BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.4273.p (396 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value tyrB [E] COG1448 Aspartate/tyrosine/aromatic aminotransferase Ec... 454 e-127 ZtyrB [E] COG1448 Aspartate/tyrosine/aromatic aminotransferase E... 453 e-127 ECs5036 [E] COG1448 Aspartate/tyrosine/aromatic aminotransferase... 453 e-127 STM4248 [E] COG1448 Aspartate/tyrosine/aromatic aminotransferase... 449 e-126 YPO0322 [E] COG1448 Aspartate/tyrosine/aromatic aminotransferase... 445 e-124 >tyrB [E] COG1448 Aspartate/tyrosine/aromatic aminotransferase Eco Escherichia coli K12 Length = 397 Score = 454 bits (1169), Expect = e-127, Method: Compositional matrix adjust. Identities = 218/397 (54%), Positives = 279/397 (70%), Gaps = 3/397 (0%) Query: 1 MFSHLPPYAGDPILSLMEQFQRDERSNKVNLSIGIYTDGRGVVPVLPTVRAAAAAV-AEA 59 MF + YAGDPIL+LME+F+ D RS+KVNLSIG+Y + G++P L V A A + A+ Sbjct: 1 MFQKVDAYAGDPILTLMERFKEDPRSDKVNLSIGLYYNEDGIIPQLQAVAEAEARLNAQP 60 Query: 60 GAPYVYLPMEGHAAYRQAVAKLLFGADLP--STEHLAIVQTLGGSGALKVGADLIARFFP 117 +YLPMEG YR A+A LLFGAD P + +A +QTLGGSGALKVGAD + R+FP Sbjct: 61 HGASLYLPMEGLNCYRHAIAPLLFGADHPVLKQQRVATIQTLGGSGALKVGADFLKRYFP 120 Query: 118 QPTIWLPDPTWDNHVGIFEGAGFKTERYPYYDAQTKGLDFPAMLAKLDSLSKGAVVLLHP 177 + +W+ DPTW+NHV IF GAGF+ YP+YD T G+ F +LA L +L ++VLLHP Sbjct: 121 ESGVWVSDPTWENHVAIFAGAGFEVSTYPWYDEATNGVRFNDLLATLKTLPARSIVLLHP 180 Query: 178 CCHNPTGVDPTRAQWEEIIAVVEKRGLLPFFDLAYQGFAESLDEDIWPVREAVRRQIPFF 237 CCHNPTG D T QW+ +I +++ R L+PF D+AYQGF ++ED + +R +P Sbjct: 181 CCHNPTGADLTNDQWDAVIEILKARELIPFLDIAYQGFGAGMEEDAYAIRAIASAGLPAL 240 Query: 238 LSNSFSKIFSLYSERIGALSVFCPQSGQAANVLGQLKLTVRRNYSSPARNGALLVAHVLG 297 +SNSFSKIFSLY ER+G LSV C + A VLGQLK TVRRNYSSP GA +VA VL Sbjct: 241 VSNSFSKIFSLYGERVGGLSVMCEDAEAAGRVLGQLKATVRRNYSSPPNFGAQVVAAVLN 300 Query: 298 DDKLATQWRAEVEEMRVRVRDMRVKLASQLKSAVPDQDFSFLLRQNGMFGYTGLSSAQVD 357 D+ L W AEVEEMR R+ MR +L L + +P+++F +LL Q GMF YTGLS+AQVD Sbjct: 301 DEALKASWLAEVEEMRTRILAMRQELVKVLSTEMPERNFDYLLNQRGMFSYTGLSAAQVD 360 Query: 358 RLREEFGVYAVGTGRICVAGLNDSNVARVAETMAEVL 394 RLREEFGVY + +GR+CVAGLN +NV RVA+ A V+ Sbjct: 361 RLREEFGVYLIASGRMCVAGLNTANVQRVAKAFAAVM 397 >ZtyrB [E] COG1448 Aspartate/tyrosine/aromatic aminotransferase EcZ Escherichia coli O157:H7 EDL933 Length = 397 Score = 453 bits (1165), Expect = e-127, Method: Compositional matrix adjust. Identities = 218/397 (54%), Positives = 279/397 (70%), Gaps = 3/397 (0%) Query: 1 MFSHLPPYAGDPILSLMEQFQRDERSNKVNLSIGIYTDGRGVVPVLPTVRAAAAAV-AEA 59 MF + YAGDPIL+LME+F+ D RS+KVNLSIG+Y + G++P L V A A + A Sbjct: 1 MFQKVDAYAGDPILTLMERFKEDPRSDKVNLSIGLYYNEDGIIPQLKAVAEAEARLNAVP 60 Query: 60 GAPYVYLPMEGHAAYRQAVAKLLFGADLP--STEHLAIVQTLGGSGALKVGADLIARFFP 117 +YLPMEG +YR A+A LLFGAD P + +A +QTLGGSGALKVGAD + R+FP Sbjct: 61 HGASLYLPMEGLNSYRHAIAPLLFGADHPVLQQQRVATIQTLGGSGALKVGADFLKRYFP 120 Query: 118 QPTIWLPDPTWDNHVGIFEGAGFKTERYPYYDAQTKGLDFPAMLAKLDSLSKGAVVLLHP 177 + +W+ DPTW+NHV IF GAGF+ YP+YD T G+ F +LA L +L ++VLLHP Sbjct: 121 ESGVWVSDPTWENHVAIFAGAGFEVSTYPWYDEATNGVRFNDLLAMLKTLPARSIVLLHP 180 Query: 178 CCHNPTGVDPTRAQWEEIIAVVEKRGLLPFFDLAYQGFAESLDEDIWPVREAVRRQIPFF 237 CCHNPTG D T QW+ +I +++ R L+PF D+AYQGF ++ED + +R +P Sbjct: 181 CCHNPTGADLTNDQWDAVIEILKARELIPFLDIAYQGFGAGMEEDAYAIRAIASAGLPAL 240 Query: 238 LSNSFSKIFSLYSERIGALSVFCPQSGQAANVLGQLKLTVRRNYSSPARNGALLVAHVLG 297 +SNSFSKIFSLY ER+G LSV C + A VLGQLK TVRRNYSSP GA +VA VL Sbjct: 241 VSNSFSKIFSLYGERVGGLSVLCEDAEAAGRVLGQLKATVRRNYSSPPNFGAQVVAAVLN 300 Query: 298 DDKLATQWRAEVEEMRVRVRDMRVKLASQLKSAVPDQDFSFLLRQNGMFGYTGLSSAQVD 357 D+ L W AEVEEMR R+ MR +L L + +P+++F +LL Q GMF YTGLS+AQVD Sbjct: 301 DEALKASWLAEVEEMRTRILAMRQELVKVLSTEMPERNFDYLLNQRGMFSYTGLSAAQVD 360 Query: 358 RLREEFGVYAVGTGRICVAGLNDSNVARVAETMAEVL 394 RLREEFGVY + +GR+CVAGLN +NV RVA+ A V+ Sbjct: 361 RLREEFGVYLIASGRMCVAGLNTANVQRVAKAFAAVM 397 >ECs5036 [E] COG1448 Aspartate/tyrosine/aromatic aminotransferase Ecs Escherichia coli O157:H7 Length = 397 Score = 453 bits (1165), Expect = e-127, Method: Compositional matrix adjust. Identities = 218/397 (54%), Positives = 279/397 (70%), Gaps = 3/397 (0%) Query: 1 MFSHLPPYAGDPILSLMEQFQRDERSNKVNLSIGIYTDGRGVVPVLPTVRAAAAAV-AEA 59 MF + YAGDPIL+LME+F+ D RS+KVNLSIG+Y + G++P L V A A + A Sbjct: 1 MFQKVDAYAGDPILTLMERFKEDPRSDKVNLSIGLYYNEDGIIPQLKAVAEAEARLNAVP 60 Query: 60 GAPYVYLPMEGHAAYRQAVAKLLFGADLP--STEHLAIVQTLGGSGALKVGADLIARFFP 117 +YLPMEG +YR A+A LLFGAD P + +A +QTLGGSGALKVGAD + R+FP Sbjct: 61 HGASLYLPMEGLNSYRHAIAPLLFGADHPVLQQQRVATIQTLGGSGALKVGADFLKRYFP 120 Query: 118 QPTIWLPDPTWDNHVGIFEGAGFKTERYPYYDAQTKGLDFPAMLAKLDSLSKGAVVLLHP 177 + +W+ DPTW+NHV IF GAGF+ YP+YD T G+ F +LA L +L ++VLLHP Sbjct: 121 ESGVWVSDPTWENHVAIFAGAGFEVSTYPWYDEATNGVRFNDLLAMLKTLPARSIVLLHP 180 Query: 178 CCHNPTGVDPTRAQWEEIIAVVEKRGLLPFFDLAYQGFAESLDEDIWPVREAVRRQIPFF 237 CCHNPTG D T QW+ +I +++ R L+PF D+AYQGF ++ED + +R +P Sbjct: 181 CCHNPTGADLTNDQWDAVIEILKARELIPFLDIAYQGFGAGMEEDAYAIRAIASAGLPAL 240 Query: 238 LSNSFSKIFSLYSERIGALSVFCPQSGQAANVLGQLKLTVRRNYSSPARNGALLVAHVLG 297 +SNSFSKIFSLY ER+G LSV C + A VLGQLK TVRRNYSSP GA +VA VL Sbjct: 241 VSNSFSKIFSLYGERVGGLSVLCEDAEAAGRVLGQLKATVRRNYSSPPNFGAQVVAAVLN 300 Query: 298 DDKLATQWRAEVEEMRVRVRDMRVKLASQLKSAVPDQDFSFLLRQNGMFGYTGLSSAQVD 357 D+ L W AEVEEMR R+ MR +L L + +P+++F +LL Q GMF YTGLS+AQVD Sbjct: 301 DEALKASWLAEVEEMRTRILAMRQELVKVLSTEMPERNFDYLLNQRGMFSYTGLSAAQVD 360 Query: 358 RLREEFGVYAVGTGRICVAGLNDSNVARVAETMAEVL 394 RLREEFGVY + +GR+CVAGLN +NV RVA+ A V+ Sbjct: 361 RLREEFGVYLIASGRMCVAGLNTANVQRVAKAFAAVM 397 >STM4248 [E] COG1448 Aspartate/tyrosine/aromatic aminotransferase Sty Salmonella typhimurium LT2 Length = 397 Score = 449 bits (1154), Expect = e-126, Method: Compositional matrix adjust. Identities = 218/397 (54%), Positives = 279/397 (70%), Gaps = 3/397 (0%) Query: 1 MFSHLPPYAGDPILSLMEQFQRDERSNKVNLSIGIYTDGRGVVPVLPTVRAAAAAV-AEA 59 MF + YAGDPILSLME+F+ D R +KVNLSIG+Y + G++P L TV A A + A+ Sbjct: 1 MFQKVDAYAGDPILSLMERFKDDSRHDKVNLSIGLYYNEDGIIPQLKTVAEAEARLNAQP 60 Query: 60 GAPYVYLPMEGHAAYRQAVAKLLFGADLP--STEHLAIVQTLGGSGALKVGADLIARFFP 117 +YLPMEG YR +A LLFGAD P + +A +QTLGGSGALKVGAD + R+FP Sbjct: 61 HGASLYLPMEGLNTYRHTIAPLLFGADHPVLQQQRVATIQTLGGSGALKVGADFLKRYFP 120 Query: 118 QPTIWLPDPTWDNHVGIFEGAGFKTERYPYYDAQTKGLDFPAMLAKLDSLSKGAVVLLHP 177 +W+ DPTW+NH+ IF GAGF+ YP+YD T G+ F +LA L++L ++VLLHP Sbjct: 121 DAGVWVSDPTWENHIAIFAGAGFEVSTYPWYDDATNGIRFNDLLATLNTLPARSIVLLHP 180 Query: 178 CCHNPTGVDPTRAQWEEIIAVVEKRGLLPFFDLAYQGFAESLDEDIWPVREAVRRQIPFF 237 CCHNPTG D T +QW+ +I +V+ R L+PF D+AYQGF +D+D + +R +P Sbjct: 181 CCHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFGAGMDDDAYVIRAIASAGLPAL 240 Query: 238 LSNSFSKIFSLYSERIGALSVFCPQSGQAANVLGQLKLTVRRNYSSPARNGALLVAHVLG 297 +SNSFSKIFSLY ER+G LSV C + AA VLGQLK TVRR YSSP GA +VA VLG Sbjct: 241 VSNSFSKIFSLYGERVGGLSVVCEDAEIAARVLGQLKATVRRIYSSPPCFGAQVVATVLG 300 Query: 298 DDKLATQWRAEVEEMRVRVRDMRVKLASQLKSAVPDQDFSFLLRQNGMFGYTGLSSAQVD 357 D+ L W AEV+ MR R+ MR L +LK+ +PD++F +LL+Q GMF YTGLS QVD Sbjct: 301 DEALKAGWLAEVDAMRNRIISMRQTLVKELKAEMPDRNFDYLLQQRGMFSYTGLSEEQVD 360 Query: 358 RLREEFGVYAVGTGRICVAGLNDSNVARVAETMAEVL 394 RLR+EFGVY + +GR+CVAGLN SNV RVA+ A V+ Sbjct: 361 RLRDEFGVYLIASGRMCVAGLNASNVHRVAKAFAAVM 397 >YPO0322 [E] COG1448 Aspartate/tyrosine/aromatic aminotransferase Ype Yersinia pestis Length = 397 Score = 445 bits (1144), Expect = e-124, Method: Compositional matrix adjust. Identities = 215/397 (54%), Positives = 277/397 (69%), Gaps = 5/397 (1%) Query: 1 MFSHLPPYAGDPILSLMEQFQRDERSNKVNLSIGIYTDGRGVVPVLPTVRAAAAAVAEA- 59 MF ++ YAGDPILSLME F+ D R++KVNLSIG+Y + +G +P + V AA A ++ Sbjct: 1 MFQNVDAYAGDPILSLMESFKADNRAHKVNLSIGLYYNEQGEIPQMQAVDAAEAQLSTQP 60 Query: 60 -GAPYVYLPMEGHAAYRQAVAKLLFGADLPS--TEHLAIVQTLGGSGALKVGADLIARFF 116 G P VYLPMEG +YR A+ +LLFG D P + +A +QT+GGSGALKVGAD + +F Sbjct: 61 HGTP-VYLPMEGLQSYRTAIQQLLFGHDHPMLVQQRVATIQTVGGSGALKVGADFLNHYF 119 Query: 117 PQPTIWLPDPTWDNHVGIFEGAGFKTERYPYYDAQTKGLDFPAMLAKLDSLSKGAVVLLH 176 P +W+ DPTW+NHV IF GAGFK YPY+D + F MLA L L ++VLLH Sbjct: 120 PDSQVWVSDPTWENHVAIFSGAGFKVNTYPYFDNDKLAVKFDPMLATLQQLPARSIVLLH 179 Query: 177 PCCHNPTGVDPTRAQWEEIIAVVEKRGLLPFFDLAYQGFAESLDEDIWPVREAVRRQIPF 236 PCCHNPTG D T AQW+ +I VV++R L+PF D+AYQGF L+ED + +R +P Sbjct: 180 PCCHNPTGSDLTNAQWDRLIDVVKERELIPFLDIAYQGFGAGLNEDAYAIRAMAAVGLPC 239 Query: 237 FLSNSFSKIFSLYSERIGALSVFCPQSGQAANVLGQLKLTVRRNYSSPARNGALLVAHVL 296 +SNSFSKIFSLY+ER+G LSV C A VLGQLK TVRRNYSSP GA +V+ VL Sbjct: 240 LISNSFSKIFSLYNERVGGLSVVCESDEAAGRVLGQLKATVRRNYSSPPNFGAQVVSKVL 299 Query: 297 GDDKLATQWRAEVEEMRVRVRDMRVKLASQLKSAVPDQDFSFLLRQNGMFGYTGLSSAQV 356 D L QW+AEVE+MR+R+ DMR L LK+++P+++F +LL+Q GMF YTG S AQV Sbjct: 300 NDTVLRAQWQAEVEQMRLRILDMRHTLVEALKASLPERNFDYLLQQRGMFSYTGFSEAQV 359 Query: 357 DRLREEFGVYAVGTGRICVAGLNDSNVARVAETMAEV 393 + LREEFGVY + +GR+C+AG+N NV +VA A V Sbjct: 360 ESLREEFGVYLIASGRMCMAGVNHQNVEQVAVAFAAV 396