BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.4442.p (590 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA2265 [E] COG2303 Choline dehydrogenase and related flavoprotei... 582 e-166 Cj0415 [E] COG2303 Choline dehydrogenase and related flavoprotei... 368 e-101 RSp0904 [E] COG2303 Choline dehydrogenase and related flavoprote... 118 3e-26 VNG1035C [E] COG2303 Choline dehydrogenase and related flavoprot... 107 1e-22 AGl980 [E] COG2303 Choline dehydrogenase and related flavoprotei... 103 1e-21 >PA2265 [E] COG2303 Choline dehydrogenase and related flavoproteins Pae Pseudomonas aeruginosa Length = 591 Score = 582 bits (1500), Expect = e-166, Method: Compositional matrix adjust. Identities = 283/584 (48%), Positives = 388/584 (66%), Gaps = 4/584 (0%) Query: 9 VDVVIVGLGWAGSLMAIELAQAGLKVRALERGPDRPP-EDFAYPKPADQYGYATRNKVFA 67 VD V+VG GW G+++A EL +AGL V ALERG +R D AYP D+ Y TR K+F Sbjct: 8 VDAVVVGFGWTGAILAKELTEAGLNVVALERGENRDTYPDGAYPNTLDELTYNTRGKLFQ 67 Query: 68 TPRDAALTVRYNTAQQALPTRKWGAFAPGTGVGGSGLHWTAVLIRPTPTDIKLKTYADQA 127 + +++R+ ALP R+ AF PG GVGG+GLHW+ V R P +++L+++ ++ Sbjct: 68 NLSKSTVSIRHGINDTALPYRQLSAFLPGDGVGGAGLHWSGVHFRIMPEELRLRSHYEER 127 Query: 128 YKHSKLDPEMRIKDFPFTWNEIEPHFDFFEKVCGQSGKTGNLRGQIQPGGDPFEGPRSNP 187 Y + M I+D+ ++ E+EPHFDF EKV G SG ++GQ+ G+PF RS+ Sbjct: 128 YGKKFIPEGMTIQDYGVSYEELEPHFDFAEKVFGTSGTAHTVKGQVVGKGNPFAADRSDD 187 Query: 188 YPLPPLHDTYNNSLFAEVARKLGYHPFPNPSANVSQAWTNPYGAQIAPCNYCGFCSKYPC 247 +PLP L Y+ LF + A +LG HP+ P+AN S WTNPYG Q+ PCN+CGFCS Y C Sbjct: 188 FPLPALRQVYSAQLFRKAAEELGLHPYDLPAANASGPWTNPYGVQMGPCNFCGFCSGYAC 247 Query: 248 LNYSKASPQTTILDVVKRMPNFDYKVNANVIRVDLHADKKTARGVTYIDENMKEVFQPAK 307 YSKASP IL +++ P F+ + N NV++V+L +D + A GVTY+D +E+ QPAK Sbjct: 248 YMYSKASPNLNILPALRQTPLFELRANCNVLKVNLDSDGRQATGVTYVDAQGREIVQPAK 307 Query: 308 IVILSSFQFANVRLMLLSGIGKPYDPITETGVIGRNYAFLSNGGATLFF-KDKHFNSFAT 366 +VI+S+FQF NVRL+LLSGIGKPYDP T GV+G+N+A+ + FF KD H N F Sbjct: 308 LVIISAFQFHNVRLLLLSGIGKPYDPRTGEGVVGKNFAYQNMATIKAFFDKDVHTNPFVG 367 Query: 367 AGATGEMFNDISPGNFDDGIKLGFIGGAKIHSSQASGAPI-GTALPPGTPSWGRGWKEGM 425 G G +D + NFD G LGF+GG+ + +QA PI G A+PPGTPSWG GWK+ + Sbjct: 368 TGGGGVAVDDFNADNFDHG-PLGFVGGSPMWVNQAGSKPIGGLAVPPGTPSWGSGWKQAV 426 Query: 426 IDWYDHSMKISITTTCMSYRGHFLDLDPNYKDPWGQPLLRMTFDWRQNELKLQRYLRDIV 485 D Y H++ + + M+YR ++LDLDP YKD +GQPLLRMTFDW+ NE+++ RY+ + + Sbjct: 427 KDAYTHTVSMDAHGSNMTYRDNYLDLDPTYKDAYGQPLLRMTFDWKDNEIRMSRYVTEHM 486 Query: 486 LKISKELNPDHMSESFLALDSHWDITKYVSTHNVGGAIMGDSPRDSALNKYLQSWDVHNV 545 KI++ +NP +S S H++ Y +TH +GGAIMG P+ S LN+YLQSWDVHNV Sbjct: 487 RKIAEAMNPKAISVSVKNFGDHFNTRVYQTTHLLGGAIMGSDPKTSVLNRYLQSWDVHNV 546 Query: 546 FVPGGNAFPQNFQANPTDTIGAITLMAAQAIKTQYLKNPGPLVQ 589 FV G +AFPQ NPT + A+ +A+AI+ QYLKNPGPLVQ Sbjct: 547 FVMGASAFPQGTGYNPTGLVAALAYWSAKAIREQYLKNPGPLVQ 590 >Cj0415 [E] COG2303 Choline dehydrogenase and related flavoproteins Cje Campylobacter jejuni Length = 573 Score = 368 bits (944), Expect = e-101, Method: Compositional matrix adjust. Identities = 205/570 (35%), Positives = 310/570 (54%), Gaps = 17/570 (2%) Query: 9 VDVVIVGLGWAGSLMAIELAQAGLKVRALERGPDRPPEDFAYPKPADQYGYATRNKVFAT 68 VDVV VG GW G ++A EL +AGL V +LERG + E+F Y D++ Y + Sbjct: 8 VDVVTVGAGWTGGIVAAELTKAGLNVLSLERGHMQSTENFNYIH--DEWRYGINYGLMQD 65 Query: 69 PRDAALTVRYNTAQQALPTRKWGAFAPGTGVGGSGLHWTAVLIRPTPTDIKLKTYADQAY 128 +T R++ + ALP RK G+F G VGG+G+HW R P D +++T + Q Y Sbjct: 66 CSKDTVTFRHDPSGLALPYRKMGSFLLGNNVGGAGVHWNGWTFRFMPYDFEIQTLSKQRY 125 Query: 129 KHSKLDPEMRIKDFPFTWNEIEPHFDFFEKVCGQSGKTGNLRGQIQPGGDPFEGPRSNPY 188 + KL + ++D+ T+ ++EP++D FEK CG SG + P + RS+PY Sbjct: 126 GN-KLGNDYTLQDWGVTYKDMEPYYDRFEKTCGVSG-------EPNPLAEKMGAFRSSPY 177 Query: 189 PLPPLHDTYNNSLFAEVARKLGYHPFPNPSANVSQAWTNPYGAQIAPCNYCGFCSKYPCL 248 P PL +T F A+ H + P++N +TNP G +APC YC +C ++ C Sbjct: 178 PQEPLENTKMLKRFESAAKSSNLHTYRLPASNSKGGYTNPDGQDLAPCQYCAYCERFGCE 237 Query: 249 NYSKASPQTTILDVVKRMPNFDYKVNANVIRVDLHADKKTARGVTYID-ENMKEVFQPAK 307 +KASP T++ + + +NV ++ L D K GV ++D MKE QPA Sbjct: 238 YGAKASPLNTVIPKAMSTGKYTIRTYSNVTQI-LKKDGKVT-GVKFVDTRTMKEYIQPAD 295 Query: 308 IVILSSFQFANVRLMLLSGIGKPYDPITETGVIGRNYAFLSNGGATLFFKDKHFNSFATA 367 IV+L+S+ F N +L+++S IG+ YDP T G +GRNY + N G T FF D+ FN+F + Sbjct: 296 IVVLTSYMFNNAKLLMVSNIGEQYDPKTGKGTLGRNYCYQMNMGTTAFF-DEQFNTFMGS 354 Query: 368 GATGEMFNDISPGNFDDGIKLGFIGGAKIHSSQASGAPIGTA-LPPGTPSWGRGWKEGMI 426 GA G +D + NFD K F+ GA I+S Q PI +A LP G P+WG +K+ + Sbjct: 355 GALGTTSDDFNGDNFDHS-KEKFLHGAMIYSVQLGTRPIQSAPLPAGAPTWGAEFKKALN 413 Query: 427 DWYDHSMKISITTTCMSYRGHFLDLDPNYKDPWGQPLLRMTFDWRQNELKLQRYLRDIVL 486 + ++ + + ++ ++L LDP YKD +G PLLR+T+++ + L +++ D Sbjct: 414 YNFTRAITVGGQGASLPHKNNYLSLDPTYKDAFGMPLLRLTYNFTDQDRALHKFITDKTA 473 Query: 487 KISKELNPDHMSESFLALDSHWDITKYVSTHNVGGAIMGDSPRDSALNKYLQSWDVHNVF 546 +++K + + L + + Y STHN GG MG S +N YLQ WD N+F Sbjct: 474 EVAKRMQGVKSIKKGAYLKD-YSVVPYQSTHNTGGTTMGADRETSVVNTYLQHWDADNLF 532 Query: 547 VPGGNAFPQNFQANPTDTIGAITLMAAQAI 576 V G F N NPTDT+GA+ A+ I Sbjct: 533 VVGAGNFQHNSGYNPTDTVGALAYRCAEGI 562 >RSp0904 [E] COG2303 Choline dehydrogenase and related flavoproteins Rso Ralstonia solanacearum Length = 647 Score = 118 bits (296), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 145/576 (25%), Positives = 227/576 (39%), Gaps = 91/576 (15%) Query: 86 PTRKWGAFAPGTGVGGSGLHWTAVLIRPTPTDIKLKTYADQAYKHSKLDPE-MRIKDFPF 144 P R + G+ +GG + W RP P D +LKTY ++ + +L E + D+P Sbjct: 86 PARAFDGGWTGSVLGGGSVLWGTWSFRPLPIDFRLKTYYERTGELGQLQKEGYNVADWPL 145 Query: 145 TWNEIEPHFDFFEKVCGQSGKTGNLRGQIQP-----------GGDPFEGPRSN-----PY 188 + E+ P+F E + G SG + I+ GG+ + G + + Sbjct: 146 AYQEMMPYFHVAETLLGVSGDRAGMNRSIRESAWYQDLRTRFGGEAWFGTDAQWLPDAAF 205 Query: 189 PLPPLHDTYNNSLFAEVARKLGYHPFPNPSANV--------SQA---------------- 224 PL T + ++ G HPFP P+A V +QA Sbjct: 206 PLGAYPTTPVGRIVSDGMDHKGMHPFPTPTAIVQPGSAGFGTQAAIANALNQHRDELDGV 265 Query: 225 -WTNP----YGAQI-APCNYCGFCSKYPCLNYSKASPQ-----TTILDVVKRMPNFDYKV 273 W P + +QI CN CG+C +Y C + + SP+ TT+ ++ +R N + + Sbjct: 266 LWNRPAEQLWSSQIRQACNMCGYCGEYLC--WGRTSPKWGTADTTLRELGQR-DNAEIRC 322 Query: 274 NANVIRVDLHADKKTARGVTYID----ENMKEVFQPAKIVILSSFQFANVRLMLLSGIGK 329 NA + V A + A GV Y+D ++ + V Q A+ VI+S RL+LLSG Sbjct: 323 NAKTLEVLYDAASRRATGVAYLDLTDPDHPRRVEQFAETVIISCGAVQTSRLLLLSG--P 380 Query: 330 PYDPITETGVIGRNYAFLSNGGATLFFKDKHFNSFATAGATGEMFNDISP-GN---FD-- 383 P +G +GRN F G + F G + ++ P GN FD Sbjct: 381 PEGLGNSSGQLGRNAMFHLFGLGMRTVLGEAFQ--------GRLHGELGPTGNTSTFDTY 432 Query: 384 ---DGIKLGFIGGAKIHSSQASGAPIGTALPPGTPSWGRGWKEGMIDWYDHSMKISITTT 440 DG GG +S A P+ A+ S G + + + +I +T Sbjct: 433 FVRDGDGRWIKGGHL--TSAAKKNPLEDAVNAVNGSSKAGAFLDQLLVNNRTFEIRLTGD 490 Query: 441 CMSYRGHFLDLDPNYKDPWGQPLLRMTFDWRQ----------NELKLQRYLRDIVLKISK 490 + + + LDP + D +G P+ R++ NE +L + +K Sbjct: 491 DLPCPENRVSLDPTHVDEYGVPVARISRRSISDAAGNKFVGPNEQRLDAAAQG-AMKAVF 549 Query: 491 ELNPDHMSESFLALDSHWDITKYVSTHNVGGAIMGDSPRDSALNKYLQSWDVHNVFVPGG 550 EL A I V H +G MG+ P S +N+Y + DV NVFV Sbjct: 550 ELYAARRGALAAAPKPTQAILSLVGDHQMGTCRMGEDPATSVVNRYGRLHDVENVFVVDS 609 Query: 551 NAFPQNFQANPTDTIGAITLMAAQAIKTQYLKNPGP 586 + P NP T+ A L I T+ + P Sbjct: 610 SFMPTGLGLNPMVTVVANALRVGTHIVTRLQQGSMP 645 >VNG1035C [E] COG2303 Choline dehydrogenase and related flavoproteins Hbs Halobacterium sp. NRC-1 Length = 529 Score = 107 bits (266), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 147/598 (24%), Positives = 234/598 (39%), Gaps = 103/598 (17%) Query: 8 DVDVVIVGLGWAGSLMAIELAQAGLKVRALERGP-----DRPPEDFAYPKPADQYGYATR 62 + DV ++G G AG L+A LA G V LE GP DR +PA +G A+ Sbjct: 8 NADVCVIGAGPAGGLIADRLASDGHSVVVLEAGPRFDAADRERRMERSIRPA--HGPASV 65 Query: 63 NKVFATPRDAALTVRYNTAQQALPTRKWGAFAPGTGVGGSGLHWTAVLIRPTPTDIKLKT 122 ++ PRDA + T + P A GVGGS LHW +++R D +L + Sbjct: 66 WEM-GGPRDAYAS----TGDRYYPLNA----ARVKGVGGSTLHWQGMVMRLHEQDFRLAS 116 Query: 123 YADQAYKHSKLDPEMRIKDFPFTWNEIEPHFDFFEKVCGQSGKTGNLRGQIQPGGDPFEG 182 D+PF ++ ++P++ E G SG + N PF Sbjct: 117 ATGVG------------ADWPFDYDTLKPYYAAAESALGVSGASDN----------PFAP 154 Query: 183 PRSNPYPLPPLHDTYNNSLFAEVARKLGYHPFPNPSANVSQAWTNPYGAQIAPCNYCGFC 242 PR P+P P +Y++SLFA+ LG P+A +S G Sbjct: 155 PREQPHPQPAFPPSYSDSLFADACESLGIATHSVPNARLS----------------AGRE 198 Query: 243 SKYPCLNYSKASP--------QTTILDVVKRMPNFDYKV--NANVIRVDLHADKKTARGV 292 ++ C+ Y P T+ V R + +V A V R++ A G Sbjct: 199 TRRACVGYGTCQPVCPSGAKYDATVH--VDRATDAGARVIDEAPVQRLEHDAAGDRVTGA 256 Query: 293 TYIDENMKEVFQPAKIVILSSFQFANVRLMLLSGIGKPYDPIT-ETGVIGR---NYAFLS 348 Y + Q A +L++ RL+LLS + D + +G++GR ++ F Sbjct: 257 VYATPDGTTHRQSATEFVLAAGGIETPRLLLLSDSDRYPDGLANSSGLVGRYFMDHLFAG 316 Query: 349 NGGATLFFKDKHFNSFATAGATGEMFNDISPGNFDDGIKLGFIGGAKIHSSQASGAPIGT 408 GG ++ F T + D P IKL F+ + A +P Sbjct: 317 AGGTLDEPTRQNHVGFNTT--ESHQYYD-RPDGSRGAIKLEFL-------NYAGPSPAEM 366 Query: 409 ALPPGTPSWGRGWKEGMIDWYDHSMKISITTTCMSYRG----HFLDLDPNYKDPWGQPLL 464 AL G W + M D + I + + + + L P D G P+ Sbjct: 367 ALS------GDDWGDAMCDRIRDASGTHIAVGGLVEQQPRPENRVRLHPERTDVHGNPVP 420 Query: 465 RMTFDWRQNELKLQRYLRDIVLKISKELNPDHMSESFLALDSHWDITKYVST---HNVGG 521 + + L Y R + + + E+ + ++E L D W + + H++G Sbjct: 421 DVVW-------SLSAYERRTIER-ANEIQREILTE--LGADIEWTVGPEDTGPAFHHMGT 470 Query: 522 AIMGDSPRDSALNKYLQSWDVHNVFVPGGNAFPQNFQANPTDTIGAITLMAAQAIKTQ 579 MG P +S ++ L++ D+ N+ V + FP NPT TI A+ L AA I + Sbjct: 471 TRMGTDPAESVVDPRLRTHDLSNLSVASSSVFPTAGAMNPTLTIAALALKAADHIAAR 528 >AGl980 [E] COG2303 Choline dehydrogenase and related flavoproteins Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 561 Score = 103 bits (258), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 142/604 (23%), Positives = 228/604 (37%), Gaps = 87/604 (14%) Query: 4 ITNDDVDVVIVGLGWAGSLMAIELAQAGLKVRALERGPDRPPEDFAYPKPADQ--YGYAT 61 + ++ D ++VG G +G A EL Q GLKV LERG R E + AD+ + Y Sbjct: 1 MADNHYDAIVVGSGISGGWAAKELTQKGLKVLMLERG--RNIEHVTDYQNADKEAWDYPH 58 Query: 62 RNKVFATPR-------------DAALTVRYNTAQQALPTRKWGAFAPGTGVGGSGLHWTA 108 RN+ + +A L + + + K + G VGG L W Sbjct: 59 RNRATQEMKAKYPVLSRDYLLEEATLGMWADEQETPYVEEKRFDWFRGYHVGGRSLLW-- 116 Query: 109 VLIRPTPTDIKLKTYADQAYKHSKLDPEMRIKD-----FPFTWNEIEPHFDFFEKVCGQS 163 Q Y+ S+ D E KD +P + ++ P +D+ E+ G S Sbjct: 117 ---------------GRQTYRWSQTDFEANAKDGIAVDWPIRYEDVSPWYDYVERFAGIS 161 Query: 164 GKTGNLRGQIQPGGDPFEGPRSNPYPLPPLHDTYNNSLFAEVARKLGYHPFPNPSANVSQ 223 G L I P G+ P PL + + L + A K H + AN++Q Sbjct: 162 GSREGL--DILPDGEFLP-----PIPLNFVEQDVASRL--KKAFKGTRHLINSRCANITQ 212 Query: 224 AWTNPYGAQIAPCNYCGFCSKYPCLNYSKASPQTTILDVVKRMPNFDYKVNANVIRVDLH 283 + + PC + C + C S Q + L N + + V + Sbjct: 213 ELPDQ---ERTPCQFRNKC-RLGCPFGGYFSTQASTLPAAVATGNLTLRPFSIVKEILYD 268 Query: 284 ADKKTARGVTYIDENMKEVFQPAKIVILSSFQFANVRLMLLSGIGKPYDPI--TETGVIG 341 DKK ARGV ID ++ +I + N +L++ ++ + +G +G Sbjct: 269 KDKKKARGVEIIDAETNLTYEYTADIIFLNASTLNSTWVLMNSATDVWEGGLGSSSGELG 328 Query: 342 RN----YAFLSNGGATLFFKDKHFNSFATAGATGEMFNDISPGNFDDGIKLGFIGGAKIH 397 N + + G F+D +F AG F + G+ G A Sbjct: 329 HNVMDHHFRMGATGQVDGFEDFYFKGRRPAGFYIPRFRNTGDDKRKYLRGFGYQGSASRS 388 Query: 398 SSQASGAPIG-------TALPPGTPSWGRGWKEGMIDWYDHSMKISITTTCMSYRGHFLD 450 + A + T PG GW GM + + + Y + + Sbjct: 389 RWEREIAELNIGADYKDTLTEPG------GWTIGMTAFGE----------MLPYHDNRVK 432 Query: 451 LDPNYKDPWGQPLLRMTFDWRQNELKLQRYLRDIVLKISKELNPDHMSESFLALDSHWDI 510 LD + KD WG P+L M + +QNEL ++ + + +++ + + ++ S Sbjct: 433 LDHDKKDKWGLPVLSMNVEMKQNELDMREDMVNDAVEMFEAVGIKNVKPS------RGTY 486 Query: 511 TKYVSTHNVGGAIMGDSPRDSALNKYLQSWDVHNVFVPGGNAFPQNFQANPTDTIGAITL 570 + H +G A MG P+ S LN Q WD NVFV G NP+ T A+T Sbjct: 487 APGMGIHEMGTARMGRDPKTSVLNGNNQVWDAPNVFVTDGACMTSASCVNPSLTYMALTA 546 Query: 571 MAAQ 574 AA+ Sbjct: 547 RAAE 550