BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.4378.p (263 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value CC0821 [IQR] COG1028 Dehydrogenases with different specificities... 298 7e-81 mll7191 [IQR] COG1028 Dehydrogenases with different specificitie... 267 2e-71 SMc00880 [IQR] COG1028 Dehydrogenases with different specificiti... 213 3e-55 AGc1273 [IQR] COG1028 Dehydrogenases with different specificitie... 200 3e-51 mlr4741 [IQR] COG1028 Dehydrogenases with different specificitie... 192 7e-49 >CC0821 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Ccr Caulobacter vibrioides Length = 248 Score = 298 bits (764), Expect = 7e-81, Method: Compositional matrix adjust. Identities = 153/249 (61%), Positives = 184/249 (73%), Gaps = 5/249 (2%) Query: 12 ALYRSLAGKRVVITGGGSGIGAALVEAFVAQGAQVYFLDIATAPSEALVEALKAAPVAPR 71 A+Y SL GKRVVITGGGSGIGA L F QGA+V FLDIA S AL L +P+ P Sbjct: 4 AIYPSLKGKRVVITGGGSGIGAGLTAGFARQGAEVIFLDIADEDSRALEAELAGSPIPPV 63 Query: 72 FFPCNLMNLEALRATFTEIETIAGGVDILINNAANDDRHKTADVTPAYWDERLAVNLRHQ 131 + C+LMNLEA++A F EI G VD+L+NNA NDDRHK ADVT AYWDER+ VNLRH Sbjct: 64 YKRCDLMNLEAIKAVFAEI----GDVDVLVNNAGNDDRHKLADVTGAYWDERINVNLRHM 119 Query: 132 FFCAQAVLPGMRERKSGVILNFGSISWHLGLPDLTLYMTAKAGIEGMTHGMARDFGRDGV 191 FC QAV PGM++R G ++NFGSISWHLGL DL LY TAKAGIEGMT +AR+ G D + Sbjct: 120 LFCTQAVAPGMKKRGGGAVINFGSISWHLGLEDLVLYETAKAGIEGMTRALARELGPDDI 179 Query: 192 RVNAIIPGAIRTPRQTLLWHTPEEEAKILAAQCLPVRVDPHDVAALALFLSSDSGAKCTG 251 RV ++PG ++T RQ W+TPE EA+I+AAQCL R+ P +VAAL LFL+SD + CTG Sbjct: 180 RVTCVVPGNVKTKRQE-KWYTPEGEAQIVAAQCLKGRIVPENVAALVLFLASDDASLCTG 238 Query: 252 REYYVDAGW 260 EY++DAGW Sbjct: 239 HEYWIDAGW 247 >mll7191 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Mlo Mesorhizobium loti Length = 258 Score = 267 bits (683), Expect = 2e-71, Method: Compositional matrix adjust. Identities = 129/252 (51%), Positives = 172/252 (68%), Gaps = 1/252 (0%) Query: 11 HALYRSLAGKRVVITGGGSGIGAALVEAFVAQGAQVYFLDIATAPSEALVEALKA-APVA 69 +A+Y SL G+ V ITGGGSGIG +LV F AQG++V F+D++ PS LVEA+ A A Sbjct: 7 YAIYPSLKGRSVFITGGGSGIGESLVRHFCAQGSRVAFVDLSEEPSRHLVEAIAAEGHPA 66 Query: 70 PRFFPCNLMNLEALRATFTEIETIAGGVDILINNAANDDRHKTADVTPAYWDERLAVNLR 129 P F PC+L ++E L+A + G + +L NNA NDDRH+T DVT AYWD+R+AVNLR Sbjct: 67 PLFIPCDLRDVEQLQAATAQAMQHNGPIQVLCNNAGNDDRHQTKDVTVAYWDDRMAVNLR 126 Query: 130 HQFFCAQAVLPGMRERKSGVILNFGSISWHLGLPDLTLYMTAKAGIEGMTHGMARDFGRD 189 HQFF AQAV P M + G I+NFGSI+W +G PD Y+TAKA + GMT +AR+ G + Sbjct: 127 HQFFAAQAVRPQMSAQGGGSIINFGSITWMVGDPDCPAYVTAKAAVYGMTRALARELGPE 186 Query: 190 GVRVNAIIPGAIRTPRQTLLWHTPEEEAKILAAQCLPVRVDPHDVAALALFLSSDSGAKC 249 +RVN ++PG + T RQ LW P E +I QCLP R+ P D+A +ALFL++D C Sbjct: 187 RIRVNCMVPGWVMTERQMRLWLNPAGERQIAERQCLPDRLQPADIARMALFLAADDSRMC 246 Query: 250 TGREYYVDAGWL 261 T +++ VDAGW+ Sbjct: 247 TSQQFIVDAGWV 258 >SMc00880 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Sme Sinorhizobium meliloti Length = 256 Score = 213 bits (543), Expect = 3e-55, Method: Compositional matrix adjust. Identities = 118/247 (47%), Positives = 150/247 (60%), Gaps = 1/247 (0%) Query: 14 YRSLAGKRVVITGGGSGIGAALVEAFVAQGAQVYFLDIATAPSEALVEALKAAP-VAPRF 72 + L + V++TGGGSGIGAALVEAF QGA+V F+DIA S AL E + A AP F Sbjct: 8 FPDLRDRGVLVTGGGSGIGAALVEAFARQGARVAFVDIAAESSLALCEKVAAQTGQAPHF 67 Query: 73 FPCNLMNLEALRATFTEIETIAGGVDILINNAANDDRHKTADVTPAYWDERLAVNLRHQF 132 +L N+EA+RA E G V +L+NNAA DDR VT WDE L+VNLRH F Sbjct: 68 IQADLRNVEAVRAAADEAVAKLGSVRVLVNNAARDDRQALEAVTEESWDESLSVNLRHLF 127 Query: 133 FCAQAVLPGMRERKSGVILNFGSISWHLGLPDLTLYMTAKAGIEGMTHGMARDFGRDGVR 192 F QAV P M+ + G I+NF SI++ L +P++ Y TAKAGI G+T +A G D +R Sbjct: 128 FMCQAVAPHMQRQGGGSIVNFSSIAFLLNMPEIPAYSTAKAGIIGLTKSLAGKLGPDNIR 187 Query: 193 VNAIIPGAIRTPRQTLLWHTPEEEAKILAAQCLPVRVDPHDVAALALFLSSDSGAKCTGR 252 VNAI+PG I T RQ LW T E A++ QCL + D+ LFL+SDS A T + Sbjct: 188 VNAILPGMIVTERQRRLWLTEESIARMQERQCLKRMLVADDLVGPCLFLASDSSAAMTAQ 247 Query: 253 EYYVDAG 259 +D G Sbjct: 248 AMIIDGG 254 >AGc1273 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 260 Score = 200 bits (508), Expect = 3e-51, Method: Compositional matrix adjust. Identities = 114/257 (44%), Positives = 153/257 (59%), Gaps = 2/257 (0%) Query: 6 TPVFEHALYRSLAGKRVVITGGGSGIGAALVEAFVAQGAQVYFLDIATAPSEALVEALKA 65 TP+ + A + L V++TGGGSGIGA+LVEAF QGA+V F+DIA PS ALVE L A Sbjct: 5 TPMMQ-AQFPDLKDAGVLVTGGGSGIGASLVEAFAMQGAKVSFIDIAEQPSIALVERLAA 63 Query: 66 A-PVAPRFFPCNLMNLEALRATFTEIETIAGGVDILINNAANDDRHKTADVTPAYWDERL 124 P +F +L +++A++ T + GG+ +L+NNAA DDRH VT AYWD Sbjct: 64 TVPHPVHYFRADLSDIDAIKRTVDMAASATGGIKVLVNNAAWDDRHDIDSVTEAYWDANQ 123 Query: 125 AVNLRHQFFCAQAVLPGMRERKSGVILNFGSISWHLGLPDLTLYMTAKAGIEGMTHGMAR 184 AVNL+ FF QA LP +R+ K I+NF SIS+ L + +L Y AKAGI G+T +A Sbjct: 124 AVNLKQMFFTVQAALPHLRQAKDASIVNFSSISFLLNMGELPSYAAAKAGIIGLTKSLAG 183 Query: 185 DFGRDGVRVNAIIPGAIRTPRQTLLWHTPEEEAKILAAQCLPVRVDPHDVAALALFLSSD 244 G + +RVN ++PG I T RQ LW T E A QCL + D++ LFL+S Sbjct: 184 RLGPENIRVNTLLPGMIVTERQKELWLTDEGITATTARQCLKRTLVAADLSGPCLFLASS 243 Query: 245 SGAKCTGREYYVDAGWL 261 + + T + VD G L Sbjct: 244 ASSAITAQSIIVDGGLL 260 >mlr4741 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Mlo Mesorhizobium loti Length = 254 Score = 192 bits (488), Expect = 7e-49, Method: Compositional matrix adjust. Identities = 114/251 (45%), Positives = 146/251 (58%), Gaps = 1/251 (0%) Query: 12 ALYRSLAGKRVVITGGGSGIGAALVEAFVAQGAQVYFLDIATAPSEALVEAL-KAAPVAP 70 A + L G V+ITGGGSGIGAAL E FV QGA V F+DIA PS L + + K P Sbjct: 4 ADFADLKGASVLITGGGSGIGAALTEGFVRQGANVAFIDIAEGPSTLLADRIEKEFGRRP 63 Query: 71 RFFPCNLMNLEALRATFTEIETIAGGVDILINNAANDDRHKTADVTPAYWDERLAVNLRH 130 + +L ++EALRA+ G V +LINNAA D+RH DVT +WD A+NLR Sbjct: 64 LYLKTDLRDIEALRASAARAAEAHGDVTVLINNAAWDERHAVEDVTVEFWDNNQAINLRP 123 Query: 131 QFFCAQAVLPGMRERKSGVILNFGSISWHLGLPDLTLYMTAKAGIEGMTHGMARDFGRDG 190 FF AQAV PGM+ G I+NF S S+ + PD+ Y AKAGI G+T G+A G D Sbjct: 124 HFFTAQAVAPGMKRAGGGSIINFTSTSYLINHPDMPAYTAAKAGILGLTKGLAGKLGPDR 183 Query: 191 VRVNAIIPGAIRTPRQTLLWHTPEEEAKILAAQCLPVRVDPHDVAALALFLSSDSGAKCT 250 +RVNA+ PG + T RQ W T A +A QC+ + P D+ LFL+SD+ T Sbjct: 184 IRVNAVAPGWVITERQQERWVTEGALAAHVAKQCIKEVMRPDDMVGTVLFLASDASRMLT 243 Query: 251 GREYYVDAGWL 261 + VD G+L Sbjct: 244 AQMLIVDGGFL 254