BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.4426.p (550 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value FN1406 [E] COG2986 Histidine ammonia-lyase Fnu Fusobacterium nuc... 378 e-104 BS_hutH [E] COG2986 Histidine ammonia-lyase Bsu Bacillus subtilis 344 3e-94 BH1982 [E] COG2986 Histidine ammonia-lyase Bha Bacillus halodurans 339 9e-93 TVN1353 [E] COG2986 Histidine ammonia-lyase Tvo Thermoplasma vol... 335 1e-91 SPy2089 [E] COG2986 Histidine ammonia-lyase Spy Streptococcus py... 335 2e-91 >FN1406 [E] COG2986 Histidine ammonia-lyase Fnu Fusobacterium nucleatum Length = 511 Score = 378 bits (971), Expect = e-104, Method: Compositional matrix adjust. Identities = 215/514 (41%), Positives = 305/514 (59%), Gaps = 32/514 (6%) Query: 10 QTITIDGFTLTAAQVLSVARAPHLKVALAESSRAALKQSRDYIESTWMHDEAPMMYSFNT 69 + I I+G LT V++VAR KV L E + + +SR Y+E + ++ P+ Y NT Sbjct: 3 KIIEINGSNLTIEDVVAVARYGA-KVKLDEKQKDKILESRKYVEEA-LSNKMPI-YGINT 59 Query: 70 GVGLLKDTRIKVEHIELFQTQMIRAHSAGIGEPFSEEVSRATMLLRANAFASNYSAPRVE 129 G G ++ I E +EL Q +I + + G+GE F E+ RA M+LRANA + +S +E Sbjct: 60 GFGKFENVPISEEELELLQKNLIYSDACGVGEAFDTEIVRAMMILRANAISKGFSGVMIE 119 Query: 130 VVDRLLAFINAGIHPIMPQKGSVGASGDLAPLAYLAAAIAGFDEAEVMYQGQRMRATQAI 189 V+ LL +NAG+HPI+ KGSVG+SGDL PLA++ + G EAE Y+G+ + +A+ Sbjct: 120 TVECLLNMLNAGVHPIVRSKGSVGSSGDLCPLAHMVLPMIGEGEAE--YKGEILSGKEAM 177 Query: 190 EQAGIGPVKFDLKAKDASALINGCTASLAVAILAAHDARNLLTDACLSLGLTLEAMRAEM 249 ++AG+ + LKAK+ ALING A + A+LA +DA LL A + L+++A+ + Sbjct: 178 KKAGVSTIT--LKAKEGLALINGTQAMMGNAVLAVYDAEKLLKQADIVASLSIDALGGII 235 Query: 250 SAFDARIQQARPHAGQIKTAAVIRTLLNGSTRTTHDARAVQLPDELRRTDIPYTARIQDV 309 AFD RI RPH GQI +A +R LL GS RTT R+QD Sbjct: 236 DAFDERIHLIRPHKGQIYSAENLRKLLKGSKRTTRQGE----------------KRMQDA 279 Query: 310 YSLRCAPQVYGPVFDALDYIDTIIEKETNSATDNPLIFNKEDGEGFEIISGGNFHGQYLA 369 YSLRC PQV+G A DY+ +E E NS TDNPLIF E+G ISGGNFHGQ +A Sbjct: 280 YSLRCTPQVHGASRLAFDYVKQTVETEINSVTDNPLIFPGENG---ACISGGNFHGQPIA 336 Query: 370 QAMDLLAMAITDLGSICERRIARLIDPTLSWGLPRNLMSGIRGVNTGYPVVQCSMSSLVM 429 AMD L + ++++ +I ERRI +L++P LS GLP L+ G+N G+ + Q ++LV Sbjct: 337 IAMDTLGILMSEIANISERRIEKLVNPALSHGLPAFLVKN-GGINDGFMIPQYVAAALVS 395 Query: 430 ENRTLCMPGSVDSIPSKGNSEDHISNSTWCARKAMTVVQNTQYIVGVEMLLAAQALTMTD 489 EN+ L P SVDSIP+ N EDH+S T ARKA T+V + Q++V +E+L AAQA Sbjct: 396 ENKVLAHPASVDSIPTSANQEDHVSMGTIGARKARTIVDHAQHVVSIELLCAAQAA---- 451 Query: 490 DLLKDFTLGQGTQAAYAEIRCQIPACLDGDRWFH 523 D LG GT+ AY +R ++ ++ D F+ Sbjct: 452 DFWDSKNLGVGTKEAYRTLREKVD-FMENDVIFY 484 >BS_hutH [E] COG2986 Histidine ammonia-lyase Bsu Bacillus subtilis Length = 508 Score = 344 bits (883), Expect = 3e-94, Method: Compositional matrix adjust. Identities = 213/527 (40%), Positives = 308/527 (58%), Gaps = 34/527 (6%) Query: 12 ITIDGFTLTAAQVLSVARAPHLKVALAESSRAALKQSRDYIESTWMHDEAPMMYSFNTGV 71 +T+DG +LT A V V + A +E S +K+SR +E + DE +Y NTG Sbjct: 2 VTLDGSSLTTADVARVL-FDFEEAAASEESMERVKKSRAAVERI-VRDEK-TIYGINTGF 58 Query: 72 GLLKDTRIKVEHIELFQTQMIRAHSAGIGEPFSEEVSRATMLLRANAFASNYSAPRVEVV 131 G D I+ E Q +I +H+ G+G+PF E VSRA +LLRANA +S R E++ Sbjct: 59 GKFSDVLIQKEDSAALQLNLILSHACGVGDPFPECVSRAMLLLRANALLKGFSGVRAELI 118 Query: 132 DRLLAFINAGIHPIMPQKGSVGASGDLAPLAYLAAAIAGFDEAEVMYQGQRMRATQAIEQ 191 ++LLAF+N +HP++PQ+GS+GASGDLAPL++LA A+ G + EV ++G+RM A +++ Sbjct: 119 EQLLAFLNKRVHPVIPQQGSLGASGDLAPLSHLALALIG--QGEVFFEGERMPAMTGLKK 176 Query: 192 AGIGPVKFDLKAKDASALINGCTASLAVAILAAHDARNLLTDACLSLGLTLEAMRAEMSA 251 AGI PV L +K+ ALING A A+ ++A +A L LT+E ++ + A Sbjct: 177 AGIQPVT--LTSKEGLALINGTQAMTAMGVVAYIEAEKLAYQTERIASLTIEGLQGIIDA 234 Query: 252 FDARIQQARPHAGQIKTAAVIRTLLNGSTRTTHDARAVQLPDELRRTDIPYTARIQDVYS 311 FD I AR + QI A IR L+ S TT EL R+QD YS Sbjct: 235 FDEDIHLARGYQEQIDVAERIRFYLSDSGLTTSQG-------EL---------RVQDAYS 278 Query: 312 LRCAPQVYGPVFDALDYIDTIIEKETNSATDNPLIFNKEDGEGFEIISGGNFHGQYLAQA 371 LRC PQV+G + L Y+ +E E N+ATDNPLIFN +G ++ISGGNFHGQ +A A Sbjct: 279 LRCIPQVHGATWQTLGYVKEKLEIEMNAATDNPLIFN----DGDKVISGGNFHGQPIAFA 334 Query: 372 MDLLAMAITDLGSICERRIARLIDPTLSWGLPRNLMSGIRGVNTGYPVVQCSMSSLVMEN 431 MD L +AI++L +I ERRI RL++P L+ LP +S G+ +G ++Q + +SLV EN Sbjct: 335 MDFLKIAISELANIAERRIERLVNPQLN-DLP-PFLSPHPGLQSGAMIMQYAAASLVSEN 392 Query: 432 RTLCMPGSVDSIPSKGNSEDHISNSTWCARKAMTVVQNTQYIVGVEMLLAAQALTMTDDL 491 +TL P SVDSIPS N EDH+S T AR A V+ NT+ ++ +E + A QA+ + Sbjct: 393 KTLAHPASVDSIPSSANQEDHVSMGTIAARHAYQVIANTRRVIAIEAICALQAV----EY 448 Query: 492 LKDFTLGQGTQAAYAEIRCQIPACLDGDRWFHDDVQLAHDFVVSGSV 538 T+ + E+R +P+ + DR F D++ D++ S+ Sbjct: 449 RGIEHAASYTKQLFQEMRKVVPS-IQQDRVFSYDIERLTDWLKKESL 494 >BH1982 [E] COG2986 Histidine ammonia-lyase Bha Bacillus halodurans Length = 511 Score = 339 bits (870), Expect = 9e-93, Method: Compositional matrix adjust. Identities = 198/503 (39%), Positives = 294/503 (58%), Gaps = 33/503 (6%) Query: 35 VALAESSRAALKQSRDYIESTWMHDEAPMMYSFNTGVGLLKDTRIKVEHIELFQTQMIRA 94 V ++ S +KQSR +E + DE ++Y TG G D I + +E Q +I + Sbjct: 27 VGASDESMEKVKQSRKAVEQI-VADEK-IIYGITTGFGKFSDIFIDPDDVENLQHNLIYS 84 Query: 95 HSAGIGEPFSEEVSRATMLLRANAFASNYSAPRVEVVDRLLAFINAGIHPIMPQKGSVGA 154 H+ G+G PF E VSR ++LRANA +S R V++RLLA +NA IHP++PQ+GS+GA Sbjct: 85 HACGVGSPFPETVSRTMLVLRANALLKGFSGVRPLVIERLLALVNANIHPVIPQQGSLGA 144 Query: 155 SGDLAPLAYLAAAIAGFDEAEVMYQGQRMRATQAIEQAGIGPVKFDLKAKDASALINGCT 214 SGDLAPL++LA + G E EV Y+G + +A+ A+++ I P+ L AK+ ALING Sbjct: 145 SGDLAPLSHLALVLLG--EGEVFYKGTKTKASFALKEEEIEPIT--LTAKEGLALINGTQ 200 Query: 215 ASLAVAILAAHDARNLLTDACLSLGLTLEAMRAEMSAFDARIQQARPHAGQIKTAAVIRT 274 A A+ ++A +A L + + LT+E +R + AFD +I AR + Q+ A + + Sbjct: 201 AMTAMGVIAYLEAEKLAFQSEIIASLTMEGLRGIIDAFDEQIHFARGYVEQVDVARRMES 260 Query: 275 LLNGSTRTTHDARAVQLPDELRRTDIPYTARIQDVYSLRCAPQVYGPVFDALDYIDTIIE 334 L S TT R+ ++ R+QD YSLRC PQV+G + L Y+ +E Sbjct: 261 YLQDSQLTT------------RQGEL----RVQDAYSLRCIPQVHGATWQTLRYVKEKLE 304 Query: 335 KETNSATDNPLIFNKEDGEGFEIISGGNFHGQYLAQAMDLLAMAITDLGSICERRIARLI 394 E N+ATDNPLIF+ G ++ISGGNFHGQ +A AMD L +A+ +L +I ERRI RL+ Sbjct: 305 IEMNAATDNPLIFDN----GQKVISGGNFHGQQIALAMDFLGIAMAELANISERRIERLV 360 Query: 395 DPTLSWGLPRNLMSGIRGVNTGYPVVQCSMSSLVMENRTLCMPGSVDSIPSKGNSEDHIS 454 +P L+ LP +S GV +G ++Q +SLV EN+TL P SVDSIPS N EDH+S Sbjct: 361 NPQLN-DLP-PFLSAAPGVQSGVMILQYCAASLVSENKTLAHPASVDSIPSSANQEDHVS 418 Query: 455 NSTWCARKAMTVVQNTQYIVGVEMLLAAQALTMTDDLLKDFTLGQGTQAAYAEIRCQIPA 514 T +R A ++QN + ++ +E++ A QA+ D+ + T+ + R +P Sbjct: 419 MGTIGSRHAYQIIQNVRNVLAIELICAMQAV----DIRGREKMASFTKKILEKGREHVP- 473 Query: 515 CLDGDRWFHDDVQLAHDFVVSGS 537 +D DR F D++ A ++ GS Sbjct: 474 YIDQDRMFAKDIERAAKWLKDGS 496 >TVN1353 [E] COG2986 Histidine ammonia-lyase Tvo Thermoplasma volcanium Length = 495 Score = 335 bits (860), Expect = 1e-91, Method: Compositional matrix adjust. Identities = 208/532 (39%), Positives = 301/532 (56%), Gaps = 41/532 (7%) Query: 12 ITIDGFTLTAAQVLSVARAPHLKVALAESSRAALKQ-SRDYIESTWMHDEAPMMYSFNTG 70 I IDG LT V SV+ H V L+ +R + + R +++ + +Y NTG Sbjct: 2 IEIDGDNLTLEDVYSVS-VLHEPVELSTKARNKVAEIHRKFLD---LISSGQTIYGVNTG 57 Query: 71 VGLLKDTRI-KVEHIELFQTQMIRAHSAGIGEPFSEEVSRATMLLRANAFASNYSAPRVE 129 G L + +I + E IEL Q +IR+HSAG+G+ +V R+ M++RAN A YSA E Sbjct: 58 FGGLLNIKISREEEIEL-QRNLIRSHSAGVGKYLPTDVVRSIMVIRANTLAKGYSAVSTE 116 Query: 130 VVDRLLAFINAGIHPIMPQKGSVGASGDLAPLAYLAAAIAGFDEAEVMYQGQRMRATQAI 189 ++D LLA IN + P +P+ GSVGASGDLAPLA++ A+ G E + G+ MR+ A+ Sbjct: 117 LIDALLAMINKDVVPAVPEFGSVGASGDLAPLAHIGLAMMG--EGQAFLNGELMRSDIAL 174 Query: 190 EQAGIGPVKFDLKAKDASALINGCTASLAVAILAAHDARNLLTDACLSLGLTLEAMRAEM 249 + G+ P +F K K+ ALING + + L A + +A S L+ EA+R Sbjct: 175 SKVGLKPYEF--KEKEGVALINGTSMMAGIMALVTSRAYRTIENAVRSSLLSFEALRGTS 232 Query: 250 SAFDARIQQARPHAGQIKTAAVIRTLLNGSTRTTHDARAVQLPDELRRTDIPYTARIQDV 309 AF I ARPH GQI A +R L GS + V+ D+ ++QD Sbjct: 233 KAFSDWIVSARPHLGQIAIAEKMRKYLAGS-------KNVEKSDK---------EKVQDA 276 Query: 310 YSLRCAPQVYGPVFDALDYIDTIIEKETNSATDNPLIFNKEDGEGFEIISGGNFHGQYLA 369 Y+LRC PQVYG V D L+Y+ +++ E NSATDNPL FN G E++SGGNFHG+ +A Sbjct: 277 YTLRCIPQVYGAVLDTLEYVSSVLVTEINSATDNPL-FN-----GKEVVSGGNFHGEPIA 330 Query: 370 QAMDLLAMAITDLGSICERRIARLIDPTLSWGLPRNLMSGIRGVNTGYPVVQCSMSSLVM 429 A D L++A+TD+G++ ERRIARL+D LS GLP L+ G+N+GY + Q + ++L Sbjct: 331 LAADFLSIALTDMGNMIERRIARLVDTNLS-GLPPFLVKN-SGLNSGYMIPQYTAAALCN 388 Query: 430 ENRTLCMPGSVDSIPSKGNSEDHISNSTWCARKAMTVVQNTQYIVGVEMLLAAQALTMTD 489 N+ L P S DSIP+ N EDH+S + K + + +N +YIV +E LL AQAL + Sbjct: 389 RNKVLSYPSSADSIPTSANQEDHVSMGSTSTLKLLEIEENLEYIVAIEFLLGAQALEFSQ 448 Query: 490 DLLKDFTLGQGTQAAYAEIRCQIPACLDGDRWFHDDVQLAHDFVVSGSVRNA 541 D + T+A Y +IR + LD DR + D++ + + + NA Sbjct: 449 DPISPV-----TKAIYTKIREYVKP-LDKDRPSYLDIEKIREIMNKNELINA 494 >SPy2089 [E] COG2986 Histidine ammonia-lyase Spy Streptococcus pyogenes M1 GAS Length = 513 Score = 335 bits (858), Expect = 2e-91, Method: Compositional matrix adjust. Identities = 194/507 (38%), Positives = 293/507 (57%), Gaps = 39/507 (7%) Query: 9 TQTITIDGFTLTAAQVLSVAR---APHLKVALAESSRAALKQSRDYIESTWMHDEAPMMY 65 T+ I +DG +LT V+++AR A H+ + E+ A+ K D + E ++Y Sbjct: 2 TRVINLDGESLTIEDVIAIARQGVACHIDDSAIEAVNASRKIVDDIV------SEKRVVY 55 Query: 66 SFNTGVGLLKDTRIKVEHIELFQTQMIRAHSAGIGEPFSEEVSRATMLLRANAFASNYSA 125 TG G L + I E Q +IR H++G G+P E+ RA ML+R N+ YS Sbjct: 56 GVTTGFGSLCNVSISPEDTVQLQENLIRTHASGFGDPLPEDAVRAIMLIRINSLVKGYSG 115 Query: 126 PRVEVVDRLLAFINAGIHPIMPQKGSVGASGDLAPLAYLAAAIAGFDEAEVMYQGQRMRA 185 R+ +++LL +N G+HP +P+KGS+GASGDLAPLA++ + G +A Y+G+ + Sbjct: 116 IRLSTIEKLLELLNKGVHPYIPEKGSLGASGDLAPLAHMVLPMLGLGKA--YYKGELLSG 173 Query: 186 TQAIEQAGIGPVKFDLKAKDASALINGCTASLAVAILAAHDARNLLTDACLSLGLTLEAM 245 +A+++AGI K L AK+ ALING T AV LA +DA LL + L+ L+LE Sbjct: 174 QEALDKAGID--KISLAAKEGLALINGTTVLTAVGALATYDAIQLLKLSDLAGALSLEVH 231 Query: 246 RAEMSAFDARIQQARPHAGQIKTAAVIRTLLNGSTRTTHDARAVQLPDELRRTDIPYTAR 305 S F+ + RP +GQ+ TA IR LL GS TT + +R Sbjct: 232 NGITSPFEENLHTIRPQSGQLATARNIRNLLEGSQNTT----------------VATQSR 275 Query: 306 IQDVYSLRCAPQVYGPVFDALDYIDTIIEKETNSATDNPLIFNKEDGEGFEIISGGNFHG 365 +QD Y+LRC PQ++G D++ Y+ + ++ E NS TDNP+I +DG +ISGGNFHG Sbjct: 276 VQDPYTLRCMPQIHGASKDSIAYVKSKVDIEINSVTDNPIIC--KDG---HVISGGNFHG 330 Query: 366 QYLAQAMDLLAMAITDLGSICERRIARLIDPTLSWGLPRNLMSGIRGVNTGYPVVQCSMS 425 + +AQ D L +AI+++G++ ERR+ RL++ LS LP L+ G+N+G+ + Q + + Sbjct: 331 EPMAQPFDFLGIAISEIGNVSERRVERLVNSQLSK-LPSFLVK-YPGLNSGFMITQYACA 388 Query: 426 SLVMENRTLCMPGSVDSIPSKGNSEDHISNSTWCARKAMTVVQNTQYIVGVEMLLAAQAL 485 SL EN+ L P SVDSIPS N ED +S T ARKA +++N++ IV E++ A QAL Sbjct: 389 SLASENKVLAHPASVDSIPSCENQEDFVSMGTTAARKAFEILKNSRRIVATEIMAACQAL 448 Query: 486 TMTDDLLKDFTLGQGTQAAYAEIRCQI 512 + + + LG+GT+ AY R ++ Sbjct: 449 DLKPE---NHELGKGTKVAYDLFRKEV 472