y R+S + ++++V L Sbjct: 833 VSTGTAMDVMEKLVSQL----PNGFGLEWTGMSYQE----RLSGSQAPALYAISLLVVFL 884 Query: 356 IMYLFLQNIRATFIPAITVPVVLLGTFGILAMFGYSINTLTMFGMVLAIGLLVDDAIVVV 415 + ++ F + VP+ ++G M G + G++ IGL +AI++V Sbjct: 885 CLAALYESWSIPFSVMLVVPLGVIGAVAATWMRGLENDVYFQVGLLTIIGLSAKNAILIV 944 Query: 416 ENVERLMSEEK---LSPKEATRKSMQEITGALVGIAMVLSAVFIPMAFFGGSTGVIYRQF 472 E L + K + EA+R+ ++ I + +A + +PMA G+ Sbjct: 945 EFANELNNRGKDLVEATLEASRQRLRPIL--MTSLAFIFGV--LPMAISQGAGSGSQHAV 1000 Query: 473 SITIVSAMALSVTVALTLTPALCASLLKPHPGGHVPH 509 ++ M + +A+ P + + PG +P+ Sbjct: 1001 GTGVMGGMISATVLAIFFVPLFFVLVRRRFPGRIIPN 1037 >STM3391 [V] COG0841 Cation/multidrug efflux pump Sty Salmonella typhimurium LT2 Length = 1037 Score = 1264 bits (3272), Expect = 0.0, Method: Compositional matrix adjust. Identities = 622/1022 (60%), Positives = 772/1022 (75%), Gaps = 10/1022 (0%) Query: 1 MARFFIDRPIFAWVMAIIIMLGGMMSIRSLSLEQYPNIAPPQVNIKATYTGASAKTLEDS 60 MA FFI RPIFAWV+AII+M+ G ++I L + QYP IAPP V+I ATY GA A+T++D+ Sbjct: 1 MANFFIRRPIFAWVLAIILMMAGALAIMQLPVAQYPTIAPPAVSISATYPGADAQTVQDT 60 Query: 61 VTQIIEQQMKGLDNLQYMSASSSSAGSSTVTLTFTAGTNPDVAQMQVQNKLQQVTARLPQ 120 VTQ+IEQ M G+DNL YMS++S SAGS T+TLTF +GT+PD+AQ+QVQNKLQ T LPQ Sbjct: 61 VTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQ 120 Query: 121 AVQNNGVTVTKASTDILMVLSLSSDDPRITSIDIGDFINSSLTDQISRVPGVGDVTAFGT 180 VQ G++V K+S+ LMV SD+P T DI D++ S++ D ISR+ GVGDV FG Sbjct: 121 EVQQQGISVEKSSSSFLMVAGFVSDNPNTTQDDISDYVASNIKDSISRLNGVGDVQLFGA 180 Query: 181 NYAMRIWLDPAKLQKYALMPSDITSALEAQNTEVSAGEIGALPAQPGQQINATITARSKL 240 YAMRIWLD L KY L P D+ + L+ QN +++AG++G PA PGQQ+NA+I A+++L Sbjct: 181 QYAMRIWLDANLLNKYQLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTRL 240 Query: 241 TTAEEFRNIVVKSSSDGSVVKMSDVARVELGGESYQTASRQDGKPSSALAIQLATGANAL 300 EEF + ++ ++DGSVV + DVAR+ELGGE+Y +R +GKP+S L I+LATGANAL Sbjct: 241 KDPEEFGKVTLRVNTDGSVVHLKDVARIELGGENYNVVARINGKPASGLGIKLATGANAL 300 Query: 301 STADAVKKKMAELEPYFPASMKLKTHIAYDTTPFVRVSLEEVVKTLLEAIVLVVLIMYLF 360 TA A+K K+AEL+P+FP MK+ YDTTPFV++S+ EVVKTL EAI+LV L+MYLF Sbjct: 301 DTATAIKVKLAELQPFFPQGMKVV--YPYDTTPFVKISIHEVVKTLFEAIILVFLVMYLF 358 Query: 361 LQNIRATFIPAITVPVVLLGTFGILAMFGYSINTLTMFGMVLAIGLLVDDAIVVVENVER 420 LQNIRAT IP I VPVVLLGTF +LA FGYSINTLTMFGMVLAIGLLVDDAIVVVENVER Sbjct: 359 LQNIRATLIPTIAVPVVLLGTFAVLAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVER 418 Query: 421 LMSEEKLSPKEATRKSMQEITGALVGIAMVLSAVFIPMAFFGGSTGVIYRQFSITIVSAM 480 +M E+ LSP+EAT KSM +I GALVGIAMVLSAVFIPMAFFGGSTG IYRQFSITIVSAM Sbjct: 419 VMMEDNLSPREATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAM 478 Query: 481 ALSVTVALTLTPALCASLLKPHPGGHVPHGK---FFTWFNRSFDRNATRYRGGVGGLLKR 537 ALSV VAL LTPALCA+LLKP H H K FF WFN FD + Y V G+++ Sbjct: 479 ALSVLVALILTPALCATLLKPVSAEH--HEKKSGFFGWFNTRFDHSVNHYTNSVSGIVRN 536 Query: 538 GKRGLLMYALIAVAMAVLFMRLPTSFLPEEDQGVLMAQIQLPTGATAEQTATVVKTVQDY 597 R L++Y LI V MAVLF+RLPTSFLPEEDQGV + IQLP+GAT E+T V+ V Y Sbjct: 537 TGRYLIIYLLIVVGMAVLFLRLPTSFLPEEDQGVFLTMIQLPSGATQERTQKVLDQVTHY 596 Query: 598 FLNKPE-SVESVLAIVGSGVGGNSQNSARAFIRLKQWDERTAADQSALALVRRANADLSK 656 +LN + +VESV + G G QNS AF+ LK W+ER + S A++ RA S+ Sbjct: 597 YLNNEKANVESVFTVNGFSFSGQGQNSGMAFVSLKPWEERNGEENSVEAVIARATRAFSQ 656 Query: 657 IRGARVFLMNPPVVRGLGQSSGFDFELKDVGGVGHDALLKARDQFL-RAARSSAVLANVR 715 IR VF N P + LG ++GFDFEL D GG+GHDAL KAR+Q L A+ +L VR Sbjct: 657 IRDGLVFPFNMPAIVELGTATGFDFELIDQGGLGHDALTKARNQLLGMVAKHPDLLVRVR 716 Query: 716 TTGLDDTPQLRVAIDDRKADALSVATSDINSSLATVMGGTYVNDFLSNGRVKKVYVQGDA 775 GL+DTPQ ++ +D KA AL V+ SDIN +++ +GG YVNDF+ GRVKKVYVQ DA Sbjct: 717 PNGLEDTPQFKLDVDQEKAQALGVSLSDINETISAALGGYYVNDFIDRGRVKKVYVQADA 776 Query: 776 PFRMQAEDLNRWYVRNSASQMVPFSAFMTSKWSYGPSLLERYNGVSSFEIVGEPAAGVSS 835 FRM D+N YVR++ +MVPFS F +++W YG LERYNG+ S E++GE A G S+ Sbjct: 777 QFRMLPGDINNLYVRSANGEMVPFSTFSSARWIYGSPRLERYNGMPSMELLGEAAPGRST 836 Query: 836 GTAMAEVEKLAAQLPAGIGFEWTGSSYQERLSGNQAPMLYAISILFVFLCLAALYESWSV 895 G AM+ +E LA+QLP GIG++WTG SYQERLSGNQAP LYAIS++ VFLCLAALYESWS+ Sbjct: 837 GEAMSLMENLASQLPNGIGYDWTGMSYQERLSGNQAPALYAISLIVVFLCLAALYESWSI 896 Query: 896 PFAVILAVPLGIIGTVLLTGIFGMSNDVYFQVGLLTTVGLSAKNAILIVEFAKQLHE-SG 954 PF+V+L VPLG++G +L + G++NDVYFQVGLLTT+GLSAKNAILIVEFAK L E G Sbjct: 897 PFSVMLVVPLGVVGALLAASLRGLNNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMEKEG 956 Query: 955 KSLWDATLEAVQLRLRPILMTSLAFVFGVLPLAVATGAGSASRRAIGTGVMGGMLSATML 1014 + L +ATLEA ++RLRPILMTSLAF+ GV+PL ++ GAGS ++ A+GTGVMGGML+AT+L Sbjct: 957 RGLIEATLEASRMRLRPILMTSLAFILGVMPLVISRGAGSGAQNAVGTGVMGGMLTATLL 1016 Query: 1015 GI 1016 I Sbjct: 1017 AI 1018 >STM2481 [V] COG0841 Cation/multidrug efflux pump Sty Salmonella typhimurium LT2 Length = 1037 Score = 1262 bits (3266), Expect = 0.0, Method: Compositional matrix adjust. Identities = 622/1041 (59%), Positives = 775/1041 (74%), Gaps = 8/1041 (0%) Query: 1 MARFFIDRPIFAWVMAIIIMLGGMMSIRSLSLEQYPNIAPPQVNIKATYTGASAKTLEDS 60 MA FFIDRPIFAWV+AI++ L G ++I SL +EQYP++APP V I A Y GASA+TLE++ Sbjct: 1 MANFFIDRPIFAWVLAILLCLTGALAIFSLPVEQYPDLAPPNVRITANYPGASAQTLENT 60 Query: 61 VTQIIEQQMKGLDNLQYMSASSSSAGSSTVTLTFTAGTNPDVAQMQVQNKLQQVTARLPQ 120 VTQ+IEQ M GLDNL YMS+ SS G +T+TL+F AGT+PD A QVQN+LQ +LPQ Sbjct: 61 VTQVIEQNMTGLDNLMYMSSQSSGTGQATITLSFIAGTDPDEAVQQVQNQLQSAMRKLPQ 120 Query: 121 AVQNNGVTVTKASTDILMVLSLSSDDPRITSIDIGDFINSSLTDQISRVPGVGDVTAFGT 180 AVQ+ GVTV K ++ ++ S D + DI D++ S++ D +SRV GVGD+ A+G+ Sbjct: 121 AVQDQGVTVRKTGDTNILTIAFVSTDGSMDKQDIADYVASNIQDPLSRVNGVGDIDAYGS 180 Query: 181 NYAMRIWLDPAKLQKYALMPSDITSALEAQNTEVSAGEIGALPAQPGQQINATITARSKL 240 Y+MRIWLDPAKL + + D+T A+E+QN +++ G++G P+ Q +NATI A+S L Sbjct: 181 QYSMRIWLDPAKLNSFQMTTKDVTDAIESQNAQIAVGQLGGTPSVDKQALNATINAQSLL 240 Query: 241 TTAEEFRNIVVKSSSDGSVVKMSDVARVELGGESYQTASRQDGKPSSALAIQLATGANAL 300 T ++FR+I ++ + DGS VK+ DVA VELG E Y SR +G P+S L ++LA+GAN + Sbjct: 241 QTPQQFRDITLRVNQDGSEVKLGDVATVELGAEKYDYLSRFNGNPASGLGVKLASGANEM 300 Query: 301 STADAVKKKMAELEPYFPASMKLKTHIAYDTTPFVRVSLEEVVKTLLEAIVLVVLIMYLF 360 +TA V ++ EL YFP ++ K IAY+TT FV+ S+ +VVKTLLEAI LV L+MYLF Sbjct: 301 ATAKLVLDRLNELAQYFPHGLEYK--IAYETTSFVKASIIDVVKTLLEAIALVFLVMYLF 358 Query: 361 LQNIRATFIPAITVPVVLLGTFGILAMFGYSINTLTMFGMVLAIGLLVDDAIVVVENVER 420 LQN RAT IP I VPVVL+GTF +L FGYSINTLTMF MVLAIGLLVDDAIVVVENVER Sbjct: 359 LQNFRATLIPTIAVPVVLMGTFSVLYAFGYSINTLTMFAMVLAIGLLVDDAIVVVENVER 418 Query: 421 LMSEEKLSPKEATRKSMQEITGALVGIAMVLSAVFIPMAFFGGSTGVIYRQFSITIVSAM 480 +MSEE L+P+EATRKSM +I GALVGIAMVLSAVF+PMAFFGG+TG IYRQFSITIVSAM Sbjct: 419 IMSEEGLTPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVSAM 478 Query: 481 ALSVTVALTLTPALCASLLKP-HPGGHVPHGKFFTWFNRSFDRNATRYRGGVGGLLKRGK 539 LSV VA+ LTPALCA+LLKP H G FF WFNR+F+RNA RY GV +L R Sbjct: 479 VLSVLVAMILTPALCATLLKPLHKGEQHGQRGFFGWFNRTFNRNAERYEKGVAKILHRSL 538 Query: 540 RGLLMYALIAVAMAVLFMRLPTSFLPEEDQGVLMAQIQLPTGATAEQTATVVKTVQDY-F 598 R +L+Y L+ M LF+RLPTSFLP+ED+G+ IQLP+G+T +QT VV+ V++Y F Sbjct: 539 RWILIYVLLLGGMVFLFLRLPTSFLPQEDRGMFTTSIQLPSGSTQQQTLKVVEKVENYYF 598 Query: 599 LNKPESVESVLAIVGSGVGGNSQNSARAFIRLKQWDERTAADQSALALVRRANADLSKIR 658 ++ +++ SV + VGSG GGN QN AR F+RLK WD R S+ A++ RA ++I+ Sbjct: 599 THEKDNIMSVFSTVGSGPGGNGQNVARMFVRLKDWDARDPTTGSSFAIIERATKAFNQIK 658 Query: 659 GARVFLMNPPVVRGLGQSSGFDFELKDVGGVGHDALLKARDQFLRAARSSAVLANVRTTG 718 ARVF +PP + GLG S+GFD EL+D G GHDAL+ ARDQ + A ++ L VR G Sbjct: 659 EARVFASSPPAISGLGSSAGFDMELQDHAGAGHDALMAARDQLIELAGKNSSLTRVRHNG 718 Query: 719 LDDTPQLRVAIDDRKADALSVATSDINSSLATVMGGTYVNDFLSNGRVKKVYVQGDAPFR 778 LDD+PQL++ ID RKA AL V+ DIN +L T G +YVNDF+ GRVKKVYVQ A +R Sbjct: 719 LDDSPQLQIDIDQRKAQALGVSIDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQAAAKYR 778 Query: 779 MQAEDLNRWYVRNSASQMVPFSAFMTSKWSYGPSLLERYNGVSSFEIVGEPAAGVSSGTA 838 M +D+N WYVRN MVPFSAF TS+W G LERYNG S+ EIVGE A GVS+GTA Sbjct: 779 MLPDDINLWYVRNKDGGMVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGVSTGTA 838 Query: 839 MAEVEKLAAQLPAGIGFEWTGSSYQERLSGNQAPMLYAISILFVFLCLAALYESWSVPFA 898 M +E L QLP G G EWT SYQERLSG QAP LYAIS+L VFLCLAALYESWSVPF+ Sbjct: 839 MDVMESLVHQLPGGFGLEWTAMSYQERLSGAQAPALYAISLLVVFLCLAALYESWSVPFS 898 Query: 899 VILAVPLGIIGTVLLTGIFGMSNDVYFQVGLLTTVGLSAKNAILIVEFAKQLHESGKSLW 958 V+L VPLG+IG +L T + G+ NDVYFQVGLLT +GLSAKNAILIVEFA ++++ G +L Sbjct: 899 VMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIVEFANEMNQKGHALL 958 Query: 959 DATLEAVQLRLRPILMTSLAFVFGVLPLAVATGAGSASRRAIGTGVMGGMLSATMLGIFF 1018 DATL A + RLRPILMTSLAF+FGVLP+A +TGAGS S+ A+GTGVMGGM+SAT+L IFF Sbjct: 959 DATLYASRQRLRPILMTSLAFIFGVLPMATSTGAGSGSQHAVGTGVMGGMISATVLAIFF 1018 Query: 1019 VPLFYYLIGTWLDRRAANKPR 1039 VPLF+ LI RR KPR Sbjct: 1019 VPLFFVLI----RRRFPLKPR 1035 >acrF [V] COG0841 Cation/multidrug efflux pump Eco Escherichia coli K12 Length = 1034 Score = 1260 bits (3260), Expect = 0.0, Method: Compositional matrix adjust. Identities = 625/1020 (61%), Positives = 770/1020 (75%), Gaps = 6/1020 (0%) Query: 1 MARFFIDRPIFAWVMAIIIMLGGMMSIRSLSLEQYPNIAPPQVNIKATYTGASAKTLEDS 60 MA FFI RPIFAWV+AII+M+ G ++I L + QYP IAPP V++ A Y GA A+T++D+ Sbjct: 1 MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDT 60 Query: 61 VTQIIEQQMKGLDNLQYMSASSSSAGSSTVTLTFTAGTNPDVAQMQVQNKLQQVTARLPQ 120 VTQ+IEQ M G+DNL YMS++S SAGS T+TLTF +GT+PD+AQ+QVQNKLQ T LPQ Sbjct: 61 VTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQ 120 Query: 121 AVQNNGVTVTKASTDILMVLSLSSDDPRITSIDIGDFINSSLTDQISRVPGVGDVTAFGT 180 VQ G++V K+S+ LMV SD+P T DI D++ S++ D +SR+ GVGDV FG Sbjct: 121 EVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFGA 180 Query: 181 NYAMRIWLDPAKLQKYALMPSDITSALEAQNTEVSAGEIGALPAQPGQQINATITARSKL 240 YAMRIWLD L KY L P D+ + L+ QN +++AG++G PA PGQQ+NA+I A+++ Sbjct: 181 QYAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTRF 240 Query: 241 TTAEEFRNIVVKSSSDGSVVKMSDVARVELGGESYQTASRQDGKPSSALAIQLATGANAL 300 EEF + ++ +SDGSVV++ DVARVELGGE+Y +R +GKP++ L I+LATGANAL Sbjct: 241 KNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKLATGANAL 300 Query: 301 STADAVKKKMAELEPYFPASMKLKTHIAYDTTPFVRVSLEEVVKTLLEAIVLVVLIMYLF 360 TA A+K K+AEL+P+FP MK+ YDTTPFV++S+ EVVKTL EAI+LV L+MYLF Sbjct: 301 DTAKAIKAKLAELQPFFPQGMKV--LYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLF 358 Query: 361 LQNIRATFIPAITVPVVLLGTFGILAMFGYSINTLTMFGMVLAIGLLVDDAIVVVENVER 420 LQN+RAT IP I VPVVLLGTF ILA FGYSINTLTMFGMVLAIGLLVDDAIVVVENVER Sbjct: 359 LQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVER 418 Query: 421 LMSEEKLSPKEATRKSMQEITGALVGIAMVLSAVFIPMAFFGGSTGVIYRQFSITIVSAM 480 +M E+KL PKEAT KSM +I GALVGIAMVLSAVFIPMAFFGGSTG IYRQFSITIVSAM Sbjct: 419 VMMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAM 478 Query: 481 ALSVTVALTLTPALCASLLKPHPGGHVPH-GKFFTWFNRSFDRNATRYRGGVGGLLKRGK 539 ALSV VAL LTPALCA+LLKP H + G FF WFN +FD + Y VG +L Sbjct: 479 ALSVLVALILTPALCATLLKPVSAEHHENKGGFFGWFNTTFDHSVNHYTNSVGKILGSTG 538 Query: 540 RGLLMYALIAVAMAVLFMRLPTSFLPEEDQGVLMAQIQLPTGATAEQTATVVKTVQDYFL 599 R LL+YALI M VLF+RLP+SFLPEEDQGV + IQLP GAT E+T V+ V DY+L Sbjct: 539 RYLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQVTDYYL 598 Query: 600 -NKPESVESVLAIVGSGVGGNSQNSARAFIRLKQWDERTAADQSALALVRRANADLSKIR 658 N+ +VESV + G G +QN+ AF+ LK W+ER + SA A++ RA +L KIR Sbjct: 599 KNEKANVESVFTVNGFSFSGQAQNAGMAFVSLKPWEERNGDENSAEAVIHRAKMELGKIR 658 Query: 659 GARVFLMNPPVVRGLGQSSGFDFELKDVGGVGHDALLKARDQFL-RAARSSAVLANVRTT 717 V N P + LG ++GFDFEL D G+GHDAL +AR+Q L AA+ A L +VR Sbjct: 659 DGFVIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQLLGMAAQHPASLVSVRPN 718 Query: 718 GLDDTPQLRVAIDDRKADALSVATSDINSSLATVMGGTYVNDFLSNGRVKKVYVQGDAPF 777 GL+DT Q ++ +D KA AL V+ SDIN +++T +GGTYVNDF+ GRVKK+YVQ DA F Sbjct: 719 GLEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRGRVKKLYVQADAKF 778 Query: 778 RMQAEDLNRWYVRNSASQMVPFSAFMTSKWSYGPSLLERYNGVSSFEIVGEPAAGVSSGT 837 RM ED+++ YVR++ +MVPFSAF TS W YG LERYNG+ S EI GE A G SSG Sbjct: 779 RMLPEDVDKLYVRSANGEMVPFSAFTTSHWVYGSPRLERYNGLPSMEIQGEAAPGTSSGD 838 Query: 838 AMAEVEKLAAQLPAGIGFEWTGSSYQERLSGNQAPMLYAISILFVFLCLAALYESWSVPF 897 AMA +E LA++LPAGIG++WTG SYQERLSGNQAP L AIS + VFLCLAALYESWS+P Sbjct: 839 AMALMENLASKLPAGIGYDWTGMSYQERLSGNQAPALVAISFVVVFLCLAALYESWSIPV 898 Query: 898 AVILAVPLGIIGTVLLTGIFGMSNDVYFQVGLLTTVGLSAKNAILIVEFAKQLHE-SGKS 956 +V+L VPLGI+G +L +F NDVYF VGLLTT+GLSAKNAILIVEFAK L E GK Sbjct: 899 SVMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAKNAILIVEFAKDLMEKEGKG 958 Query: 957 LWDATLEAVQLRLRPILMTSLAFVFGVLPLAVATGAGSASRRAIGTGVMGGMLSATMLGI 1016 + +ATL AV++RLRPILMTSLAF+ GVLPLA++ GAGS ++ A+G GVMGGM+SAT+L I Sbjct: 959 VVEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQNAVGIGVMGGMVSATLLAI 1018