BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.4393.p (315 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value YPO1933 [R] COG3618 Predicted metal-dependent hydrolase of the T... 199 8e-51 AGl3341 [R] COG3618 Predicted metal-dependent hydrolase of the T... 115 1e-25 RSp0233 [R] COG3618 Predicted metal-dependent hydrolase of the T... 103 7e-22 Cgl0451 Non COG 73 8e-13 Cj0556 [R] COG3618 Predicted metal-dependent hydrolase of the TI... 67 7e-11 >YPO1933 [R] COG3618 Predicted metal-dependent hydrolase of the TIM-barrel fold Ype Yersinia pestis Length = 289 Score = 199 bits (505), Expect = 8e-51, Method: Compositional matrix adjust. Identities = 110/268 (41%), Positives = 144/268 (53%), Gaps = 2/268 (0%) Query: 50 LPANACDCHMHIYDAR--FPWAPGAKLLHPPATVAMYRQIQQRLGSTRNVVVTPSAYGVD 107 LP +ACD H H+ R +P PPA Y + G +R V+V S YG D Sbjct: 22 LPEDACDSHAHVISPRAIYPMVAERSYTPPPAPEEKYLSMLAATGMSRGVLVQISVYGSD 81 Query: 108 NRCTLDALAQFGATARGVAVVNDQVSDEELQRLHQAGVRGLRFNLALGSVTTVAMMEPLA 167 NR L L + RGVAVV + V+D+ELQ + AGVRGLR N+ G ME LA Sbjct: 82 NRYMLQVLKRHPEYLRGVAVVTEDVTDQELQDMALAGVRGLRINVLFGGGIGFDAMENLA 141 Query: 168 RRVAALGWHLQVNMSNEVLLANGALLARLAVPVVFDHFARIPLQAGAGDPVFDLVTSLMR 227 ++A LGWH+Q M L A + +L P V DH +P+ G P + + ++R Sbjct: 142 SKIAPLGWHMQFLMDVRQLPALIPRMKKLPCPCVIDHMGHMPVSLGLNHPGYQTLLHMVR 201 Query: 228 EQRASVKLSGAYLFSKRGAPAYEDVAPLARALVEVAPTQVVWGSDWPHPTEQHKPDDARL 287 E VKLSGAY S+ Y DV P A+ L+E AP ++VWGSDWPH + PD L Sbjct: 202 EYGWWVKLSGAYRISESWQDGYLDVVPFAQKLIETAPDRMVWGSDWPHVSVSRMPDTGGL 261 Query: 288 LDALIGWLGSEQMIHTVLVDNPARLYHF 315 + L W+ EQ+ + +LVDNPARLY F Sbjct: 262 RNLLAAWVPDEQVRNRILVDNPARLYDF 289 >AGl3341 [R] COG3618 Predicted metal-dependent hydrolase of the TIM-barrel fold Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 292 Score = 115 bits (289), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 78/281 (27%), Positives = 125/281 (44%), Gaps = 18/281 (6%) Query: 46 PVARLPANACDCHMHIYDARFPWAPGAKLLHPPATVAM--------YRQIQQRLGSTRNV 97 P P A D MH+Y PG L + YR++ Q LG R + Sbjct: 13 PNPAFPRGAVDTQMHMY------LPGYPALPGGPGLPPGALPGPEDYRRLMQWLGIDRVI 66 Query: 98 VVTPSAYGVDNRCTLDALAQFGATARGVAVVNDQVSDEELQRLHQAGVRGLRFNLALGSV 157 + +A+ DN TL +A+ G A V +++ +++++++L AG G R G Sbjct: 67 ITQGNAHQRDNGNTLACVAEMGEAAHAVVIIDATTTEKDMEKLTAAGTVGARIMDLPGGA 126 Query: 158 TTVAMMEPLARRVAALGWHLQVNMSNEVLLANGALLARLAVPVVFDHFARIPLQAGAGDP 217 ++ ++ + R A W + V LL + L ++ VFDH + P Sbjct: 127 VNLSELDAVDERAHAADWMVAVQFDGNGLLDHLPRLQKIRSRWVFDHHGKFFKGIRTDGP 186 Query: 218 VFDLVTSLMREQRASVKLSGAYLFSKRGAPAYEDVAPLARALVEVAPTQVVWGSDWPHPT 277 + L+ K +G Y S++ P Y DVA +R + AP ++VWG++WPH + Sbjct: 187 EMAALLKLIDRGNLWFKFAGVYESSRKSWP-YADVAAFSRVIAAHAPERIVWGTNWPHNS 245 Query: 278 EQHK---PDDARLLDALIGWLGSEQMIHTVLVDNPARLYHF 315 + PDDARL + +GWL E H LV+NP L+ Sbjct: 246 VRETAAYPDDARLAELTLGWLPDEAARHRALVENPEALFKL 286 >RSp0233 [R] COG3618 Predicted metal-dependent hydrolase of the TIM-barrel fold Rso Ralstonia solanacearum Length = 302 Score = 103 bits (256), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 91/277 (32%), Positives = 126/277 (45%), Gaps = 13/277 (4%) Query: 46 PVARLPANACDCHMHIYDARFPWAPGAKLLHPP--ATVAMYRQIQQRLGSTRNVVVTPSA 103 P AR+ D H H++ P A GA+ P AT+ Y G + V++ PS Sbjct: 31 PTARI--TGIDTHAHVFKRGLPLA-GARRYAPSYDATLPAYLAQLDAHGLSHGVLIQPSF 87 Query: 104 YGVDNRCTLDALAQFGATARGVAVVNDQVSDEELQRLHQAGVRGLRFNL--ALGSVTTVA 161 G DN L AL Q RGVAV++ + L +L+ G+ G+R NL A Sbjct: 88 LGGDNSYLLAALRQAPQRLRGVAVIDPAAPEPFLAQLNAEGIVGIRLNLIGAPDPQLRAP 147 Query: 162 MMEPLARRVAALGWHLQVNMSNEVLLANGALLARLAVPVVFDHFARIPLQAGAGDPVFDL 221 + R+ ALGWH++++ L A L V VV DHF R DP F Sbjct: 148 AWQAALHRLHALGWHVELHTQAHRLPALLPPLLEAQVDVVVDHFGRPDPALSVEDPGFAA 207 Query: 222 VTSLMREQRASVKLSGAYLFSKRGAPAYEDVAPLARALVEVAPTQVVWGSDWPHPTEQHK 281 + + R +R VK+SGAY G +A + R + ++VWGSDWPH + + Sbjct: 208 LLAAGRTRRVWVKVSGAYRNGDAGRGEAIALAAMPRLKDALGTDRLVWGSDWPHTQYESR 267 Query: 282 P--DDAR-LLDALIGWLGSEQMIHTVLVDNPARLYHF 315 D AR D L+ G H VLV+ PARL+ F Sbjct: 268 IGYDSARAFADTLLPDAGDR---HQVLVETPARLFRF 301 >Cgl0451 Non COG Length = 250 Score = 73.2 bits (178), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 77/265 (29%), Positives = 109/265 (41%), Gaps = 23/265 (8%) Query: 52 ANACDCHMHIYDARFPWAPGAKLLHPPATVAMYRQIQQRLGSTRNVVVTPSAYGVDNRCT 111 A D H HI D + P L P TV Y + L +V+ S D Sbjct: 2 AKLFDSHFHIIDPQHPLIENNGYLPEPFTVEDYTARVEGLEVAGGAIVSGSFQAFDQGYL 61 Query: 112 LDALAQFGATARGVAVVNDQVSDEELQRLHQAGVRGLRFNLALGSVTTVAMMEPLARRVA 171 DALA G GV + SD+E+ L +AGV+ +R NL G + +E LARRV Sbjct: 62 KDALAVLGPGYVGVTQIPADTSDQEILDLDKAGVKAVRLNLKRGGSAGLDDLETLARRVH 121 Query: 172 AL-GWHLQVNMSNEVLLANGALLARLAVPVVFDHFARIPLQAGAGDPVFDLVTSLMR--E 228 L GWH ++ + L + LA L V DH D + +L+R E Sbjct: 122 DLAGWHTELYVDARELDELESTLASLPA-VSIDHLGLHR----------DGLPALLRLVE 170 Query: 229 QRASVKLSGAYLFSKRGAPAYEDVAPLARALVEVAPTQVVWGSDWPHPTEQHKPDDARLL 288 VK +G F + D + +A++ V PT ++ G+D P + +DA L Sbjct: 171 NGIKVKATG---FGR----VELDPTEVIQAIMAVDPTALMIGTDLPSTRTKRPFEDADL- 222 Query: 289 DALIGWLGSEQMIHTVLVDNPARLY 313 LI E + V +N A Y Sbjct: 223 -DLIAETVGEDHVDNVFWNNAAAFY 246 >Cj0556 [R] COG3618 Predicted metal-dependent hydrolase of the TIM-barrel fold Cje Campylobacter jejuni Length = 265 Score = 66.6 bits (161), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 64/275 (23%), Positives = 117/275 (42%), Gaps = 28/275 (10%) Query: 56 DCHMHIYDARFPWAPGAKLLHPPATVAMYRQIQQRLGS---TRNVVVTPSAYGVDNRCTL 112 D H HI+ + A+ + P A ++ + L + V+V PS G+DN L Sbjct: 4 DTHAHIFLKKLNTVANAR--YKPDYDASFKDYKANLDHYDFNKGVLVQPSFLGIDNEFLL 61 Query: 113 DALAQFGATARGVAVVNDQVSDEELQRLHQAGVRGLRFNLA------LGSVTTVAMMEPL 166 ++ + + + VV++ + +EL++L + G+R NL S+ E L Sbjct: 62 QSIEK-DENIKAIVVVDENIKFDELKKLKERKACGVRLNLIGKELPNFKSMVWTQFFENL 120 Query: 167 ARRVAALGWHLQVNMSNEVLLANGALLARLAVPVVFDHFARIPLQAGAG-DPVFDLVTSL 225 ++ + +Q ++ N ++ L+ +V DH AR A A + DL+ Sbjct: 121 SK--LKMQIEIQRDLDNNLVDIVENLIP-YGCNIVIDHLAR----ANANLTNLEDLIC-- 171 Query: 226 MREQRASVKLSGAYLFSKRGAPAYEDVAPLARALVEVAP-----TQVVWGSDWPHPTEQH 280 ++ R K+SG Y +K E A+ + E+ + V+GSDWPH + Sbjct: 172 LKNSRIFFKISGFYR-AKIDYANNEQAVKFAKKIYEILKEHFPLSNFVFGSDWPHTNFEA 230 Query: 281 KPDDARLLDALIGWLGSEQMIHTVLVDNPARLYHF 315 + + L A + S++ +L DN L+ F Sbjct: 231 NINFSSALVAFNEVVVSKKEQEQILGDNACALFGF 265