BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.4386.p (309 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value YPO1933 [R] COG3618 Predicted metal-dependent hydrolase of the T... 202 8e-52 AGl3341 [R] COG3618 Predicted metal-dependent hydrolase of the T... 123 6e-28 RSp0233 [R] COG3618 Predicted metal-dependent hydrolase of the T... 116 7e-26 Cgl0451 Non COG 77 5e-14 Cj0556 [R] COG3618 Predicted metal-dependent hydrolase of the TI... 72 2e-12 >YPO1933 [R] COG3618 Predicted metal-dependent hydrolase of the TIM-barrel fold Ype Yersinia pestis Length = 289 Score = 202 bits (514), Expect = 8e-52, Method: Compositional matrix adjust. Identities = 113/278 (40%), Positives = 156/278 (56%), Gaps = 6/278 (2%) Query: 33 QPPRLTAPALSCDSHHHIYDAR--FPVSPHWRGGRPDGATVADYRLLMAKLGIARHVVVQ 90 +P P +CDSH H+ R +P+ R P A Y ++A G++R V+VQ Sbjct: 16 EPSIFALPEDACDSHAHVISPRAIYPMVAE-RSYTPPPAPEEKYLSMLAATGMSRGVLVQ 74 Query: 91 PSTYGSDNRCLLDALRQFGTRARGIVVIEDEVTMVQLQEMHQLGVRGVRVNFLSPQTWGI 150 S YGSDNR +L L++ RG+ V+ ++VT +LQ+M GVRG+R+N L G Sbjct: 75 ISVYGSDNRYMLQVLKRHPEYLRGVAVVTEDVTDQELQDMALAGVRGLRINVLFGGGIGF 134 Query: 151 TTVERLRRTAEKIAPLGWHVQVLMSGAQIAEHEAVLAGLPTPVVIDHLGRIPQPAGLDHP 210 +E L A KIAPLGWH+Q LM Q+ + LP P VIDH+G +P GL+HP Sbjct: 135 DAMENL---ASKIAPLGWHMQFLMDVRQLPALIPRMKKLPCPCVIDHMGHMPVSLGLNHP 191 Query: 211 GAQAILRLLRQGHTWIKLSEAYADTLQGPPDYPDTSLLARAYVQAAPQRAIWGSDWPHPT 270 G Q +L ++R+ W+KLS AY + Y D A+ ++ AP R +WGSDWPH + Sbjct: 192 GYQTLLHMVREYGWWVKLSGAYRISESWQDGYLDVVPFAQKLIETAPDRMVWGSDWPHVS 251 Query: 271 EKIKPDDAVLFDLLSAWAPDAATREQILVHNPAALFGF 308 PD L +LL+AW PD R +ILV NPA L+ F Sbjct: 252 VSRMPDTGGLRNLLAAWVPDEQVRNRILVDNPARLYDF 289 >AGl3341 [R] COG3618 Predicted metal-dependent hydrolase of the TIM-barrel fold Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 292 Score = 123 bits (308), Expect = 6e-28, Method: Compositional matrix adjust. Identities = 74/240 (30%), Positives = 115/240 (47%), Gaps = 7/240 (2%) Query: 73 DYRLLMAKLGIARHVVVQPSTYGSDNRCLLDALRQFGTRARGIVVIEDEVTMVQLQEMHQ 132 DYR LM LGI R ++ Q + + DN L + + G A +V+I+ T ++++ Sbjct: 52 DYRRLMQWLGIDRVIITQGNAHQRDNGNTLACVAEMGEAAHAVVIIDATTTEKDMEKLTA 111 Query: 133 LGVRGVRVNFLSPQTWGITTVERLRRTAEKIAPLGWHVQVLMSGAQIAEHEAVLAGLPTP 192 G G R+ L G + L E+ W V V G + +H L + + Sbjct: 112 AGTVGARIMDLPG---GAVNLSELDAVDERAHAADWMVAVQFDGNGLLDHLPRLQKIRSR 168 Query: 193 VVIDHLGRIPQPAGLDHPGAQAILRLLRQGHTWIKLSEAYADTLQGPPDYPDTSLLARAY 252 V DH G+ + D P A+L+L+ +G+ W K + Y + + P Y D + +R Sbjct: 169 WVFDHHGKFFKGIRTDGPEMAALLKLIDRGNLWFKFAGVYESSRKSWP-YADVAAFSRVI 227 Query: 253 VQAAPQRAIWGSDWPHPTEK---IKPDDAVLFDLLSAWAPDAATREQILVHNPAALFGFT 309 AP+R +WG++WPH + + PDDA L +L W PD A R + LV NP ALF + Sbjct: 228 AAHAPERIVWGTNWPHNSVRETAAYPDDARLAELTLGWLPDEAARHRALVENPEALFKLS 287 >RSp0233 [R] COG3618 Predicted metal-dependent hydrolase of the TIM-barrel fold Rso Ralstonia solanacearum Length = 302 Score = 116 bits (290), Expect = 7e-26, Method: Compositional matrix adjust. Identities = 100/314 (31%), Positives = 142/314 (45%), Gaps = 19/314 (6%) Query: 1 MLSRRHFLAGSLLACSGLRAALAQSVPNSAGQQPPRLTAPALSCDSHHHIYDARFPVSPH 60 M +RR F G LLA G A ++ + P TA D+H H++ P++ Sbjct: 1 MPTRRAFNTG-LLAMLG-----ATALAGCVTRGMPAPTARITGIDTHAHVFKRGLPLAGA 54 Query: 61 WRGGRPDGATVADYRLLMAKLGIARHVVVQPSTYGSDNRCLLDALRQFGTRARGIVVIED 120 R AT+ Y + G++ V++QPS G DN LL ALRQ R RG+ VI+ Sbjct: 55 RRYAPSYDATLPAYLAQLDAHGLSHGVLIQPSFLGGDNSYLLAALRQAPQRLRGVAVIDP 114 Query: 121 EVTMVQLQEMHQLGVRGVRVNFLS---PQTWGITTVERLRRTAEKIAPLGWHVQVLMSGA 177 L +++ G+ G+R+N + PQ L R + LGWHV++ Sbjct: 115 AAPEPFLAQLNAEGIVGIRLNLIGAPDPQLRAPAWQAALHR----LHALGWHVELHTQAH 170 Query: 178 QIAEHEAVLAGLPTPVVIDHLGRIPQPA-GLDHPGAQAILRLLRQGHTWIKLSEAYADTL 236 ++ L VV+DH GR P PA ++ PG A+L R W+K+S AY + Sbjct: 171 RLPALLPPLLEAQVDVVVDHFGR-PDPALSVEDPGFAALLAAGRTRRVWVKVSGAYRNGD 229 Query: 237 QGPPDYPDTSLLARAYVQAAPQRAIWGSDWPHP--TEKIKPDDAVLFDLLSAWAPDAATR 294 G + + + R R +WGSDWPH +I D A F PDA R Sbjct: 230 AGRGEAIALAAMPRLKDALGTDRLVWGSDWPHTQYESRIGYDSARAF--ADTLLPDAGDR 287 Query: 295 EQILVHNPAALFGF 308 Q+LV PA LF F Sbjct: 288 HQVLVETPARLFRF 301 >Cgl0451 Non COG Length = 250 Score = 77.0 bits (188), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 74/262 (28%), Positives = 120/262 (45%), Gaps = 21/262 (8%) Query: 45 DSHHHIYDARFPVSPHWRGGRPDGATVADYRLLMAKLGIARHVVVQPSTYGSDNRCLLDA 104 DSH HI D + P+ + G P+ TV DY + L +A +V S D L DA Sbjct: 6 DSHFHIIDPQHPLIEN-NGYLPEPFTVEDYTARVEGLEVAGGAIVSGSFQAFDQGYLKDA 64 Query: 105 LRQFGTRARGIVVIEDEVTMVQLQEMHQLGVRGVRVNFLSPQTWGITTVERLRRTAEKIA 164 L G G+ I + + ++ ++ + GV+ VR+N + G+ +E L R +A Sbjct: 65 LAVLGPGYVGVTQIPADTSDQEILDLDKAGVKAVRLNLKRGGSAGLDDLETLARRVHDLA 124 Query: 165 PLGWHVQVLMSGAQIAEHEAVLAGLPTPVVIDHLGRIPQPAGLDHPGAQAILRLLRQGHT 224 GWH ++ + ++ E E+ LA LP V IDHL GL G A+LRL+ G Sbjct: 125 --GWHTELYVDARELDELESTLASLPA-VSIDHL-------GLHRDGLPALLRLVENG-- 172 Query: 225 WIKLSEAYADTLQGPPDYPDTSLLARAYVQAAPQRAIWGSDWPHPTEKIKPDDAVLFDLL 284 IK+ ++ P + + +A + P + G+D P K +DA L DL+ Sbjct: 173 -IKVKATGFGRVELDP-----TEVIQAIMAVDPTALMIGTDLPSTRTKRPFEDADL-DLI 225 Query: 285 SAWAPDAATREQILVHNPAALF 306 + + + + +N AA + Sbjct: 226 AETVGEDHV-DNVFWNNAAAFY 246 >Cj0556 [R] COG3618 Predicted metal-dependent hydrolase of the TIM-barrel fold Cje Campylobacter jejuni Length = 265 Score = 71.6 bits (174), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 63/280 (22%), Positives = 120/280 (42%), Gaps = 28/280 (10%) Query: 42 LSCDSHHHIYDARFPVSPHWRGGRPD-GATVADYRLLMAKLGIARHVVVQPSTYGSDNRC 100 + D+H HI+ + + R +PD A+ DY+ + + V+VQPS G DN Sbjct: 1 MKIDTHAHIFLKKLNTVANARY-KPDYDASFKDYKANLDHYDFNKGVLVQPSFLGIDNEF 59 Query: 101 LLDALRQFGTRARGIVVIEDEVTMVQLQEMHQLGVRGVRVNFLSPQTWGITTVERLRRTA 160 LL ++ + + IVV+++ + +L+++ + GVR+N + + ++ + Sbjct: 60 LLQSIEK-DENIKAIVVVDENIKFDELKKLKERKACGVRLNLIGKELPNFKSM-VWTQFF 117 Query: 161 EKIAPLGWHVQVL----MSGAQIAEHEAVLAGLPTPVVIDHLGRIPQPAGLDHPGAQAIL 216 E ++ L +++ + I E+ L +VIDHL R A + + ++ Sbjct: 118 ENLSKLKMQIEIQRDLDNNLVDIVEN---LIPYGCNIVIDHLAR----ANANLTNLEDLI 170 Query: 217 RLLRQGHTWIKLSEAYADTLQGPPDYPDTS---LLARAYVQAAPQ-----RAIWGSDWPH 268 L+ + K+S Y + DY + A+ + + ++GSDWPH Sbjct: 171 -CLKNSRIFFKISGFY----RAKIDYANNEQAVKFAKKIYEILKEHFPLSNFVFGSDWPH 225 Query: 269 PTEKIKPDDAVLFDLLSAWAPDAATREQILVHNPAALFGF 308 + + + + +EQIL N ALFGF Sbjct: 226 TNFEANINFSSALVAFNEVVVSKKEQEQILGDNACALFGF 265