BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.4388.p (443 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSp0182 [GEPR] COG0477 Permeases of the major facilitator superf... 344 3e-94 STM1107 [GEPR] COG0477 Permeases of the major facilitator superf... 314 3e-85 BMEII1096 [GEPR] COG0477 Permeases of the major facilitator supe... 300 6e-81 YPO2237 [GEPR] COG0477 Permeases of the major facilitator superf... 292 9e-79 RSc2352 [GEPR] COG0477 Permeases of the major facilitator superf... 292 9e-79 >RSp0182 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 453 Score = 344 bits (882), Expect = 3e-94, Method: Compositional matrix adjust. Identities = 176/395 (44%), Positives = 246/395 (62%), Gaps = 7/395 (1%) Query: 11 ERETVRKVTWRLLPFLMLCYLFAFIDRGNIGMAALQMNHDLGLSPKMFGFASSLFFIAYF 70 ER VRK+TWR+LPF+ Y+ +++DR NIG AALQMN +L LS + FGF S +FFI YF Sbjct: 26 ERAIVRKITWRILPFVFALYIISYLDRANIGYAALQMNQELALSSEAFGFVSGIFFIGYF 85 Query: 71 IFEVPSNLALQKFGARKWLARIMITWGLISASTALVQGPHSLYVARFILGAAEAGFFPGV 130 +FEVPSNL L +FGAR+W+ARI++TWGL++ +A VQ LY RF+LG AEAGFFPG+ Sbjct: 86 LFEVPSNLMLNRFGARRWIARILVTWGLVAMGSAFVQSATQLYALRFLLGVAEAGFFPGI 145 Query: 131 VLYLTYWVPSAYRARMVALFMVAIPAASFVASPVSALLLQMDGIGGLR--GWHWLFVLEG 188 ++YLTYW + A VALF AIP + V +P+S + MD + L+ GW W+ +LEG Sbjct: 146 IVYLTYWFRARELATTVALFTAAIPVSYVVGAPLSTWI--MDHVHWLQWSGWRWMLLLEG 203 Query: 189 LPTVLLGVVCLMFLTDRPEQARWLDEHQRNWLVATMNREAASRAAKQHIPLWKLFSQPHV 248 P V+ G++C +L DRP+ ARWL E +R+WL+A + R+ +R A H+ K+ + P V Sbjct: 204 APAVIGGLLCYGYLADRPKDARWLSEAERDWLLAELERDRKARPAAAHLATLKVMTHPRV 263 Query: 249 WGMALVCACASAAGSVLNVWQPQLLKSF--GLSVMQTGLVNSIPYLIASVLMVWWGRHSD 306 +A + + W PQ++K F LS + GL+ +PY+ A+ +M+WW R SD Sbjct: 264 LYLAFIYFVYQCGSLGIGYWMPQIIKGFSSALSHTEVGLIAMLPYVFATAVMIWWSRRSD 323 Query: 307 RSGERRWHTAIPLMLIGGGLACATLIHSLIPVVLMLTLVLIGAYCFKGPFWAMATNWLAT 366 ERR H+A+PL + A I + ML+L L G Y FK PFWA+ T +L Sbjct: 324 LRAERRLHSAVPLGVAALAFVGAGFIGHPAVAMAMLSLSLAGLYAFKSPFWALPTLFLTR 383 Query: 367 GSVAAGLAGINAVSNLIGGGLMVNVYGWVKGATGS 401 + A +A IN+V NL GG + G+ KG S Sbjct: 384 STAAVSIAVINSVGNL-GGFVGPFAIGYFKGQMHS 417 >STM1107 [GEPR] COG0477 Permeases of the major facilitator superfamily Sty Salmonella typhimurium LT2 Length = 458 Score = 314 bits (804), Expect = 3e-85, Method: Compositional matrix adjust. Identities = 180/448 (40%), Positives = 257/448 (57%), Gaps = 19/448 (4%) Query: 2 ETIQDEKRL---ERETVRKVTWRLLPFLMLCYLFAFIDRGNIGMAALQMNHDLGLSPKMF 58 E++ L ++ + K+ RL+ FL + ++F+F+DR NIG A L M DLGLS MF Sbjct: 13 ESVSSHNALSTGQQTVINKLFRRLIVFLFVLFIFSFLDRINIGFAGLTMGQDLGLSATMF 72 Query: 59 GFASSLFFIAYFIFEVPSNLALQKFGARKWLARIMITWGLISASTALVQGPHSLYVARFI 118 G A++LF+ Y IF +PSN+ L GAR W+A IM+ WG+ S +T GP SLYV R + Sbjct: 73 GLATTLFYATYVIFGIPSNVMLSIVGARHWIATIMVLWGIASTATMFAVGPKSLYVLRML 132 Query: 119 LGAAEAGFFPGVVLYLTYWVPSAYRARMVALFMVAIPAASFVASPVSALLLQMDGIGGLR 178 +G EAGF PG++LYLTYW P+ +RAR ALFM+A+PA + + S VS +L +DGI L Sbjct: 133 VGITEAGFLPGILLYLTYWFPAFFRARANALFMIAMPATTALGSIVSGYILSLDGIFNLH 192 Query: 179 GWHWLFVLEGLPTVLLGVVCLMFLTDRPEQARWLDEHQRNWLVATMNRE---------AA 229 GW WLF+LEG P+VLLG++ +L D P +A+WL + L M+ + A Sbjct: 193 GWQWLFLLEGFPSVLLGIMVWFYLDDTPAKAKWLTAEDKKCLQEMMDSDRLTLVQPEGAI 252 Query: 230 SRAAKQHIPLWKLFSQPHVWGMALVCACASAAGSVLNVWQPQLLKSF--GLSVMQTGLVN 287 S A Q LW+ P V L C + S +++W PQ+LKSF G S + GL+ Sbjct: 253 SHNAMQQRSLWREVFTPIVLMYTLAYFCLTNTLSAISIWTPQILKSFNEGSSNITIGLLA 312 Query: 288 SIPYLIASVLMVWWGRHSDRSGERRWHTAIPLMLIGGG--LACATLIHSLIPVVLMLTLV 345 +IP + + M++W RHSD+ ER+ HTA+P + G LA AT H+LI +L + + Sbjct: 313 AIPQICTILGMIYWSRHSDKHQERKHHTALPFLFAAAGWLLASAT-DHNLIQ-LLGIVMA 370 Query: 346 LIGAYCFKGPFWAMATNWLATGSVAAGLAGINAVSNLIGGGLMVNVYGWVKGATGSFALA 405 G++ FW ++ + A G+A INA N IG L + GW+K TGSF Sbjct: 371 STGSFSAMAIFWTTPDQSISLRARAIGIAVINATGN-IGSALSPFMIGWLKDITGSFNSG 429 Query: 406 LLPLVGLSVLSVAILLFLSRKSRTPAAT 433 L + L V+ AI+ + K+ P AT Sbjct: 430 LWFVASLLVVGAAIIWLIPMKASRPRAT 457 >BMEII1096 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 451 Score = 300 bits (767), Expect = 6e-81, Method: Compositional matrix adjust. Identities = 170/420 (40%), Positives = 248/420 (59%), Gaps = 5/420 (1%) Query: 4 IQDEKRLERETVRKVTWRLLPFLMLCYLFAFIDRGNIGMAALQMNHDLGLSPKMFGFASS 63 I + +E T RKV +R++P LM+CY+ A++DR N+G A LQM+ +LG S ++G + Sbjct: 26 ITSPEVVENMTYRKVAFRIIPLLMICYIIAYLDRVNVGFAKLQMSEELGFSEAIYGLGAG 85 Query: 64 LFFIAYFIFEVPSNLALQKFGARKWLARIMITWGLISASTALVQGPHSLYVARFILGAAE 123 LFFI YF FE+PSN+ L K GAR W+ARIMITWGL+SA A VQ Y+ RF+LGAAE Sbjct: 86 LFFIGYFFFEIPSNILLHKLGARLWIARIMITWGLLSALFAFVQTEWQFYILRFLLGAAE 145 Query: 124 AGFFPGVVLYLTYWVPSAYRARMVALFMVAIPAASFVASPVSA-LLLQMDGIGGLRGWHW 182 AGF+PGV+LYLTYW PS R M ALF PAA +P+S ++ Q G +GW W Sbjct: 146 AGFYPGVILYLTYWFPSHRRGNMFALFQAGSPAAGIFGNPLSGWIMDQFHDTAGWQGWQW 205 Query: 183 LFVLEGLPTVLLGVVCLMFLTDRPEQARWLDEHQRNWLVATMNREAASRAAKQHIPLWKL 242 +FVLE +P V+LGVV L++L + + A+WL E ++ + + + EA S+ L L Sbjct: 206 MFVLEAIPAVVLGVVILLYLDNSVKAAKWLTEEEKA--IISRDIEADSKGKAASHSLMSL 263 Query: 243 FSQPHVWGMALVCACASAAGSVLNVWQPQLLKSFGL-SVMQTGLVNSIPYLIASVLMVWW 301 P +W M L+ C L +W P L+++ G+ S + GL+ +IP++ A + MV + Sbjct: 264 VKNPMLWVMMLIYFCFVMGQHGLTLWMPTLIRASGVTSNVTIGLLGAIPFICAIIAMVIF 323 Query: 302 GRHSDRSGERRWHTAIPLMLIGGGLACATLIHSLIPVVLMLTLVLIGAYCFKGPFWAMAT 361 R +D ERRWH +P +L G A + ++ L++ G FW++ T Sbjct: 324 SRSADHYRERRWHLVVPALLGAVGFVVAASATNTTVSIIFLSMAAAGVLACAPLFWSLPT 383 Query: 362 NWLATGSVAAGLAGINAVSNLIGGGLMVNVYGWVKGATGSFALALLPLVGLSVLSVAILL 421 L+ + AAG+A IN+V+NL G + + G ++ AT S L + L G +L AI+L Sbjct: 384 AILSGAAAAAGIALINSVANL-AGFISPYMVGIIRDATHSSELGMYVLAGFLILGAAIVL 442 >YPO2237 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 436 Score = 292 bits (748), Expect = 9e-79, Method: Compositional matrix adjust. Identities = 168/427 (39%), Positives = 252/427 (59%), Gaps = 10/427 (2%) Query: 2 ETIQDEKRLERET--VRKVTWRLLPFLMLCYLFAFIDRGNIGMAALQMNHDLGLSPKMFG 59 E++ +L+ E RK W LLP LMLCY+ ++DR N+G A LQM DL S ++G Sbjct: 7 ESLSQPTQLQEENNAYRKTVWHLLPLLMLCYVLNYLDRVNVGFAKLQMADDLQFSDTVYG 66 Query: 60 FASSLFFIAYFIFEVPSNLALQKFGARKWLARIMITWGLISASTALVQGPHSLYVARFIL 119 + +FFI YF E+PSNL L + GAR W+ARIMITWG+ISA A V P S YV RF+L Sbjct: 67 LGAGMFFIGYFFLEIPSNLILHRVGARLWIARIMITWGIISACMAFVTTPMSFYVMRFLL 126 Query: 120 GAAEAGFFPGVVLYLTYWVPSAYRARMVALFMVAIPAASFVASPVSALLLQ-MDGIGGLR 178 G AEAGFFPG++LY++YW PS R R+ LF++++P + + +P+S ++Q +G G Sbjct: 127 GVAEAGFFPGIILYISYWFPSHRRGRVYGLFVISVPLSGIIGAPLSGWIMQYFNGFQGYA 186 Query: 179 GWHWLFVLEGLPTVLLGVVCLMFLTDRPEQARWLDEHQRNWLVATMNREAASRAAKQHIP 238 GW W+F+LEG+P+VL+G++ + L DR A WL + +++ L + EAA A H Sbjct: 187 GWQWMFILEGIPSVLVGILIIYKLKDRITHATWLTDKEKDILQTNIENEAAHYA---HSR 243 Query: 239 LWKLFSQPHVWGMALVCACASAAGSVLNVWQPQLLKSFGL-SVMQTGLVNSIPYLIASVL 297 L F QP VW + L+ C + + W P L++ G+ ++ G + +IP A+V Sbjct: 244 LRDAFLQPRVWLLTLIYFCLISGFYTIGFWLPTLIRDSGVKDILSIGFLTAIPSAAAAVT 303 Query: 298 MVWWGRHSDRSGERRWHTAIPLMLIGGGLACATLIHSLIPVVLM-LTLVLIGAYCFKGPF 356 M+ R +DR ERRWH A+ +L G+ +T I V ++ LT+ +GA F Sbjct: 304 MIVVSRSADRLRERRWHLALTAVLGAVGIILSTYFSDNIVVAMVCLTIGAMGALSTIPLF 363 Query: 357 WAMATNWLATGSVAAGLAGINAVSNLIGGGLMVNVYGWVKGATGSFALALLPLVGLSVLS 416 W++ T +L + AAG+A IN+ NL GG + + G++K T S +L ++ ++ Sbjct: 364 WSLPTAFLGGSAAAAGIAFINSWGNL-GGFVAPYMMGYLKDLTQSTTTGML-IISTTLFI 421 Query: 417 VAILLFL 423 A L+FL Sbjct: 422 GAALVFL 428 >RSc2352 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 442 Score = 292 bits (748), Expect = 9e-79, Method: Compositional matrix adjust. Identities = 177/428 (41%), Positives = 251/428 (58%), Gaps = 9/428 (2%) Query: 5 QDEKRLERETVRKVTWRLLPFLMLCYLFAFIDRGNIGMAALQMNHDLGLSPKMFGFASSL 64 Q E T RKV+WRL+PFL+LCY+ A++DR N+G A LQM +DL S ++G + + Sbjct: 18 QSASGFEEATYRKVSWRLIPFLLLCYVVAYLDRVNVGFAKLQMLNDLKFSETVYGLGAGI 77 Query: 65 FFIAYFIFEVPSNLALQKFGARKWLARIMITWGLISASTALVQGPHSLYVARFILGAAEA 124 FFI YF+FEVPSN+ L + GAR W+ARIMI+WGLISA+ V P YV RF+LG AEA Sbjct: 78 FFIGYFLFEVPSNVILHRVGARMWIARIMISWGLISAAMMFVTTPAMFYVMRFLLGLAEA 137 Query: 125 GFFPGVVLYLTYWVPSAYRARMVALFMVAIPAASFVASPVSALLLQ-MDGIGGLRGWHWL 183 GFFPG++LYLTYW P+ R R FM A+ + + P+S L+ G+ GL GW W+ Sbjct: 138 GFFPGIILYLTYWYPAERRGRTTTFFMTAVALSGVIGGPISGWALKTFGGVYGLAGWQWM 197 Query: 184 FVLEGLPTVLLGVVCLMFLTDRPEQARWLDEHQRNWLVATMNREAASRAAKQHIPLWKLF 243 F++EG+P+V++G+ L +L +R ARWL + ++ L + AA A K+ P+ + Sbjct: 198 FLIEGIPSVVIGLCVLAYLDNRISHARWLTDEEKALLTRNI---AAEEAQKEDAPIAAIM 254 Query: 244 SQPHVWGMALVCACASAAGSVLNVWQPQLLKSFGLSV-MQTGLVNSIPYLIASVLMVWWG 302 + P VW M+L+ ++ W P L+K G++ + GL+ +IPY A V MV Sbjct: 255 ASPRVWLMSLIYFSFVMGLYGVSFWLPTLIKQTGVADPLSVGLLTAIPYGAAVVAMVLVA 314 Query: 303 RHSDRSGERRWHTAIPLMLIGGGLACATLIHSLIPVVL-MLTLVLIGAYCFKGPFWAMAT 361 R +DR+ ERRWH AIP + GL + + H+ + + LTL +G FW++ T Sbjct: 315 RSADRTRERRWHIAIPALAGAIGLVLSAVWHTNTTLAMAALTLGTMGILTTLPLFWSLPT 374 Query: 362 NWLATGSVAAGLAGINAVSNLIGGGLMVNVYGWVKGATGSFALALLPLVGLSVLSVAILL 421 +LA AAG+A IN++ NL G L GW+K T S + L VL LL Sbjct: 375 AFLAGTGAAAGIALINSLGNL-AGFLSPYAVGWLKDTTRSTDSGMYLLAASMVLGA--LL 431 Query: 422 FLSRKSRT 429 LS +RT Sbjct: 432 TLSVPART 439