BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.3745.p (279 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA3975 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidi... 150 3e-36 PH1155_1 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimi... 99 1e-20 ZthiD [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidin... 97 3e-20 ECs2906 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimid... 97 3e-20 thiD [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine... 97 3e-20 >PA3975 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Pae Pseudomonas aeruginosa Length = 265 Score = 150 bits (379), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 92/257 (35%), Positives = 139/257 (54%), Gaps = 7/257 (2%) Query: 7 PLILTFGAADPVGATGVQADLATFAAMGCHGLSVVTALLIGDTARVEDVQVVEVDWVADQ 66 P++L DP G G+QAD+ A GCH VTAL + DT V D +V++ +WV Q Sbjct: 8 PVVLCLSGHDPSGGAGLQADIEALLAQGCHAAPAVTALTVQDTVNVSDFRVLDREWVLAQ 67 Query: 67 ARVILEDMAVSAFKVGALGSIENISVIAEIVSDYPDVPLILDPFIS-ALANQEDEDDRLI 125 A +L D+ V+A K+G LGS+E + +AEI++ +P +P++ DP + + D Sbjct: 68 ANAVLADLPVAAVKLGMLGSLEMVDTVAEILAAHPHLPVVCDPVLRAGGGGALGKGDVGF 127 Query: 126 AIRELLIPQATVLVCSAGELTRLAETWREPALGDTLMLDAMRIIELGCEYLLVTNTQTDL 185 A+RE L+P+AT+ + E LA+ A D A R++E CE+LL+T D Sbjct: 128 AMRERLLPRATIATPNLPEARLLADLPEGSA--DQC---AERLLE-HCEHLLITGGHGDE 181 Query: 186 QEVANSLFDESGLVRQDAWPRLPGSFVGAGTTLSAAMAAMLANDLEAPLAASEAQEFTLA 245 EV N L+ G R RLPGS+ G+G TL++A+A +A A A ++T Sbjct: 182 SEVHNRLYSRDGSRRTFTCQRLPGSYHGSGCTLASALAGRIALGEALHGAVQSALDYTWR 241 Query: 246 ALANAQRIGMGKLLPDR 262 L +A+ G G+ +P R Sbjct: 242 TLRDAESPGHGQYVPRR 258 >PH1155_1 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Pho Pyrococcus horikoshii Length = 260 Score = 98.6 bits (244), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 75/240 (31%), Positives = 123/240 (51%), Gaps = 12/240 (5%) Query: 23 VQADLATFAAMGCHGLSVVTALLIGDTARVEDVQVVEVDWVADQARVILEDMAVSAFKVG 82 ++ADL TF A G HGL +T++ +T V + + + V++Q RV+ ED+ V A K G Sbjct: 21 IEADLKTFTAFGVHGLVAITSVTAQNTQTVTAIHDIPPEVVSEQIRVVAEDIGVDAAKTG 80 Query: 83 ALGSIENISVIAEIVSDYPDVPLILDPFISALAN----QEDEDDRLIAIRELLIPQATVL 138 L + E I +A+ V +Y D PL++DP + A + +ED D LI + ++P AT++ Sbjct: 81 MLSNAEIIKAVAKTVKNY-DFPLVVDPVMIAKSGAPLLREDAVDALI---KYILPLATLV 136 Query: 139 VCSAGELTRLAETWREPALGDTLMLDAMRII-ELGCEYLLVTNTQTDLQEVANSLFDESG 197 + E +L T E + L A +I E G + ++V + +E + L+ +G Sbjct: 137 TPNRFEAEKL--TGMEIRNVNDAKLAAKKIAEETGAKAVIVKGGHLEGKEAIDVLY-HNG 193 Query: 198 LVRQDAWPRLPGSFVGAGTTLSAAMAAMLANDLEAPLAASEAQEFTLAALANAQRIGMGK 257 + P++ G G G + SAA+ A LA L A S A+EF ++ +IG G Sbjct: 194 AYKLYRAPKVDGCTHGTGCSFSAAITANLAKGLSLEDAVSVAKEFITLGISTGHKIGHGH 253 >ZthiD [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase EcZ Escherichia coli O157:H7 EDL933 Length = 266 Score = 97.4 bits (241), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 80/263 (30%), Positives = 130/263 (49%), Gaps = 11/263 (4%) Query: 10 LTFGAADPVGATGVQADLATFAAMGCHGLSVVTALLIGDTARVEDVQVVEVDWVADQARV 69 LT DP G G+QADL TF+A+G +G SV+TAL+ +T V+ V +E D+VA Q Sbjct: 7 LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66 Query: 70 ILEDMAVSAFKVGALGSIENISVIAEIVSDYPDVPLILDPFISALANQED---EDDRLIA 126 + D+ + K+G L + + +AE + Y ++LD + LA D + Sbjct: 67 VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVM--LAKSGDPLLSPSAVAT 124 Query: 127 IRELLIPQATVLVCSAGELTRLAETWREPALGDTLMLDAMR-IIELGCEYLLVTNTQTDL 185 +R L+PQ +++ + E L + A + ML+ R ++ +GC +L+ D Sbjct: 125 LRSRLLPQVSLITPNLPEAAALLDA--PHARTEQEMLEQGRALLAMGCGAVLMKGGHLDD 182 Query: 186 QEVANSLFDESGLVRQDAWPR-LPGSFVGAGTTLSAAMAAMLANDLEAPLAASEAQEFTL 244 ++ + LF G R A PR + + G G TLSAA+AA+ EA+ + Sbjct: 183 EQSPDWLFTREGEQRFTA-PRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241 Query: 245 AALANAQRIGMGK-LLPDRYFWA 266 +ALA A + +G + P +F A Sbjct: 242 SALAQADTLEVGHGIGPVHHFHA 264 >ECs2906 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Ecs Escherichia coli O157:H7 Length = 266 Score = 97.4 bits (241), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 80/263 (30%), Positives = 130/263 (49%), Gaps = 11/263 (4%) Query: 10 LTFGAADPVGATGVQADLATFAAMGCHGLSVVTALLIGDTARVEDVQVVEVDWVADQARV 69 LT DP G G+QADL TF+A+G +G SV+TAL+ +T V+ V +E D+VA Q Sbjct: 7 LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66 Query: 70 ILEDMAVSAFKVGALGSIENISVIAEIVSDYPDVPLILDPFISALANQED---EDDRLIA 126 + D+ + K+G L + + +AE + Y ++LD + LA D + Sbjct: 67 VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVM--LAKSGDPLLSPSAVAT 124 Query: 127 IRELLIPQATVLVCSAGELTRLAETWREPALGDTLMLDAMR-IIELGCEYLLVTNTQTDL 185 +R L+PQ +++ + E L + A + ML+ R ++ +GC +L+ D Sbjct: 125 LRSRLLPQVSLITPNLPEAAALLDA--PHARTEQEMLEQGRALLAMGCGAVLMKGGHLDD 182 Query: 186 QEVANSLFDESGLVRQDAWPR-LPGSFVGAGTTLSAAMAAMLANDLEAPLAASEAQEFTL 244 ++ + LF G R A PR + + G G TLSAA+AA+ EA+ + Sbjct: 183 EQSPDWLFTREGEQRFTA-PRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241 Query: 245 AALANAQRIGMGK-LLPDRYFWA 266 +ALA A + +G + P +F A Sbjct: 242 SALAQADTLEVGHGIGPVHHFHA 264 >thiD [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Eco Escherichia coli K12 Length = 266 Score = 97.4 bits (241), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 80/263 (30%), Positives = 130/263 (49%), Gaps = 11/263 (4%) Query: 10 LTFGAADPVGATGVQADLATFAAMGCHGLSVVTALLIGDTARVEDVQVVEVDWVADQARV 69 LT DP G G+QADL TF+A+G +G SV+TAL+ +T V+ V +E D+VA Q Sbjct: 7 LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66 Query: 70 ILEDMAVSAFKVGALGSIENISVIAEIVSDYPDVPLILDPFISALANQED---EDDRLIA 126 + D+ + K+G L + + +AE + Y ++LD + LA D + Sbjct: 67 VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVM--LAKSGDPLLSPSAVAT 124 Query: 127 IRELLIPQATVLVCSAGELTRLAETWREPALGDTLMLDAMR-IIELGCEYLLVTNTQTDL 185 +R L+PQ +++ + E L + A + ML+ R ++ +GC +L+ D Sbjct: 125 LRSRLLPQVSLITPNLPEAAALLDA--PHARTEQEMLEQGRSLLAMGCGAVLMKGGHLDD 182 Query: 186 QEVANSLFDESGLVRQDAWPR-LPGSFVGAGTTLSAAMAAMLANDLEAPLAASEAQEFTL 244 ++ + LF G R A PR + + G G TLSAA+AA+ EA+ + Sbjct: 183 EQSPDWLFTREGEQRFTA-PRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLS 241 Query: 245 AALANAQRIGMGK-LLPDRYFWA 266 +ALA A + +G + P +F A Sbjct: 242 SALAQADTLEVGHGIGPVHHFHA 264