BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.4208.p (1247 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc0294 [E] COG1410 Methionine synthase I, cobalamin-binding dom... 1410 0.0 PA1843_2 [E] COG1410 Methionine synthase I, cobalamin-binding do... 1151 0.0 VC0390_2 [E] COG1410 Methionine synthase I, cobalamin-binding do... 1150 0.0 ECs4937_2 [E] COG1410 Methionine synthase I, cobalamin-binding d... 1140 0.0 ZmetH_2 [E] COG1410 Methionine synthase I, cobalamin-binding dom... 1140 0.0 >RSc0294 [E] COG1410 Methionine synthase I, cobalamin-binding domain Rso Ralstonia solanacearum Length = 905 Score = 1410 bits (3651), Expect = 0.0, Method: Compositional matrix adjust. Identities = 689/903 (76%), Positives = 777/903 (86%), Gaps = 4/903 (0%) Query: 348 HEMRLSGLEPFTINDDSLYVNVGERTNVTGSKAFARLILNEQYDEALAVARQQVENGAQI 407 H MRLSGLEPF I +D+L+VNVGERTNVTGSKAFAR+ILN Q+DEALAVARQQVENGAQ+ Sbjct: 4 HLMRLSGLEPFNIGEDTLFVNVGERTNVTGSKAFARMILNSQFDEALAVARQQVENGAQV 63 Query: 408 IDINMDEAMLDSVAAMTRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKCVQGKSIVNSI 467 IDINMDEAMLDS AAM RFLNLIASEPDIARVPIMIDSSKWEVIEAGLKCVQGK+IVNSI Sbjct: 64 IDINMDEAMLDSKAAMVRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKCVQGKAIVNSI 123 Query: 468 SMKEGEEKFLREAKLCRRYGAAVIVMAFDEVGQADTFARKIEICERAYRLLVDKLDFPPE 527 S+KEGEE+F AKL +RYGAA +VMAFDE GQADTFARK EIC+R+Y LV+++ F PE Sbjct: 124 SLKEGEEQFAHHAKLIKRYGAAAVVMAFDEQGQADTFARKTEICKRSYDFLVNQVGFAPE 183 Query: 528 DIIFDPNIFAVATGIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSFSFRGNDPARE 587 DIIFDPNIFAVATGIEEHNNYAVDFIEATRWI Q LP+AK+SGGVSNVSFSFRGND RE Sbjct: 184 DIIFDPNIFAVATGIEEHNNYAVDFIEATRWIKQKLPHAKVSGGVSNVSFSFRGNDVVRE 243 Query: 588 AIHTVFLYHAIKAGMTMGIVNAGMIGVYDDLPAELRERVEDVVLNRREDATERMIEYAAT 647 AIHTVFLYHAI AGM MGIVNAG +GVY++L ELRERVEDVVLNRR DAT+R++E A Sbjct: 244 AIHTVFLYHAIGAGMDMGIVNAGQLGVYENLAPELRERVEDVVLNRRPDATDRLLEIADR 303 Query: 648 LKAGDKKEEATLEWRNLPVAKRLSHALVHGITQWIVEDTEEVRQQIAADGGRPIHVIEGP 707 K G K E L WR PV KRL+HALVHGIT ++VEDTEEVRQ+I A GGRPI VIEGP Sbjct: 304 YKGGGAKREENLAWRQEPVEKRLAHALVHGITDYVVEDTEEVRQKIFAAGGRPIQVIEGP 363 Query: 708 LMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQLEIATGEVVKPKGK 767 LMDGMN+VGDLFG GKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQ+ A G+ V+ +GK Sbjct: 364 LMDGMNIVGDLFGAGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQIAAAGGD-VRSRGK 422 Query: 768 IVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAKEEKADIIGLSGLIT 827 IVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPC EILAKAK E ADIIGLSGLIT Sbjct: 423 IVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPCNEILAKAKVEGADIIGLSGLIT 482 Query: 828 PSLEEMAYVAKEMQRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNYEGPVVYVPDASRAV 887 PSLEEMAYVA EMQRD YF K+PL+IGGATTSR HTAVKIAPNYEGPVVYVPDASR+V Sbjct: 483 PSLEEMAYVASEMQRDEYFRVKKIPLLIGGATTSRVHTAVKIAPNYEGPVVYVPDASRSV 542 Query: 888 SVAQSLLADEQKTQYVAELNADYDRIREQHASKKAAPMLSLAAARANKTKLE---FAPVK 944 SVA SLL+DE +Y+ EL+ADYDRIR QHASKKA PM+SLAAARANKT+++ + P K Sbjct: 543 SVASSLLSDEAAARYIEELHADYDRIRTQHASKKAMPMVSLAAARANKTRIDWSNYTPPK 602 Query: 945 PKFIGRRLFKNVDLGLLANYIDWGPFFQTWDLAGPYPAILTDEVVGEAATKVYQEAQAML 1004 PKF+GRR+F+N DL LA YIDWGPFFQTWDLAG +P IL D +VGE+A +V+ + ++ML Sbjct: 603 PKFVGRRVFRNYDLNELAQYIDWGPFFQTWDLAGKFPDILNDAIVGESARRVFSDGKSML 662 Query: 1005 KKIIDGRWLTANGVISLLPANTVNEDDIEIYTDDSRSQVAFTYYGLRQQTEKPVVDGVAR 1064 ++I GRWLTANGVI+LLPANTVN+DDIEIYTD++RS+VA T+ +RQQ+E+P++DGV R Sbjct: 663 ARLIAGRWLTANGVIALLPANTVNDDDIEIYTDETRSEVALTWRNIRQQSERPIIDGVMR 722 Query: 1065 PNQCLSDFIAPKDSGVPDYIGMFAVTAGLGIEKYEKRFEDAHDDYSSIMLKALADRLAEA 1124 PN+CL+DFIAPKD+G+ DYIG+FAVT G+GI+K E FE HDDYS+IMLKALADR AEA Sbjct: 723 PNRCLADFIAPKDTGIADYIGLFAVTGGIGIDKREAAFEADHDDYSAIMLKALADRFAEA 782 Query: 1125 FAEYLHERVRKDLWGYAADENLDSAELIKEKYLGIRPAPGYPACPEHTVKADAFRVMQCD 1184 FAE LH RVR+DLWGYA DE LD+ LI+E+Y GIRPAPGYPACPEHTVK D FRV+ Sbjct: 783 FAECLHARVRRDLWGYAQDETLDNDALIREEYRGIRPAPGYPACPEHTVKRDLFRVLDAQ 842 Query: 1185 EIGMQLTESYAMFPGASVSGFYFAHPQSKYFVVGKIGEDQVIDMAQRRHVPKEDVERWLA 1244 EIGM LTE+ AM P ASVSGF +HP S YF +GKIG+DQV DMA R + +VER LA Sbjct: 843 EIGMNLTEALAMTPAASVSGFQLSHPDSTYFTIGKIGQDQVDDMAARSGEDRRNVERALA 902 Query: 1245 PNL 1247 PNL Sbjct: 903 PNL 905 >PA1843_2 [E] COG1410 Methionine synthase I, cobalamin-binding domain Pae Pseudomonas aeruginosa Length = 898 Score = 1151 bits (2977), Expect = 0.0, Method: Compositional matrix adjust. Identities = 595/915 (65%), Positives = 691/915 (75%), Gaps = 28/915 (3%) Query: 340 PRKVPEPTHEMRLSGLEPFTINDDSLYVNVGERTNVTGSKAFARLILNEQYDEALAVARQ 399 PR +PE RLSGLEPFTI+ SL+VNVGERTN+TGS FARLI E Y EAL VA+Q Sbjct: 1 PRAIPEIPRACRLSGLEPFTIDRSSLFVNVGERTNITGSAKFARLIREENYAEALEVAQQ 60 Query: 400 QVENGAQIIDINMDEAMLDSVAAMTRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKCVQ 459 QVE GAQ+IDINMDE MLDS AAM FLNLIASEPDI+RVPIMIDSSKWEVIEAGLKC+Q Sbjct: 61 QVEAGAQVIDINMDEGMLDSKAAMVTFLNLIASEPDISRVPIMIDSSKWEVIEAGLKCIQ 120 Query: 460 GKSIVNSISMKEGEEKFLREAKLCRRYGAAVIVMAFDEVGQADTFARKIEICERAYRLLV 519 GK IVNSISMKEG E F A+LC+RYGAAV+VMAFDE GQADT ARK EIC+R+Y +LV Sbjct: 121 GKGIVNSISMKEGVEAFKHHARLCKRYGAAVVVMAFDEDGQADTQARKEEICKRSYDILV 180 Query: 520 DKLDFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSFSF 579 D++ FPPEDIIFD NIFA+ATGIEEHNNYAVDFI A +I NLPYA SGGVSNVSFSF Sbjct: 181 DEVGFPPEDIIFDANIFAIATGIEEHNNYAVDFINACAYIRDNLPYALSSGGVSNVSFSF 240 Query: 580 RGNDPAREAIHTVFLYHAIKAGMTMGIVNAGMIGVYDDLPAELRERVEDVVLNRREDATE 639 RGN+P REAIH+VFLY+AI+ G+TMGIVNAG + +YD++P LR+RVEDVVLNR +ATE Sbjct: 241 RGNNPVREAIHSVFLYYAIRNGLTMGIVNAGQLEIYDEIPKALRDRVEDVVLNRTPEATE 300 Query: 640 RMIEYAATLKAGDK-KEEATLEWRNLPVAKRLSHALVHGITQWIVEDTEEVRQQIAADGG 698 ++ A K G KE EWR+ V KRL HALV GIT WIVEDTEE RQQ A Sbjct: 301 ALLAIADDYKGGGAVKEAEDEEWRSYSVEKRLEHALVKGITTWIVEDTEECRQQCA---- 356 Query: 699 RPIHVIEGPLMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQLEIAT 758 RPI VIEGPLM GMNVVGDLFG GKMFLPQVVKSARVMKQAVAHLIPFIE EK Sbjct: 357 RPIEVIEGPLMSGMNVVGDLFGAGKMFLPQVVKSARVMKQAVAHLIPFIEAEK------- 409 Query: 759 GEVVKPKGKIVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAKEEKAD 818 G+ + KGKI++ATVKGDVHDIGKNIV VVL CN ++VV++GVMVP +IL A EK D Sbjct: 410 GDKPEAKGKILMATVKGDVHDIGKNIVGVVLGCNGYDVVDLGVMVPAEKILQTAIAEKCD 469 Query: 819 IIGLSGLITPSLEEMAYVAKEMQRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNYEG-PV 877 IIGLSGLITPSL+EM +VAKEMQR + ++PLMIGGATTS+AHTAVKI P Y V Sbjct: 470 IIGLSGLITPSLDEMVHVAKEMQRQNF----QLPLMIGGATTSKAHTAVKIDPQYSNDAV 525 Query: 878 VYVPDASRAVSVAQSLLADEQKTQYVAELNADYDRIREQHASKKA-APMLSLAAARANKT 936 VYV DASRAV VA SLL+ E K YVA ADY +RE+ A++ A LS A ANK Sbjct: 526 VYVTDASRAVGVATSLLSKELKADYVARTRADYAVVRERTANRSARTERLSYEQAIANKP 585 Query: 937 KLEFAPVK---PKFIGRRLFKNVDLGLLANYIDWGPFFQTWDLAGPYPAILTDEVVGEAA 993 ++A + P F G R+ +DL +LA YIDW PFF +WDLAG YP ILTDEVVGEAA Sbjct: 586 AFDWAGYQAPTPSFTGVRVLDEIDLAVLAEYIDWTPFFISWDLAGKYPRILTDEVVGEAA 645 Query: 994 TKVYQEAQAMLKKIIDGRWLTANGVISLLPANTVNEDDIEIYTDDSRSQVAFTYYGLRQQ 1053 T ++ +AQAMLKK+ID + + A V PAN V DD+E+Y D + T + LRQQ Sbjct: 646 TSLFNDAQAMLKKLIDEKLIKARAVFGFWPANQVEHDDLEVYGADGETLA--TLHHLRQQ 703 Query: 1054 TEKPVVDGVARPNQCLSDFIAPKDSGVPDYIGMFAVTAGLGIEKYEKRFEDAHDDYSSIM 1113 T KP DG +PN L+DF+APK+SGV DYIG F TAG+G E+ K +E DDY+SIM Sbjct: 704 TIKP--DG--KPNLSLADFVAPKESGVRDYIGGFITTAGIGAEEVAKAYEAKGDDYNSIM 759 Query: 1114 LKALADRLAEAFAEYLHERVRKDLWGYAADENLDSAELIKEKYLGIRPAPGYPACPEHTV 1173 +KALADRLAEA AE+LHERVRK+ WGYA DE+LD+ LIKE+Y+GIRPAPGYPACP+HT Sbjct: 760 VKALADRLAEACAEWLHERVRKEYWGYARDEHLDNEALIKEQYVGIRPAPGYPACPDHTE 819 Query: 1174 KADAFRVMQCDEI-GMQLTESYAMFPGASVSGFYFAHPQSKYFVVGKIGEDQVIDMAQRR 1232 K F ++ + G+ LTE YAMFP A+VSG+YFAHPQ++YF VGKI +DQV +QR+ Sbjct: 820 KGTLFELLDPQGLSGVSLTEHYAMFPAAAVSGWYFAHPQAQYFAVGKIDKDQVERYSQRK 879 Query: 1233 HVPKEDVERWLAPNL 1247 ERWLAPNL Sbjct: 880 GQEASVSERWLAPNL 894 >VC0390_2 [E] COG1410 Methionine synthase I, cobalamin-binding domain Vch Vibrio cholerae Length = 899 Score = 1150 bits (2976), Expect = 0.0, Method: Compositional matrix adjust. Identities = 576/919 (62%), Positives = 706/919 (76%), Gaps = 32/919 (3%) Query: 338 IAPRKVPEPTHEMRLSGLEPFTINDDSLYVNVGERTNVTGSKAFARLILNEQYDEALAVA 397 + PR +P+ E RLSGLEP I ++L+VNVGERTNVTGS F RLI EQYDEAL VA Sbjct: 2 VKPRALPDLKVECRLSGLEPLNIGPETLFVNVGERTNVTGSARFKRLIKEEQYDEALDVA 61 Query: 398 RQQVENGAQIIDINMDEAMLDSVAAMTRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKC 457 R+QVENGAQIIDINMDE MLD+ A M RFLNL ASEP+I++VP+M+DSSKWEVIEAGLKC Sbjct: 62 REQVENGAQIIDINMDEGMLDAEACMVRFLNLCASEPEISKVPVMVDSSKWEVIEAGLKC 121 Query: 458 VQGKSIVNSISMKEGEEKFLREAKLCRRYGAAVIVMAFDEVGQADTFARKIEICERAYRL 517 +QGK IVNSIS+KEG+EKF+ +AKL RRYGAAVIVMAFDEVGQADT RK+EIC RAY + Sbjct: 122 IQGKGIVNSISLKEGKEKFIAQAKLVRRYGAAVIVMAFDEVGQADTRERKLEICRRAYHI 181 Query: 518 LVDKLDFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSF 577 LVD++ FPPEDIIFDPNIFAVATGI+EHNNYA+DFI A I + LP+A ISGGVSNVSF Sbjct: 182 LVDEVGFPPEDIIFDPNIFAVATGIDEHNNYALDFINAVADIKRELPHAMISGGVSNVSF 241 Query: 578 SFRGNDPAREAIHTVFLYHAIKAGMTMGIVNAGMIGVYDDLPAELRERVEDVVLNRREDA 637 SFRGN+ REAIH VFLYH K GM MGIVNAG + +YD++P +LRE VEDV+LNRR D Sbjct: 242 SFRGNNYVREAIHAVFLYHCFKHGMDMGIVNAGQLEIYDNVPLKLREAVEDVILNRRSDG 301 Query: 638 TERMIEYAATLK---AGDKKEEATLEWRNLPVAKRLSHALVHGITQWIVEDTEEVRQQIA 694 TER++E A + G +++ + LEWR PVAKRL HALV GIT++IV+DTEE RQQ Sbjct: 302 TERLLEIAEAYRENSVGKEEDASALEWRAWPVAKRLEHALVKGITEFIVQDTEEARQQ-- 359 Query: 695 ADGGRPIHVIEGPLMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQL 754 +P+ VIEGPLMDGMNVVGDLFG+GKMFLPQVVKSARVMKQAVA+L PFI +K Sbjct: 360 --ASKPLEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVMKQAVAYLEPFINAQK--- 414 Query: 755 EIATGEVVKPKGKIVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAKE 814 +G GKI++ATVKGDVHDIGKNIV VVLQCNNFE++++GVMVPC +IL A+E Sbjct: 415 ---SGST--SNGKILLATVKGDVHDIGKNIVGVVLQCNNFEIIDLGVMVPCEQILKVARE 469 Query: 815 EKADIIGLSGLITPSLEEMAYVAKEMQRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNYE 874 + DIIGLSGLITPSL+EM +VAKEM+R G ++PL+IGGATTS+AHTAVKI NY Sbjct: 470 QNVDIIGLSGLITPSLDEMVHVAKEMERQ----GFELPLLIGGATTSKAHTAVKIEQNYH 525 Query: 875 GPVVYVPDASRAVSVAQSLLADEQKTQYVAELNADYDRIREQHASK--KAAPMLSLAAAR 932 PVVYV +ASRAV V SLL+DEQ+ ++ L+ DY+R R+QHA K K+ P ++L AR Sbjct: 526 APVVYVNNASRAVGVCTSLLSDEQRPGFIERLDLDYERTRDQHARKTPKSRP-VTLEQAR 584 Query: 933 ANKTKLEFA---PVKPKFIGRRLFKNVDLGLLANYIDWGPFFQTWDLAGPYPAILTDEVV 989 ANK L++A P P G +F+N+ L L YIDW PFF TW L G YPAIL E V Sbjct: 585 ANKAALDWANYTPPAPAKPGVHVFENIALATLRPYIDWTPFFMTWSLMGKYPAILEHEEV 644 Query: 990 GEAATKVYQEAQAMLKKIIDGRWLTANGVISLLPANTVNEDDIEIYTDDSRSQVAFTYYG 1049 GE A +++ +A A+L K+ L A+G+ +L PA +V DDIE+Y+D+SR+QVA Y Sbjct: 645 GEEAKRLFHDANALLDKVEREGLLKASGMCALFPAASVG-DDIEVYSDESRTQVAHVLYN 703 Query: 1050 LRQQTEKPVVDGVARPNQCLSDFIAPKDSGVPDYIGMFAVTAGLGIEKYEKRFEDAHDDY 1109 LRQQTEKP N CLSD++APK+SG D+IG FAVT G+G ++ DDY Sbjct: 704 LRQQTEKP-----KGANYCLSDYVAPKESGKRDWIGAFAVTGGIGERALADAYKAQGDDY 758 Query: 1110 SSIMLKALADRLAEAFAEYLHERVRKDLWGYAADENLDSAELIKEKYLGIRPAPGYPACP 1169 ++IM++A+ADRLAEAFAEYLHE+VRK++WGYA+DENL + +LI+E+Y GIRPAPGYPACP Sbjct: 759 NAIMIQAVADRLAEAFAEYLHEKVRKEIWGYASDENLSNDDLIRERYQGIRPAPGYPACP 818 Query: 1170 EHTVKADAFRVMQCDE-IGMQLTESYAMFPGASVSGFYFAHPQSKYFVVGKIGEDQVIDM 1228 EHT KA ++++ +E IGM LT SYAM+PGASVSG+YF+HP S+YF V +I DQ+ Sbjct: 819 EHTEKATLWQMLNVEETIGMSLTTSYAMWPGASVSGWYFSHPDSRYFAVAQIQPDQLHSY 878 Query: 1229 AQRRHVPKEDVERWLAPNL 1247 A+R+ E+ E+WLAPNL Sbjct: 879 AERKGWRLEEAEKWLAPNL 897 >ECs4937_2 [E] COG1410 Methionine synthase I, cobalamin-binding domain Ecs Escherichia coli O157:H7 Length = 901 Score = 1140 bits (2948), Expect = 0.0, Method: Compositional matrix adjust. Identities = 586/917 (63%), Positives = 684/917 (74%), Gaps = 29/917 (3%) Query: 338 IAPRKVPEPTHEMRLSGLEPFTINDDSLYVNVGERTNVTGSKAFARLILNEQYDEALAVA 397 +APRK+PE RLSGLEP I DDSL+VNVGERTNVTGS F RLI E+Y EAL VA Sbjct: 2 LAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVGERTNVTGSAKFKRLIKEEKYSEALDVA 61 Query: 398 RQQVENGAQIIDINMDEAMLDSVAAMTRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKC 457 RQQVENGAQIIDINMDE MLD+ AAM RFLNLIA EPDIARVPIMIDSSKWEVIE GLKC Sbjct: 62 RQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPDIARVPIMIDSSKWEVIEKGLKC 121 Query: 458 VQGKSIVNSISMKEGEEKFLREAKLCRRYGAAVIVMAFDEVGQADTFARKIEICERAYRL 517 +QGK IVNSISMKEG + F+ AKL RRYGAAV+VMAFDE GQADT ARKIEIC RAY++ Sbjct: 122 IQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAFDEQGQADTRARKIEICRRAYKI 181 Query: 518 LVDKLDFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSF 577 L +++ FPPEDIIFDPNIFAVATGIEEHNNYA DFI A I + LP+A ISGGVSNVSF Sbjct: 182 LTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGACEDIKRELPHALISGGVSNVSF 241 Query: 578 SFRGNDPAREAIHTVFLYHAIKAGMTMGIVNAGMIGVYDDLPAELRERVEDVVLNRREDA 637 SFRGNDP REAIH VFLY+AI+ GM MGIVNAG + +YDDLPAELR+ VEDV+LNRR+D Sbjct: 242 SFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIYDDLPAELRDAVEDVILNRRDDG 301 Query: 638 TERMIEYAATLKAGDKKEEAT---LEWRNLPVAKRLSHALVHGITQWIVEDTEEVRQQIA 694 TER++E A + + A EWR+ V KRL ++LV GIT++I +DTEE RQQ Sbjct: 302 TERLLELAEKYRGSKTDDTANAQQAEWRSWEVNKRLEYSLVKGITEFIEQDTEEARQQAT 361 Query: 695 ADGGRPIHVIEGPLMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQL 754 RPI VIEGPLMDGMNVVGDLFG+GKMFLPQVVKSARVMKQAVA+L PFIE K Q Sbjct: 362 ----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVMKQAVAYLEPFIEASKEQ- 416 Query: 755 EIATGEVVKPKGKIVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAKE 814 K GK+VIATVKGDVHDIGKNIV VVLQCNN+E+V++GVMVP +IL AKE Sbjct: 417 -------GKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDLGVMVPAEKILRTAKE 469 Query: 815 EKADIIGLSGLITPSLEEMAYVAKEMQRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNYE 874 AD+IGLSGLITPSL+EM VAKEM+R G +PL+IGGATTS+AHTAVKI NY Sbjct: 470 VNADLIGLSGLITPSLDEMVNVAKEMERQ----GFTIPLLIGGATTSKAHTAVKIEQNYS 525 Query: 875 GPVVYVPDASRAVSVAQSLLADEQKTQYVAELNADYDRIREQHASKKA-APMLSLAAARA 933 GP VYV +ASR V V +LL+D Q+ +VA +Y+ +R QH KK P ++L AAR Sbjct: 526 GPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHGRKKPRTPPVTLEAARD 585 Query: 934 NKTKLEFAPVKPKFIGRRLFKNVDLGL--LANYIDWGPFFQTWDLAGPYPAILTDEVVGE 991 N ++ P R + V+ + L NYIDW PFF TW LAG YP IL DEVVG Sbjct: 586 NDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKYPRILEDEVVGV 645 Query: 992 AATKVYQEAQAMLKKIIDGRWLTANGVISLLPANTVNEDDIEIYTDDSRSQVAFTYYGLR 1051 A +++++A ML K+ + L GV+ L PAN V DDIEIY D++R+ V + LR Sbjct: 646 EAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVG-DDIEIYRDETRTHVINVSHHLR 704 Query: 1052 QQTEKPVVDGVARPNQCLSDFIAPKDSGVPDYIGMFAVTAGLGIEKYEKRFEDAHDDYSS 1111 QQTEK G A N CL+DF+APK SG DYIG FAVT GL + FE HDDY+ Sbjct: 705 QQTEKT---GFA--NYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQHDDYNK 759 Query: 1112 IMLKALADRLAEAFAEYLHERVRKDLWGYAADENLDSAELIKEKYLGIRPAPGYPACPEH 1171 IM+KALADRLAEAFAEYLHERVRK WGYA +ENL + ELI+E Y GIRPAPGYPACPEH Sbjct: 760 IMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYPACPEH 819 Query: 1172 TVKADAFRVMQCDE-IGMQLTESYAMFPGASVSGFYFAHPQSKYFVVGKIGEDQVIDMAQ 1230 T KA + +++ ++ GM+LTES+AM+PGASVSG+YF+HP SKY+ V +I DQV D A+ Sbjct: 820 TEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQVEDYAR 879 Query: 1231 RRHVPKEDVERWLAPNL 1247 R+ + DVERWLAPNL Sbjct: 880 RKGMSVSDVERWLAPNL 896 >ZmetH_2 [E] COG1410 Methionine synthase I, cobalamin-binding domain EcZ Escherichia coli O157:H7 EDL933 Length = 901 Score = 1140 bits (2948), Expect = 0.0, Method: Compositional matrix adjust. Identities = 586/917 (63%), Positives = 684/917 (74%), Gaps = 29/917 (3%) Query: 338 IAPRKVPEPTHEMRLSGLEPFTINDDSLYVNVGERTNVTGSKAFARLILNEQYDEALAVA 397 +APRK+PE RLSGLEP I DDSL+VNVGERTNVTGS F RLI E+Y EAL VA Sbjct: 2 LAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVGERTNVTGSAKFKRLIKEEKYSEALDVA 61 Query: 398 RQQVENGAQIIDINMDEAMLDSVAAMTRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKC 457 RQQVENGAQIIDINMDE MLD+ AAM RFLNLIA EPDIARVPIMIDSSKWEVIE GLKC Sbjct: 62 RQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPDIARVPIMIDSSKWEVIEKGLKC 121 Query: 458 VQGKSIVNSISMKEGEEKFLREAKLCRRYGAAVIVMAFDEVGQADTFARKIEICERAYRL 517 +QGK IVNSISMKEG + F+ AKL RRYGAAV+VMAFDE GQADT ARKIEIC RAY++ Sbjct: 122 IQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAFDEQGQADTRARKIEICRRAYKI 181 Query: 518 LVDKLDFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSF 577 L +++ FPPEDIIFDPNIFAVATGIEEHNNYA DFI A I + LP+A ISGGVSNVSF Sbjct: 182 LTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGACEDIKRELPHALISGGVSNVSF 241 Query: 578 SFRGNDPAREAIHTVFLYHAIKAGMTMGIVNAGMIGVYDDLPAELRERVEDVVLNRREDA 637 SFRGNDP REAIH VFLY+AI+ GM MGIVNAG + +YDDLPAELR+ VEDV+LNRR+D Sbjct: 242 SFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIYDDLPAELRDAVEDVILNRRDDG 301 Query: 638 TERMIEYAATLKAGDKKEEAT---LEWRNLPVAKRLSHALVHGITQWIVEDTEEVRQQIA 694 TER++E A + + A EWR+ V KRL ++LV GIT++I +DTEE RQQ Sbjct: 302 TERLLELAEKYRGSKTDDTANAQQAEWRSWEVNKRLEYSLVKGITEFIEQDTEEARQQAT 361 Query: 695 ADGGRPIHVIEGPLMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQL 754 RPI VIEGPLMDGMNVVGDLFG+GKMFLPQVVKSARVMKQAVA+L PFIE K Q Sbjct: 362 ----RPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVMKQAVAYLEPFIEASKEQ- 416 Query: 755 EIATGEVVKPKGKIVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPCAEILAKAKE 814 K GK+VIATVKGDVHDIGKNIV VVLQCNN+E+V++GVMVP +IL AKE Sbjct: 417 -------GKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDLGVMVPAEKILRTAKE 469 Query: 815 EKADIIGLSGLITPSLEEMAYVAKEMQRDPYFAGLKMPLMIGGATTSRAHTAVKIAPNYE 874 AD+IGLSGLITPSL+EM VAKEM+R G +PL+IGGATTS+AHTAVKI NY Sbjct: 470 VNADLIGLSGLITPSLDEMVNVAKEMERQ----GFTIPLLIGGATTSKAHTAVKIEQNYS 525 Query: 875 GPVVYVPDASRAVSVAQSLLADEQKTQYVAELNADYDRIREQHASKKA-APMLSLAAARA 933 GP VYV +ASR V V +LL+D Q+ +VA +Y+ +R QH KK P ++L AAR Sbjct: 526 GPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHGRKKPRTPPVTLEAARD 585 Query: 934 NKTKLEFAPVKPKFIGRRLFKNVDLGL--LANYIDWGPFFQTWDLAGPYPAILTDEVVGE 991 N ++ P R + V+ + L NYIDW PFF TW LAG YP IL DEVVG Sbjct: 586 NDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKYPRILEDEVVGV 645 Query: 992 AATKVYQEAQAMLKKIIDGRWLTANGVISLLPANTVNEDDIEIYTDDSRSQVAFTYYGLR 1051 A +++++A ML K+ + L GV+ L PAN V DDIEIY D++R+ V + LR Sbjct: 646 EAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVG-DDIEIYRDETRTHVINVSHHLR 704 Query: 1052 QQTEKPVVDGVARPNQCLSDFIAPKDSGVPDYIGMFAVTAGLGIEKYEKRFEDAHDDYSS 1111 QQTEK G A N CL+DF+APK SG DYIG FAVT GL + FE HDDY+ Sbjct: 705 QQTEKT---GFA--NYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQHDDYNK 759 Query: 1112 IMLKALADRLAEAFAEYLHERVRKDLWGYAADENLDSAELIKEKYLGIRPAPGYPACPEH 1171 IM+KALADRLAEAFAEYLHERVRK WGYA +ENL + ELI+E Y GIRPAPGYPACPEH Sbjct: 760 IMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYPACPEH 819 Query: 1172 TVKADAFRVMQCDE-IGMQLTESYAMFPGASVSGFYFAHPQSKYFVVGKIGEDQVIDMAQ 1230 T KA + +++ ++ GM+LTES+AM+PGASVSG+YF+HP SKY+ V +I DQV D A+ Sbjct: 820 TEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQVEDYAR 879 Query: 1231 RRHVPKEDVERWLAPNL 1247 R+ + DVERWLAPNL Sbjct: 880 RKGMSVSDVERWLAPNL 896