BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.3750.p (345 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA0662 [E] COG0002 Acetylglutamate semialdehyde dehydrogenase Pa... 439 e-123 NMB1787 [E] COG0002 Acetylglutamate semialdehyde dehydrogenase N... 397 e-110 NMA0676 [E] COG0002 Acetylglutamate semialdehyde dehydrogenase N... 390 e-108 TM1782 [E] COG0002 Acetylglutamate semialdehyde dehydrogenase Tm... 313 3e-85 CAC2390 [E] COG0002 Acetylglutamate semialdehyde dehydrogenase C... 289 8e-78 >PA0662 [E] COG0002 Acetylglutamate semialdehyde dehydrogenase Pae Pseudomonas aeruginosa Length = 344 Score = 439 bits (1128), Expect = e-123, Method: Compositional matrix adjust. Identities = 217/347 (62%), Positives = 258/347 (74%), Gaps = 5/347 (1%) Query: 1 MIKVGIVGGTGYTGVELLRIFATHPQARVQAVTSRKEDGMPVAEMYPSLRGRVD-VAFSS 59 MIKVGIVGGTGYTGVELLR+ A HPQARV+ +TSR E G+ VA+MYP+LRG D + FS Sbjct: 1 MIKVGIVGGTGYTGVELLRLLAQHPQARVEVITSRSEAGVKVADMYPNLRGHYDDLQFSV 60 Query: 60 PDKAQLNDCDVVFFATPHGVAMAQAPELVAAGVKVIDLAADFRMQDVAAFEKWYKLPHSC 119 PD +L CDVVFFATPHGVA A A EL+ AG +VIDL+ADFR+ D + +WY PH Sbjct: 61 PDAQRLGACDVVFFATPHGVAHALAGELLDAGTRVIDLSADFRLADAEEWARWYGQPHGA 120 Query: 120 TELLKEAAYGLPELNREAIRKARVVGNPGCYPTTMQLGFAPLLKAGVIDASHLIADCKSG 179 LL EA YGLPE+NRE IR+AR++ PGCYPT QLG PLL+AG+ DAS LIADCKSG Sbjct: 121 PALLDEAVYGLPEVNREKIRQARLIAVPGCYPTATQLGLIPLLEAGLADASRLIADCKSG 180 Query: 180 VSGAGRKAELSLLFSEASDNFKAYGVSGHRHSPETIERLSHLTSDKVGLLFTPHLVPMIR 239 VSGAGR A++ LF EA ++ AY V GHRH PE + L + VGL F PHL PMIR Sbjct: 181 VSGAGRGAKVGSLFCEAGESMMAYAVKGHRHLPEISQGLRRASGGDVGLTFVPHLTPMIR 240 Query: 240 GMHSTLYARLT-RDIDNAALQALFEEAYKDEPFVDVLPFGSHPETRTTRASNMLRLAVHR 298 G+H+TLYA + R +D LQALFE+ Y DEPFVDV+P GSHPETR+ R +N+ R+AVHR Sbjct: 241 GIHATLYAHVADRSVD---LQALFEKRYADEPFVDVMPAGSHPETRSVRGANVCRIAVHR 297 Query: 299 PDNGDTVVVLVVQDNLVKGASGQAVQCMNLMFGLEETSGLQQVPVLP 345 P GD VVVL V DNLVKGASGQA+Q MN++FGL+E GL +LP Sbjct: 298 PQGGDLVVVLSVIDNLVKGASGQALQNMNILFGLDERLGLSHAALLP 344 >NMB1787 [E] COG0002 Acetylglutamate semialdehyde dehydrogenase Nme Neisseria meningitidis MC58 Length = 347 Score = 397 bits (1021), Expect = e-110, Method: Compositional matrix adjust. Identities = 192/346 (55%), Positives = 246/346 (71%), Gaps = 5/346 (1%) Query: 2 IKVGIVGGTGYTGVELLRIFATHPQARVQAVTSRKEDGMPVAEMYPSLRGRVDVAFSSPD 61 IKVGIVG TGYTGVELLR+ A HP V AVTSR E G VA+ +PSLRG +AF +PD Sbjct: 5 IKVGIVGATGYTGVELLRLLAAHPDVEVAAVTSRSEAGTAVADYFPSLRGVYGLAFQTPD 64 Query: 62 KAQLNDCDVVFFATPHGVAMAQAPELVAAGVKVIDLAADFRMQDVAAFEKWYKLPHSCTE 121 +A L CD+VFFATP+G+AM AP L+ GV+VIDL+ADFR++D+ +E WY + H+ + Sbjct: 65 EAGLEQCDIVFFATPNGIAMKDAPRLIEQGVRVIDLSADFRIRDIPTWEHWYGMTHAAPD 124 Query: 122 LLKEAAYGLPELNREAIRKARVVGNPGCYPTTMQLGFAPLLKAGVIDASH-LIADCKSGV 180 L+ +A YGL ELNREA+ +AR+V NPGCYPT + L PLL+ + LIADCKSGV Sbjct: 125 LVSQAVYGLSELNREAVAQARLVANPGCYPTCVSLPLVPLLRQCRLKPGMPLIADCKSGV 184 Query: 181 SGAGRKAELSLLFSEASDNFKAYGVSGHRHSPETIERLSHLTSDKV-GLLFTPHLVPMIR 239 SGAGRK + L EA DNFKAYG++GHRH PE + ++ L G +FTPHL PMIR Sbjct: 185 SGAGRKGNVGSLLCEAGDNFKAYGIAGHRHLPEIRQTIAGLQDGIAEGFVFTPHLAPMIR 244 Query: 240 GMHSTLYARLTRDIDNAALQALFEEAYKDEPFVDVLPFGSHPETRTTRASNMLRLAVHRP 299 GMH+T+Y L+ D + + + + Y+D PFVD+LP GS PETR+ R +N+ R+++ + Sbjct: 245 GMHATVYLHLS---DGSDPETVLRDYYRDSPFVDILPTGSAPETRSVRGANLCRISIQQA 301 Query: 300 DNGDTVVVLVVQDNLVKGASGQAVQCMNLMFGLEETSGLQQVPVLP 345 D VVL V DNLVKGA+GQAVQ MN+MFGLEET GL +P+LP Sbjct: 302 AQSDVWVVLSVIDNLVKGAAGQAVQNMNIMFGLEETHGLDAIPLLP 347 >NMA0676 [E] COG0002 Acetylglutamate semialdehyde dehydrogenase NmA Neisseria meningitidis Z2491 Length = 347 Score = 390 bits (1002), Expect = e-108, Method: Compositional matrix adjust. Identities = 189/346 (54%), Positives = 243/346 (70%), Gaps = 5/346 (1%) Query: 2 IKVGIVGGTGYTGVELLRIFATHPQARVQAVTSRKEDGMPVAEMYPSLRGRVDVAFSSPD 61 IKVGIVG TGYTGVELLR+ A HP V AVTSR E G VA+ +PSLRG +AF +PD Sbjct: 5 IKVGIVGATGYTGVELLRLLAAHPDVEVAAVTSRSEAGTAVADYFPSLRGVYGLAFQTPD 64 Query: 62 KAQLNDCDVVFFATPHGVAMAQAPELVAAGVKVIDLAADFRMQDVAAFEKWYKLPHSCTE 121 +A L CD+VFFATP+G+AM AP L+ GV+VIDL+ADFR++D+ +E WY + H+ + Sbjct: 65 EAGLEQCDIVFFATPNGIAMKDAPRLIEQGVRVIDLSADFRIRDIPTWEHWYGMTHAAPD 124 Query: 122 LLKEAAYGLPELNREAIRKARVVGNPGCYPTTMQLGFAPLLKAGVIDASH-LIADCKSGV 180 L+ +A YGL ELNREA+ +AR+V NPGCYPT + L PLL+ + LIADCKSGV Sbjct: 125 LVSQAVYGLSELNREAVAQARLVANPGCYPTCVSLPLVPLLRQCRLKPGMPLIADCKSGV 184 Query: 181 SGAGRKAELSLLFSEASDNFKAYGVSGHRHSPETIERLSHLTSDKV-GLLFTPHLVPMIR 239 SGAGRK + L E DNFKAYG++GHRH PE + ++ L G +FTPHL PMIR Sbjct: 185 SGAGRKGNVGSLLCEVGDNFKAYGIAGHRHLPEIRQTIAGLQDGIAEGFVFTPHLAPMIR 244 Query: 240 GMHSTLYARLTRDIDNAALQALFEEAYKDEPFVDVLPFGSHPETRTTRASNMLRLAVHRP 299 GMH+T+Y L+ D + + + Y+D FVD+LP GS PETR+ R +N+ R+++ + Sbjct: 245 GMHATVYLHLS---DGICPETILRDYYRDSLFVDILPAGSTPETRSVRGANLCRISIQQA 301 Query: 300 DNGDTVVVLVVQDNLVKGASGQAVQCMNLMFGLEETSGLQQVPVLP 345 D VVL V DNLVKGA+GQAVQ MN+MFGL+ET GL +P+LP Sbjct: 302 AQSDVWVVLSVIDNLVKGAAGQAVQNMNIMFGLKETHGLGAIPLLP 347 >TM1782 [E] COG0002 Acetylglutamate semialdehyde dehydrogenase Tma Thermotoga maritima Length = 339 Score = 313 bits (803), Expect = 3e-85, Method: Compositional matrix adjust. Identities = 155/345 (44%), Positives = 222/345 (64%), Gaps = 6/345 (1%) Query: 1 MIKVGIVGGTGYTGVELLRIFATHPQARVQAVTSRKEDGMPVAEMYPSLRGRVDVAFSSP 60 MI+ GI+G TGYTG+EL+R+ HP+A++ ++SR G + E++PS ++ P Sbjct: 1 MIRAGIIGATGYTGLELVRLLKNHPEAKITYLSSRTYAGKKLEEIFPSTLENSILSEFDP 60 Query: 61 DKAQLNDCDVVFFATPHGVAMAQAPELVAAGVKVIDLAADFRMQDVAAFEKWYKLPHSCT 120 +K N CDV+F A P G + EL GVK+IDL ADFR D + +WY S Sbjct: 61 EKVSKN-CDVLFTALPAGASYDLVREL--KGVKIIDLGADFRFDDPGVYREWYGKELSGY 117 Query: 121 ELLKEAAYGLPELNREAIRKARVVGNPGCYPTTMQLGFAPLLKAGVIDASHLIADCKSGV 180 E +K YGLPEL+RE I+ A+VVGNPGCYPT++ L AP LK ++D ++ D KSGV Sbjct: 118 ENIKRV-YGLPELHREEIKNAQVVGNPGCYPTSVILALAPALKHNLVDPETILVDAKSGV 176 Query: 181 SGAGRKAELSLLFSEASDNFKAYGVSGHRHSPETIERLSHLTSDKVGLLFTPHLVPMIRG 240 SGAGRK ++ LFSE +++ + Y V+ HRH PE + L ++ KV ++FTPHLVPM RG Sbjct: 177 SGAGRKEKVDYLFSEVNESLRPYNVAKHRHVPEMEQELGKISGKKVNVVFTPHLVPMTRG 236 Query: 241 MHSTLYARLTRDIDNAALQALFEEAYKDEPFVDVLPFGSHPETRTTRASNMLRLAVHRPD 300 + ST+Y + + ++ + + E YK+EPFV VLP G +P T+ SN + + + + Sbjct: 237 ILSTIYVKTDKSLEE--IHEAYLEFYKNEPFVHVLPMGIYPSTKWCYGSNHVFIGMQMEE 294 Query: 301 NGDTVVVLVVQDNLVKGASGQAVQCMNLMFGLEETSGLQQVPVLP 345 +T++++ DNLVKGASGQAVQ MN+MFGL+ET GL+ P+ P Sbjct: 295 RTNTLILMSAIDNLVKGASGQAVQNMNIMFGLDETKGLEFTPIYP 339 >CAC2390 [E] COG0002 Acetylglutamate semialdehyde dehydrogenase Cac Clostridium acetobutylicum Length = 345 Score = 289 bits (739), Expect = 8e-78, Method: Compositional matrix adjust. Identities = 137/347 (39%), Positives = 208/347 (59%), Gaps = 4/347 (1%) Query: 1 MIKVGIVGGTGYTGVELLRIFATHPQARVQAVTSRKEDGMPVAEMYPSLRGRVDVAFSSP 60 MI+ GI+G TGY G L + HP + + S Y + ++ Sbjct: 1 MIQAGIIGATGYAGEVLTWLLNNHPNVNLVFLASHSHGNSSFNSTYGNFTNVIENLCIDD 60 Query: 61 DKAQ--LNDCDVVFFATPHGVAMAQAPELVAAGVKVIDLAADFRMQDVAAFEKWYKLPHS 118 ++ + L++ D++F A P G + + V VKVIDL AD+R++ +++WY + H Sbjct: 61 NEVEDNLDNIDILFTALPSGKTFSIVKKAVEEKVKVIDLGADYRLKSAEVYKEWYNINHE 120 Query: 119 CTELLKEAAYGLPELNREAIRKARVVGNPGCYPTTMQLGFAPLLKAGVIDASHLIADCKS 178 C +LLK+A YGL E+ RE I+ + ++ NPGCYPT L PLLK +ID S +I D KS Sbjct: 121 CKKLLKDAVYGLSEIYREKIKTSNLIANPGCYPTASSLALIPLLKNNLIDTSSIIIDAKS 180 Query: 179 GVSGAGRKAELSLLFSEASDNFKAYGVSGHRHSPETIERLSHLTSDKVGLLFTPHLVPMI 238 GVSGAGRKA + LF E +D+ KAYGV+ HRH+PE + L++ +K+ L FTPHLVPM Sbjct: 181 GVSGAGRKASTNNLFIECNDSIKAYGVASHRHTPEIEQTLTNEAKEKITLTFTPHLVPMN 240 Query: 239 RGMHSTLYARLTRDIDNAALQALFEEAYKDEPFVDVLPFGSHPETRTTRASNMLRLAVHR 298 RG+ S Y+ L ++I+ + ++++ YK+EPF+ ++ + PETR + SN +A+ Sbjct: 241 RGILSVCYSNLKKEIELNEVYDIYKKFYKNEPFIRII--DTLPETRWVKGSNYCDIAIRI 298 Query: 299 PDNGDTVVVLVVQDNLVKGASGQAVQCMNLMFGLEETSGLQQVPVLP 345 + ++VL DNL+KGA+ QAVQ MN+M+GL E +G+ P+ P Sbjct: 299 DKRTNKIIVLSAIDNLMKGAASQAVQNMNIMYGLAEKTGIDLTPMFP 345