BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.4447.p (299 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2507 [GER] COG0697 Permeases of the drug/metabolite transport... 173 6e-43 VCA0090 [GER] COG0697 Permeases of the drug/metabolite transport... 160 3e-39 AGc3767 [GER] COG0697 Permeases of the drug/metabolite transport... 124 3e-28 BH0396 [GER] COG0697 Permeases of the drug/metabolite transporte... 115 9e-26 SMc01844 [GER] COG0697 Permeases of the drug/metabolite transpor... 90 8e-18 >RSc2507 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Rso Ralstonia solanacearum Length = 310 Score = 173 bits (438), Expect = 6e-43, Method: Compositional matrix adjust. Identities = 122/283 (43%), Positives = 174/283 (61%), Gaps = 2/283 (0%) Query: 1 MSSSNIAKLLLLAAIWGTSFMLMRIAAPIFGPMLTTFGRAALATLALLAYARVRGVPLHW 60 M S+ +LL+LAA+WG SF+ MR+AAP FGP+ R A+A+ LL +RG Sbjct: 1 MRRSDAIELLILAALWGGSFLFMRVAAPPFGPVALIALRVAIASAFLLPVLAMRGGLGAL 60 Query: 61 RRNWLPYLIIGVFNTALPFALFAWSALHIPSAYMATMNSLAPIFTAMFGFLLMGERLSLL 120 R +W L +GV N+A+PF L A++ L + + + + +N+ AP+F A+ F +GER+S Sbjct: 61 RPHWPHLLAVGVLNSAVPFCLLAYAELTLTAGFTSVLNAAAPLFAAIVAFAWLGERMSAW 120 Query: 121 RTAAFVLGLVGVAVLVGIGPAPADALVIAGVLAAMGAAVSYGFAATFTRMRAGGIPPIAM 180 R +G VGV VLVG A V AA+GA V YG A ++ + G+PP+A+ Sbjct: 121 RVLGLAIGFVGVIVLVGGSSALDARQGGLAVAAALGATVLYGLAGSYAKRYLTGVPPLAV 180 Query: 181 ATGSQFAAALCLLPLAAPSVPHALQAGTLPALLSVLVLGVVCTGLAYALFFQLIAAEGAT 240 ATGSQ AAA+ L PLA P G++ L V+ LG+ CTG+AY LFF+LIA G T Sbjct: 181 ATGSQIAAAVVLAPLAVWLWPAHTPTGSV--WLHVIGLGIACTGIAYILFFRLIAHVGPT 238 Query: 241 KAITVTFLVPMTASLWAWLLLDEAVTLGTVAGIAIVLVATAIA 283 +A++VTFLVP+ LW L L E +TL VAG A++L+ T+++ Sbjct: 239 RAVSVTFLVPVFGVLWGILFLGEQLTLNMVAGCAVILLGTSLS 281 Score = 34.3 bits (77), Expect = 0.38, Method: Compositional matrix adjust. Identities = 20/75 (26%), Positives = 39/75 (52%) Query: 64 WLPYLIIGVFNTALPFALFAWSALHIPSAYMATMNSLAPIFTAMFGFLLMGERLSLLRTA 123 WL + +G+ T + + LF H+ ++ L P+F ++G L +GE+L+L A Sbjct: 210 WLHVIGLGIACTGIAYILFFRLIAHVGPTRAVSVTFLVPVFGVLWGILFLGEQLTLNMVA 269 Query: 124 AFVLGLVGVAVLVGI 138 + L+G ++ G+ Sbjct: 270 GCAVILLGTSLSTGV 284 >VCA0090 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Vch Vibrio cholerae Length = 297 Score = 160 bits (405), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 119/291 (40%), Positives = 172/291 (59%), Gaps = 25/291 (8%) Query: 1 MSSSNIAKLLLLAAIWGTSFMLMRIAAPIFGPMLTTFGRAALATLALLAYARV--RGVPL 58 MS N+ +LL LAAIWG SF+ MRIAA FGP R A L+L A++ R +P+ Sbjct: 1 MSLVNLLQLLCLAAIWGGSFLFMRIAAHSFGPAYLIEARVGFAALSLFLVAQLLRRSLPI 60 Query: 59 HWRRNWLPYLIIGVFNTALPFALFAWSALHIPSAYMATMNSLAPIFTAMFGFLLMGERLS 118 R++W +LI+G+ NTA+PF LFA++AL + + ++ +NS API+ A+ GFL G LS Sbjct: 61 --RQHWPHFLILGLINTAVPFLLFAYAALTLNVSTLSILNSTAPIWGAVIGFLWHGTPLS 118 Query: 119 LLRTAAFVLGLVGVAVLVG-----IGPAPADALVIAGVLAAMGAAVSYGFAATFTRMRAG 173 A +LG+ GVAV+VG IG A +V A + AA SYG A +T+ +A Sbjct: 119 RKAVAGLLLGVSGVAVIVGWDMVAIGHHAALPMVCAAL-----AAASYGLATNYTK-QAP 172 Query: 174 GIPPIAMATGSQFAAALCLLPL----AAPSVPHALQAGTLPALLSVLVLGVVCTGLAYAL 229 + A GS +AA L + PL P +L+ G +V++LGV+CTGLAY + Sbjct: 173 QLSAFENAHGSMWAACLWVAPLMWFVPLRETPSSLEWG------AVILLGVICTGLAYLI 226 Query: 230 FFQLIAAEGATKAITVTFLVPMTASLWAWLLLDEAVTLGTVAGIAIVLVAT 280 +F+L+ A GA ++VTFL+P+ LW + +LDE + L T+ G +VL T Sbjct: 227 YFRLVKAIGAASTLSVTFLIPVFGILWGYWILDEPIGLNTLFGTLLVLAGT 277 >AGc3767 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 329 Score = 124 bits (310), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 98/291 (33%), Positives = 154/291 (52%), Gaps = 27/291 (9%) Query: 1 MSSSNIAKLLLLAAIWGTSFMLMRIAAPIFGPMLTTFGRAALATLALLAYARVRGV--PL 58 M + A L+ L+ +WG SF + +A P+ R +LA +ALL R+ G+ P Sbjct: 27 MDAREWAMLIALSLLWGGSFFFIGVAVKELPPVTIVTLRVSLAAVALLVVCRIMGLRLPR 86 Query: 59 HWRRNWLPYLIIGVFNTALPFALFAWSALHIPSAYMATMNSLAPIFTAMFG-FLLMGERL 117 W W + +G+ N +PF L W I S + +N+ P+FT + FL E++ Sbjct: 87 EWAV-WRAFFGMGLLNNIIPFCLIVWGQTQIASGLASILNATTPLFTVIVAHFLTADEKM 145 Query: 118 SLLRTAAFVLGLVGVAVLVGIGPAP-ADALVIAGVLAAMGAAVSYGFAATF-TRMRAGGI 175 + + A ++G VGVA + IGPA + + G +A +GAA+SY FA F R +A G+ Sbjct: 146 TGNKLAGVLIGFVGVATM--IGPAAFGGSSGLWGQIAILGAAISYSFAGIFGRRFKAMGV 203 Query: 176 PPIAMATGSQFAAALCLLP----------LAAPSVPHALQAGTLPALLSVLVLGVVCTGL 225 PP+ ATG ++ L L+P LA P + GT AL+ + +L T L Sbjct: 204 PPLMTATGQISSSTLMLIPAALLIDKPWTLAMPGL------GTWGALIGIALL---STAL 254 Query: 226 AYALFFQLIAAEGATKAITVTFLVPMTASLWAWLLLDEAVTLGTVAGIAIV 276 AY +FF+++A+ GAT VTFL+P++A L L+L E + + AG+A++ Sbjct: 255 AYLIFFRILASAGATNLALVTFLIPVSAILLGSLILGEQLEIKHFAGMAMI 305 >BH0396 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Bha Bacillus halodurans Length = 305 Score = 115 bits (289), Expect = 9e-26, Method: Compositional matrix adjust. Identities = 88/295 (29%), Positives = 139/295 (47%), Gaps = 8/295 (2%) Query: 9 LLLLAAIWGTSFMLMRIAAPIFGPMLTTFGRAALATLALLAYARVRGVPLHWRRNWLPYL 68 LL L+ IWG SF+ + I G T R + LL +R + W + Sbjct: 7 LLSLSLIWGFSFVFIEHLLGIVGVWGTVVVRCFAGAIILLPILLMRRKLFYRPAPWKALM 66 Query: 69 IIGVFNTALPFALFAWSALHIPSAYMATMNSLAPIFTAMFGFLLMGERLSLLRTAAFVLG 128 I+G+FN LP+ L A S I S+ A +N+L P+FT + GFLL LS + VLG Sbjct: 67 IVGIFNAGLPWGLIALSQTEIYSSTAAVLNALTPLFTGLIGFLLYSNALSRQQWGGIVLG 126 Query: 129 LVGVAVLVGIGPAPADALVIAGVLAAMGAAVSYGFAATFTRMRAGGIPPIAMATGSQFAA 188 GV VL G GV + A + YGFA+ + + + + T S Sbjct: 127 FSGVVVLTGFQLQLLAPEHFVGVGTMILATICYGFASQYVKRHLHDTDVVLITTFSLLFG 186 Query: 189 ALCLLPLAAPSVPHALQAGTLP------ALLSVLVLGVVCTGLAYALFFQLIAAEGATKA 242 L+ L + +L +P +L+S++ LG + +G+A+ L++ L+ G A Sbjct: 187 G--LVGLIGMWITDSLHVVRVPLTIDWLSLISIIGLGCLGSGMAHLLYYDLMKKGGPEFA 244 Query: 243 ITVTFLVPMTASLWAWLLLDEAVTLGTVAGIAIVLVATAIALRAKPAVALKDKKA 297 TVT+L+PMTA +W L LDE +T V G+ ++L+ R + + ++ + Sbjct: 245 TTVTYLIPMTAIIWGKLFLDELITKNIVIGMLMILMGVYFTSRKRNVCSKANEDS 299 >SMc01844 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Sme Sinorhizobium meliloti Length = 314 Score = 89.7 bits (221), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 78/232 (33%), Positives = 118/232 (50%), Gaps = 18/232 (7%) Query: 63 NWLPYLIIGVFNTALPFALFAWSALHIPSAYMATMNSLAPIFTAMFGFL-LMGERLSLLR 121 W +L++G+ N A+P A HI + A +N+ P++T + + E+LS + Sbjct: 75 RWREFLLMGLINNAIPHAFIFLGQTHIGAGLAAILNATTPVWTVLIANVATEDEKLSTAK 134 Query: 122 TAAFVLGLVGVAVLVG----------IGPAPADALVIAGVLAAMGAAVSYGFAATFTRMR 171 + +LGL G VL+G G P ALV+ VLAA VSYGF+AT+ + Sbjct: 135 FSGCLLGLAGTVVLIGPSALAGLFGTAGDVPLWALVLP-VLAA----VSYGFSATYGKRF 189 Query: 172 AGGIPPIAMATGSQFAAALCLLPLAA-PSVPHALQAGTLPALLSVLVLGVVCTGLAYALF 230 PP+ A G A+ L +LP+A +P + L +L++L L +V T AY LF Sbjct: 190 RDLAPPVT-AAGQLTASTLIMLPVAVLVDMPWTMPMPPLTTVLAILGLALVSTAYAYILF 248 Query: 231 FQLIAAEGATKAITVTFLVPMTASLWAWLLLDEAVTLGTVAGIAIVLVATAI 282 F+++A GAT VT LVP +A L +L L E + V G+ ++ AI Sbjct: 249 FRIMAEAGATNTSLVTLLVPPSAILLGYLFLGEMLQATDVGGMLLIAAGLAI 300