BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.4344.p (1207 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value CC1829_1 [I] COG0439 Biotin carboxylase Ccr Caulobacter vibrioides 482 e-135 YBR208c_2 [I] COG0439 Biotin carboxylase Sce Saccharomyces cerev... 462 e-129 alr0939 [I] COG0439 Biotin carboxylase Nos Nostoc sp. PCC 7120 397 e-110 MJ1229 [I] COG0439 Biotin carboxylase Mja Methanococcus jannaschii 392 e-108 DR0117 [I] COG0439 Biotin carboxylase Dra Deinococcus radiodurans 390 e-107 >CC1829_1 [I] COG0439 Biotin carboxylase Ccr Caulobacter vibrioides Length = 448 Score = 482 bits (1240), Expect = e-135, Method: Compositional matrix adjust. Identities = 271/454 (59%), Positives = 332/454 (73%), Gaps = 6/454 (1%) Query: 1 MFDHLLIANRGAIACRILRTLRTLEVTGVCVYSEADLGSLHVLQADRAISLGEGAAAQTY 60 MFD +LIANRGAIACRI+RTLR + V V V+S+AD GSLHV AD A+ LG AA++Y Sbjct: 1 MFDKVLIANRGAIACRIIRTLRAMGVKSVAVFSDADAGSLHVSMADEAVRLGPAPAAESY 60 Query: 61 LAVDKILAAARDSGAQAIHPGYGFLSENAAFAEACEAAGIAFVGPTPAQLRLFGLKHTAR 120 L D +LAAA+ +GAQAIHPGYGFLSE+AAFA+ACE AG+ F+GP+ +R FGLKHTAR Sbjct: 61 LRADLVLAAAQATGAQAIHPGYGFLSESAAFAQACEDAGVTFIGPSADNIRAFGLKHTAR 120 Query: 121 ALAREQGVPMLEGTGLLENLQEALAAAAQVAYPVMLKSTAGGGGIGMRVCRSDEELVDAF 180 LA+ GVP+ GT LL + ALAAA ++ +PV+LK+TAGGGGIGMRVC S E + +AF Sbjct: 121 DLAQAHGVPLAPGTDLLTDPAAALAAAQRIGFPVILKATAGGGGIGMRVCESAEAVEEAF 180 Query: 181 ESVRRLGQNNFSDAGVFIEKYIERARHLEVQVFGDGQGEVIALGVRDCSVQRRNQKVLEE 240 +VRRL NFSD GVF+E+Y+ +ARH+EVQVFGDG G V ALG RDCS+QRRNQKV+EE Sbjct: 181 AAVRRLATGNFSDGGVFLERYVHKARHIEVQVFGDGAGRVAALGERDCSLQRRNQKVVEE 240 Query: 241 TPAPNLPAGMADALCAAAIKLARAVNYRSAGTVEFVYDSQAGQFYFLEVNTRLQVEHGVT 300 TPAP LPA AL AA++LA+A NYRSAGTVEF+YD+ F+FLEVNTRLQVEHGVT Sbjct: 241 TPAPGLPAATRTALLDAAVRLAKAANYRSAGTVEFLYDADRDDFFFLEVNTRLQVEHGVT 300 Query: 301 EQVWGVDLVRWMIELAAGELPPLEQLAATLQPSGHAIQARLYAEDPGRQFQPCPGLLTAV 360 EQV GVDLV WM+ AAG+ L+ P G AIQ RLYAEDP + ++P G+LT V Sbjct: 301 EQVTGVDLVEWMVRGAAGDFSFLDTPPPA--PRGAAIQVRLYAEDPAQDYRPSAGVLTEV 358 Query: 361 AFPPADGRALRIDTWVEAGCEIPPYFDPMIAKLISWQPTREAARLALDAALEATQLYGVE 420 AFP +R D WV G E+ ++DPM+AKLI R AA AL AAL+AT+L G+E Sbjct: 359 AFP----EGVRADGWVVDGTEVSAFYDPMLAKLIVIAEHRPAAVAALQAALDATRLAGIE 414 Query: 421 TNQHYLRQILADAPFASGQPWTRCLEHLTYHADT 454 TN +LR + PF SG+ TR LE + + DT Sbjct: 415 TNLDWLRTVTRSQPFVSGEVSTRALETIAWAPDT 448 >YBR208c_2 [I] COG0439 Biotin carboxylase Sce Saccharomyces cerevisiae Length = 448 Score = 462 bits (1190), Expect = e-129, Method: Compositional matrix adjust. Identities = 231/451 (51%), Positives = 312/451 (69%), Gaps = 6/451 (1%) Query: 1 MFDHLLIANRGAIACRILRTLRTLEVTGVCVYSEADLGSLHVLQADRAISLGEGAAAQTY 60 +FD +LIANRG IA RI++TL+ L + V VYS+ D S HV AD ++ L AAQTY Sbjct: 1 LFDTVLIANRGEIAVRIIKTLKKLGIRSVAVYSDPDKYSQHVTDADVSVPLHGTTAAQTY 60 Query: 61 LAVDKILAAARDSGAQAIHPGYGFLSENAAFAEACEAAGIAFVGPTPAQLRLFGLKHTAR 120 L ++KI+ AA+ + AQAI PGYGFLSENA F++AC +AGI FVGP+ +R GLKH+AR Sbjct: 61 LDMNKIIDAAKQTNAQAIIPGYGFLSENADFSDACTSAGITFVGPSGDIIRGLGLKHSAR 120 Query: 121 ALAREQGVPMLEGTGLLENLQEALAAAAQVAYPVMLKSTAGGGGIGMRVCRSDEELVDAF 180 +A++ GVP++ G+ L+ +++EA AA++ YPVM+KSTAGGGGIG++ S+E++ F Sbjct: 121 QIAQKAGVPLVPGSLLITSVEEAKKVAAELEYPVMVKSTAGGGGIGLQKVDSEEDIEHIF 180 Query: 181 ESVRRLGQNNFSDAGVFIEKYIERARHLEVQVFGDGQGEVIALGVRDCSVQRRNQKVLEE 240 E+V+ G+ F DAGVF+E++IE ARH+EVQ+ GDG G+ IALG RDCS+QRRNQKV+EE Sbjct: 181 ETVKHQGETFFGDAGVFLERFIENARHVEVQLMGDGFGKAIALGERDCSLQRRNQKVIEE 240 Query: 241 TPAPNLPAGMADALCAAAIKLARAVNYRSAGTVEFVYDSQAGQFYFLEVNTRLQVEHGVT 300 TPAPNLP AL AA L +NY+ AGTVEF+YD + +FYFLEVNTRLQVEH +T Sbjct: 241 TPAPNLPEKTRLALRKAAESLGSLLNYKCAGTVEFIYDEKKDEFYFLEVNTRLQVEHPIT 300 Query: 301 EQVWGVDLVRWMIELAAGELPPLEQLAATLQPSGHAIQARLYAEDPGRQFQPCPGLLTAV 360 E V G+DLV WMI +AA + P + + ++ +G +++ARLYAE+P + F+P PGLL V Sbjct: 301 EMVTGLDLVEWMIRIAANDAPDFD--STKVEVNGVSMEARLYAENPLKNFRPSPGLLVDV 358 Query: 361 AFPPADGRALRIDTWVEAGCEIPPYFDPMIAKLISWQPTREAARLALDAALEATQLYGVE 420 FP R+DTWV+ G I P +DP +AK+I R+ A L+ ALE T++YG Sbjct: 359 KFPD----WARVDTWVKKGTNISPEYDPTLAKIIVHGKDRDDAISKLNQALEETKVYGCI 414 Query: 421 TNQHYLRQILADAPFASGQPWTRCLEHLTYH 451 TN YL+ I+ FA + T L Y Sbjct: 415 TNIDYLKSIITSDFFAKAKVSTNILNSYQYE 445 >alr0939 [I] COG0439 Biotin carboxylase Nos Nostoc sp. PCC 7120 Length = 447 Score = 397 bits (1021), Expect = e-110, Method: Compositional matrix adjust. Identities = 210/449 (46%), Positives = 285/449 (63%), Gaps = 6/449 (1%) Query: 2 FDHLLIANRGAIACRILRTLRTLEVTGVCVYSEADLGSLHVLQADRAISLGEGAAAQTYL 61 FD +LIANRG IA RILR + + + V+S D +LHV AD A+ +GE A+A++YL Sbjct: 3 FDKILIANRGEIALRILRACEEMGIATIAVHSTVDRNALHVQLADEAVCIGEPASAKSYL 62 Query: 62 AVDKILAAARDSGAQAIHPGYGFLSENAAFAEACEAAGIAFVGPTPAQLRLFGLKHTARA 121 + I+AAA A AIHPGYGFLSENA FAE C IAF+GPTP +RL G K TA+ Sbjct: 63 NIPNIIAAALTRNASAIHPGYGFLSENAKFAEICADHHIAFIGPTPEAIRLMGDKSTAKE 122 Query: 122 LAREQGVPMLEGT-GLLENLQEALAAAAQVAYPVMLKSTAGGGGIGMRVCRSDEELVDAF 180 ++ GVP + G+ GL+E QE L A + YPVM+K+TAGGGG GMR+ RS +E V F Sbjct: 123 TMQKAGVPTVPGSEGLVETEQEGLELAKDIGYPVMIKATAGGGGRGMRLVRSPDEFVKLF 182 Query: 181 ESVRRLGQNNFSDAGVFIEKYIERARHLEVQVFGDGQGEVIALGVRDCSVQRRNQKVLEE 240 + + F +AGV+IEK+IER RH+E Q+ D G VI LG RDCS+QRRNQK+LEE Sbjct: 183 LAAQGEAGAAFGNAGVYIEKFIERPRHIEFQILADNYGNVIHLGERDCSIQRRNQKLLEE 242 Query: 241 TPAPNLPAGMADALCAAAIKLARAVNYRSAGTVEFVYDSQAGQFYFLEVNTRLQVEHGVT 300 P+P L + + + + AA+K A+ +NY AGT+EF+ D ++GQFYF+E+NTR+QVEH VT Sbjct: 243 APSPALDSDLREKMGQAAVKAAQFINYTGAGTIEFLLD-RSGQFYFMEMNTRIQVEHPVT 301 Query: 301 EQVWGVDLVRWMIELAAGELPPLEQLAATLQPSGHAIQARLYAEDPGRQFQPCPGLLTAV 360 E V GVDL+ I +A GE L Q L+ GHAI+ R+ AEDP F+P PG ++ Sbjct: 302 EMVTGVDLLVEQIRIAQGERLRLTQDQVVLR--GHAIECRINAEDPDHDFRPAPGRIS-- 357 Query: 361 AFPPADGRALRIDTWVEAGCEIPPYFDPMIAKLISWQPTREAARLALDAALEATQLYGVE 420 + P G +RID+ V +IPPY+D +I KLI W P R A + AL + G+ Sbjct: 358 GYLPPGGPGVRIDSHVYTDYQIPPYYDSLIGKLIVWGPDRATAINRMKRALRECAITGLP 417 Query: 421 TNQHYLRQILADAPFASGQPWTRCLEHLT 449 T + ++I+ + F G T ++ + Sbjct: 418 TTIGFHQRIMENPQFLQGNVSTSFVQEMN 446 >MJ1229 [I] COG0439 Biotin carboxylase Mja Methanococcus jannaschii Length = 501 Score = 392 bits (1006), Expect = e-108, Method: Compositional matrix adjust. Identities = 211/448 (47%), Positives = 291/448 (64%), Gaps = 7/448 (1%) Query: 1 MFDHLLIANRGAIACRILRTLRTLEVTGVCVYSEADLGSLHVLQADRAISLGEGAAAQTY 60 MF+ +LIANRG IA RI+R L + V VYSEAD SLH AD A +G AA++Y Sbjct: 1 MFNKVLIANRGEIAIRIIRACWELGIKTVAVYSEADKRSLHATLADEAYCIGPAPAAKSY 60 Query: 61 LAVDKILAAARDSGAQAIHPGYGFLSENAAFAEACEAAGIAFVGPTPAQLRLFGLKHTAR 120 L +D IL A + AIHPGYGFL+ENA FA A + AG F+GP P + G K A+ Sbjct: 61 LNIDAILNVAEKAKVDAIHPGYGFLAENAEFARAVKKAGFEFIGPNPDAIEAMGSKINAK 120 Query: 121 ALAREQGVPMLEGT-GLLENLQEALAAAAQVAYPVMLKSTAGGGGIGMRVCRSDEELVDA 179 + ++ GVP++ G+ G +E++ EA+ A + +PV++K++AGGGG+GM V S EEL + Sbjct: 121 KIMKKAGVPLIPGSEGAIEDIDEAIEIAEAIGFPVVVKASAGGGGMGMSVAYSKEELKEV 180 Query: 180 FESVRRLGQNNFSDAGVFIEKYIERARHLEVQVFGDGQGEVIALGVRDCSVQRRNQKVLE 239 ES R + ++ F D VFIEKY+E RH+E+Q+ GD G +I LG R+CS+QRR+QK++E Sbjct: 181 IESARNIAKSAFGDPTVFIEKYLENPRHIEIQLLGDKHGNIIHLGDRECSIQRRHQKLIE 240 Query: 240 ETPAPNLPAGMADALCAAAIKLARAVNYRSAGTVEFVYDSQAGQFYFLEVNTRLQVEHGV 299 E P+P + + + + AAIK +A+NY SAGTVEF+Y++ G FYFLE+NTR+QVEH V Sbjct: 241 EAPSPIMTEELRERMGEAAIKAGKAINYDSAGTVEFLYEN--GNFYFLEMNTRIQVEHTV 298 Query: 300 TEQVWGVDLVRWMIELAAGELPPLEQLAATLQPSGHAIQARLYAEDPGRQFQPCPGLLTA 359 TEQV G+DLV+ MI++AAGE L+Q ++ GHAI+ R+ AEDP F PCPG + Sbjct: 299 TEQVTGIDLVKAMIKIAAGEELTLKQEDVKIR--GHAIECRINAEDPLNDFVPCPGKIKL 356 Query: 360 VAFPPADGRALRIDTWVEAGCEIPPYFDPMIAKLISWQPTREAARLALDAALEATQLYGV 419 P G +RID+ V G EIPPY+D MIAKLI++ +RE A + AL + GV Sbjct: 357 YRSPGGPG--VRIDSGVYGGAEIPPYYDSMIAKLITYGNSREEAIARMKRALREYVIIGV 414 Query: 420 ETNQHYLRQILADAPFASGQPWTRCLEH 447 +TN + R +L + F G T +E Sbjct: 415 KTNIPFHRAVLEEENFLKGNISTHYVEQ 442 >DR0117 [I] COG0439 Biotin carboxylase Dra Deinococcus radiodurans Length = 445 Score = 390 bits (1002), Expect = e-107, Method: Compositional matrix adjust. Identities = 204/446 (45%), Positives = 284/446 (63%), Gaps = 6/446 (1%) Query: 1 MFDHLLIANRGAIACRILRTLRTLEVTGVCVYSEADLGSLHVLQADRAISLGEGAAAQTY 60 MF +LIANRG IA R++RT R + + V VYS AD SL VL AD ++ +G A+ Q+Y Sbjct: 1 MFKKILIANRGEIALRVIRTAREMGIQTVVVYSTADEKSLPVLLADESVCVGPPASNQSY 60 Query: 61 LAVDKILAAARDSGAQAIHPGYGFLSENAAFAEACEAAGIAFVGPTPAQLRLFGLKHTAR 120 L + IL+AA +GA+AIHPGYGF++EN FAE C GI F+GPTP +R G K R Sbjct: 61 LNIPNILSAALMTGAEAIHPGYGFMAENPDFAEMCREHGIVFIGPTPESMRALGSKAGGR 120 Query: 121 ALAREQGVPMLEGTGLLENLQEALAAAAQVAYPVMLKSTAGGGGIGMRVCRSDEELVDAF 180 +A + VP + GTG+LE++ AL AA Q+ YPV+LK++AGGGG G +V R+ EEL F Sbjct: 121 EIAAQSNVPTVPGTGVLESVDAALLAAKQIGYPVLLKASAGGGGRGQKVIRTQEELQKGF 180 Query: 181 ESVRRLGQNNFSDAGVFIEKYIERARHLEVQVFGDGQGEVIALGVRDCSVQRRNQKVLEE 240 + + F D + +EK++E RH+EVQV GDGQG VI +G RDCS+QRRNQK++EE Sbjct: 181 NQAQEEARLYFGDPAIIMEKFLEEFRHIEVQVMGDGQGHVIHIGERDCSIQRRNQKLIEE 240 Query: 241 TPAPNLPAGMADALCAAAIKLARAVNYRSAGTVEFVYDSQAGQFYFLEVNTRLQVEHGVT 300 P+ LP + + AA ++LA+ VNY AGT+EF+ D + G +YF+E+NTR+QVEH V+ Sbjct: 241 APS-TLPESLRQEILAAGVRLAQFVNYAGAGTLEFIMD-RDGNYYFMEMNTRIQVEHCVS 298 Query: 301 EQVWGVDLVRWMIELAAGELPPLEQLAATLQPSGHAIQARLYAEDPGRQFQPCPGLLTAV 360 E + +DLVR IE+AAG ++Q L GHAI+ R+ AEDP + F+P G + Sbjct: 299 EMISSLDLVRLQIEIAAGLGLNIQQDDVKLH--GHAIECRINAEDPDKDFRPAAGKIDDA 356 Query: 361 AFPPADGRALRIDTWVEAGCEIPPYFDPMIAKLISWQPTREAARLALDAALEATQLYGVE 420 F A G +R+DT V +G IPP++D +I KLI W R+ A + ALE T + G + Sbjct: 357 HF--AGGAGVRVDTHVYSGYSIPPHYDSLIGKLIVWHEDRDKAVSRMKRALEETVIQGPK 414 Query: 421 TNQHYLRQILADAPFASGQPWTRCLE 446 T +I+ + + G T L+ Sbjct: 415 TTIPLYIKIMDNPFYKRGAVMTNFLK 440