BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.4331.p (1030 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA4207 [V] COG0841 Cation/multidrug efflux pump Pae Pseudomonas ... 1144 0.0 PA4375 [V] COG0841 Cation/multidrug efflux pump Pae Pseudomonas ... 994 0.0 VC0164 [V] COG0841 Cation/multidrug efflux pump Vch Vibrio cholerae 926 0.0 mlr3649 [V] COG0841 Cation/multidrug efflux pump Mlo Mesorhizobi... 872 0.0 BMEI0893 [V] COG0841 Cation/multidrug efflux pump Bme Brucella m... 853 0.0 >PA4207 [V] COG0841 Cation/multidrug efflux pump Pae Pseudomonas aeruginosa Length = 1029 Score = 1144 bits (2960), Expect = 0.0, Method: Compositional matrix adjust. Identities = 578/1026 (56%), Positives = 764/1026 (74%), Gaps = 5/1026 (0%) Query: 1 MYFTDIFIRRPILALVVSLLILLMGATAVFLLPVRQYPYLENATITISTMLPGATQDVMQ 60 M FTD+F+RRP+LALVVS LILL+G ++ LP+RQYP LE++TIT++T PGA+ D+MQ Sbjct: 1 MTFTDLFVRRPVLALVVSTLILLLGLFSLGKLPIRQYPLLESSTITVTTEYPGASADLMQ 60 Query: 61 GFVTTPISQSIATASGIEYLSSTTKQGRSEIKARLVLNANADRTMTEILAKVQQVKYQLP 120 GFVT PI+Q++++ GI+YLSST+ QGRS + R++LN ++ + MTE +AKV V+Y+LP Sbjct: 61 GFVTQPIAQAVSSVEGIDYLSSTSVQGRSVVTIRMLLNRDSTQAMTETMAKVNSVRYKLP 120 Query: 121 AGVTDPVISKSTEGGTAVQYIAFYSNTLSIPQVTDFASRVAQPLLTSIPGVASADVFGGQ 180 D VI +S+ TAV Y+ F S TL IP +TD+ SRV +P+ +SI GVA FGGQ Sbjct: 121 ERAYDSVIERSSGETTAVAYVGFSSKTLPIPALTDYLSRVVEPMFSSIDGVAKVQTFGGQ 180 Query: 181 ALAMRIWIDPVRLAAHGLSAGEISAALRANNVQSAPGQLKSSLTVTNISAATDLRGVDDF 240 LAMR+W+D RLA GL+A +++ A+R NN Q+APG +K ++N+ TDL VDDF Sbjct: 181 RLAMRLWLDADRLAGRGLTASDVAEAIRRNNYQAAPGMVKGQYVLSNVRVNTDLTNVDDF 240 Query: 241 RQMVVKSSPAGGIVRLSDVATIEVGGQNYNNLSFASGVPAIFVALQPTPDGNPLEIVKRA 300 R+MV+++ G+VRL DV T+E+G + G PA+ + L PTP GNPL IV Sbjct: 241 REMVIRND-GNGLVRLRDVGTVELGAAATETSALMDGDPAVHLGLFPTPTGNPLVIVDGI 299 Query: 301 NALLPKIRAMAPPGLTVAPNYDVARFVNASIEEVQHTLVEAIAIVIVVIFLFLGTFRAVI 360 LLP+I+ PP + V Y+ +RF+ ASI+EV TLVEA+ IV++VI+L LG+ R+V+ Sbjct: 300 RKLLPEIQKTLPPDVRVDLAYETSRFIQASIDEVVRTLVEALLIVVLVIYLCLGSLRSVL 359 Query: 361 IPVVTIPLSLVGTAALMLACGFSINLLTLLAMVLAIGLVVDDAIVVVENIHRHIEEGLSP 420 IPV TIPLS++G AALMLA GFS+NLLTLLAMVLAIGLVVDDAIVVVEN+HRHIEEG SP Sbjct: 360 IPVATIPLSMLGAAALMLAFGFSVNLLTLLAMVLAIGLVVDDAIVVVENVHRHIEEGKSP 419 Query: 421 VRAALLGAREIVGPVIAMTITLAAVYAPIGMMGGLTGALFKEFAFTLAGSVIVSGVVALT 480 V AAL+GARE+ GPVIAMTITLAAVY PIG+MGGLTGALF+EFA TLAG+VIVSGVVALT Sbjct: 420 VAAALIGAREVAGPVIAMTITLAAVYTPIGLMGGLTGALFREFALTLAGAVIVSGVVALT 479 Query: 481 LSPVMSSMLLSSRQGEGRLAKRIEHSMEALTAIYQRILAHTLAARGAVLLVGAVVLAAIV 540 LSPVMSS+LL + Q EGR+ + E LT Y ++L +L R + +V ++ Sbjct: 480 LSPVMSSLLLQAHQNEGRMGRAAEWFFGGLTRRYGQVLEFSLGHRWLTGGLALLVCISLP 539 Query: 541 VLFAGTRRELAPTEDQGAIIVVTKAPQYAGVGYTARYAQQIEKLFESIPEFDSSFMNIGD 600 +L++ +RELAPTEDQ A++ KAPQ+A + Y +A+++++++ SIPE S+++ G Sbjct: 540 LLYSMPKRELAPTEDQAAVLTAIKAPQHANLDYVELFARKLDQVYTSIPETVSTWIING- 598 Query: 601 YAGGQNMMIGGAILKDWSERKRSATDIQSQIQAAGGAIDGETLTAVQLPPLPGSSGGLPV 660 G GG L W +R+R A+ IQS++Q G ++G ++ A QL LPGS+GGLPV Sbjct: 599 -TDGPAASFGGINLAAWEKRERDASAIQSELQGKVGDVEGSSIFAFQLAALPGSTGGLPV 657 Query: 661 QMVLRSPDDFKMLYETGEKIKNAAYASGLFLYAQNDLSYDSPQAHITIDNAKASQMGLSM 720 QMVLRSP D+ +LY T E+IK A SGLF+ +DL Y++P + ID AKA+ +G+ M Sbjct: 658 QMVLRSPQDYPVLYRTMEEIKQKARQSGLFVVVDSDLDYNNPVVQVRIDRAKANSLGIRM 717 Query: 721 QSIADTLAVLVGENYVNRFNFHDRSYDVIPQVRGSERMTPEDIGRFYVKASSGAMVPLST 780 Q I ++LAVLVGENYVNRF RSYDVIPQ +R TP+ + R +V+ G +VPLST Sbjct: 718 QDIGESLAVLVGENYVNRFGMEGRSYDVIPQSLRDQRFTPQALARQFVRTQDGNLVPLST 777 Query: 781 VIQVEMRPQANQLAQFNQMNSTTLELLPAPGVSMGEAVAFLQ--SQPLPPGTSVDWLSDS 838 V++V ++ + N+L QF+Q N+ TL+ +PAPGVSMG+AVAFL ++ LP G S DW SDS Sbjct: 778 VVRVALQVEPNKLIQFDQQNAATLQAIPAPGVSMGQAVAFLDDVARGLPAGFSHDWQSDS 837 Query: 839 RQFVQEGNRLLVSFCFALVVIFLVLAAQFESLRDPLVILVTVPLAVCGALVPLWLGYATL 898 RQ+ QEGN L+ +F ALVVI+LVLAAQ+ESL DPL+IL+TVPL++CGAL+PL LGYAT+ Sbjct: 838 RQYTQEGNTLVFAFLAALVVIYLVLAAQYESLADPLIILITVPLSICGALLPLALGYATM 897 Query: 899 NIYTQIGLVTLIGLISKHGILMVTFANHIQHHENLSRIDAIEKAAAVRMRPVLMTTAAMV 958 NIYTQIGLVTLIGLISKHGILMV FAN +Q HE L R AI +AA +R+RPVLMTTAAMV Sbjct: 898 NIYTQIGLVTLIGLISKHGILMVEFANELQLHERLDRRAAILRAAQIRLRPVLMTTAAMV 957 Query: 959 AGLVPLLFANGAGSASRFSIGIVVVMGMMIGTFFTLFVLPTIYSFIAKDHRALAQSARAR 1018 GLVPLLFA+GAG+ASRF +G+V+V GM++GT FTLFVLPT+Y+ +A++H + +S R+R Sbjct: 958 FGLVPLLFASGAGAASRFGLGVVIVSGMLVGTLFTLFVLPTVYTLLARNHAEVDKSPRSR 1017 Query: 1019 ELATAE 1024 +LA A+ Sbjct: 1018 QLAEAD 1023 >PA4375 [V] COG0841 Cation/multidrug efflux pump Pae Pseudomonas aeruginosa Length = 1018 Score = 994 bits (2569), Expect = 0.0, Method: Compositional matrix adjust. Identities = 524/1009 (51%), Positives = 704/1009 (69%), Gaps = 8/1009 (0%) Query: 1 MYFTDIFIRRPILALVVSLLILLMGATAVFLLPVRQYPYLENATITISTMLPGATQDVMQ 60 M FTD FIRRP+LA VVSLLI+L+G A L +R+YP +ENA IT++T+ GA + +Q Sbjct: 1 MAFTDPFIRRPVLASVVSLLIVLLGMQAFSKLVIREYPQMENALITVTTLYAGANAETIQ 60 Query: 61 GFVTTPISQSIATASGIEYLSSTTKQGRSEIKARLVLNANADRTMTEILAKVQQVKYQLP 120 G++T P+ QS+A+A GI+Y++S ++Q S I + AN DR +TE+LAK +VK QLP Sbjct: 61 GYITQPLQQSLASAEGIDYMTSVSRQNYSTISIYARIGANTDRLVTELLAKSNEVKSQLP 120 Query: 121 AGVTDPVISKSTEGGTAVQYIAFYSNTLSIPQVTDFASRVAQPLLTSIPGVASADVFGGQ 180 DPV+ K +A+ YI+FYS ++ PQ+TD+ SRV QP L ++PG+A A++ G Q Sbjct: 121 PDAEDPVLQKEAADASALMYISFYSEQMNNPQITDYLSRVIQPKLATLPGIAEAEILGNQ 180 Query: 181 ALAMRIWIDPVRLAAHGLSAGEISAALRANNVQSAPGQLKSSLTVTNISAATDLRGVDDF 240 AMR+W+DPV++AA G++AGEI+ A++ N +A G++K L VT+++A+TDL+ F Sbjct: 181 VFAMRLWLDPVKMAAFGVTAGEINQAVQQYNFLAAAGEVKGQLVVTSVNASTDLKSPQAF 240 Query: 241 RQMVVKSSPAGGIVRLSDVATIEVGGQNYNNLSFASGVPAIFVALQPTPDGNPLEIVKRA 300 + VK+ V + DVA +E+G +Y+ +S +G+P++++ ++ TP NPL+++K Sbjct: 241 AAIPVKTD-GDRRVLMGDVARVELGAASYDAISSFNGIPSVYIGIKGTPSANPLDVIKEV 299 Query: 301 NALLPKIRAMAPPGLTVAPNYDVARFVNASIEEVQHTLVEAIAIVIVVIFLFLGTFRAVI 360 A +P++ PP L V+ YD RF+ ASI+EV TL EA+ IVIVV+FLFLG FR+V+ Sbjct: 300 RAKMPELEEQLPPNLKVSIAYDATRFIQASIDEVVKTLGEAVLIVIVVVFLFLGAFRSVL 359 Query: 361 IPVVTIPLSLVGTAALMLACGFSINLLTLLAMVLAIGLVVDDAIVVVENIHRHIEEGLSP 420 IPVVTIPLS++G M A G+SINLLTLLAMVLAIGLVVDDAIVVVENIHRHIEEG P Sbjct: 360 IPVVTIPLSMIGVLFFMQAMGYSINLLTLLAMVLAIGLVVDDAIVVVENIHRHIEEGKPP 419 Query: 421 VRAALLGAREIVGPVIAMTITLAAVYAPIGMMGGLTGALFKEFAFTLAGSVIVSGVVALT 480 AAL GAREI PV++MTITLAAVYAPIG + GLTGALFKEFAFTLAG+VI+SG+VALT Sbjct: 420 FEAALEGAREIAVPVVSMTITLAAVYAPIGFLTGLTGALFKEFAFTLAGAVIISGIVALT 479 Query: 481 LSPVMSSMLLSSRQGEGRLAKRIEHSMEALTAIYQRILAHTLAARGAVLLVGAVVLAAIV 540 LSP+M S LL + LA R++ E L YQR L TL R VL+ +VLA I Sbjct: 480 LSPMMCSRLLRHEENPSGLAHRLDLIFEGLKQRYQRALHGTLDTRPVVLVFAVLVLALIP 539 Query: 541 VLFAGTRRELAPTEDQGAIIVVTKAPQYAGVGYTARYAQQIEKLFESIPEFDSSFMNIGD 600 VL T++ELAP EDQG + ++T +PQ A + Y RY + E +F S PE+ S+F I Sbjct: 540 VLLMFTKKELAPEEDQGIVFLMTNSPQTANLDYLNRYTAEFEGIFRSFPEYYSAF-QING 598 Query: 601 YAGGQNMMIGGAILKDWSERKRSATDIQSQIQAAGGAIDGETLTAVQLPPLPGSSGGLPV 660 Y G Q IGG +LK W ER++S ++ +QA I G + A LP LPG+ GLP Sbjct: 599 YNGVQ-AGIGGMLLKPWDEREKSQMELLHAVQAKLNEIPGVQIFAFNLPSLPGTGEGLPF 657 Query: 661 QMVLRSPDDFKMLYETGEKIKNAAYASGLFLYAQNDLSYDSPQAHITIDNAKASQMGLSM 720 Q VL + +D++ L + +++K A SG F + DL++D P+ + ID KA+QMG+SM Sbjct: 658 QFVLNTANDYESLLQVAQRVKQRASESGKFAFLDLDLAFDKPELVVDIDREKAAQMGVSM 717 Query: 721 QSIADTLAVLVGENYVNRFNFHDRSYDVIPQVRGSERMTPEDIGRFYVKASSGAMVPLST 780 Q + LA L+GE +NRF RSY VI QV R P +G +YVK+ +G +V LST Sbjct: 718 QDLGVALASLLGEGEINRFTIDGRSYKVIAQVERPYRDNPGWLGSYYVKSRNGQLVALST 777 Query: 781 VIQVEMRPQANQLAQFNQMNSTTLELLPAPGVSMGEAVAFLQS---QPLPPGTSVDWLSD 837 +I+ R + QL QF Q+NS + P VSMGEA+ +Q + P G +VD+ Sbjct: 778 LIETHERARPRQLNQFQQLNSAIISGFPI--VSMGEAIETVQQIAREEAPRGFAVDYAGA 835 Query: 838 SRQFVQEGNRLLVSFCFALVVIFLVLAAQFESLRDPLVILVTVPLAVCGALVPLWLGYAT 897 SRQ+VQEG+ LLV+F AL +IFLVLAAQFES RDPLVI+VTVPL++CGAL+PL+LG ++ Sbjct: 836 SRQYVQEGSALLVTFGLALAIIFLVLAAQFESFRDPLVIMVTVPLSICGALIPLFLGVSS 895 Query: 898 LNIYTQIGLVTLIGLISKHGILMVTFANHIQHHENLSRIDAIEKAAAVRMRPVLMTTAAM 957 LNIYTQ+GLVTLIGLISKHGIL+V FAN ++H + L R +AIE+AAA+R+RPVLMTTAAM Sbjct: 896 LNIYTQVGLVTLIGLISKHGILIVEFANQLRHEQGLGRREAIEQAAAIRLRPVLMTTAAM 955 Query: 958 VAGLVPLLFANGAGSASRFSIGIVVVMGMMIGTFFTLFVLPTIYSFIAK 1006 V G++PL+ A GAG+ SRF IGIV+ GM +GT FTLFVLP IY+ +A+ Sbjct: 956 VLGVIPLILATGAGAVSRFDIGIVIATGMSVGTLFTLFVLPCIYTLVAR 1004 >VC0164 [V] COG0841 Cation/multidrug efflux pump Vch Vibrio cholerae Length = 1036 Score = 926 bits (2392), Expect = 0.0, Method: Compositional matrix adjust. Identities = 466/1023 (45%), Positives = 673/1023 (65%), Gaps = 6/1023 (0%) Query: 1 MYFTDIFIRRPILALVVSLLILLMGATAVFLLPVRQYPYLENATITISTMLPGATQDVMQ 60 M FTD+FI+RP+LA+ +S LI+L+G A+F + VR+YP + N IT+ST GA+ D++Q Sbjct: 1 MRFTDVFIKRPVLAVSISFLIVLLGLQAIFKMQVREYPEMTNTVITVSTGYYGASADLIQ 60 Query: 61 GFVTTPISQSIATASGIEYLSSTTKQGRSEIKARLVLNANADRTMTEILAKVQQVKYQLP 120 GF+T P+ Q++A A I++++S + GRS I + LN + + ++++LAK V+ QLP Sbjct: 61 GFITQPLEQAVAQADNIDFMTSQSVLGRSTITVTMKLNTDPNAALSDVLAKTNSVRSQLP 120 Query: 121 AGVTDPVISKSTEGGTAVQYIAFYSNTLSIPQVTDFASRVAQPLLTSIPGVASADVFGGQ 180 DP ++ ST TAV YI F SN L+ Q+TD+ RV P L ++ GV+S D++GG Sbjct: 121 KEAEDPTVTMSTGSTTAVLYIGFTSNELASSQITDYLERVVNPQLYAVNGVSSIDLYGGM 180 Query: 181 ALAMRIWIDPVRLAAHGLSAGEISAALRANNVQSAPGQLKSSLTVTNISAATDLRGVDDF 240 A+R+W+DP ++AA LSA ++ + L ANN QSA GQ + N SA T + V+D Sbjct: 181 KYALRVWLDPAKMAALNLSAADVMSILNANNYQSATGQAIGEFVLYNGSADTQVSTVEDL 240 Query: 241 RQMVVKSSPAGGIVRLSDVATIEVGGQNYNNLSFASGVPAIFVALQPTPDGNPLEIVKRA 300 +VVK+ G + RL D+A + + + + A+G A+ A+ P NP+ I K Sbjct: 241 ESLVVKAE-KGTVTRLGDIAKVTLAKSHDTYRASANGREAVVAAINAAPSANPINIAKDV 299 Query: 301 NALLPKIRAMAPPGLTVAPNYDVARFVNASIEEVQHTLVEAIAIVIVVIFLFLGTFRAVI 360 +LP+++ P + + YD +N SI EV T+VEA IV+VVI LFLG+ RAV+ Sbjct: 300 LEMLPELQKNMPSNIEMNVLYDSTVAINESIHEVIKTIVEAALIVLVVITLFLGSLRAVL 359 Query: 361 IPVVTIPLSLVGTAALMLACGFSINLLTLLAMVLAIGLVVDDAIVVVENIHRHIEEGLSP 420 IP+VTIPLSL+G A +M GFS NL+TLLAMVLAIGLVVDDAIVV+EN+ RHI+EG SP Sbjct: 360 IPIVTIPLSLIGVAMVMQMMGFSWNLMTLLAMVLAIGLVVDDAIVVLENVDRHIKEGESP 419 Query: 421 VRAALLGAREIVGPVIAMTITLAAVYAPIGMMGGLTGALFKEFAFTLAGSVIVSGVVALT 480 RAA++G REI PVIAMT+TL AVYAPI +MGG+TG+LFKEFA TLAGSV VSG+VALT Sbjct: 420 FRAAIIGTREIAIPVIAMTLTLGAVYAPIALMGGITGSLFKEFALTLAGSVFVSGIVALT 479 Query: 481 LSPVMSSMLLSSRQGEGRLAKRIEHSMEALTAIYQRILAHTLAARGAVLLVGAVVLAAIV 540 LSP+M S +L + + + ++ H ++ +TA Y+R+L +A R V+ +V A++ Sbjct: 480 LSPMMCSKMLKANEAPNKFELKVHHLLDRMTARYERMLTAVMAHRPVVIAFAFIVFASLP 539 Query: 541 VLFAGTRRELAPTEDQGAIIVVTKAPQYAGVGYTARYAQQIEKLFESIPEFDSSFMNIGD 600 +LF ELAP+ED+G I+++ P A + Y A + K+ PE F + Sbjct: 540 MLFKFIPSELAPSEDKGVIMLMGTGPSNANLDYLANTMDDVNKILSDQPEV--QFAQVFT 597 Query: 601 YAGGQNMMIGGAILKDWSERKRSATDIQSQIQAAGGAIDGETLTAVQLPPLPGSSGGLPV 660 N G A + WS+R+ S + +++ I G +TA Q+P LPG+ GLP+ Sbjct: 598 GVPNSNQAFGIASMVPWSQREASQATVTNRVGTLVQDIPGMAVTAFQMPELPGAGSGLPI 657 Query: 661 QMVLRSPDDFKMLYETGEKIKNAAYASGLFLYAQNDLSYDSPQAHITIDNAKASQMGLSM 720 Q V+ +P +F+ L+ + A+ +F+Y+ DL++DS I ID KA G++M Sbjct: 658 QFVITTPSNFESLFTIATDVLTEVKANPMFVYSDLDLNFDSATMKINIDKDKAGAYGVTM 717 Query: 721 QSIADTLAVLVGENYVNRFNFHDRSYDVIPQVRGSERMTPEDIGRFYVKASSGAMVPLST 780 Q I TL+ ++ + YVNR + + RSY+VIPQV R+ PE + +YV+A+ G ++PL + Sbjct: 718 QDIGITLSTMMADGYVNRIDLNGRSYEVIPQVERKWRLNPESMNSYYVRAADGKVIPLGS 777 Query: 781 VIQVEMRPQANQLAQFNQMNSTTLELLPAPGVSMGEAVAFLQ---SQPLPPGTSVDWLSD 837 ++ +++ + L FNQ+NS T+ +PAPG +MG+A+ + + S LP G S D++ + Sbjct: 778 LVTIDVVAEPRSLPHFNQLNSATVGAVPAPGTAMGDAINWFENLASSKLPKGYSHDYMGE 837 Query: 838 SRQFVQEGNRLLVSFCFALVVIFLVLAAQFESLRDPLVILVTVPLAVCGALVPLWLGYAT 897 +RQ+V EG+ L +F AL +IFLVLA QFESLRDPLVI+V+VPLA+CGAL+ L G AT Sbjct: 838 ARQYVTEGSALYATFGLALAIIFLVLAIQFESLRDPLVIMVSVPLAICGALIALAWGTAT 897 Query: 898 LNIYTQIGLVTLIGLISKHGILMVTFANHIQHHENLSRIDAIEKAAAVRMRPVLMTTAAM 957 +NIY+Q+GL+TL+GLI+KHGIL+ A Q H LSRI+A+ AA VR+RP+LMTTAAM Sbjct: 898 MNIYSQVGLITLVGLITKHGILICEVAKEEQLHNKLSRIEAVMHAAKVRLRPILMTTAAM 957 Query: 958 VAGLVPLLFANGAGSASRFSIGIVVVMGMMIGTFFTLFVLPTIYSFIAKDHRALAQSARA 1017 +AGL+PL++A GAG+A RFSIGIV+V G+ IGT FTLFVLP IYS++A+ H+ L Sbjct: 958 IAGLIPLMYATGAGAAQRFSIGIVIVSGLAIGTLFTLFVLPVIYSYLAEKHKPLPVFVED 1017 Query: 1018 REL 1020 ++L Sbjct: 1018 KDL 1020 >mlr3649 [V] COG0841 Cation/multidrug efflux pump Mlo Mesorhizobium loti Length = 1027 Score = 872 bits (2254), Expect = 0.0, Method: Compositional matrix adjust. Identities = 461/1023 (45%), Positives = 679/1023 (66%), Gaps = 8/1023 (0%) Query: 1 MYFTDIFIRRPILALVVSLLILLMGATAVFLLPVRQYPYLENATITISTMLPGATQDVMQ 60 M F+D+FIRRP+L+ V+ LILL+G +F L +RQYP ++ ITI+T PGA+ D++Q Sbjct: 1 MSFSDLFIRRPVLSTVLGCLILLLGFQGIFNLSIRQYPKVDETAITITTAYPGASADLIQ 60 Query: 61 GFVTTPISQSIATASGIEYLSSTTKQGRSEIKARLVLNANADRTMTEILAKVQQVKYQLP 120 GF++ PI++++A+ I+Y++S+++ S + ++ L +N D +TE+L+KVQ V+ LP Sbjct: 61 GFISAPIARAVASTENIDYVTSSSRPSSSTVTVQMKLGSNPDVALTEVLSKVQGVRGTLP 120 Query: 121 AGVTDPVISKSTEGGTAVQYIAFYSNTLSIPQVTDFASRVAQPLLTSIPGVASADVFGGQ 180 DPVI K T A+ YI+ + ++ Q+T++ RV +P ++++ GVA +FG Q Sbjct: 121 DASKDPVIVKGTGQQFAMMYISMQNPNMTKEQLTEYIERVIRPRMSTVEGVADVQIFGAQ 180 Query: 181 ALAMRIWIDPVRLAAHGLSAGEISAALRANNVQSAPGQLKSSLTVTNISAATDLRGVDDF 240 +MR+WIDP+RLAA G++A E+ A+ +N SAPG ++ V++IS + L+ + F Sbjct: 181 EYSMRVWIDPIRLAARGVTAAEVLTAINNSNFLSAPGNTQNEYVVSSISVRSTLQTPEAF 240 Query: 241 RQMVVKSSPAGGIVRLSDVATIEVGGQNYNNLSFASGVPAIFVALQPTPDGNPLEIVKRA 300 ++ ++S+ G +VRL DVA +E+G N + +G P F+A+ PTP NPL Sbjct: 241 AELPLRSTD-GNVVRLRDVARVELGAANTDTRVSFNGKPGTFLAIFPTPAANPLTTAAAL 299 Query: 301 NALLPKIRAMAPPGLTVAPNYDVARFVNASIEEVQHTLVEAIAIVIVVIFLFLGTFRAVI 360 L+P+I+ P G+T+ YD ++ASIEEV T+ EA+AIV+VVI LFLG+FR+V+ Sbjct: 300 TKLVPQIQETLPKGMTIEVVYDATGQISASIEEVFKTIGEAVAIVVVVILLFLGSFRSVM 359 Query: 361 IPVVTIPLSLVGTAALMLACGFSINLLTLLAMVLAIGLVVDDAIVVVENIHRHIEEG-LS 419 +P++TIPLSL+G L+ A G+SINLL+LLAMVLAIGLVVDDAIVVVENIHRH+EE ++ Sbjct: 360 MPIITIPLSLIGVCFLLFAVGYSINLLSLLAMVLAIGLVVDDAIVVVENIHRHMEEDHMT 419 Query: 420 PVRAALLGAREIVGPVIAMTITLAAVYAPIGMMGGLTGALFKEFAFTLAGSVIVSGVVAL 479 P++AA G REI ++AMT+TLAAV+AP+ GGLTGALF+EFA TLAGSV++SGV+A+ Sbjct: 420 PMQAAFSGMREIASAIVAMTMTLAAVFAPLAFTGGLTGALFREFAVTLAGSVVLSGVIAV 479 Query: 480 TLSPVMSSMLLSSRQGEGRLAKRIEHSMEALTAIYQRILAHTLAARGAVLLVGAVVLAAI 539 T++P+MS+ LL + GR + ++ + +Y+R + +L R L++ ++ Sbjct: 480 TITPMMSARLLKAGT-PGRFQRIVDGIFARVEHVYERAVTGSLNYRPLTLIIVLALVGVT 538 Query: 540 VVLFAGTRRELAPTEDQGAIIVVTKAPQYAGVGYTARYAQQIEKLFESIPEFDSSFMNIG 599 +F T ELAP EDQG ++ + AP YA YT Y Q+ L IPE + F + Sbjct: 539 GFMFTKTSSELAPEEDQGFLLSLVTAPTYATSDYTETYVNQMLGLVRDIPETRAQFSAVA 598 Query: 600 DYAGGQNMMIGGAILKDWSERKRSATDIQSQIQAAGGAIDGETLTAVQLPPLPGSSGGLP 659 + G N G KDW+ERKR++ ++Q+ I A + G P LPGS GGLP Sbjct: 599 -FGGTTNSAFVGFAFKDWAERKRNSKELQADITARLAKVAGVQAFVFAPPTLPGSGGGLP 657 Query: 660 VQMVLRSPDDFKMLYETGEKIKNAAYASGLFLYAQNDLSYDSPQAHITIDNAKASQMGLS 719 + +V+RS D +Y+ E+IKN A ASG F+ QN +SYDSPQ +TID +A+ + L Sbjct: 658 IALVVRSTGDSAEVYKAAEQIKNKAQASGRFIVVQNSMSYDSPQVTVTIDRDRAAALNLP 717 Query: 720 MQSIADTLAVLVGENYVNRFNFHDRSYDVIPQVRGSERMTPEDIGRFYVKASSGAMVPLS 779 + I TL +LVG V +F+ SYD+IPQV R PE +G ++V++ +G MVPLS Sbjct: 718 IADIGRTLTLLVGGAEVAQFDRDSNSYDIIPQVPQQFRDNPERLGEYFVRSVTGEMVPLS 777 Query: 780 TVIQVEMRPQANQLAQFNQMNSTTLELLPAPGVSMGEAVAFLQS---QPLPPGTSVDWLS 836 V+ + + QFNQ+NS+T+ LP PGV+ G+ + L+ + LP +D+ Sbjct: 778 AVVNISNNASPAAIEQFNQLNSSTISALPLPGVTTGDGLKVLEDIARESLPDTFFIDYSG 837 Query: 837 DSRQFVQEGNRLLVSFCFALVVIFLVLAAQFESLRDPLVILVTVPLAVCGALVPLWLGYA 896 SRQ ++GN +L++F A++VI+LVLAAQFES RDPL+I++ VPL++ GA+VPL LG Sbjct: 838 QSRQEKEQGNTILIAFAAAVIVIYLVLAAQFESFRDPLIIMMAVPLSIFGAIVPLNLGLG 897 Query: 897 TLNIYTQIGLVTLIGLISKHGILMVTFANHIQHHENLSRIDAIEKAAAVRMRPVLMTTAA 956 TLNIYTQ+GL+TLIGLI+KHGIL+V FAN + + R DAI +A VR+RP+LMTTAA Sbjct: 898 TLNIYTQVGLITLIGLITKHGILLVEFANQQREAHGMRRRDAIIASAKVRLRPILMTTAA 957 Query: 957 MVAGLVPLLFANGAGSASRFSIGIVVVMGMMIGTFFTLFVLPTIYSFIA-KDHRALAQSA 1015 M G+VPL+ ++GAG+A+R+S+G+V+ G+++GT FTLFV+P Y+FIA KD LA+ Sbjct: 958 MALGVVPLITSSGAGAAARYSMGLVIFTGILVGTMFTLFVVPMFYTFIASKDLPHLAEKP 1017 Query: 1016 RAR 1018 R Sbjct: 1018 DPR 1020 >BMEI0893 [V] COG0841 Cation/multidrug efflux pump Bme Brucella melitensis Length = 1029 Score = 853 bits (2204), Expect = 0.0, Method: Compositional matrix adjust. Identities = 460/1009 (45%), Positives = 665/1009 (65%), Gaps = 6/1009 (0%) Query: 1 MYFTDIFIRRPILALVVSLLILLMGATAVFLLPVRQYPYLENATITISTMLPGATQDVMQ 60 M F+DIFIRRP+LA VVSL+I+L+G + L VR+YP ++ IT++T GA+ D++Q Sbjct: 1 MNFSDIFIRRPVLATVVSLMIVLLGLQGIAQLSVREYPKVDETVITVTTAYAGASADLIQ 60 Query: 61 GFVTTPISQSIATASGIEYLSSTTKQGRSEIKARLVLNANADRTMTEILAKVQQVKYQLP 120 GF+T PI++++AT I+Y++S+++ S + ++ L A+ D +TE++AKV QV+ LP Sbjct: 61 GFITAPIAEAVATTENIDYVTSSSRPSSSTVTVQMKLGADPDAALTEVIAKVNQVRGNLP 120 Query: 121 AGVTDPVISKSTEGGTAVQYIAFYSNTLSIPQVTDFASRVAQPLLTSIPGVASADVFGGQ 180 DPVI K T A Y+A + ++ Q+T++ RV QP +++I GVA A++ GGQ Sbjct: 121 DESDDPVIVKGTGQSFATMYLAAQNPNMTSEQITEYLKRVIQPRMSTIQGVAKAEILGGQ 180 Query: 181 ALAMRIWIDPVRLAAHGLSAGEISAALRANNVQSAPGQLKSSLTVTNISAATDLRGVDDF 240 +MR+W+DP++LAA ++A E+ +A++A+N SAPG+ K+ T+I+ + L+ + F Sbjct: 181 VYSMRVWLDPIQLAARQITAPEVLSAIKASNFLSAPGKTKNEYVATSITLKSTLQTPEAF 240 Query: 241 RQMVVKSSPAGGIVRLSDVATIEVGGQNYNNLSFASGVPAIFVALQPTPDGNPLEIVKRA 300 M +K+ +VRL DVA +E+ ++ + + +G F+ + PTP NP+++ Sbjct: 241 GAMPIKAL-GDEVVRLRDVAKVELAAESTDTIVSFNGSAGTFLGVYPTPAANPIDMAAAV 299 Query: 301 NALLPKIRAMAPPGLTVAPNYDVARFVNASIEEVQHTLVEAIAIVIVVIFLFLGTFRAVI 360 LP I+A P G+++ YD +++SI EV T+ EA+AIVI+VI +FLG+FR+V+ Sbjct: 300 RKELPSIQASLPEGMSLVLVYDATEQISSSINEVFTTIGEAVAIVILVIIVFLGSFRSVL 359 Query: 361 IPVVTIPLSLVGTAALMLACGFSINLLTLLAMVLAIGLVVDDAIVVVENIHRHIEEGLSP 420 IP+VTIP+SL+G + GFSINLL+LLAMVLAIGLVVDDAIVV+ENIHRHIEEGL P Sbjct: 360 IPIVTIPISLIGVCFFLYVLGFSINLLSLLAMVLAIGLVVDDAIVVLENIHRHIEEGLHP 419 Query: 421 VRAALLGAREIVGPVIAMTITLAAVYAPIGMMGGLTGALFKEFAFTLAGSVIVSGVVALT 480 + AA G +EI G ++AMTITLAAV+ P+G GGLTG+LF+EFAFTLAG+VI+SG+ ALT Sbjct: 420 IDAAFKGMKEITGSIVAMTITLAAVFTPLGFTGGLTGSLFREFAFTLAGAVIISGIAALT 479 Query: 481 LSPVMSSMLLSSRQGEGRLAKRIEHSMEALTAIYQRILAHTLAARGAVLLVGAVVLAAIV 540 +SP+M S +L + R K I+ + Y ++++L R L + ++ Sbjct: 480 ISPMMCSRML-KHGDQTRFQKFIDRTFSRFEKWYHARVSNSLNYRWITLAIVLCLMGLTG 538 Query: 541 VLFAGTRRELAPTEDQGAIIVVTKAPQYAGVGYTARYAQQIEKLFESIPEFDSSFMNIGD 600 LF T ELAP ED GA+ + +APQYA YT YA+QI+ L + +PE + F +G Sbjct: 539 FLFMNTSSELAPEEDSGALFSMFQAPQYATSAYTNLYAEQIDALTKDLPEQKTRFQIVG- 597 Query: 601 YAGGQNMMIGGAILKDWSERKRSATDIQSQIQAAGGAIDGETLTAVQLPPLPGSSGGLPV 660 GG I +LKDW+ER RS IQ + A + G P LPG+ GGLP+ Sbjct: 598 MDGGTTSGIALWVLKDWNERDRSQKQIQQDLTARISKVAGVQAFIFAPPSLPGTGGGLPI 657 Query: 661 QMVLRSPDDFKMLYETGEKIKNAAYASGLFLYAQNDLSYDSPQAHITIDNAKASQMGLSM 720 + L+S ++ E+IK A ASG F+ QN LS+++PQ ITID +A+ +G+ + Sbjct: 658 SIALQSTGPADQVFALAEEIKAEAQASGQFIIVQNSLSFNAPQTTITIDRDRAATLGVQV 717 Query: 721 QSIADTLAVLVGENYVNRFNFHDRSYDVIPQVRGSERMTPEDIGRFYVKASSGAMVPLST 780 I TL +L G + +F+ SYD+I QV S R PE +G FYV++ SG+MVPLS+ Sbjct: 718 SDIGSTLGLLTGGASIAKFDRDSNSYDIITQVPDSYRANPEMLGNFYVRSVSGSMVPLSS 777 Query: 781 VIQVEMRPQANQLAQFNQMNSTTLELLPAPGVSMGEAVAFL---QSQPLPPGTSVDWLSD 837 VIQ+ + QFNQ+NS T+ LP PGV+ G+ + L +P G +D+ Sbjct: 778 VIQINENAAPAAIEQFNQLNSATISALPLPGVTTGQGLQTLVDIARSKMPEGFFLDYSCQ 837 Query: 838 SRQFVQEGNRLLVSFCFALVVIFLVLAAQFESLRDPLVILVTVPLAVCGALVPLWLGYAT 897 SR V++GN +L++F FA+ VI+LVLAAQFES RDP +I+++VPL++ GA+VPL +G T Sbjct: 838 SRLEVEQGNTILIAFGFAVFVIYLVLAAQFESFRDPFIIMMSVPLSIFGAIVPLNIGLGT 897 Query: 898 LNIYTQIGLVTLIGLISKHGILMVTFANHIQHHENLSRIDAIEKAAAVRMRPVLMTTAAM 957 LNIYTQ+GL+TL+GLI+KHGILMV FAN + LSR DAI AA R+RP+LMTTAAM Sbjct: 898 LNIYTQVGLITLVGLITKHGILMVEFANQQRRLHGLSRRDAIVVAAETRLRPILMTTAAM 957 Query: 958 VAGLVPLLFANGAGSASRFSIGIVVVMGMMIGTFFTLFVLPTIYSFIAK 1006 G+VPL+ A GAG+A+R+S+G+V+ G+ IGT FTLFV+P Y+FIAK Sbjct: 958 ALGVVPLIIATGAGAAARYSMGLVIFTGITIGTIFTLFVVPMFYTFIAK 1006