BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.3843.p (413 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc0421 [GEPR] COG0477 Permeases of the major facilitator superf... 403 e-112 NMA1673 [GEPR] COG0477 Permeases of the major facilitator superf... 330 3e-90 STM0436 [GEPR] COG0477 Permeases of the major facilitator superf... 321 2e-87 yajR [GEPR] COG0477 Permeases of the major facilitator superfami... 321 2e-87 ZyajR [GEPR] COG0477 Permeases of the major facilitator superfam... 320 3e-87 >RSc0421 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 387 Score = 403 bits (1035), Expect = e-112, Method: Compositional matrix adjust. Identities = 222/385 (57%), Positives = 286/385 (74%), Gaps = 6/385 (1%) Query: 16 MSRAEVRASASLASIFSLRMLGLFLVLPVFAVHAHSLPGGDSDTLVGVALGIYGLAQACG 75 M+ E+RA+ SLA IF+LRMLGLF+++PVFAV A SLP G + LV A+G+YGL QA Sbjct: 1 MTGFELRAATSLAGIFALRMLGLFMIMPVFAVFAKSLPDGGNTQLVAFAIGVYGLTQAVL 60 Query: 76 QIPYGIASDRYGRKRIIVIGLLLFALGSFVAAGAHNVLWLLIGRALQGSGAISAAITAFI 135 IPYG SDR+GRK +IV GLL+FA GS VAA +H+V + +GRA+QG+GAIS+A+ AF+ Sbjct: 61 YIPYGWLSDRFGRKPVIVAGLLIFAAGSLVAAFSHSVAGIAVGRAIQGAGAISSAVIAFV 120 Query: 136 ADSTREEHRTKAMAMVGASIGVTFAVSMVASPLLYKSIGMGGIFGLTGVLSLIAIAVVLW 195 AD TREEHRTKAMAM+G SIGV+FAV++V++P++++ IGM G+F G+L+LIAI VVLW Sbjct: 121 ADLTREEHRTKAMAMIGGSIGVSFAVAIVSAPVIFRWIGMPGMFLAIGILALIAIGVVLW 180 Query: 196 VVPTAPMVQAK-RVPLREVLRHAELLRLNFGVFTLHLTQVAMFMVVPAALVQMAGLPLGE 254 VVP AP A P REVL + ELLRLNFGVF LH TQ A+F+V+P +++ AGLP+ Sbjct: 181 VVPDAPRPAAHVSAPFREVLHNRELLRLNFGVFALHATQTALFVVLP-HMLETAGLPVDS 239 Query: 255 HWKIYLPVVLASFVLMLPPIIVAEKYGRMKSVFVAAISLMLLVQLGFWAVLSHPLAHLWM 314 HWKIYLPV+ SFVLM+P II AEK G+MK+V ++A++L+++ QL L L Sbjct: 240 HWKIYLPVMGVSFVLMVPAIIAAEKRGKMKAVLLSAVALVMVAQLA----LGEAQPTLAS 295 Query: 315 LVGLLFLFFVAFNILEAAQPSLVSRIAPPAAKGAALGVYNTLQALGLSCGGALGGWLKQH 374 L L ++F+ FN+LEA+QPSLVS+ AP KGAA+GVYNT QALGL GGA GGW+ H Sbjct: 296 LTVALLVYFLGFNVLEASQPSLVSKYAPGVRKGAAMGVYNTTQALGLFTGGAGGGWILLH 355 Query: 375 VNNSAVFLLCAVLTATWLIIAANMK 399 AVF CA L A WLIIA+ M+ Sbjct: 356 AGQHAVFFTCAGLAAAWLIIASPMR 380 >NMA1673 [GEPR] COG0477 Permeases of the major facilitator superfamily NmA Neisseria meningitidis Z2491 Length = 461 Score = 330 bits (846), Expect = 3e-90, Method: Compositional matrix adjust. Identities = 183/383 (47%), Positives = 266/383 (69%), Gaps = 12/383 (3%) Query: 20 EVRASASLASIFSLRMLGLFLVLPVFAVHAHSLPGGDSD-TLVGVALGIYGLAQACGQIP 78 E RAS +L+ +++LRMLG+FLVLPV AV+A SLPG + + TLVG+A+GIYGL QA Q+P Sbjct: 14 EWRASTTLSGVYALRMLGMFLVLPVLAVYAASLPGAEGNKTLVGLAMGIYGLTQALLQLP 73 Query: 79 YGIASDRYGRKRIIVIGLLLFALGSFVAAGAHNVLWLLIGRALQGSGAISAAITAFIADS 138 GIASD++GRK+ I +GL++FA GSF+AA A + L+ RA+QG+GA+SAA+TA +AD Sbjct: 74 LGIASDKFGRKKTIYVGLIVFAAGSFLAAAADTLPMLVAARAIQGAGAVSAAVTALLADL 133 Query: 139 TREEHRTKAMAMVGASIGVTFAVSMVASPLLYKSIGMGGIFGLTGVLSLIAIAVVLWVVP 198 TR+ RT+AMAM+G SIG+TF+VS+V +P++ ++G+ G+F LTG+L++ +I VV W+ P Sbjct: 134 TRDGVRTRAMAMIGLSIGLTFSVSLVVAPVIADAVGVRGLFLLTGILTVASIGVVAWMTP 193 Query: 199 TAPM------VQAKRVPLREVLRHAELLRLNFGVFTLHLTQVAMFMVVPAALVQMAGLPL 252 + QA+ + EVL++ LL L+FG+F LH Q+A+F +P A+ Q+ GL Sbjct: 194 DPEVSKLHEDTQAQPSRIGEVLKNRRLLTLDFGIFALHAAQMALFTALPFAMTQL-GLEK 252 Query: 253 GEHWKIYLPVVLASFVLMLPPIIVAEKYGRMKSVFVAAISLMLLVQLGFWAVLSHPLAHL 312 +HWK+YLP + V+M+P IIV E ++K VF+ I+ + QLG L + + Sbjct: 253 IQHWKVYLPSTITGLVVMVPLIIVGETRNKLKQVFILGIACIAAAQLG----LLSGMRSV 308 Query: 313 WMLVGLLFLFFVAFNILEAAQPSLVSRIAPPAAKGAALGVYNTLQALGLSCGGALGGWLK 372 ++ L ++F+ FN+LEA+ PS+VS+IAP KG A+GVYNT+Q+LGL GG GG L Sbjct: 309 GLITAYLVVYFIGFNVLEASLPSMVSKIAPSDLKGTAMGVYNTMQSLGLFAGGVAGGLLF 368 Query: 373 QHVNNSAVFLLCAVLTATWLIIA 395 Q S VF C++L WL+IA Sbjct: 369 QKYGFSGVFAFCSILMLLWLVIA 391 >STM0436 [GEPR] COG0477 Permeases of the major facilitator superfamily Sty Salmonella typhimurium LT2 Length = 449 Score = 321 bits (823), Expect = 2e-87, Method: Compositional matrix adjust. Identities = 173/393 (44%), Positives = 255/393 (64%), Gaps = 12/393 (3%) Query: 16 MSRAEVRASASLASIFSLRMLGLFLVLPVFAVHAHSLPGGDSDTLVGVALGIYGLAQACG 75 M+ E+RA+ L ++FSLRMLG+F+VLPV + +L G S+ L+G+A+GIYGLAQA Sbjct: 1 MTPGELRATWGLGTVFSLRMLGMFMVLPVLTTYGMALQGA-SEALIGIAIGIYGLAQAIF 59 Query: 76 QIPYGIASDRYGRKRIIVIGLLLFALGSFVAAGAHNVLWLLIGRALQGSGAISAAITAFI 135 QIP+G+ SDR GRK +IV GL +F GS +AA +H++ +++GRALQGSGAI+AA+ A + Sbjct: 60 QIPFGLLSDRIGRKPLIVGGLAVFVAGSVIAALSHSIWGIILGRALQGSGAIAAAVMALL 119 Query: 136 ADSTREEHRTKAMAMVGASIGVTFAVSMVASPLLYKSIGMGGIFGLTGVLSLIAIAVVLW 195 +D TRE++RTKAMA +G S G+TFA++MV P++ S+G+ +F + L+ + I + +W Sbjct: 120 SDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIVTHSLGLNALFWMIAALATLGILLTIW 179 Query: 196 VVPTAPMVQAKRV------PLREVLRHAELLRLNFGVFTLHLTQVAMFMVVPAALVQMAG 249 VVP + R +VL LL+LNFG+ LH+ ++ F+ +P L AG Sbjct: 180 VVPNSTNHVLNRESGMVKGSFSKVLAEPRLLKLNFGIMCLHILLMSTFVALPGQLAD-AG 238 Query: 250 LPLGEHWKIYLPVVLASFVLMLPPIIVAEKYGRMKSVFVAAISLMLLVQLGFWAVLSHPL 309 P EHWK+YL ++ +F ++P II AE RMK VF+ + L+++ ++ W Sbjct: 239 FPAAEHWKVYLATMVIAFAAVVPFIIYAEVKRRMKQVFLFCVGLIVVAEIVLWGAGQ--- 295 Query: 310 AHLWMLVGLLFLFFVAFNILEAAQPSLVSRIAPPAAKGAALGVYNTLQALGLSCGGALGG 369 H W LV + LFF+AFN++EA PSL+S+ +P KG A+GVY+T Q LG++ GG+LGG Sbjct: 296 -HFWELVIGVQLFFLAFNLMEALLPSLISKESPAGYKGTAMGVYSTSQFLGVALGGSLGG 354 Query: 370 WLKQHVNNSAVFLLCAVLTATWLIIAANMKNLP 402 W+ + VFL AVL WL +A+ MK P Sbjct: 355 WIDGTFDGQTVFLAGAVLAMVWLAVASTMKEPP 387 >yajR [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 456 Score = 321 bits (822), Expect = 2e-87, Method: Compositional matrix adjust. Identities = 173/393 (44%), Positives = 254/393 (64%), Gaps = 12/393 (3%) Query: 16 MSRAEVRASASLASIFSLRMLGLFLVLPVFAVHAHSLPGGDSDTLVGVALGIYGLAQACG 75 M+ E RA+ L ++FSLRMLG+F+VLPV + +L G S+ L+G+A+GIYGL QA Sbjct: 8 MTPGERRATWGLGTVFSLRMLGMFMVLPVLTTYGMALQGA-SEALIGIAIGIYGLTQAVF 66 Query: 76 QIPYGIASDRYGRKRIIVIGLLLFALGSFVAAGAHNVLWLLIGRALQGSGAISAAITAFI 135 QIP+G+ SDR GRK +IV GL +FA GS +AA + ++ +++GRALQGSGAI+AA+ A + Sbjct: 67 QIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQGSGAIAAAVMALL 126 Query: 136 ADSTREEHRTKAMAMVGASIGVTFAVSMVASPLLYKSIGMGGIFGLTGVLSLIAIAVVLW 195 +D TRE++RTKAMA +G S G+TFA++MV P++ +G+ +F + +L+ IA+ +W Sbjct: 127 SDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATTGIALTIW 186 Query: 196 VVPTAPMVQAKRV------PLREVLRHAELLRLNFGVFTLHLTQVAMFMVVPAALVQMAG 249 VVP + R +VL LL+LNFG+ LH+ ++ F+ +P L AG Sbjct: 187 VVPNSSTHVLNRESGMVKGSFSKVLAEPRLLKLNFGIMCLHILLMSTFVALPGQLAD-AG 245 Query: 250 LPLGEHWKIYLPVVLASFVLMLPPIIVAEKYGRMKSVFVAAISLMLLVQLGFWAVLSHPL 309 P EHWK+YL +L +F ++P II AE +MK VFV + L+++ ++ W + Sbjct: 246 FPAAEHWKVYLATMLIAFGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLW----NAQ 301 Query: 310 AHLWMLVGLLFLFFVAFNILEAAQPSLVSRIAPPAAKGAALGVYNTLQALGLSCGGALGG 369 W LV + LFFVAFN++EA PSL+S+ +P KG A+GVY+T Q LG++ GG+LGG Sbjct: 302 TQFWQLVVGVQLFFVAFNLMEALLPSLISKESPAGYKGTAMGVYSTSQFLGVAIGGSLGG 361 Query: 370 WLKQHVNNSAVFLLCAVLTATWLIIAANMKNLP 402 W+ + VFL A+L A WL +A+ MK P Sbjct: 362 WINGMFDGQGVFLAGAMLAAVWLTVASTMKEPP 394 >ZyajR [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 456 Score = 320 bits (820), Expect = 3e-87, Method: Compositional matrix adjust. Identities = 174/393 (44%), Positives = 255/393 (64%), Gaps = 12/393 (3%) Query: 16 MSRAEVRASASLASIFSLRMLGLFLVLPVFAVHAHSLPGGDSDTLVGVALGIYGLAQACG 75 M+ E RA+ L ++FSLRMLG+F+VLPV + +L G S+ L+G+A+GIYGL QA Sbjct: 8 MTPGERRATWGLGTVFSLRMLGMFMVLPVLTTYGMALQGA-SEALIGIAIGIYGLTQAVF 66 Query: 76 QIPYGIASDRYGRKRIIVIGLLLFALGSFVAAGAHNVLWLLIGRALQGSGAISAAITAFI 135 QIP+G+ SDR GRK +IV GL +FA GS +AA + ++ +++GRALQGSGAI+AA+ A + Sbjct: 67 QIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQGSGAIAAAVMALL 126 Query: 136 ADSTREEHRTKAMAMVGASIGVTFAVSMVASPLLYKSIGMGGIFGLTGVLSLIAIAVVLW 195 +D TRE++RTKAMA +G S G+TFA++MV P++ +G+ +F + +L+ IA+ +W Sbjct: 127 SDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATTGIALTIW 186 Query: 196 VVPTAPMVQAKRV------PLREVLRHAELLRLNFGVFTLHLTQVAMFMVVPAALVQMAG 249 VVP + R +VL LL+LNFG+ LH+ ++ F+ +P L AG Sbjct: 187 VVPNSSTHVLNRESGMVKGSFSKVLAEPRLLKLNFGIMCLHILLMSTFVALPGQLAD-AG 245 Query: 250 LPLGEHWKIYLPVVLASFVLMLPPIIVAEKYGRMKSVFVAAISLMLLVQLGFWAVLSHPL 309 P EHWK+YL +L +F ++P II AE +MK VFV + L+++ ++ VL + Sbjct: 246 FPAAEHWKVYLATMLIAFGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAEI----VLRNAQ 301 Query: 310 AHLWMLVGLLFLFFVAFNILEAAQPSLVSRIAPPAAKGAALGVYNTLQALGLSCGGALGG 369 W LV + LFFVAFN++EA PSL+S+ +P KG A+GVY+T Q LG++ GG+LGG Sbjct: 302 TQFWQLVVGVQLFFVAFNLMEALLPSLISKESPAGYKGTAMGVYSTSQFLGVAIGGSLGG 361 Query: 370 WLKQHVNNSAVFLLCAVLTATWLIIAANMKNLP 402 W+ + VFL A+L A WL +A+ MK P Sbjct: 362 WIDGMFDGQGVFLAGAMLAAVWLAVASTMKEPP 394