BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.4392.p (446 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSp0182 [GEPR] COG0477 Permeases of the major facilitator superf... 327 5e-89 YPO2237 [GEPR] COG0477 Permeases of the major facilitator superf... 326 7e-89 RSc2352 [GEPR] COG0477 Permeases of the major facilitator superf... 322 1e-87 BMEII1096 [GEPR] COG0477 Permeases of the major facilitator supe... 313 4e-85 STM1107 [GEPR] COG0477 Permeases of the major facilitator superf... 300 5e-81 >RSp0182 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 453 Score = 327 bits (837), Expect = 5e-89, Method: Compositional matrix adjust. Identities = 189/420 (45%), Positives = 263/420 (62%), Gaps = 6/420 (1%) Query: 17 AAVSEQATMKKVMRRLIPFILLCYVVSYLDRINVGFAALTMNKELGLTPSQFGLGAGLFF 76 AA E+A ++K+ R++PF+ Y++SYLDR N+G+AAL MN+EL L+ FG +G+FF Sbjct: 22 AAPDERAIVRKITWRILPFVFALYIISYLDRANIGYAALQMNQELALSSEAFGFVSGIFF 81 Query: 77 IGYFFFEIPSNLALHRFGARMWISRIMISWGLISMATAFVVGPKSFALARFLLGMAEAGF 136 IGYF FE+PSNL L+RFGAR WI+RI+++WGL++M +AFV RFLLG+AEAGF Sbjct: 82 IGYFLFEVPSNLMLNRFGARRWIARILVTWGLVAMGSAFVQSATQLYALRFLLGVAEAGF 141 Query: 137 TPGIYLYFTQWFPGPWRAKATAFFLIGIPVANIIGSPLSGALMELHGMW-GFQGWQVLLL 195 PGI +Y T WF A A F IPV+ ++G+PLS +M+ H W + GW+ +LL Sbjct: 142 FPGIIVYLTYWFRARELATTVALFTAAIPVSYVVGAPLSTWIMD-HVHWLQWSGWRWMLL 200 Query: 196 LEALPAVLLGVLCLFLLPDRPAKANWLNPAEKQWLENELSTEQNVL-AQRHGNKLKDAFT 254 LE PAV+ G+LC L DRP A WL+ AE+ WL EL ++ A H LK T Sbjct: 201 LEGAPAVIGGLLCYGYLADRPKDARWLSEAERDWLLAELERDRKARPAAAHLATLK-VMT 259 Query: 255 NWRVFALAGANFCGIIGSLSIGLWLPQIIKEF--GLPAHQVGLVAALPYVVGAIAMTLWA 312 + RV LA F GSL IG W+PQIIK F L +VGL+A LPYV M W+ Sbjct: 260 HPRVLYLAFIYFVYQCGSLGIGYWMPQIIKGFSSALSHTEVGLIAMLPYVFATAVMIWWS 319 Query: 313 RLANRSQRRLLFVAGAIVLAAVSLAVSAFLHTPLLKMLAITVAVASILSFQATFWAIPSG 372 R ++ R L A + +AA++ + F+ P + M +++++A + +F++ FWA+P+ Sbjct: 320 RRSDLRAERRLHSAVPLGVAALAFVGAGFIGHPAVAMAMLSLSLAGLYAFKSPFWALPTL 379 Query: 373 FLTGRAAAGGLALIVSIGNLGGFVGPSVIGFIREATQGFTYPLLFVAGALLLGAVITLAL 432 FLT AA +A+I S+GNLGGFVGP IG+ + T LLF+AG L + V+TL L Sbjct: 380 FLTRSTAAVSIAVINSVGNLGGFVGPFAIGYFKGQMHSTTAGLLFLAGLLAVSFVMTLRL 439 >YPO2237 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 436 Score = 326 bits (836), Expect = 7e-89, Method: Compositional matrix adjust. Identities = 187/442 (42%), Positives = 272/442 (61%), Gaps = 9/442 (2%) Query: 1 MSQASINFIASAPVSTAAVSEQATMKKVMRRLIPFILLCYVVSYLDRINVGFAALTMNKE 60 MS++S + S P T E +K + L+P ++LCYV++YLDR+NVGFA L M + Sbjct: 1 MSESSTESL-SQP--TQLQEENNAYRKTVWHLLPLLMLCYVLNYLDRVNVGFAKLQMADD 57 Query: 61 LGLTPSQFGLGAGLFFIGYFFFEIPSNLALHRFGARMWISRIMISWGLISMATAFVVGPK 120 L + + +GLGAG+FFIGYFF EIPSNL LHR GAR+WI+RIMI+WG+IS AFV P Sbjct: 58 LQFSDTVYGLGAGMFFIGYFFLEIPSNLILHRVGARLWIARIMITWGIISACMAFVTTPM 117 Query: 121 SFALARFLLGMAEAGFTPGIYLYFTQWFPGPWRAKATAFFLIGIPVANIIGSPLSGALME 180 SF + RFLLG+AEAGF PGI LY + WFP R + F+I +P++ IIG+PLSG +M+ Sbjct: 118 SFYVMRFLLGVAEAGFFPGIILYISYWFPSHRRGRVYGLFVISVPLSGIIGAPLSGWIMQ 177 Query: 181 -LHGMWGFQGWQVLLLLEALPAVLLGVLCLFLLPDRPAKANWLNPAEKQWLENELSTEQN 239 +G G+ GWQ + +LE +P+VL+G+L ++ L DR A WL EK L+ + E Sbjct: 178 YFNGFQGYAGWQWMFILEGIPSVLVGILIIYKLKDRITHATWLTDKEKDILQTNIENEA- 236 Query: 240 VLAQRHGNKLKDAFTNWRVFALAGANFCGIIGSLSIGLWLPQIIKEFGLPA-HQVGLVAA 298 A ++L+DAF RV+ L FC I G +IG WLP +I++ G+ +G + A Sbjct: 237 --AHYAHSRLRDAFLQPRVWLLTLIYFCLISGFYTIGFWLPTLIRDSGVKDILSIGFLTA 294 Query: 299 LPYVVGAIAMTLWARLANRSQRRLLFVAGAIVLAAVSLAVSAFLHTPL-LKMLAITVAVA 357 +P A+ M + +R A+R + R +A VL AV + +S + + + M+ +T+ Sbjct: 295 IPSAAAAVTMIVVSRSADRLRERRWHLALTAVLGAVGIILSTYFSDNIVVAMVCLTIGAM 354 Query: 358 SILSFQATFWAIPSGFLTGRAAAGGLALIVSIGNLGGFVGPSVIGFIREATQGFTYPLLF 417 LS FW++P+ FL G AAA G+A I S GNLGGFV P ++G++++ TQ T +L Sbjct: 355 GALSTIPLFWSLPTAFLGGSAAAAGIAFINSWGNLGGFVAPYMMGYLKDLTQSTTTGMLI 414 Query: 418 VAGALLLGAVITLALGDPARVH 439 ++ L +GA + + A H Sbjct: 415 ISTTLFIGAALVFLIPAKAVNH 436 >RSc2352 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 442 Score = 322 bits (825), Expect = 1e-87, Method: Compositional matrix adjust. Identities = 188/429 (43%), Positives = 273/429 (63%), Gaps = 8/429 (1%) Query: 13 PVSTAAVSEQATMKKVMRRLIPFILLCYVVSYLDRINVGFAALTMNKELGLTPSQFGLGA 72 P +A+ E+AT +KV RLIPF+LLCYVV+YLDR+NVGFA L M +L + + +GLGA Sbjct: 16 PPQSASGFEEATYRKVSWRLIPFLLLCYVVAYLDRVNVGFAKLQMLNDLKFSETVYGLGA 75 Query: 73 GLFFIGYFFFEIPSNLALHRFGARMWISRIMISWGLISMATAFVVGPKSFALARFLLGMA 132 G+FFIGYF FE+PSN+ LHR GARMWI+RIMISWGLIS A FV P F + RFLLG+A Sbjct: 76 GIFFIGYFLFEVPSNVILHRVGARMWIARIMISWGLISAAMMFVTTPAMFYVMRFLLGLA 135 Query: 133 EAGFTPGIYLYFTQWFPGPWRAKATAFFLIGIPVANIIGSPLSG-ALMELHGMWGFQGWQ 191 EAGF PGI LY T W+P R + T FF+ + ++ +IG P+SG AL G++G GWQ Sbjct: 136 EAGFFPGIILYLTYWYPAERRGRTTTFFMTAVALSGVIGGPISGWALKTFGGVYGLAGWQ 195 Query: 192 VLLLLEALPAVLLGVLCLFLLPDRPAKANWLNPAEKQWLENELSTEQNVLAQRHGNKLKD 251 + L+E +P+V++G+ L L +R + A WL EK L ++ E+ AQ+ + Sbjct: 196 WMFLIEGIPSVVIGLCVLAYLDNRISHARWLTDEEKALLTRNIAAEE---AQKEDAPIAA 252 Query: 252 AFTNWRVFALAGANFCGIIGSLSIGLWLPQIIKEFGLPAH-QVGLVAALPYVVGAIAMTL 310 + RV+ ++ F ++G + WLP +IK+ G+ VGL+ A+PY +AM L Sbjct: 253 IMASPRVWLMSLIYFSFVMGLYGVSFWLPTLIKQTGVADPLSVGLLTAIPYGAAVVAMVL 312 Query: 311 WARLANRSQRRLLFVAGAIVLAAVSLAVSAFLHT-PLLKMLAITVAVASILSFQATFWAI 369 AR A+R++ R +A + A+ L +SA HT L M A+T+ IL+ FW++ Sbjct: 313 VARSADRTRERRWHIAIPALAGAIGLVLSAVWHTNTTLAMAALTLGTMGILTTLPLFWSL 372 Query: 370 PSGFLTGRAAAGGLALIVSIGNLGGFVGPSVIGFIREATQGFTYPLLFVAGALLLGAVIT 429 P+ FL G AA G+ALI S+GNL GF+ P +G++++ T+ + +A +++LGA++T Sbjct: 373 PTAFLAGTGAAAGIALINSLGNLAGFLSPYAVGWLKDTTRSTDSGMYLLAASMVLGALLT 432 Query: 430 LALGDPARV 438 L++ PAR Sbjct: 433 LSV--PART 439 >BMEII1096 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 451 Score = 313 bits (803), Expect = 4e-85, Method: Compositional matrix adjust. Identities = 176/425 (41%), Positives = 264/425 (62%), Gaps = 4/425 (0%) Query: 10 ASAPVSTAAVSEQATMKKVMRRLIPFILLCYVVSYLDRINVGFAALTMNKELGLTPSQFG 69 ++ +++ V E T +KV R+IP +++CY+++YLDR+NVGFA L M++ELG + + +G Sbjct: 22 SNTAITSPEVVENMTYRKVAFRIIPLLMICYIIAYLDRVNVGFAKLQMSEELGFSEAIYG 81 Query: 70 LGAGLFFIGYFFFEIPSNLALHRFGARMWISRIMISWGLISMATAFVVGPKSFALARFLL 129 LGAGLFFIGYFFFEIPSN+ LH+ GAR+WI+RIMI+WGL+S AFV F + RFLL Sbjct: 82 LGAGLFFIGYFFFEIPSNILLHKLGARLWIARIMITWGLLSALFAFVQTEWQFYILRFLL 141 Query: 130 GMAEAGFTPGIYLYFTQWFPGPWRAKATAFFLIGIPVANIIGSPLSGALME-LHGMWGFQ 188 G AEAGF PG+ LY T WFP R A F G P A I G+PLSG +M+ H G+Q Sbjct: 142 GAAEAGFYPGVILYLTYWFPSHRRGNMFALFQAGSPAAGIFGNPLSGWIMDQFHDTAGWQ 201 Query: 189 GWQVLLLLEALPAVLLGVLCLFLLPDRPAKANWLNPAEKQWLENELSTEQNVLAQRHGNK 248 GWQ + +LEA+PAV+LGV+ L L + A WL EK + ++ + A H Sbjct: 202 GWQWMFVLEAIPAVVLGVVILLYLDNSVKAAKWLTEEEKAIISRDIEADSKGKAASH--S 259 Query: 249 LKDAFTNWRVFALAGANFCGIIGSLSIGLWLPQIIKEFGLPAH-QVGLVAALPYVVGAIA 307 L N ++ + FC ++G + LW+P +I+ G+ ++ +GL+ A+P++ IA Sbjct: 260 LMSLVKNPMLWVMMLIYFCFVMGQHGLTLWMPTLIRASGVTSNVTIGLLGAIPFICAIIA 319 Query: 308 MTLWARLANRSQRRLLFVAGAIVLAAVSLAVSAFLHTPLLKMLAITVAVASILSFQATFW 367 M +++R A+ + R + +L AV V+A + ++ +++A A +L+ FW Sbjct: 320 MVIFSRSADHYRERRWHLVVPALLGAVGFVVAASATNTTVSIIFLSMAAAGVLACAPLFW 379 Query: 368 AIPSGFLTGRAAAGGLALIVSIGNLGGFVGPSVIGFIREATQGFTYPLLFVAGALLLGAV 427 ++P+ L+G AAA G+ALI S+ NL GF+ P ++G IR+AT + +AG L+LGA Sbjct: 380 SLPTAILSGAAAAAGIALINSVANLAGFISPYMVGIIRDATHSSELGMYVLAGFLILGAA 439 Query: 428 ITLAL 432 I L + Sbjct: 440 IVLCI 444 >STM1107 [GEPR] COG0477 Permeases of the major facilitator superfamily Sty Salmonella typhimurium LT2 Length = 458 Score = 300 bits (767), Expect = 5e-81, Method: Compositional matrix adjust. Identities = 168/423 (39%), Positives = 246/423 (58%), Gaps = 13/423 (3%) Query: 18 AVSEQATMKKVMRRLIPFILLCYVVSYLDRINVGFAALTMNKELGLTPSQFGLGAGLFFI 77 + +Q + K+ RRLI F+ + ++ S+LDRIN+GFA LTM ++LGL+ + FGL LF+ Sbjct: 22 STGQQTVINKLFRRLIVFLFVLFIFSFLDRINIGFAGLTMGQDLGLSATMFGLATTLFYA 81 Query: 78 GYFFFEIPSNLALHRFGARMWISRIMISWGLISMATAFVVGPKSFALARFLLGMAEAGFT 137 Y F IPSN+ L GAR WI+ IM+ WG+ S AT F VGPKS + R L+G+ EAGF Sbjct: 82 TYVIFGIPSNVMLSIVGARHWIATIMVLWGIASTATMFAVGPKSLYVLRMLVGITEAGFL 141 Query: 138 PGIYLYFTQWFPGPWRAKATAFFLIGIPVANIIGSPLSGALMELHGMWGFQGWQVLLLLE 197 PGI LY T WFP +RA+A A F+I +P +GS +SG ++ L G++ GWQ L LLE Sbjct: 142 PGILLYLTYWFPAFFRARANALFMIAMPATTALGSIVSGYILSLDGIFNLHGWQWLFLLE 201 Query: 198 ALPAVLLGVLCLFLLPDRPAKANWLNPAEKQWLENELSTEQNVLAQRHGNKLKDAFTN-- 255 P+VLLG++ F L D PAKA WL +K+ L+ + +++ L Q G +A Sbjct: 202 GFPSVLLGIMVWFYLDDTPAKAKWLTAEDKKCLQEMMDSDRLTLVQPEGAISHNAMQQRS 261 Query: 256 -WR------VFALAGANFCGIIGSLS-IGLWLPQIIKEF--GLPAHQVGLVAALPYVVGA 305 WR V A FC + +LS I +W PQI+K F G +GL+AA+P + Sbjct: 262 LWREVFTPIVLMYTLAYFC-LTNTLSAISIWTPQILKSFNEGSSNITIGLLAAIPQICTI 320 Query: 306 IAMTLWARLANRSQRRLLFVAGAIVLAAVSLAVSAFLHTPLLKMLAITVAVASILSFQAT 365 + M W+R +++ Q R A + AA +++ L+++L I +A S A Sbjct: 321 LGMIYWSRHSDKHQERKHHTALPFLFAAAGWLLASATDHNLIQLLGIVMASTGSFSAMAI 380 Query: 366 FWAIPSGFLTGRAAAGGLALIVSIGNLGGFVGPSVIGFIREATQGFTYPLLFVAGALLLG 425 FW P ++ RA A G+A+I + GN+G + P +IG++++ T F L FVA L++G Sbjct: 381 FWTTPDQSISLRARAIGIAVINATGNIGSALSPFMIGWLKDITGSFNSGLWFVASLLVVG 440 Query: 426 AVI 428 A I Sbjct: 441 AAI 443