BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.4469.p (413 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSp0234 [GEPR] COG0477 Permeases of the major facilitator superf... 578 e-164 YPO1932 [GEPR] COG0477 Permeases of the major facilitator superf... 432 e-121 PA2114 [GEPR] COG0477 Permeases of the major facilitator superfa... 421 e-117 PM0835 [GEPR] COG0477 Permeases of the major facilitator superfa... 193 5e-49 HI1104 [GEPR] COG0477 Permeases of the major facilitator superfa... 179 2e-44 >RSp0234 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 416 Score = 578 bits (1489), Expect = e-164, Method: Compositional matrix adjust. Identities = 293/413 (70%), Positives = 343/413 (83%), Gaps = 6/413 (1%) Query: 1 MFSWYRQVTAKERKTFWACFSGWALDALDVQMFSLAIPALIAAFSLSKADAGMISGATLV 60 MF W+++++A E++TFWACF GWALDALDVQMFSL IP +IAA+ + K +AG++SG TLV Sbjct: 1 MFGWFKEISAGEKRTFWACFGGWALDALDVQMFSLVIPTIIAAWHIGKTEAGLVSGITLV 60 Query: 61 ASAIGGWFAGALSDRYGRVKTLQITIIWFSLFTFLSAFAQSYPQLLILKALQGFGFGGEW 120 ASA+GGW AGA++DR GRV+TLQIT+ WFSL TF SAFAQ++ Q L LKA+QGFGFGGEW Sbjct: 61 ASALGGWIAGAMTDRLGRVRTLQITVAWFSLATFASAFAQNFEQFLALKAVQGFGFGGEW 120 Query: 121 AAGAVLMAETIRAEHRGKAMGSVQSAWAVGWGGAVLLFSVLFTMLPQEMAWRVMFVIGLL 180 AAGAVLMAE+IRA HRGKAMG+VQSAWAVGWG AVLL+++ ++++ ++AWRVMF G+L Sbjct: 121 AAGAVLMAESIRASHRGKAMGTVQSAWAVGWGAAVLLYALTYSLVEPDLAWRVMFAAGVL 180 Query: 181 PALLVVYVRRSVPETEAFLAGQKAAAGKPATST----LLGIFRPDVLRLTIIGSLLGVGA 236 PALL++Y+RR V E AG KA AG LL IFRP VLR+T+IG+LLGVGA Sbjct: 181 PALLIIYIRRGVQEPAP--AGAKAEAGPDGMPVSRFPLLDIFRPRVLRMTLIGALLGVGA 238 Query: 237 HGGYYALMTWLPTYLKTEKHLSVLSTGGYLAVIIVAFWCGCIVSAQLLDRIGRRRTVAFF 296 HGGYYALMTWLPTYLKTE+HLSVL TGGYLAVII AFWCGC+ SA LLD IGRR + F Sbjct: 239 HGGYYALMTWLPTYLKTERHLSVLGTGGYLAVIIFAFWCGCVASAWLLDVIGRRGNILLF 298 Query: 297 ALCCVATVLCYIFLPLSDTQMLVCGFPLGFFAAGIPASLGALFNELYPSGIRGTGVGFCY 356 + CCV TVL Y+ +PLSD MLV GFPLGFFAAGIPAS+GALFNELYP G+RGTGVGFCY Sbjct: 299 SCCCVVTVLVYLLVPLSDGAMLVLGFPLGFFAAGIPASMGALFNELYPHGVRGTGVGFCY 358 Query: 357 NFGRVASAGFPVLVGHMSDSMPLGQAIGIDAAIAYSLVVIAVLMLPETRGRKM 409 NFGRV SA FPVLVG MS SM LG AIGIDAAIAYS+V +AVLMLPETRGR + Sbjct: 359 NFGRVVSAAFPVLVGKMSASMSLGTAIGIDAAIAYSIVAVAVLMLPETRGRDL 411 >YPO1932 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 409 Score = 432 bits (1111), Expect = e-121, Method: Compositional matrix adjust. Identities = 214/407 (52%), Positives = 284/407 (69%) Query: 4 WYRQVTAKERKTFWACFSGWALDALDVQMFSLAIPALIAAFSLSKADAGMISGATLVASA 63 W+ + ERKTF A F GWALDALD +F+ I L+A + + AGM+S TL+ SA Sbjct: 3 WFSDLNQTERKTFIAAFGGWALDALDFMVFTFVIATLMALWQIDAGQAGMLSTVTLLFSA 62 Query: 64 IGGWFAGALSDRYGRVKTLQITIIWFSLFTFLSAFAQSYPQLLILKALQGFGFGGEWAAG 123 IGGW AG L+DRYGRV+ LQITI+WFSL T L FAQ++ + IL+ALQG GFGGEWA G Sbjct: 63 IGGWGAGILADRYGRVRILQITILWFSLCTVLIGFAQNFEHVFILRALQGLGFGGEWAVG 122 Query: 124 AVLMAETIRAEHRGKAMGSVQSAWAVGWGGAVLLFSVLFTMLPQEMAWRVMFVIGLLPAL 183 +VLM E +RAEHRGKA+G+VQS WA+GWG A LL++++F++L +E AWR +F IG+LPAL Sbjct: 123 SVLMGEIVRAEHRGKAVGTVQSGWAIGWGAAALLYTLMFSVLSEEWAWRALFWIGVLPAL 182 Query: 184 LVVYVRRSVPETEAFLAGQKAAAGKPATSTLLGIFRPDVLRLTIIGSLLGVGAHGGYYAL 243 LV+Y+R++VPE FL + K + IF P +L+ T++ SLL G GGYYA+ Sbjct: 183 LVLYIRKNVPEPALFLKSRHEQQAKDRRVSSFAIFSPALLKTTVLASLLCTGVQGGYYAI 242 Query: 244 MTWLPTYLKTEKHLSVLSTGGYLAVIIVAFWCGCIVSAQLLDRIGRRRTVAFFALCCVAT 303 TWLPT+LK E++LSV+ TGGYL VII + G I A L D++GRR + F+L T Sbjct: 243 TTWLPTFLKLERNLSVIGTGGYLMVIIFGSFVGYICGAYLTDKLGRRANLIIFSLLSCIT 302 Query: 304 VLCYIFLPLSDTQMLVCGFPLGFFAAGIPASLGALFNELYPSGIRGTGVGFCYNFGRVAS 363 + Y L L++TQMLV GFPLGF A+GI + +GA EL+PS +R TG GF Y+FGR Sbjct: 303 IFAYTQLTLTNTQMLVLGFPLGFSASGIFSGMGAFLTELFPSAVRATGQGFTYSFGRAVG 362 Query: 364 AGFPVLVGHMSDSMPLGQAIGIDAAIAYSLVVIAVLMLPETRGRKME 410 A FP LVG++S S L AIG+ A AY +V++ L+LPET+ +++E Sbjct: 363 ALFPGLVGYLSQSSSLAFAIGVFAGSAYCIVLVMSLLLPETKNKQLE 409 >PA2114 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 423 Score = 421 bits (1083), Expect = e-117, Method: Compositional matrix adjust. Identities = 210/409 (51%), Positives = 281/409 (68%), Gaps = 1/409 (0%) Query: 2 FSWYRQVTAKERKTFWACFSGWALDALDVQMFSLAIPALIAAFSLSKADAGMISGATLVA 61 F WYR + +ER+ FW+C G+ LD +D QM S IP LIA + + +AG I TL+A Sbjct: 15 FGWYRALDKQERRAFWSCKIGYGLDGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLA 74 Query: 62 SAIGGWFAGALSDRYGRVKTLQITIIWFSLFTFLSAFAQSYPQLLILKALQGFGFGGEWA 121 SA GGW AG LSDR GRV TLQ+T++WF+ FTFL AQ+Y QLL+ + L GFGFGGEW Sbjct: 75 SAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGFGGEWT 134 Query: 122 AGAVLMAETIRAEHRGKAMGSVQSAWAVGWGGAVLLFSVLFTMLPQEMAWRVMFVIGLLP 181 AGAVL+ E I+A RGKA+G VQS WA+GWG +L+S++F++LP E AWR +F++GLLP Sbjct: 135 AGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLPPEEAWRALFMLGLLP 194 Query: 182 ALLVVYVRRSVPETEAFLAGQKAAAGKPATSTLLGIFRPDVLRLTIIGSLLGVGAHGGYY 241 AL V+ VRR V E E + ++ G S IF P +L +T+ SLL GA GGYY Sbjct: 195 ALFVLVVRRLVKEPEIYREARQRNQGADKVS-FYEIFAPGMLSITLRASLLTTGALGGYY 253 Query: 242 ALMTWLPTYLKTEKHLSVLSTGGYLAVIIVAFWCGCIVSAQLLDRIGRRRTVAFFALCCV 301 A+ WLPT+LKTE+ L+VL T GYLA++I+ + G +VSA L D IGR++ FA+ Sbjct: 254 AITAWLPTFLKTERGLTVLGTSGYLAMVILGSYVGYVVSAFLTDLIGRKKNFVLFAVGSF 313 Query: 302 ATVLCYIFLPLSDTQMLVCGFPLGFFAAGIPASLGALFNELYPSGIRGTGVGFCYNFGRV 361 VL Y LP+S+ ML GFPLGFFA+GI + +G+ EL+P+ IRG+G GFCYN GR Sbjct: 314 TVVLLYTQLPVSNGAMLWLGFPLGFFASGIFSGMGSFLTELFPTRIRGSGQGFCYNAGRA 373 Query: 362 ASAGFPVLVGHMSDSMPLGQAIGIDAAIAYSLVVIAVLMLPETRGRKME 410 +A FP+L+G + + LG IG AA++Y +V++A L LPETRG+++E Sbjct: 374 IAALFPMLIGMLGQKLSLGLGIGAFAAVSYGVVILAALSLPETRGKQLE 422 >PM0835 [GEPR] COG0477 Permeases of the major facilitator superfamily Pmu Pasteurella multocida Length = 405 Score = 193 bits (491), Expect = 5e-49, Method: Compositional matrix adjust. Identities = 133/394 (33%), Positives = 202/394 (51%), Gaps = 12/394 (3%) Query: 22 GWALDALDVQMFSLAIPALIAAFSLSKADAGMISGATLVASAIGGWFAGALSDRYGRVKT 81 G+A+D D+ + + A+ A +L+ A +G + TL+ + GG GALSD+YGRV+ Sbjct: 19 GYAMDGFDLLILGFMLSAISADLALTPAQSGSLVTWTLIGAVAGGIIFGALSDKYGRVRV 78 Query: 82 LQITIIWFSLFTFLSAFAQSYPQLLILKALQGFGFGGEWAAGAVLMAETIRAEHRGKAMG 141 L TI+ F++FT L AFAQ Y LLI + + G G GGE+ G L AE A HR KA Sbjct: 79 LTWTIVLFAVFTGLCAFAQGYWDLLIYRTIAGIGLGGEFGIGMALAAEAWPARHRAKASS 138 Query: 142 SVQSAWAVGWGGAVLLFSVLFTMLPQEMAWRVMFVIGLLPALLVVYVRRSVPETEAFLAG 201 V W VG VL ++L +L + WR MF++G+ PA + Y+R + E E F+ Sbjct: 139 YVALGWQVG----VLGAALLTPLLLPHIGWRGMFLVGIFPAFVAWYLRAKLHEPEIFVKK 194 Query: 202 QKAAAGKPATSTL----LGIFRPDVLRLTIIGSLLGVGAHGGYYALMTWLPTYLKTEKHL 257 Q A + TS L L I +++ +L + GYY +M W+P +L + Sbjct: 195 QTALE-RQKTSRLEPFRLLIKDKATAKISAGIVVLTSVQNFGYYGIMIWMPNFLSKQLGF 253 Query: 258 SVLSTGGYLAVIIVAFWCGCIVSAQLLDRIGRRRTVAFFALCCVATVLCYIFLPLSD-TQ 316 S+ +G + AV I G + QL DRIGR+ + F V ++ Y +SD T Sbjct: 254 SLTKSGVWTAVTICGMMFGIWLFGQLADRIGRKPSFLLFQFGAVISIFTYS--QMSDPTY 311 Query: 317 MLVCGFPLGFFAAGIPASLGALFNELYPSGIRGTGVGFCYNFGRVASAGFPVLVGHMSDS 376 ML G LG F G+ GAL +E YP+ R T +N GR P++VG + + Sbjct: 312 MLFAGAVLGMFVNGMMGGYGALMSEAYPTQARATAQNVLFNLGRAVGGFGPIVVGALVST 371 Query: 377 MPLGQAIGIDAAIAYSLVVIAVLMLPETRGRKME 410 AI A+I ++ + ++PE +G++++ Sbjct: 372 YSFQLAIAFLASIYIIDMIATIFLIPELKGKQLD 405 >HI1104 [GEPR] COG0477 Permeases of the major facilitator superfamily Hin Haemophilus influenzae Length = 407 Score = 179 bits (453), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 129/394 (32%), Positives = 197/394 (50%), Gaps = 10/394 (2%) Query: 22 GWALDALDVQMFSLAIPALIAAFSLSKADAGMISGATLVASAIGGWFAGALSDRYGRVKT 81 G+ +D D+ + + A+ A +L+ A G + TL+ + GG GALSD+YGRV+ Sbjct: 19 GYGMDGFDLLILGFMLSAISADLNLTPAQGGSLVTWTLIGAVFGGILFGALSDKYGRVRV 78 Query: 82 LQITIIWFSLFTFLSAFAQSYPQLLILKALQGFGFGGEWAAGAVLMAETIRAEHRGKAMG 141 L TI+ F++FT L A AQ Y LLI + + G G GGE+ G L AE A HR KA Sbjct: 79 LTWTILLFAVFTGLCAIAQGYWDLLIYRTIAGIGLGGEFGIGMALAAEAWPARHRAKAAS 138 Query: 142 SVQSAWAVGWGGAVLLFSVLFTMLPQEMAWRVMFVIGLLPALLVVYVRRSVPETEAFLAG 201 V W VG VL ++L +L + WR MF++G+ PA + ++R + E E F Sbjct: 139 YVALGWQVG----VLGAALLTPLLLPHIGWRGMFLVGIFPAFVAWFLRSHLHEPEIFTQK 194 Query: 202 QKAAAGKPATSTLLGIFRPDVLRLTIIGSLLGVGA-----HGGYYALMTWLPTYLKTEKH 256 Q A + + + + L F+ + LG+ + GYY +M WLP +L + Sbjct: 195 QTALSTQSSFTDKLRSFQLLIKDKATSKISLGIVVLTSVQNFGYYGIMIWLPNFLSKQLG 254 Query: 257 LSVLSTGGYLAVIIVAFWCGCIVSAQLLDRIGRRRTVAFFALCCVATVLCYIFLPLSDTQ 316 S+ +G + AV + G + QL DRIGR+ + F L V +++ Y L D Sbjct: 255 FSLTKSGLWTAVTVCGMMAGIWIFGQLADRIGRKPSFLLFQLGAVISIVVYSQLTDPDI- 313 Query: 317 MLVCGFPLGFFAAGIPASLGALFNELYPSGIRGTGVGFCYNFGRVASAGFPVLVGHMSDS 376 ML+ G LG F G+ GAL E YP+ R T +N GR PV+VG + + Sbjct: 314 MLLAGAFLGMFVNGMLGGYGALMAEAYPTEARATAQNVLFNIGRAVGGFGPVVVGSVVLA 373 Query: 377 MPLGQAIGIDAAIAYSLVVIAVLMLPETRGRKME 410 AI + A I ++ + ++PE +G+ ++ Sbjct: 374 YSFQTAIALLAIIYVIDMLATIFLIPELKGKALD 407