BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.4159.p (257 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value VC0319_2 [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase Vch ... 130 2e-30 RSc0312 [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase Rso R... 126 5e-29 NMA0357_1 [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase NmA... 126 5e-29 YPO3759_2 [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase Ype... 124 2e-28 PA4280_2 [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase Pae ... 118 2e-26 >VC0319_2 [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase Vch Vibrio cholerae Length = 237 Score = 130 bits (328), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 88/238 (36%), Positives = 129/238 (54%), Gaps = 8/238 (3%) Query: 23 GSTNIDLMQRLSSLQRPLLLVADRQTAGRGRAGRPWRAQPQDSLTFSLAWRLQRPTHALL 82 GSTN L+ + +L + +A+ Q +GRGR GR W + +L S+ WRL A + Sbjct: 4 GSTNQYLLDHVETLVSGTVCLAEYQASGRGRRGRHWVSPFGANLYLSIYWRLDAGMAAAM 63 Query: 83 GLPLAVGVALAEALEVFGIR-PQLKWPNDVLRDGAKLAGILIETAAEGGRADATWAVIGI 141 GL L VGVA+ EALE G+ +LKWPND+ KLAGIL+E + + G A VIG+ Sbjct: 64 GLSLVVGVAIVEALEAMGVDGVKLKWPNDLYYQDKKLAGILVEMSGQAGAAAHL--VIGM 121 Query: 142 GLNLGVPSGLEDELQRAVGSAPELQKPPR--ETVLAI-IVSALSEVLTEFEQRGFGAFVK 198 G+NL + E + + S E+ R LAI +++AL L ++E G FV+ Sbjct: 122 GINLAMRDN-EGNIDQPWISLAEVTGQSRIDRNALAINLIAALDRTLRQYEISGMQNFVE 180 Query: 199 RWETFHAYAGQSVKIVDNGRVVHEGIALGVDMMGRFLIDTEAGQIEVLAGDVSLRLQD 256 RW + + G+ VK++ V GI G+D G L++TE G + G++SLR D Sbjct: 181 RWNRWDNFIGRPVKLLMGANEVR-GIERGIDEHGGVLLETEEGLKSFIGGEISLRKND 237 >RSc0312 [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase Rso Ralstonia solanacearum Length = 291 Score = 126 bits (317), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 116/266 (43%), Positives = 143/266 (53%), Gaps = 31/266 (11%) Query: 16 VEAVAQTGSTNIDLMQRLSSLQRPL---------------LLVADRQTAGRGRAGRPWRA 60 VE V TGSTN DLM + P+ +L A RQTAGRGR GRPW Sbjct: 28 VEVVESTGSTNADLMAAVRDAAWPVAAGVPAGTAPLVGGRVLAALRQTAGRGRQGRPWDG 87 Query: 61 QPQDSLTFSLAWRLQRPTHALLGLPLAVGVALAEAL----EVFGIRPQ---LKWPNDVLR 113 LTFS+A L GL LAVGVA+AEA+ + G Q LKWPNDV Sbjct: 88 D--HGLTFSVACAFAAEPAQLAGLSLAVGVAVAEAVAAYAQTHGGNAQALALKWPNDVQI 145 Query: 114 DGAKLAGILIET--AAEGGRADATWAVIGIGLNLGVPSGLEDELQRAVGSAPEL-QKPPR 170 G KLAGIL+ET AA G TWAVIGIGLNL P LE L R++ EL ++P Sbjct: 146 AGRKLAGILVETMRAAPG----QTWAVIGIGLNLERPHALEAALGRSLSGVEELVERPEP 201 Query: 171 ETVLAIIVSALSEVLTEFEQRGFGAFVKRWETFHAYAGQSVKIVDNGRVVHEGIALGVDM 230 VLA ++SAL E L F G FV + A+AG+ V++ +G VV EG+A G+D Sbjct: 202 NAVLAALLSALGEHLQRFGSHGLAPFVAPFAARDAFAGRPVRLWQDGAVVLEGVAHGIDA 261 Query: 231 MGRFLIDTEAGQIEVLAGDVSLRLQD 256 GR I++ + +G+VSLR D Sbjct: 262 QGRLAIESGGRVQWIHSGEVSLRAAD 287 >NMA0357_1 [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase NmA Neisseria meningitidis Z2491 Length = 338 Score = 126 bits (316), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 75/218 (34%), Positives = 115/218 (52%), Gaps = 5/218 (2%) Query: 41 LLVADRQTAGRGRAGRPWRAQPQDSLTFSLAWRLQRPTHALLGLPLAVGVALAEALEVFG 100 + V Q+ GRGR GR W + + L FS W RP + L L VA AL G Sbjct: 112 ICVTHLQSKGRGRQGRKWSHRLGECLMFSFGWVFDRPQYELGSLSPVAAVACRRALSRLG 171 Query: 101 IRPQLKWPNDVLRDGAKLAGILIETAAEGGRADATWAVIGIGLNLGVPSGLED--ELQRA 158 ++ Q+KWPND++ KL GILIET GG+ T AV+GIG+N +P +E+ +Q Sbjct: 172 LKTQIKWPNDLVVGRDKLGGILIETVRTGGK---TVAVVGIGINFVLPKEVENAASVQSL 228 Query: 159 VGSAPELQKPPRETVLAIIVSALSEVLTEFEQRGFGAFVKRWETFHAYAGQSVKIVDNGR 218 +A +L +++ L VL ++ + GF FV ++ + G++V ++ +G Sbjct: 229 FQTASRRGNADAAVLLETLLAELDAVLLQYARDGFAPFVAEYQAANRDHGKAVLLLRDGE 288 Query: 219 VVHEGIALGVDMMGRFLIDTEAGQIEVLAGDVSLRLQD 256 V EG GVD G ++T G+ V++G++SLR D Sbjct: 289 TVFEGTVKGVDGQGVLHLETAEGKQTVVSGEISLRSDD 326 >YPO3759_2 [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase Ype Yersinia pestis Length = 236 Score = 124 bits (311), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 80/232 (34%), Positives = 124/232 (53%), Gaps = 5/232 (2%) Query: 24 STNIDLMQRLSSLQRPLLLVADRQTAGRGRAGRPWRAQPQDSLTFSLAWRLQRPTHALLG 83 STN L+ R++ L+ VA+ Q AGRGR GR W + +L S+ WRL++ A +G Sbjct: 6 STNQYLLDRITELKSGDACVAEYQQAGRGRRGRQWVSPFGANLYLSMYWRLEQGPAAAMG 65 Query: 84 LPLAVGVALAEALEVFGI-RPQLKWPNDVLRDGAKLAGILIETAAEGGRADATWAVIGIG 142 L L VG+ +AE L+ G + ++KWPND+ + KLAGIL+E + G DA VIG G Sbjct: 66 LSLVVGIVMAEVLQNLGAEKVRVKWPNDLYLNDKKLAGILVELTGKTG--DAAQLVIGAG 123 Query: 143 LNLGVPSGLEDEL-QRAVGSAPELQKPPRETVLAIIVSALSEVLTEFEQRGFGAFVKRWE 201 +NL + + + Q + R + A I+S L + +FE G AF+ RW+ Sbjct: 124 INLTMRGSETNAINQDWINLQDAGVTIDRNKLTAEILSELRLAVVKFENEGLSAFLSRWQ 183 Query: 202 TFHAYAGQSVKIVDNGRVVHEGIALGVDMMGRFLIDTEAGQIEVLAGDVSLR 253 Y + VK++ + + GIA G+D G L++ + + G++SLR Sbjct: 184 KMDNYLNRPVKLIIGNQEIF-GIARGIDQQGALLLEQDGNIKPYIGGEISLR 234 >PA4280_2 [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase Pae Pseudomonas aeruginosa Length = 237 Score = 118 bits (295), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 84/239 (35%), Positives = 133/239 (55%), Gaps = 15/239 (6%) Query: 24 STNIDLMQRLSS-LQRPLLLVADRQTAGRGRAGRPWRAQPQDSLTFSLAWRLQRPTHALL 82 STN + M+RL++ P ++VA++QTAGRGR GR W + ++L +SLA ++ L Sbjct: 6 STNSEAMRRLAAGASTPFVIVAEQQTAGRGRRGRAWVSPYGENLYYSLAITVRGGARELE 65 Query: 83 GLPLAVGVALAEALEVFGIRPQ-LKWPNDVLRDGAKLAGILIETAAEGGRADATWAVIGI 141 GL L VG+A+ ALE G++ LKWPND+L+ G K+AGIL+E + G AD VIGI Sbjct: 66 GLSLVVGLAVLRALESLGVQDTGLKWPNDLLQGGKKIAGILLELS--GDPADLCHVVIGI 123 Query: 142 GLNLGVPSGLE-----DELQRAVGSAPELQKPPRETVLAIIVSALSEVLTEFEQRGFGAF 196 G+N+ + + + L+ A+G + R +L+ + L++ L + GF A Sbjct: 124 GINVNMKTATDIGQPWTSLREALGELVD-----RSRLLSALNRQLADYLDRHSREGFAAS 178 Query: 197 VKRWETFHAYAGQSVKIVDNGRVVHEGIALGVDMMGRFLIDTEAGQIEVLAGDVSLRLQ 255 + WE+ + + G V I+ EG LGVD G ++ + + G++SLRL+ Sbjct: 179 REEWESCNLWQGAQV-ILSTALSSIEGRVLGVDSRGALRLEVDGVEQGFSGGELSLRLR 236