BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.4199.p (422 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA0587 [S] COG2718 Uncharacterized conserved protein Pae Pseudom... 477 e-134 ZyeaH [S] COG2718 Uncharacterized conserved protein EcZ Escheric... 464 e-130 ECs2493 [S] COG2718 Uncharacterized conserved protein Ecs Escher... 464 e-130 yeaH [S] COG2718 Uncharacterized conserved protein Eco Escherich... 464 e-130 VC1873 [S] COG2718 Uncharacterized conserved protein Vch Vibrio ... 463 e-130 >PA0587 [S] COG2718 Uncharacterized conserved protein Pae Pseudomonas aeruginosa Length = 423 Score = 477 bits (1228), Expect = e-134, Method: Compositional matrix adjust. Identities = 234/420 (55%), Positives = 316/420 (75%), Gaps = 2/420 (0%) Query: 5 IIDRRLAGKNKSIANRERFLRRFKGHIQRSVADAVRDRSITDLEKSKSISIPRKDVSEPF 64 +IDRRL GKNKS NR+RFLRR++ HI+++V +AV RSITD+E + ISIP +D+ EP Sbjct: 4 VIDRRLNGKNKSTVNRQRFLRRYREHIKKAVEEAVSRRSITDMEHGEQISIPGRDIDEPV 63 Query: 65 FHHGKGGKREAVHPGNQDYLQGDRIPRQNGGSGGGGGSSASNEGEGQDDFTFELTREEFM 124 HHG+GG++ VHPGN+++ G+ I R +GG GG GG ASN GEG DDF F++T+EEF+ Sbjct: 64 LHHGRGGRQTVVHPGNKEFTAGEHIARPSGGGGGRGGGKASNSGEGMDDFVFQITQEEFL 123 Query: 125 HYFFEDLELPRLVETNLLQVPNWKNQRAGYSVDGSPNNIDVVRSLRSSLGRRIALGGPLQ 184 + FEDLELP LV+ ++ +K RAG S DG+P+ I++VR+LRS+ RRIAL G + Sbjct: 124 DFMFEDLELPNLVKRHITGTDTFKTVRAGISNDGNPSRINIVRTLRSAHARRIALSGGSR 183 Query: 185 RQLDAAEEALAEMKRQPEDHSSDIRLLEEEVKHLRARILRIPFIDPFDLRYVNRVRQPQP 244 +L AA + L +KR+ D+ DI+ LE E+ LRARI R+PF+D FDL+Y V+QP P Sbjct: 184 AKLRAALKELERIKREEPDNLGDIQELELEIAKLRARIDRVPFLDTFDLKYNLLVKQPNP 243 Query: 245 SSRAVMFCVMDVSGSMDEQRKDLSKRFFILLYLFLTRNYEHIEVVFIRHHTRADEVDENT 304 +S+AVMFC+MDVSGSM + KD++KRFFILLYLFL RNYE IEVVFIRHHT A EVDE Sbjct: 244 TSKAVMFCLMDVSGSMTQATKDIAKRFFILLYLFLKRNYEKIEVVFIRHHTSAREVDEEE 303 Query: 305 FFHSQESGGTVVSSALELMHDIITKRYSPSEWNIYGAQASDGDNWNDDSPKCRELLESSI 364 FF+S+E+GGT+VSSAL++M +I+ +RY EWNIY AQASDGDNWNDDSP CR++L I Sbjct: 304 FFYSRETGGTIVSSALKMMQEIMAERYPTHEWNIYAAQASDGDNWNDDSPVCRDILLKQI 363 Query: 365 LPLTRYFAYIQVAEPE-QNLWTEYMQLIES-HPHFAMKKVQSAAEIYPVFRELFEKQVHA 422 +P +Y+ Y+++ E Q LW EY ++ E+ FA +++ SA++IYPVFRELF++++ A Sbjct: 364 MPFVQYYTYVEITPREHQALWFEYERVREAFEDSFAQQQIVSASDIYPVFRELFQRRLVA 423 >ZyeaH [S] COG2718 Uncharacterized conserved protein EcZ Escherichia coli O157:H7 EDL933 Length = 427 Score = 464 bits (1193), Expect = e-130, Method: Compositional matrix adjust. Identities = 226/423 (53%), Positives = 310/423 (73%), Gaps = 13/423 (3%) Query: 5 IIDRRLAGKNKSIANRERFLRRFKGHIQRSVADAVRDRSITDLEKSKSISIPRKDVSEPF 64 IDRRL GKNKS+ NR+RFLRR+K I++S+++A+ RS+TD++ +S+SIP +D+SEP Sbjct: 4 FIDRRLNGKNKSMVNRQRFLRRYKAQIKQSISEAINKRSVTDVDSGESVSIPTEDISEPM 63 Query: 65 FHHGKGGKREAVHPGNQDYLQGDRI--PRQNGGSGGGGGSSASNEGEGQDDFTFELTREE 122 FH G+GG R VHPGN ++Q DRI P+ GG G G AS +GEGQD+F F+++++E Sbjct: 64 FHQGRGGLRHRVHPGNDHFVQNDRIERPQGGGGGSGSGQGQASQDGEGQDEFVFQISKDE 123 Query: 123 FMHYFFEDLELPRLVETNLLQVPNWKNQRAGYSVDGSPNNIDVVRSLRSSLGRRIALGGP 182 ++ FEDL LP L + Q+ +K RAGY+ +G P NI VVRSL++SL RR A+ Sbjct: 124 YLDLLFEDLALPNLKQNQQRQLTEYKTHRAGYTANGVPANISVVRSLQNSLARRTAMTAG 183 Query: 183 LQRQLDAAEEALAEMKRQPEDHSSDIRLLEEE-----VKHLRARILRIPFIDPFDLRYVN 237 +R+L A EE LA + +S +LLEEE + LRA+I R+PFID FDLRY N Sbjct: 184 KRRELHALEENLAIIS-----NSEPAQLLEEERLRKEIAELRAKIERVPFIDTFDLRYKN 238 Query: 238 RVRQPQPSSRAVMFCVMDVSGSMDEQRKDLSKRFFILLYLFLTRNYEHIEVVFIRHHTRA 297 ++P PSS+AVMFC+MDVSGSMD+ KD++KRF+ILLYLFL+R Y+++EVV+IRHHT+A Sbjct: 239 YEKRPDPSSQAVMFCLMDVSGSMDQSTKDMAKRFYILLYLFLSRTYKNVEVVYIRHHTQA 298 Query: 298 DEVDENTFFHSQESGGTVVSSALELMHDIITKRYSPSEWNIYGAQASDGDNWNDDSPKCR 357 EVDE+ FF+SQE+GGT+VSSAL+LM +++ +RY+P++WNIY AQASDGDNW DDSP C Sbjct: 299 KEVDEHEFFYSQETGGTIVSSALKLMDEVVKERYNPAQWNIYAAQASDGDNWADDSPLCH 358 Query: 358 ELLESSILPLTRYFAYIQVA-EPEQNLWTEYMQLIESHPHFAMKKVQSAAEIYPVFRELF 416 E+L +LP+ RY++YI++ Q LW EY L + +FAM+ ++ +IYPVFRELF Sbjct: 359 EILAKKLLPVVRYYSYIEITRRAHQTLWREYEHLQSTFDNFAMQHIRDQDDIYPVFRELF 418 Query: 417 EKQ 419 KQ Sbjct: 419 HKQ 421 >ECs2493 [S] COG2718 Uncharacterized conserved protein Ecs Escherichia coli O157:H7 Length = 427 Score = 464 bits (1193), Expect = e-130, Method: Compositional matrix adjust. Identities = 226/423 (53%), Positives = 310/423 (73%), Gaps = 13/423 (3%) Query: 5 IIDRRLAGKNKSIANRERFLRRFKGHIQRSVADAVRDRSITDLEKSKSISIPRKDVSEPF 64 IDRRL GKNKS+ NR+RFLRR+K I++S+++A+ RS+TD++ +S+SIP +D+SEP Sbjct: 4 FIDRRLNGKNKSMVNRQRFLRRYKAQIKQSISEAINKRSVTDVDSGESVSIPTEDISEPM 63 Query: 65 FHHGKGGKREAVHPGNQDYLQGDRI--PRQNGGSGGGGGSSASNEGEGQDDFTFELTREE 122 FH G+GG R VHPGN ++Q DRI P+ GG G G AS +GEGQD+F F+++++E Sbjct: 64 FHQGRGGLRHRVHPGNDHFVQNDRIERPQGGGGGSGSGQGQASQDGEGQDEFVFQISKDE 123 Query: 123 FMHYFFEDLELPRLVETNLLQVPNWKNQRAGYSVDGSPNNIDVVRSLRSSLGRRIALGGP 182 ++ FEDL LP L + Q+ +K RAGY+ +G P NI VVRSL++SL RR A+ Sbjct: 124 YLDLLFEDLALPNLKQNQQRQLTEYKTHRAGYTANGVPANISVVRSLQNSLARRTAMTAG 183 Query: 183 LQRQLDAAEEALAEMKRQPEDHSSDIRLLEEE-----VKHLRARILRIPFIDPFDLRYVN 237 +R+L A EE LA + +S +LLEEE + LRA+I R+PFID FDLRY N Sbjct: 184 KRRELHALEENLAIIS-----NSEPAQLLEEERLRKEIAELRAKIERVPFIDTFDLRYKN 238 Query: 238 RVRQPQPSSRAVMFCVMDVSGSMDEQRKDLSKRFFILLYLFLTRNYEHIEVVFIRHHTRA 297 ++P PSS+AVMFC+MDVSGSMD+ KD++KRF+ILLYLFL+R Y+++EVV+IRHHT+A Sbjct: 239 YEKRPDPSSQAVMFCLMDVSGSMDQSTKDMAKRFYILLYLFLSRTYKNVEVVYIRHHTQA 298 Query: 298 DEVDENTFFHSQESGGTVVSSALELMHDIITKRYSPSEWNIYGAQASDGDNWNDDSPKCR 357 EVDE+ FF+SQE+GGT+VSSAL+LM +++ +RY+P++WNIY AQASDGDNW DDSP C Sbjct: 299 KEVDEHEFFYSQETGGTIVSSALKLMDEVVKERYNPAQWNIYAAQASDGDNWADDSPLCH 358 Query: 358 ELLESSILPLTRYFAYIQVA-EPEQNLWTEYMQLIESHPHFAMKKVQSAAEIYPVFRELF 416 E+L +LP+ RY++YI++ Q LW EY L + +FAM+ ++ +IYPVFRELF Sbjct: 359 EILAKKLLPVVRYYSYIEITRRAHQTLWREYEHLQSTFDNFAMQHIRDQDDIYPVFRELF 418 Query: 417 EKQ 419 KQ Sbjct: 419 HKQ 421 >yeaH [S] COG2718 Uncharacterized conserved protein Eco Escherichia coli K12 Length = 427 Score = 464 bits (1193), Expect = e-130, Method: Compositional matrix adjust. Identities = 226/423 (53%), Positives = 310/423 (73%), Gaps = 13/423 (3%) Query: 5 IIDRRLAGKNKSIANRERFLRRFKGHIQRSVADAVRDRSITDLEKSKSISIPRKDVSEPF 64 IDRRL GKNKS+ NR+RFLRR+K I++S+++A+ RS+TD++ +S+SIP +D+SEP Sbjct: 4 FIDRRLNGKNKSMVNRQRFLRRYKAQIKQSISEAINKRSVTDVDSGESVSIPTEDISEPM 63 Query: 65 FHHGKGGKREAVHPGNQDYLQGDRI--PRQNGGSGGGGGSSASNEGEGQDDFTFELTREE 122 FH G+GG R VHPGN ++Q DRI P+ GG G G AS +GEGQD+F F+++++E Sbjct: 64 FHQGRGGLRHRVHPGNDHFVQNDRIERPQGGGGGSGSGQGQASQDGEGQDEFVFQISKDE 123 Query: 123 FMHYFFEDLELPRLVETNLLQVPNWKNQRAGYSVDGSPNNIDVVRSLRSSLGRRIALGGP 182 ++ FEDL LP L + Q+ +K RAGY+ +G P NI VVRSL++SL RR A+ Sbjct: 124 YLDLLFEDLALPNLKQNQQRQLTEYKTHRAGYTANGVPANISVVRSLQNSLARRTAMTAG 183 Query: 183 LQRQLDAAEEALAEMKRQPEDHSSDIRLLEEE-----VKHLRARILRIPFIDPFDLRYVN 237 +R+L A EE LA + +S +LLEEE + LRA+I R+PFID FDLRY N Sbjct: 184 KRRELHALEENLAIIS-----NSEPAQLLEEERLRKEIAELRAKIERVPFIDTFDLRYKN 238 Query: 238 RVRQPQPSSRAVMFCVMDVSGSMDEQRKDLSKRFFILLYLFLTRNYEHIEVVFIRHHTRA 297 ++P PSS+AVMFC+MDVSGSMD+ KD++KRF+ILLYLFL+R Y+++EVV+IRHHT+A Sbjct: 239 YEKRPDPSSQAVMFCLMDVSGSMDQSTKDMAKRFYILLYLFLSRTYKNVEVVYIRHHTQA 298 Query: 298 DEVDENTFFHSQESGGTVVSSALELMHDIITKRYSPSEWNIYGAQASDGDNWNDDSPKCR 357 EVDE+ FF+SQE+GGT+VSSAL+LM +++ +RY+P++WNIY AQASDGDNW DDSP C Sbjct: 299 KEVDEHEFFYSQETGGTIVSSALKLMDEVVKERYNPAQWNIYAAQASDGDNWADDSPLCH 358 Query: 358 ELLESSILPLTRYFAYIQVA-EPEQNLWTEYMQLIESHPHFAMKKVQSAAEIYPVFRELF 416 E+L +LP+ RY++YI++ Q LW EY L + +FAM+ ++ +IYPVFRELF Sbjct: 359 EILAKKLLPVVRYYSYIEITRRAHQTLWREYEHLQSTFDNFAMQHIRDQDDIYPVFRELF 418 Query: 417 EKQ 419 KQ Sbjct: 419 HKQ 421 >VC1873 [S] COG2718 Uncharacterized conserved protein Vch Vibrio cholerae Length = 423 Score = 463 bits (1191), Expect = e-130, Method: Compositional matrix adjust. Identities = 230/422 (54%), Positives = 310/422 (73%), Gaps = 5/422 (1%) Query: 2 LHQIIDRRLAGKNKSIANRERFLRRFKGHIQRSVADAVRDRSITDLEKSKSISIPRKDVS 61 + Q IDRRL GKNKS NR+RFLRR+K I+ SVADAV RSIT+ E + +SIP +D+ Sbjct: 1 MAQFIDRRLNGKNKSTVNRQRFLRRYKEQIKESVADAVNRRSITNTESGEDVSIPTRDIK 60 Query: 62 EPFFHHGKGGKREAVHPGNQDYLQGDRI--PRQNGGSGGGGGSSASNEGEGQDDFTFELT 119 EP FH GKGG RE VHPGN +++GD+I P+ GSGG G AS +GEG DDF F+++ Sbjct: 61 EPMFHQGKGGVRERVHPGNDQFIRGDKIDRPKGGQGSGGSGEGEASADGEGSDDFVFQIS 120 Query: 120 REEFMHYFFEDLELPRLVETNLLQVPNWKNQRAGYSVDGSPNNIDVVRSLRSSLGRRIAL 179 ++E++ FEDL LP L + + ++ WK RAG+ G P+NI VVRSL+ SL RR A+ Sbjct: 121 KDEYLDILFEDLALPNLKKNQVNKITEWKTHRAGFQTSGVPSNISVVRSLQQSLARRTAM 180 Query: 180 GGPLQRQLDAAEEALAEMKR-QPEDHSSDIRLLEEEVKHLRARILRIPFIDPFDLRYVNR 238 +R + EE L ++R +P ++R+ ++E++ LR +I +PFID FDLR+ N Sbjct: 181 TAGKRRLMSELEEELERIQRSEPPQIMEEMRI-KQEIEELRNKIDSVPFIDTFDLRFKNY 239 Query: 239 VRQPQPSSRAVMFCVMDVSGSMDEQRKDLSKRFFILLYLFLTRNYEHIEVVFIRHHTRAD 298 ++P PSS+AVMFC+MDVSGSMD+ KD++KRF++LLYLFLTR YE++EVVFIRHHT+A Sbjct: 240 EKRPIPSSQAVMFCLMDVSGSMDQATKDIAKRFYVLLYLFLTRTYENVEVVFIRHHTQAK 299 Query: 299 EVDENTFFHSQESGGTVVSSALELMHDIITKRYSPSEWNIYGAQASDGDNWNDDSPKCRE 358 EV+E+ FF+SQE+GGT+VSSAL+LMH+II RY EWNIYGAQASDGDNW DDSP+C+E Sbjct: 300 EVNEHDFFYSQETGGTIVSSALKLMHEIIEARYPLGEWNIYGAQASDGDNWADDSPRCKE 359 Query: 359 LLESSILPLTRYFAYIQVA-EPEQNLWTEYMQLIESHPHFAMKKVQSAAEIYPVFRELFE 417 LL + +LP +Y+AYI++ Q LW EY +L S +FAMK ++S +I+PVFRELF+ Sbjct: 360 LLSNKLLPYCQYYAYIEITRRSHQTLWHEYEKLQASFDNFAMKNIRSVEDIFPVFRELFQ 419 Query: 418 KQ 419 K+ Sbjct: 420 KE 421