BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.3955.p (254 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2946 [E] COG0107 Imidazoleglycerol-phosphate synthase Rso Ral... 418 e-117 PA5140 [E] COG0107 Imidazoleglycerol-phosphate synthase Pae Pseu... 372 e-103 NMB0628 [E] COG0107 Imidazoleglycerol-phosphate synthase Nme Nei... 360 1e-99 NMA0838 [E] COG0107 Imidazoleglycerol-phosphate synthase NmA Nei... 356 3e-98 aq_181 [E] COG0107 Imidazoleglycerol-phosphate synthase Aae Aqui... 342 4e-94 >RSc2946 [E] COG0107 Imidazoleglycerol-phosphate synthase Rso Ralstonia solanacearum Length = 256 Score = 418 bits (1074), Expect = e-117, Method: Compositional matrix adjust. Identities = 208/255 (81%), Positives = 233/255 (91%), Gaps = 4/255 (1%) Query: 3 LAKRIIPCLDVTAGRVVKGVNFLELRDAGDPVEIARRYDEQGADELTFLDITASSDGRDL 62 LAKRIIPCLDVT GRVVKGVNF+ELRDAGDPVEIARRYDEQGADE+TFLDITA+SDGRDL Sbjct: 2 LAKRIIPCLDVTNGRVVKGVNFVELRDAGDPVEIARRYDEQGADEITFLDITATSDGRDL 61 Query: 63 ILDIIEAVASQVFIPLTVGGGVRAVEDVRRLLNAGADKVGINTSAVTNPQLVADAANKYG 122 IL IIEAVASQVFIPLTVGGGVRA+EDVRRLLNAGADK+ +N+SAV NPQLV+DA+ ++G Sbjct: 62 ILHIIEAVASQVFIPLTVGGGVRALEDVRRLLNAGADKISMNSSAVANPQLVSDASARHG 121 Query: 123 SQCIVVAIDAKR-AGDG---KWEVYTHGGRNATGLDAVEWARKMAQLGAGEILLTSMDRD 178 +QCIVVAIDAK+ + DG +WEV+THGGR ATGLDAV WAR+MA+ GAGEILLTSMDRD Sbjct: 122 AQCIVVAIDAKKVSADGEPPRWEVFTHGGRKATGLDAVAWAREMARRGAGEILLTSMDRD 181 Query: 179 GTKSGFDLDLTRAVSEAVSIPVIASGGVGGLQDLADGITKGKADAVLAASIFHYGQHTVQ 238 GTKSGFDL+LTRAVS+AV +PVIASGGVG LQ LADGI G ADAVLAASIFHYG+HTV Sbjct: 182 GTKSGFDLELTRAVSDAVPVPVIASGGVGNLQHLADGIKLGHADAVLAASIFHYGEHTVG 241 Query: 239 EAKRFMADQNISMRL 253 EAKRFMA Q+I +R+ Sbjct: 242 EAKRFMAQQDIPVRM 256 >PA5140 [E] COG0107 Imidazoleglycerol-phosphate synthase Pae Pseudomonas aeruginosa Length = 256 Score = 372 bits (954), Expect = e-103, Method: Compositional matrix adjust. Identities = 184/256 (71%), Positives = 218/256 (85%), Gaps = 4/256 (1%) Query: 1 MALAKRIIPCLDVTAGRVVKGVNFLELRDAGDPVEIARRYDEQGADELTFLDITASSDGR 60 MALAKRIIPCLDV GRVVKGV F +RDAGDPVEIARRYDEQGADE+TFLDITAS DGR Sbjct: 1 MALAKRIIPCLDVDNGRVVKGVKFENIRDAGDPVEIARRYDEQGADEITFLDITASVDGR 60 Query: 61 DLILDIIEAVASQVFIPLTVGGGVRAVEDVRRLLNAGADKVGINTSAVTNPQLVADAANK 120 D L +E +ASQVFIPLTVGGGVR+V+D+R LLNAGADKV INT+AV NP+ V +AA++ Sbjct: 61 DTTLHTVERMASQVFIPLTVGGGVRSVQDIRNLLNAGADKVSINTAAVFNPEFVGEAADR 120 Query: 121 YGSQCIVVAIDAKR---AGDG-KWEVYTHGGRNATGLDAVEWARKMAQLGAGEILLTSMD 176 +GSQCIVVAIDAK+ G+ +WE++THGGR TGLDAV WA+KM LGAGEILLTSMD Sbjct: 121 FGSQCIVVAIDAKKVSAPGEAPRWEIFTHGGRKPTGLDAVLWAKKMEDLGAGEILLTSMD 180 Query: 177 RDGTKSGFDLDLTRAVSEAVSIPVIASGGVGGLQDLADGITKGKADAVLAASIFHYGQHT 236 +DG KSG+DL +TRA+SEAV++PVIASGGVG L+ LA GI +GKADAVLAASIFH+G++T Sbjct: 181 QDGVKSGYDLGVTRAISEAVNVPVIASGGVGNLEHLAAGILEGKADAVLAASIFHFGEYT 240 Query: 237 VQEAKRFMADQNISMR 252 V EAK ++A + I +R Sbjct: 241 VPEAKAYLASRGIVVR 256 >NMB0628 [E] COG0107 Imidazoleglycerol-phosphate synthase Nme Neisseria meningitidis MC58 Length = 255 Score = 360 bits (925), Expect = 1e-99, Method: Compositional matrix adjust. Identities = 183/255 (71%), Positives = 211/255 (82%), Gaps = 2/255 (0%) Query: 1 MALAKRIIPCLDVTAGRVVKGVNFLELRDAGDPVEIARRYDEQGADELTFLDITASSDGR 60 MALAKRIIPCLDV GRVVKGVNF+ LRDAGDPVE A+RY+ +GADELTFLDITASSD R Sbjct: 1 MALAKRIIPCLDVKDGRVVKGVNFIGLRDAGDPVEAAKRYNGEGADELTFLDITASSDNR 60 Query: 61 DLILDIIEAVASQVFIPLTVGGGVRAVEDVRRLLNAGADKVGINTSAVTNPQLVADAANK 120 D IL IIE VA QVFIPLTVGGGVR V D+RRLLNAGADKV INT+AVT P L+ +AA Sbjct: 61 DTILHIIEEVAGQVFIPLTVGGGVRTVADIRRLLNAGADKVSINTAAVTRPDLIDEAAGF 120 Query: 121 YGSQCIVVAIDAKRAG--DGKWEVYTHGGRNATGLDAVEWARKMAQLGAGEILLTSMDRD 178 +GSQ IV A+DAK A + +WE++THGGRN TGLDAVEWA +M + GAGEILLT MDRD Sbjct: 121 FGSQAIVAAVDAKAANPENTRWEIFTHGGRNPTGLDAVEWAVEMQKRGAGEILLTGMDRD 180 Query: 179 GTKSGFDLDLTRAVSEAVSIPVIASGGVGGLQDLADGITKGKADAVLAASIFHYGQHTVQ 238 GTK GF+L LTRAV+EAV IPVIASGGVG ++ L +GIT+GKADAVLAA IFH+G+ ++ Sbjct: 181 GTKQGFNLPLTRAVAEAVDIPVIASGGVGNVRHLIEGITEGKADAVLAAGIFHFGEIAIR 240 Query: 239 EAKRFMADQNISMRL 253 EAKR M + I +RL Sbjct: 241 EAKRAMREAGIEVRL 255 >NMA0838 [E] COG0107 Imidazoleglycerol-phosphate synthase NmA Neisseria meningitidis Z2491 Length = 255 Score = 356 bits (914), Expect = 3e-98, Method: Compositional matrix adjust. Identities = 180/255 (70%), Positives = 209/255 (81%), Gaps = 2/255 (0%) Query: 1 MALAKRIIPCLDVTAGRVVKGVNFLELRDAGDPVEIARRYDEQGADELTFLDITASSDGR 60 MALAKRIIPCLDV GRVVKGVNF+ LRDAGDPVE A+RY+ +GADELTFLDITASSD R Sbjct: 1 MALAKRIIPCLDVKDGRVVKGVNFIGLRDAGDPVEAAKRYNGEGADELTFLDITASSDNR 60 Query: 61 DLILDIIEAVASQVFIPLTVGGGVRAVEDVRRLLNAGADKVGINTSAVTNPQLVADAANK 120 D IL IIE VA QVFIPLTVGGGVR V D+RRLLNAGADKV INT+AVT P L+ +AA Sbjct: 61 DTILHIIEEVAGQVFIPLTVGGGVRTVADIRRLLNAGADKVSINTAAVTRPDLIDEAAGF 120 Query: 121 YGSQCIVVAIDAKRAG--DGKWEVYTHGGRNATGLDAVEWARKMAQLGAGEILLTSMDRD 178 +GSQ IV A+DAK + +WE++THGGRN TGLDAVEWA +M + GAGEILLT MDRD Sbjct: 121 FGSQAIVAAVDAKAVNPENTRWEIFTHGGRNPTGLDAVEWAIEMQKRGAGEILLTGMDRD 180 Query: 179 GTKSGFDLDLTRAVSEAVSIPVIASGGVGGLQDLADGITKGKADAVLAASIFHYGQHTVQ 238 GTK GF+L LTRAV+EAV IPVIASGGVG ++ L +GIT+GKADAVLAA +FH+G+ ++ Sbjct: 181 GTKQGFNLPLTRAVAEAVDIPVIASGGVGNVRHLIEGITEGKADAVLAAGVFHFGEIAIR 240 Query: 239 EAKRFMADQNISMRL 253 EAK M + I +RL Sbjct: 241 EAKHAMREAGIEVRL 255 >aq_181 [E] COG0107 Imidazoleglycerol-phosphate synthase Aae Aquifex aeolicus Length = 253 Score = 342 bits (877), Expect = 4e-94, Method: Compositional matrix adjust. Identities = 158/250 (63%), Positives = 205/250 (82%), Gaps = 1/250 (0%) Query: 3 LAKRIIPCLDVTAGRVVKGVNFLELRDAGDPVEIARRYDEQGADELTFLDITASSDGRDL 62 LAKRIIPCLDV GRVVKGV FL LRDAGDPVE+A+RY+E+GADEL FLDITAS++ R++ Sbjct: 2 LAKRIIPCLDVDKGRVVKGVKFLNLRDAGDPVEVAKRYEEEGADELVFLDITASAEDREI 61 Query: 63 ILDIIEAVASQVFIPLTVGGGVRAVEDVRRLLNAGADKVGINTSAVTNPQLVADAANKYG 122 ++D+++ VA VF+P TVGGG+R++ED+RRLL AGADK+ INT+AV NP L+ + A ++G Sbjct: 62 MIDVVKKVAETVFMPFTVGGGIRSLEDMRRLLEAGADKISINTAAVKNPNLIYEGAKRFG 121 Query: 123 SQCIVVAIDAKRAGDGKWEVYTHGGRNATGLDAVEWARKMAQLGAGEILLTSMDRDGTKS 182 SQCIVVAIDAKR G+ WEVY HGGR TGLDAVEWA+K+ LGAGEILLTSMDRDGTK Sbjct: 122 SQCIVVAIDAKRKGNS-WEVYIHGGRTPTGLDAVEWAKKVESLGAGEILLTSMDRDGTKD 180 Query: 183 GFDLDLTRAVSEAVSIPVIASGGVGGLQDLADGITKGKADAVLAASIFHYGQHTVQEAKR 242 G+D++L RA+SEAV+IPVIASGG G + + +K K +A LAAS+FH+ + ++ E K Sbjct: 181 GYDIELNRAISEAVNIPVIASGGAGKKEHFYEVFSKTKVEAALAASVFHFREISIPELKE 240 Query: 243 FMADQNISMR 252 ++ ++ I++R Sbjct: 241 YLLERGINVR 250