BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.4458.p (480 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value AGpA571 [GEPR] COG0477 Permeases of the major facilitator superf... 161 4e-39 PA3467 [GEPR] COG0477 Permeases of the major facilitator superfa... 141 4e-33 RSp0052 [GEPR] COG0477 Permeases of the major facilitator superf... 135 3e-31 PAE2330 [GEPR] COG0477 Permeases of the major facilitator superf... 121 4e-27 Cgl2919 [GEPR] COG0477 Permeases of the major facilitator superf... 119 1e-26 >AGpA571 [GEPR] COG0477 Permeases of the major facilitator superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 461 Score = 161 bits (407), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 141/477 (29%), Positives = 227/477 (47%), Gaps = 48/477 (10%) Query: 14 SANIPARLDRLPWSR---WHWRVVIALGVAWVLDGLEVTLVGSLGSVLERSDTLALDAAQ 70 A+I ARL+RLP +R W +V G A DG V + VL R L +Q Sbjct: 18 QADISARLERLPITREVFWARNIV---GAATFFDGYTVIAIAYAMPVLVRE--WGLTPSQ 72 Query: 71 VGWSGSLYIAGTVLGALLFGRLTDRLGRKRLFMLTLALYMAATLATAFAQDFLWLAVCRL 130 G S+ G ++GA+LFG L +R+GR ++ + T+ L+++ +A FA + R Sbjct: 73 TGMILSMGYLGQLIGAILFGWLAERIGRLKVLLFTILLFVSMDVACLFAAGAGMMMAFRF 132 Query: 131 VTGLGIGGEYAAINSAIDELVPARVRGRVNLIINASFWIGAALGAGLSLLLLDPQVLGPA 190 V G+G GGE ++ I+EL+ ++ RGR L+ F +G +GAGL + P Sbjct: 133 VQGIGTGGEVPVASAYINELIGSKGRGRFFLLYEVMFLLG-LVGAGLIGYFMV-----PL 186 Query: 191 LGWRACFLLGAVLAVAILLVRRHVPESPRWLLMHGRHAEAEAVVRHIEAEVAAQHGALPA 250 GW+A F++G V A+ ++ +R + ESPRWL GR+ EA +V+ +E A ALP Sbjct: 187 YGWKAMFIVGLVPAMLMIPLRWFLKESPRWLAATGRYDEANVIVKRMEESARAAGKALP- 245 Query: 251 TPDSGHPQ----PGGGMMAWREIAQVLLHRYRQRSLMVALMMVAQAFVYNAIFFTYSLVL 306 P+ P + WRE+ Q + Y +R+L + M V N + Sbjct: 246 -----EPRIIATPAKRVSDWRELFQGI---YLKRTLSIWAMWFCAYMVANGTITWLPTLY 297 Query: 307 TRFFNVPDHRVALYIFPFALGNVLGPLLLGQLFDTIGRRRMIAATYLLAGAGLAATAWAF 366 + FN+P LY F + V+ ++ L D +GR+R A LLA LA AW Sbjct: 298 RQTFNLPLETSILYGFMTSAAGVVAAVICALLIDKVGRKRWYAGALLLAPVPLAILAW-- 355 Query: 367 NAGWLDARTLALCWSAVFFVASAAASSAYLTASEVFPLRMRAMAISIFYAIGTG------ 420 G + + + + S YL ++E++P RMR AIGTG Sbjct: 356 -LGATSPMQVLIFAGLAYAIVQTVTFSLYLYSAEIYPTRMR--------AIGTGAGSAWL 406 Query: 421 -VGGFVAPVLLGWLIASGDRHAVAAGYALGAGLALLAGGCAWRWAVDAERRTLEDVA 476 +G P+L+G++++S V A +A + ++ +AV+ + + LE+++ Sbjct: 407 RLGSSAGPMLVGFVMSSMGIQYVFATFAF---ILIIGAVVTMLFAVETKGKVLEELS 460 >PA3467 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 455 Score = 141 bits (355), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 141/483 (29%), Positives = 224/483 (46%), Gaps = 40/483 (8%) Query: 4 PSSPSSSVTSSANIPARLDRLPWSRWHWRVVIALGVAWVLDGLEVTLVGSL-GSVLERSD 62 P +P+S+ RL+RLP S +H V + + +A+ D +++ ++ L GS+ Sbjct: 2 PDAPASAAE-------RLERLPLSPYHRLVFVIIALAFFFDSMDLAMMTFLLGSI---KA 51 Query: 63 TLALDAAQVGWSGSLYIAGTVLGALLFGRLTDRLGRKRLFMLTLALYMAATLATAFAQDF 122 LD+AQ G S G V+GA L G L DR GRK +F ++ L+ A+ + A D Sbjct: 52 EFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDL 111 Query: 123 LWLAVCRLVTGLGIGGEYAAINSAIDELVPARVRGRVNLIINASFWIGAALGAGLSLLLL 182 L R++ G+G+G E+ S + E++PA RG+ +++ + +G LS LL Sbjct: 112 DSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLL 171 Query: 183 DPQVLGPALGWRACFLLGAVLAVAILLVRRHVPESPRWLLMHGRHAEAEAVVRHIEAEVA 242 P GWR+ FL+ A+ AV +L +R +PESPRWL GR +A+ V+R IEA V Sbjct: 172 ------PLTGWRSIFLVLALPAVFVLAIRFLIPESPRWLEQAGRREQADRVLRDIEARVM 225 Query: 243 AQHGALPATPDSGHPQ-----PGGGMMAWREIAQVLLHRYRQRSLMV-ALMMVAQAFVYN 296 G P PQ PG + A++ YR+R+L V L A Y Sbjct: 226 RSLGLTELPPPLRQPQRERSRPG----FFSAFAELWSPAYRRRTLTVWGLWFFALLGFYG 281 Query: 297 AIFFTYSLVLTRFFNVPDHRVALYIFPFALGNVLGPLLLGQLFDTIGRRRMIAATYLLAG 356 + +L+ F V Y +L + G L L ++ GR+ + +L G Sbjct: 282 LTSWLSALLQQSGFAVTQS--VYYTVLISLAGIPGFLCAAWLVESWGRKP--SCVLMLLG 337 Query: 357 AGLAATAWAFNAGWLDARTLALCWS---AVFFVASAAASSAYLTASEVFPLRMRAMAISI 413 G A A+A+ + +LAL A+ F + Y E++P RA Sbjct: 338 GG--AMAYAYGQTAVFGGSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGF 395 Query: 414 FYAIGTGVGGFVAPVLLGWLIASGDRHAVAAGYALGAGLALLAGGCAWRWAVDAERRTLE 473 A+G +G + P++ G ++ + V AL G+A L W + ++ RTLE Sbjct: 396 ASAVGR-IGSLLGPLVTGLVLPLTGQGGVFTLGALCFGVAAL---VVWAFGIETRGRTLE 451 Query: 474 DVA 476 ++A Sbjct: 452 ELA 454 >RSp0052 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 476 Score = 135 bits (339), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 134/417 (32%), Positives = 199/417 (47%), Gaps = 22/417 (5%) Query: 20 RLDRLPWSRWHWRVVIALGVAWVLDGLEV-TLVGSLGSVLERSDTLALDAAQVGWSGSLY 78 RL+RLP+S +H R+ I + +A+ D +++ T+ LGS+ L A G S Sbjct: 16 RLERLPFSGYHKRIFIIIAIAFFFDSVDLATMTFVLGSI---KKEFGLSTATAGLVASSS 72 Query: 79 IAGTVLGALLFGRLTDRLGRKRLFMLTLALYMAATLATAFAQDFLWLAVCRLVTGLGIGG 138 G V+GA + G L DR GR+ +F ++ L+ A+ + AQ L R++ G+G+G Sbjct: 73 FFGMVIGAAVAGLLADRFGRRPVFQWSMVLWGVASYLCSTAQSVEALIAWRILLGIGMGM 132 Query: 139 EYAAINSAIDELVPARVRGRVNLIINASFWIGAALGAGLSLLLLDPQVLGPALGWRACFL 198 E+ + + E VP RGR+ +++ FW + AG+ + PQ GWRA F Sbjct: 133 EFPVAQTLLSEFVPTANRGRLIALMDG-FWPLGFITAGIVSYFVLPQ-----FGWRAVFA 186 Query: 199 LGAVLAVAILLVRRHVPESPRWLLMHGRHAEAEAVVRHIEAEV--AAQHGALPATPDSGH 256 L AV A+ +L+VRR VPESPRWL GR+A+A+ V+R IEA+V + LP Sbjct: 187 LLAVPAIFVLIVRRAVPESPRWLEHAGRNAQADTVMRGIEAKVMRSLNTTTLPPIVQHSA 246 Query: 257 PQPGGGMMAWREIAQVLLHRYRQRSLMVALM-MVAQAFVYNAIFFTYSLVLTRFFNVPDH 315 PQP A REI YR+R+ MV L+ A Y + +L+ F V Sbjct: 247 PQPVRRHSALREIWSA---AYRRRTTMVWLLWFFALLGFYGLTSWLGALLQQAGFAVTQS 303 Query: 316 RVALYIFPFALGNVLGPLLLGQLFDTIGRRRMIAATYLLAGAGLAATAWAFNAGWLDART 375 Y +LG V G L L + GR+ A+ L G G A + +A + + T Sbjct: 304 --VYYTVLISLGGVPGFLCAAWLVERWGRKPTCIASLL--GGGAMAYLYGQSALYGGSVT 359 Query: 376 LALCWS-AVFFVASAAASSAYLTASEVFPLRMRAMAISIFYAIGTGVGGFVAPVLLG 431 L +C A+ F + Y E + RA AIG VG + P ++G Sbjct: 360 LLICTGLAMQFFLFGMWAVLYTYTPEQYGTGARATGSGFASAIGR-VGSLIGPYVVG 415 >PAE2330 [GEPR] COG0477 Permeases of the major facilitator superfamily Pya Pyrobaculum aerophilum Length = 384 Score = 121 bits (303), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 74/197 (37%), Positives = 112/197 (56%), Gaps = 10/197 (5%) Query: 32 RVVIALGVAWVLDGLEVTLVGSLGSVLERSDTLALDAAQVGWSGSLYIAGTVLGALLFGR 91 R+V+ G+ W+ D L+V ++ L ++ S+ L LD+ W G ++GA+LFGR Sbjct: 5 RLVLYTGLGWMFDALDVLILSYL--LVAMSNELKLDSQAKNWIVLANNLGMLIGAMLFGR 62 Query: 92 LTDRLGRKRLFMLTLALYMAATLATAFAQDFLWLAVCRLVTGLGIGGEYAAINSAIDELV 151 L DR+GRK++FM TL Y AT +AFA+++ AV R GLG+GGE + + + E Sbjct: 63 LADRVGRKKVFMSTLLTYSIATAISAFARNWQEFAVIRFFVGLGLGGELPVVATYVSENS 122 Query: 152 PARVRGRVNLIINASFW-IGAALGAGLSLLLLDPQVLGPALGWRACFLLGAVLAVAILLV 210 P RGR N+++ SFW +GA L A +SL L +GWR+ LL A + ++ Sbjct: 123 PPERRGR-NVVLLESFWSLGAILAAAISLFLFT------TIGWRSSLLLMGATAFYVFVI 175 Query: 211 RRHVPESPRWLLMHGRH 227 R +PES RWL + + Sbjct: 176 RFTLPESQRWLELREQR 192 >Cgl2919 [GEPR] COG0477 Permeases of the major facilitator superfamily Cgl Corynebacterium glutamicum Length = 439 Score = 119 bits (299), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 129/419 (30%), Positives = 198/419 (47%), Gaps = 21/419 (5%) Query: 20 RLDRLPWSRWHWRVVIALGVAWVLDGLEVTLVGSLGSVLERSDTLALDAAQVGWSGSLYI 79 RLDRLP + H +++ G+ W LD ++V L+ + + L + L + GS+ Sbjct: 8 RLDRLPVTSKHKKILGGSGIGWALDAMDVGLISFVMAAL--ATHWGLSPTETSLLGSIGF 65 Query: 80 AGTVLGALLFGRLTDRLGRKRLFMLTLALYMAATLATAFAQDFLWLAVCRLVTGLGIGGE 139 G +GA L G L D+LGR+++F L+L +Y AT A+A + L R V GLG+G E Sbjct: 66 VGMAIGASLGGLLADKLGRRQVFALSLLVYGVATGASALSVSLAMLMALRFVVGLGLGAE 125 Query: 140 YAAINSAIDELVPARVRGRVNLIINASFWIGAALGAGLSLLLLDPQVLGPALGWRACFLL 199 ++ I E P +VRGR+ +I+ A FW ALG ++ ++ V G GWR L Sbjct: 126 LPVASTLISEFSPRKVRGRMVVILEA-FW---ALGWIMAAIVGTFVVAGSDNGWRWALAL 181 Query: 200 GAVLAVAILLVRRHVPESPRWLLMHGRHAEAEAVVRHIEAEVAAQHGALPATPDSGHPQP 259 G V A+ + VR +PES R+L GRH EAEA+V E AA+ A AT H Sbjct: 182 GCVPAIYAVYVRLGLPESVRFLEKKGRHDEAEAIVVSFEEAAAAEGKAADATTAVVHDNA 241 Query: 260 GGGMMAWREIAQVLLHRYRQRSLMVALMMVAQAFVYNAIFFTYSLVLTRFFN-VPDHRVA 318 G ++ A R R +L + + ++ Y A + SL++ F V + Sbjct: 242 AEGSVSIWSAAL----RKRTVALWIVWFCINLSY-YGAFIWIPSLLVADGFTLVKSFQFT 296 Query: 319 LYIFPFALGNVLGPLLLGQLFDTIGRRRMIAATYLLAGAGLAATAWAFNAGWLDARTLAL 378 L I L + G + L + GRR + AT+L+ A AA N W +A Sbjct: 297 LII---TLAQLPGYAVAAWLIEKWGRRSTL-ATFLVGSAISAALYGLANVEW--QILVAG 350 Query: 379 CWSAVFFVASAAASSAYLTASEVFPLRMRAMAISIFYAIGTGVGGFVAPVLLGWLIASG 437 C + F + + A Y E++P +R G + +AP+++ +IA G Sbjct: 351 CLLSFFNLGAWGA--LYAIGPELYPTNVRGTGTGAAAGFGR-IASIIAPLIVPPVIAFG 406