BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.3820.p (604 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2890 [R] COG3975 Predicted protease with the C-terminal PDZ d... 721 0.0 NMB1726 [R] COG3975 Predicted protease with the C-terminal PDZ d... 415 e-115 NMA1981 [R] COG3975 Predicted protease with the C-terminal PDZ d... 406 e-113 alr2326 [R] COG3975 Predicted protease with the C-terminal PDZ d... 385 e-106 slr0031 [R] COG3975 Predicted protease with the C-terminal PDZ d... 354 3e-97 >RSc2890 [R] COG3975 Predicted protease with the C-terminal PDZ domain Rso Ralstonia solanacearum Length = 621 Score = 721 bits (1861), Expect = 0.0, Method: Compositional matrix adjust. Identities = 371/605 (61%), Positives = 431/605 (71%), Gaps = 18/605 (2%) Query: 6 PIRYSITSLDPASHLYDITVTVDTPAADGQVFSLPAWIPGSYMIREFGKNIVTLRGESNG 65 PIRY+I P +HL+ +TVTVD P GQ FSLPAWIPGSYMIREF +NIV + Sbjct: 3 PIRYTIAPAAPEAHLFTVTVTVDAPDPQGQRFSLPAWIPGSYMIREFARNIVRIEAMCGE 62 Query: 66 RKVAVKKRDKHTWQAAPCKGALTLHYQVYAWDLSVRTAHLDRTHGFFNGTSVFLAAHGFE 125 R V + K DKHTWQAAPC G LT+ Y VYAWDLSVR AHLD THGFFNGTSVFL G E Sbjct: 63 RAVRLAKLDKHTWQAAPCSGPLTVSYDVYAWDLSVRAAHLDPTHGFFNGTSVFLRVEGGE 122 Query: 126 DGPHVVDIRRPAGEDFKRWRVATAMSE--------LKAKRYGFGTYVAQNYDELIDHPVE 177 +VDI+ PAG+ ++ WRVATA+ E + AKRYGFG Y A +YDELIDHPVE Sbjct: 123 QVRCLVDIQPPAGDAYRGWRVATALREASGRVQGRVGAKRYGFGWYEAADYDELIDHPVE 182 Query: 178 LGDFALASFQAHGVPHDVVITGRVPNLDLARLCDDLKKICEAQIAFFEPRSKRAPM---- 233 +G FAL SF+A G HD V TGRVPNLDL R+ D K+ICEAQI FEP + AP Sbjct: 183 MGTFALVSFEACGAQHDAVFTGRVPNLDLERIARDFKRICEAQIRLFEPHTAAAPFLDSN 242 Query: 234 DRYVFMTLAVGDGYGGLEHRASTALICARADLPVKGKPEQSDGYRTYLGLCSHEYFHTWN 293 RYVFMT+ DGYGGLEHRASTALICAR DLPV G+ E ++GYRT+LGL SHEYFHTWN Sbjct: 243 RRYVFMTMVTTDGYGGLEHRASTALICARNDLPVTGRDETTEGYRTFLGLVSHEYFHTWN 302 Query: 294 VKRIKPAVFAPYDLRQENYTSLLWLFEGFTSYYDDLFLVRTGVIDTEQYLKLVGKTITGV 353 VKRIKPAVF PY L +E +T LLWLFEGFTSYYDDL LVR+G+I QYL+++ KT GV Sbjct: 303 VKRIKPAVFVPYALDREVHTPLLWLFEGFTSYYDDLMLVRSGLISEAQYLEMLAKTWNGV 362 Query: 354 LRGTGRKKQSVAESSFDAWVKYYRQDENASNAIVSYYTKGSLVALGLDLSICEQTRGRRS 413 LRG+GR KQSVAESSFDAW KYYRQDENA NAIVSYYTKGSLVAL LDL+I QT G S Sbjct: 363 LRGSGRLKQSVAESSFDAWTKYYRQDENAPNAIVSYYTKGSLVALALDLTIRTQTGGEHS 422 Query: 414 LDDVMRGLWTRYGRDFYH--GKQQGVAEDEILAVMEELSGADLKRFYDRHIRGTEDVPLE 471 LDDVMR LW GRDFY Q+GV E E++A+MEE +G L+ + G +D PL Sbjct: 423 LDDVMRALWAAGGRDFYAPGHAQRGVTEAELIALMEETTGLRLRTLVRQLAEGRDDPPLP 482 Query: 472 DLLPAFGVAYDACLPADAKPWLGARIGKEGGDAKLAAVYEGGPAMQAGLSAGDKLVAIDG 531 L A GV PA+A LGA++G E G KL V++GGPA +AGLSAGD +VA+DG Sbjct: 483 ALFKAIGVTATRK-PAEAALGLGAKVGAENGFVKLLQVFDGGPAQRAGLSAGDLVVAVDG 541 Query: 532 LRVPASGADGLLARYRLNDTVRIHAFRRDELMEFSVRLKADSAPQVSLSAMGKPVAVVRR 591 LRV + D LAR+R DTV +H FRRDELM+ V L AD+ PQ +L+ +P + Sbjct: 542 LRVLSGQLDKSLARHRAGDTVPVHVFRRDELMQLDVTLSADATPQFALALSAEPSPL--- 598 Query: 592 RLAWL 596 R AWL Sbjct: 599 RSAWL 603 >NMB1726 [R] COG3975 Predicted protease with the C-terminal PDZ domain Nme Neisseria meningitidis MC58 Length = 582 Score = 415 bits (1067), Expect = e-115, Method: Compositional matrix adjust. Identities = 241/583 (41%), Positives = 324/583 (55%), Gaps = 36/583 (6%) Query: 7 IRYSITSLDPASHLYDITVTVDTPAADGQVFSLPAWIPGSYMIREFGKNIVTLRGESNGR 66 I Y IT P H + I +T SLP W+PGSY+IR+F ++I ++ NG Sbjct: 2 IHYKITP-SPLDHEWHILLTFTQDDDLPIEISLPNWVPGSYLIRDFSRHITSIHASCNGT 60 Query: 67 KVAVKKRDKHTWQAAPCKGALTLHYQVYAWDLSVRTAHLDRTHGFFNGTSVFLAAHGFED 126 + +++ K+ W AA +G + Y VYA+DLSVR + L GFF+G+ +FL G E Sbjct: 61 SMPLEQIAKNRWHAAAVRGEWQIRYTVYAFDLSVRGSFLTTERGFFDGSCLFLKVEGTET 120 Query: 127 GPHVVDIRRPAGEDFKRWRVATAMSELKAKRYGFGTYVAQNYDELIDHPVELGDFALASF 186 PH +++ E WR+AT + E G + A +Y ELID PVE+G F Sbjct: 121 LPHRLELTGIPSE----WRIATTLPET-----GRFVFQAASYAELIDRPVEMGLIEFLDF 171 Query: 187 QAHGVPHDVVITGRVPNLDLARLCDDLKKICEAQIAFFEPRSKRAPMDRYVFMTLAVGDG 246 +A G+PH + ++G P+ D RL D+KKICE ++A F S AP +Y+F+ L VGD Sbjct: 172 EAAGIPHTIALSGIYPDFDRNRLVSDIKKICETELAVF---SSPAPFQKYLFL-LHVGDH 227 Query: 247 -YGGLEHRASTALICARADLPVKGKPEQSDGYRTYLGLCSHEYFHTWNVKRIKPAVFAPY 305 YGGLEH STAL+ R LP G + D Y T LGL SHEYFH WNVK IKPA F PY Sbjct: 228 IYGGLEHTDSTALLADRHSLPPYGMTDADDTYTTLLGLFSHEYFHAWNVKSIKPAAFVPY 287 Query: 306 DLRQENYTSLLWLFEGFTSYYDDLFLVRTGVIDTEQYLKLVGKTITGVLRGTGRKKQSVA 365 DL +ENYT LW FEG TSYYDDLFL R+ I E YL L+ + IT V + GR +Q++A Sbjct: 288 DLDKENYTEQLWAFEGITSYYDDLFLARSRTISPESYLNLLAQGITRVQQTRGRLRQTLA 347 Query: 366 ESSFDAWVKYYRQDENASNAIVSYYTKGSLVALGLDLSICEQTRGRRSLDDVMRGLWTRY 425 ESSF AW K+Y+ DEN+ NAIVSYY KG+L AL LDL I ++ GR SLD +M L+ R Sbjct: 348 ESSFTAWNKFYKPDENSPNAIVSYYQKGALAALCLDLIIRNRSNGRHSLDTLMDKLY-RE 406 Query: 426 GRDFYHGKQQGVAEDEILAVMEELSGADLKRFYDRHIRGTEDVPLEDLLPAFGVAY---- 481 RD G+ E +E++G DL+ F+ + + TED+PL + L GV Sbjct: 407 WRD----THSGIPEKHWQIRCQEITGLDLEDFFQKALYSTEDLPLAECLATAGVGLTFLP 462 Query: 482 ----------DACLPADAKPWLGARIGKEGGDAKLAAVYEGGPAMQAGLSAGDKLVAIDG 531 + P + GAR + L V+ GG A A L DK++A+DG Sbjct: 463 LPRQHGGGYAEHICPVPSAGDFGARFKQNTDHIVLTHVFNGGSAESAALCPQDKIIALDG 522 Query: 532 LRVPASGADGLLARYRLNDTVRIHAFRRDELMEFSVRLKADSA 574 A ARY +N + IH FR L + + ++A +A Sbjct: 523 YACTDFTAQ--WARYHVNAKINIHFFRAGILRQTVLTVQAAAA 563 >NMA1981 [R] COG3975 Predicted protease with the C-terminal PDZ domain NmA Neisseria meningitidis Z2491 Length = 585 Score = 406 bits (1043), Expect = e-113, Method: Compositional matrix adjust. Identities = 239/583 (40%), Positives = 321/583 (55%), Gaps = 36/583 (6%) Query: 7 IRYSITSLDPASHLYDITVTVDTPAADGQVFSLPAWIPGSYMIREFGKNIVTLRGESNGR 66 I Y IT P H + I +T SLP W+PGSY+IR+F ++I ++ NG Sbjct: 5 IHYKITP-SPLDHEWHILLTFTQDDDLPIEISLPNWVPGSYLIRDFSRHITSIHASCNGT 63 Query: 67 KVAVKKRDKHTWQAAPCKGALTLHYQVYAWDLSVRTAHLDRTHGFFNGTSVFLAAHGFED 126 + +++ K+ W AA +G + Y VYA+DLSVR + L GFF+G+ +FL G E Sbjct: 64 SMPLEQIAKNRWHAAAVRGEWQIRYTVYAFDLSVRGSFLTTERGFFDGSCLFLKVEGTET 123 Query: 127 GPHVVDIRRPAGEDFKRWRVATAMSELKAKRYGFGTYVAQNYDELIDHPVELGDFALASF 186 H +++ E R+AT + E G + A +Y ELID PVE+G F Sbjct: 124 LLHRLELTGIPSER----RIATTLPET-----GRFVFQAASYAELIDRPVEMGLIEFLDF 174 Query: 187 QAHGVPHDVVITGRVPNLDLARLCDDLKKICEAQIAFFEPRSKRAPMDRYVFMTLAVGDG 246 +A G+PH + ++G P+ D RL D+KKICE ++ F S AP +Y+F+ L VGD Sbjct: 175 EAAGIPHTIALSGIYPDFDRNRLVSDIKKICETELTVF---SSPAPFQKYLFL-LHVGDH 230 Query: 247 -YGGLEHRASTALICARADLPVKGKPEQSDGYRTYLGLCSHEYFHTWNVKRIKPAVFAPY 305 YGGLEH STAL+ R LP G + D Y T LGL SHEYFH WNVK IKPA F PY Sbjct: 231 IYGGLEHTDSTALLADRHSLPPYGMTDADDTYTTLLGLFSHEYFHAWNVKSIKPAAFVPY 290 Query: 306 DLRQENYTSLLWLFEGFTSYYDDLFLVRTGVIDTEQYLKLVGKTITGVLRGTGRKKQSVA 365 DL +ENYT LW FEG TSYYDDLFL R+ I E YL L+ + IT V + GR +Q++A Sbjct: 291 DLDKENYTEQLWAFEGITSYYDDLFLARSRTISPESYLNLLAQGITRVQQTRGRLRQTLA 350 Query: 366 ESSFDAWVKYYRQDENASNAIVSYYTKGSLVALGLDLSICEQTRGRRSLDDVMRGLWTRY 425 ESSF AW K+Y+ DEN+ NAIVSYY KG+L AL LDL I ++ GR SLD VM L+ R Sbjct: 351 ESSFTAWNKFYKPDENSPNAIVSYYQKGALAALCLDLIIRNRSNGRHSLDTVMDKLY-RE 409 Query: 426 GRDFYHGKQQGVAEDEILAVMEELSGADLKRFYDRHIRGTEDVPLEDLLPAFGVAY---- 481 RD G+ E +E++G DL+ F+ + + TED+PL + L GV Sbjct: 410 WRD----THSGIPEKHWQIRCQEITGLDLEDFFQKTLYSTEDLPLAECLATAGVGLTFLP 465 Query: 482 ----------DACLPADAKPWLGARIGKEGGDAKLAAVYEGGPAMQAGLSAGDKLVAIDG 531 + P + GAR + L V+ GG A A L DK++A+DG Sbjct: 466 LPRQHGGGYAEHICPVPSAGDFGARFKQNTDHIVLTHVFNGGSAESAALCPQDKIIALDG 525 Query: 532 LRVPASGADGLLARYRLNDTVRIHAFRRDELMEFSVRLKADSA 574 A ARY +N + IH FR L + + ++A +A Sbjct: 526 YACTDFTAQ--WARYHVNAKINIHFFRAGILRQTVLTVQAAAA 566 >alr2326 [R] COG3975 Predicted protease with the C-terminal PDZ domain Nos Nostoc sp. PCC 7120 Length = 543 Score = 385 bits (988), Expect = e-106, Method: Compositional matrix adjust. Identities = 207/560 (36%), Positives = 313/560 (55%), Gaps = 27/560 (4%) Query: 39 LPAWIPGSYMIREFGKNIVTLRGESNGRKVAVKKRDKHTWQAAPCK-GALTLHYQVYAWD 97 +P W PGSY++RE+ KN+ + + + +K K+ WQ +T+ Y+++A + Sbjct: 1 MPVWTPGSYLVREYAKNLQDFTAFAGDKILPWRKISKNHWQINKGDVSEVTVRYRIFANE 60 Query: 98 LSVRTAHLDRTHGFFNGTSVFLAAHGFEDGPHVVDIRRPAGEDFKRWRVATAMSELKAKR 157 LSVRT HLD THG+FNG ++F G+E+ P V + P + +WRV T + + + Sbjct: 61 LSVRTNHLDATHGYFNGAALFFRLPGWENLPICVTVIPP----YPQWRVTTPLPTIGEQS 116 Query: 158 YGFGTYVAQNYDELIDHPVELGDFALASFQAHGVPHDVVITGRVPNLDLARLCDDLKKIC 217 T+ A ++D L+D P E+G+ L F+ G PH++ I G+ N + +L D +KI Sbjct: 117 ---NTFYAADFDTLVDSPFEIGEHQLYHFEVLGKPHELAIWGQ-GNCQVQQLIRDTQKII 172 Query: 218 EAQIAFFEPRSKRAPMDRYVFMTLAVGDGYGGLEHRASTALICARADLPVKGKPEQSDGY 277 + + F P +RYVF+ YGGLEH+ S +LI R D Y Sbjct: 173 QIEAQMF----GGLPYERYVFLLHLFAQAYGGLEHKNSCSLIYQRFGF------RSQDKY 222 Query: 278 RTYLGLCSHEYFHTWNVKRIKPAVFAPYDLRQENYTSLLWLFEGFTSYYDDLFLVRTGVI 337 ++ L +HE+FH WNVKRI+P ++ QENYT LW EG TSYYD L +R G+ Sbjct: 223 ERFIQLLAHEFFHLWNVKRIRPQALEVFNYDQENYTPSLWFCEGTTSYYDLLIPLRAGIY 282 Query: 338 DTEQYLKLVGKTITGVLRGTGRKKQSVAESSFDAWVKYYRQDENASNAIVSYYTKGSLVA 397 D + YL K I+ ++ GRK Q ++ESSFDAW+K YR D N N+ VSYY KG +++ Sbjct: 283 DAKTYLNYWSKEISRLITTPGRKVQPLSESSFDAWIKLYRPDTNTGNSQVSYYLKGEMIS 342 Query: 398 LGLDLSICEQTRGRRSLDDVMRGLWTRYGRDFYHGKQQGVAEDEILAVMEELSGADLKRF 457 L LDL I + R +RSLDDVMR +W ++G+ + G +++ AV+E ++G DL F Sbjct: 343 LLLDLLIRARYRNQRSLDDVMRQMWQKFGQ-----AEIGYTPEQLQAVIESVAGVDLTDF 397 Query: 458 YDRHIRGTEDVPLEDLLPAFGVAYDACLPADAKPWLGARIGKEGGDAKLAAVYEGGPAMQ 517 + R+I GTE++P L FG+ A + +P+LG ++ E G + V G PA Sbjct: 398 FARYIDGTEELPFNQYLEPFGLHLVA--EREEEPYLGVKVNTENGREMIKFVEAGSPAQM 455 Query: 518 AGLSAGDKLVAIDGLRVPASGADGLLARYRLNDTVRIHAFRRDELMEFSVRLKADSAPQV 577 AG+ AGD+L+AI G+++ A L Y+ NDT+++ F +DEL + V+L + Sbjct: 456 AGIDAGDELLAIAGIKITAHQLSDRLKDYQANDTIQVTVFHQDELRTYPVKLGTPRPTKY 515 Query: 578 SLSAMGKPVAVVRRRL-AWL 596 L A+ P A + AWL Sbjct: 516 QLLAIQNPNATQQENFAAWL 535 >slr0031 [R] COG3975 Predicted protease with the C-terminal PDZ domain Syn Synechocystis Length = 584 Score = 354 bits (909), Expect = 3e-97, Method: Compositional matrix adjust. Identities = 210/596 (35%), Positives = 313/596 (52%), Gaps = 28/596 (4%) Query: 7 IRYSITSLDPASHLYDITVTVDTPAADGQVFSLPAWIPGSYMIREFGKNIVTLR--GESN 64 + Y + P +H + + + + A P W PGSY++RE+ +++ + G SN Sbjct: 8 LHYQVAMPTPQTHYFTVDLHIQGFTASVLELKFPVWTPGSYLVREYERHLQDFQAQGLSN 67 Query: 65 GRKVAVKKRDKHTWQAAPC--KGALTLHYQVYAWDLSVRTAHLDRTHGFFNGTSVFLAAH 122 G + +K K W A C + + + Y++YA +L+VRT HLD +HGFF G ++F Sbjct: 68 GEYLEHQKLGKAHW-AIACGEEENIAISYRIYADELTVRTNHLDYSHGFFTGAALFFYLP 126 Query: 123 GFEDGPHVVDIRRPAGEDFKRWRVATAM-SELKAKRYGFGTYVAQNYDELIDHPVELGDF 181 G P + + P W +ATA+ + G T+ AQ++D L+D PVE+G Sbjct: 127 GHTHRPLALTVVPPE----PAWAIATALPCKATDSTTGAKTFYAQDFDTLVDSPVEVGIH 182 Query: 182 ALASFQAHGVPHDVVITGRVPNLDLARLCDDLKKICEAQIAFFEPRSKRAPMDRYVFMTL 241 +F+ G H V+ G NL+ +L D +KI + F P D Y F+ Sbjct: 183 RDYAFETQGKEHHFVVWGE-SNLNGEQLVRDTEKIIAVEAGLF----GNLPYDHYWFILH 237 Query: 242 AVGDGYGGLEHRASTALICARADLPVKGKPEQSDGYRTYLGLCSHEYFHTWNVKRIKPAV 301 GYGGLEH+ S L R PE+ Y+ +L L +HE+FH WN+KRI+P Sbjct: 238 TSNQGYGGLEHKDSCVLNYDRFGF---RDPEK---YQRFLQLVAHEFFHLWNIKRIRPIA 291 Query: 302 FAPYDLRQENYTSLLWLFEGFTSYYDDLFLVRTGVIDTEQYLKLVGKTITGVLRGTGRKK 361 +D QENYT LW EG TSYYD L +R + D + YLK +GK IT L+ GR Sbjct: 292 LEKFDYDQENYTPSLWFSEGTTSYYDLLIPLRAEIYDRQTYLKNLGKEITRYLKTLGRLV 351 Query: 362 QSVAESSFDAWVKYYRQDENASNAIVSYYTKGSLVALGLDLSICEQTRGRRSLDDVMRGL 421 Q +AESSFDAW+K YR+D N+ N+ +SYY KG LV L LDL I E+ + +RS DDV+R + Sbjct: 352 QPLAESSFDAWIKLYRRDANSDNSQMSYYLKGELVTLMLDLLIRERHQNQRSFDDVLRAM 411 Query: 422 WTRYGRDFYHGKQQGVAEDEILAVMEELSGADLKRFYDRHIRGTEDVPLEDLLPAFGVAY 481 W +GR+ + G +++ AV+ ++ DL F+ ++ T ++PL D L FG+ Sbjct: 412 WQEFGRE-----EIGFTPEQLQAVISRVADTDLTEFFHTYLHTTAELPLNDYLQPFGLVI 466 Query: 482 DACLPADAKPWLGARIGKEGGDAKLAAVYEGGPAMQAGLSAGDKLVAIDGLRVPASGADG 541 + D P+LG ++ E G K+ V PA AG+S D L+AI+G+RV A Sbjct: 467 KP-MQEDLTPYLGIKVKSEAGQEKITFVAAHSPAAMAGISPQDLLLAINGVRVGAEQLSL 525 Query: 542 LLARYRLNDTVRIHAFRRDELMEFSVRLKADSAPQVSLSAMGKPVAVVRRRLA-WL 596 L Y+ ND +++ F +D L V L + A + + + P + LA WL Sbjct: 526 RLKDYQANDMIQLTVFHQDLLRTVDVVLASPQANRYEVVPIADPSDSQLQNLAGWL 581