BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.3811.p (312 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc0405 [T] COG1493 Serine kinase of the HPr protein, regulates ... 395 e-110 NMB0737 [T] COG1493 Serine kinase of the HPr protein, regulates ... 282 6e-76 NMA0947 [T] COG1493 Serine kinase of the HPr protein, regulates ... 282 6e-76 XF1406 [T] COG1493 Serine kinase of the HPr protein, regulates c... 244 3e-64 SA0715 [T] COG1493 Serine kinase of the HPr protein, regulates c... 191 2e-48 >RSc0405 [T] COG1493 Serine kinase of the HPr protein, regulates carbohydrate metabolism Rso Ralstonia solanacearum Length = 324 Score = 395 bits (1015), Expect = e-110, Method: Compositional matrix adjust. Identities = 195/312 (62%), Positives = 241/312 (77%), Gaps = 6/312 (1%) Query: 5 SALSIQQLYEENRESLQLGWFAGFPGGERLISGD----AVSASDQVGHLNLIHPGRLQVF 60 + ++ Q ++++N L+L W AG G +R D A SA+D VGHLNLIHP R+QV Sbjct: 4 TGVTAQSIFDDNAADLKLSWVAGLEGADRAFDVDFAKEATSAADLVGHLNLIHPNRIQVL 63 Query: 61 GHQEIEYYNRLSNTSRAYQTAELVAGEPPAFIIAQGLSTPPDLLAVCDEKNIPLFSTPLP 120 G EI YY RLS +R Q EL+ EPP ++A G+ PPDL C + PLF++P+ Sbjct: 64 GKPEITYYQRLSEENRKRQMGELILLEPPFLVVADGVDPPPDLELRCTRSSTPLFTSPIS 123 Query: 121 AAQVIDYLRVYLSKKLAQQITMHGVFMDVLGVGVLITGESGLGKSELGLELISRSHGLVA 180 +A VID+LR+YLS+ A ++TMHGVF+D+LG+GVLI G+SGLGKSELGLELISR HGLVA Sbjct: 124 SAAVIDHLRLYLSRISAPRVTMHGVFLDILGMGVLIMGDSGLGKSELGLELISRGHGLVA 183 Query: 181 DDAVEFARIAPNMIEGRCPPLLQNLLEVRGLGLLDIKAIFGETAVRRKMRLKLIVHLVRR 240 DDAV+F R+ P+ IEGRCPPLLQNLLEVRGLGLLDIK IFGETAVRRKM++KLIV LVRR Sbjct: 184 DDAVDFVRLGPDFIEGRCPPLLQNLLEVRGLGLLDIKTIFGETAVRRKMKIKLIVQLVRR 243 Query: 241 STLEENYERLPLDAQYEEVLGLPIRKVVIPVAAGRNIAVLLEAAVRNTILQLRGIDTLKE 300 + E +ERLPLD+QY +VLGLPI V I VAAGRN+AVL+EAAVRNTIL+LRGIDTL++ Sbjct: 244 NDGE--FERLPLDSQYMDVLGLPIHMVKIQVAAGRNLAVLVEAAVRNTILRLRGIDTLRD 301 Query: 301 FIERQRRAMNGE 312 F++RQR AM E Sbjct: 302 FMDRQRAAMQAE 313 >NMB0737 [T] COG1493 Serine kinase of the HPr protein, regulates carbohydrate metabolism Nme Neisseria meningitidis MC58 Length = 320 Score = 282 bits (722), Expect = 6e-76, Method: Compositional matrix adjust. Identities = 146/303 (48%), Positives = 200/303 (66%), Gaps = 2/303 (0%) Query: 6 ALSIQQLYEENRESLQLGWFAGFPGGERLISGDAVS-ASDQVGHLNLIHPGRLQVFGHQE 64 ++S+++L+++N+ LQL W AG G + I +A VGHLN IHP ++QV G E Sbjct: 3 SISVRRLFDDNQYKLQLAWAAGNSGADNRIGVEADKPVLALVGHLNFIHPNQIQVVGLAE 62 Query: 65 IEYYNRLSNTSRAYQTAELVAGEPPAFIIAQGLSTPPDLLAVCDEKNIPLFSTPLPAAQV 124 EY NRL + YQ +L I+A GL P L C + +IPL ++ L + + Sbjct: 63 SEYLNRLESGETGYQFGDLFDISMSLVIVANGLPVSPGLRDYCHKNDIPLLTSKLESPYL 122 Query: 125 IDYLRVYLSKKLAQQITMHGVFMDVLGVGVLITGESGLGKSELGLELISRSHGLVADDAV 184 +D LR+YL + LA HGVF+DV +GVLITG SGLGKSEL LELISR H L+ADDAV Sbjct: 123 MDVLRIYLQRTLAASSVKHGVFLDVFEIGVLITGHSGLGKSELALELISRGHSLIADDAV 182 Query: 185 EFARIAPNMIEGRCPPLLQNLLEVRGLGLLDIKAIFGETAVRRKMRLKLIVHLVRRST-L 243 E RI P +EGRC P+L++ LEVRGLG+L+I+ IFGET++R K L+LI++LV Sbjct: 183 ELFRIGPETLEGRCSPMLRDFLEVRGLGILNIRHIFGETSIRPKKILQLIINLVEADDEY 242 Query: 244 EENYERLPLDAQYEEVLGLPIRKVVIPVAAGRNIAVLLEAAVRNTILQLRGIDTLKEFIE 303 + +RL + + E +L + +R V +PVA GRN+AVL+EAAVRN ILQLRG D+ +EF+E Sbjct: 243 MKQLDRLSIRTETESILNVNVRSVTLPVAVGRNLAVLVEAAVRNYILQLRGKDSTREFLE 302 Query: 304 RQR 306 R + Sbjct: 303 RHQ 305 >NMA0947 [T] COG1493 Serine kinase of the HPr protein, regulates carbohydrate metabolism NmA Neisseria meningitidis Z2491 Length = 320 Score = 282 bits (722), Expect = 6e-76, Method: Compositional matrix adjust. Identities = 146/303 (48%), Positives = 200/303 (66%), Gaps = 2/303 (0%) Query: 6 ALSIQQLYEENRESLQLGWFAGFPGGERLISGDAVS-ASDQVGHLNLIHPGRLQVFGHQE 64 ++S+++L+++N+ LQL W AG G + I +A VGHLN IHP ++QV G E Sbjct: 3 SISVRRLFDDNQYKLQLAWAAGNSGADNRIGVEADKPVLALVGHLNFIHPNQIQVVGLAE 62 Query: 65 IEYYNRLSNTSRAYQTAELVAGEPPAFIIAQGLSTPPDLLAVCDEKNIPLFSTPLPAAQV 124 EY NRL + YQ +L I+A GL P L C + +IPL ++ L + + Sbjct: 63 SEYLNRLESGETGYQFGDLFDISMSLVIVANGLPVSPGLRDYCHKNDIPLLTSKLESPYL 122 Query: 125 IDYLRVYLSKKLAQQITMHGVFMDVLGVGVLITGESGLGKSELGLELISRSHGLVADDAV 184 +D LR+YL + LA HGVF+DV +GVLITG SGLGKSEL LELISR H L+ADDAV Sbjct: 123 MDVLRIYLQRTLAASSVKHGVFLDVFEIGVLITGHSGLGKSELALELISRGHSLIADDAV 182 Query: 185 EFARIAPNMIEGRCPPLLQNLLEVRGLGLLDIKAIFGETAVRRKMRLKLIVHLVRRST-L 243 E RI P +EGRC P+L++ LEVRGLG+L+I+ IFGET++R K L+LI++LV Sbjct: 183 ELFRIGPETLEGRCSPMLRDFLEVRGLGILNIRHIFGETSIRPKKILQLIINLVEADDEY 242 Query: 244 EENYERLPLDAQYEEVLGLPIRKVVIPVAAGRNIAVLLEAAVRNTILQLRGIDTLKEFIE 303 + +RL + + E +L + +R V +PVA GRN+AVL+EAAVRN ILQLRG D+ +EF+E Sbjct: 243 MKQLDRLSIRTETESILNVNVRSVTLPVAVGRNLAVLVEAAVRNYILQLRGKDSTREFLE 302 Query: 304 RQR 306 R + Sbjct: 303 RHQ 305 >XF1406 [T] COG1493 Serine kinase of the HPr protein, regulates carbohydrate metabolism Xfa Xylella fastidiosa 9a5c Length = 316 Score = 244 bits (622), Expect = 3e-64, Method: Compositional matrix adjust. Identities = 126/305 (41%), Positives = 196/305 (64%), Gaps = 4/305 (1%) Query: 5 SALSIQQLYEENRESLQLGWFAGFPGGERLI-SGDAVSASDQV-GHLNLIHPGRLQVFGH 62 ++++ ++L++ R+ L L W AG G R I SGD + + G+LN I+P ++Q+ G Sbjct: 3 TSITARELFDLQRDRLSLRWIAGQQGEHRQIDSGDTRARRPSLAGYLNTIYPNKVQILGT 62 Query: 63 QEIEYYNRLSNTSRAYQTAELVAGEPPAFIIAQGLSTPPDLLAVCDEKNIPLFSTPLPAA 122 +E+ + + L R +++ +P +I++ S P D+ D IPL+ +P Sbjct: 63 EELTWLDSLEPNKRKETIEKIIQFQPLTLVISKNQSCPEDMRTAADNSQIPLWVSPKRGH 122 Query: 123 QVIDYLRVYLSKKLAQQITMHGVFMDVLGVGVLITGESGLGKSELGLELISRSHGLVADD 182 +++++L +L++ LA + T+HGVFM++ +GVLITGE+G GKSEL LEL+SR H LVADD Sbjct: 123 ELLNHLSYHLARILAPRATLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADD 182 Query: 183 AVEFARIAPNMIEGRCPPLLQNLLEVRGLGLLDIKAIFGETAVRRKMRLKLIVHLVRRST 242 A EF +IAP++++G CP +LQ+LLEVRGLG+L+++ +FG+TA+++ L+LIVHL + T Sbjct: 183 APEFTQIAPDVLDGTCPEILQDLLEVRGLGVLNVRHMFGDTAIKKNKYLRLIVHLTKPIT 242 Query: 243 --LEENYERLPLDAQYEEVLGLPIRKVVIPVAAGRNIAVLLEAAVRNTILQLRGIDTLKE 300 YERL D+ VL L + + +PV GRN+AVL EAA R IL+ +GID Sbjct: 243 EPTPSGYERLTGDSGTRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPATM 302 Query: 301 FIERQ 305 FI R Sbjct: 303 FIARH 307 >SA0715 [T] COG1493 Serine kinase of the HPr protein, regulates carbohydrate metabolism Sau Staphylococcus aureus N315 Length = 310 Score = 191 bits (484), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 107/289 (37%), Positives = 169/289 (58%), Gaps = 3/289 (1%) Query: 18 ESLQLGWFAGFPGGERLISGDAVS--ASDQVGHLNLIHPGRLQVFGHQEIEYYNRLSNTS 75 E+L+L AG G + I +S + G+ + R+Q+ G E+ +YN L + Sbjct: 9 ETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKD 68 Query: 76 RAYQTAELVAGEPPAFIIAQGLSTPPDLLAVCDEKNIPLFSTPLPAAQVIDYLRVYLSKK 135 RA + +L E PA I+ +GL P +L+ E N PL ++ L +L Sbjct: 69 RAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHA 128 Query: 136 LAQQITMHGVFMDVLGVGVLITGESGLGKSELGLELISRSHGLVADDAVEFARIAPNMIE 195 LA+ ++HGV +DV GVGVLITG+SG+GKSE LEL+ R H LVADD VE +I + + Sbjct: 129 LAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELI 188 Query: 196 GRCPPLLQNLLEVRGLGLLDIKAIFGETAVRRKMRLKLIVHLVRRSTLEENYERLPLDAQ 255 G+ P L+++LLE+RGLG++++ +FG ++ + R++L ++L + ++ Y+R+ L+ + Sbjct: 189 GKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNK-QKLYDRVGLNEE 247 Query: 256 YEEVLGLPIRKVVIPVAAGRNIAVLLEAAVRNTILQLRGIDTLKEFIER 304 +L I K IPV GRN+AV++E A N L + GI+T +EF ER Sbjct: 248 TLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSER 296