BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.3739.p (305 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2225 [GER] COG0697 Permeases of the drug/metabolite transport... 250 3e-66 NMA1785 [GER] COG0697 Permeases of the drug/metabolite transport... 149 6e-36 NMB1593 [GER] COG0697 Permeases of the drug/metabolite transport... 146 6e-35 PA2628 [GER] COG0697 Permeases of the drug/metabolite transporte... 102 1e-21 SMc02371 [GER] COG0697 Permeases of the drug/metabolite transpor... 96 2e-19 >RSc2225 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Rso Ralstonia solanacearum Length = 324 Score = 250 bits (638), Expect = 3e-66, Method: Compositional matrix adjust. Identities = 141/305 (46%), Positives = 195/305 (63%), Gaps = 6/305 (1%) Query: 2 QSLWMLVASFLFAVMGVCVKLAGSYYTTSEIVLCRGVIGVLFILGLIRLRGGTLRTPFPR 61 QSLWM++A+F F+ MGVCVKLA ++Y+T EIV R +IGV + ++ G +RTP Sbjct: 19 QSLWMVLAAFAFSAMGVCVKLASAHYSTGEIVFYRSLIGVALMGAVLYHTGAGVRTPHFA 78 Query: 62 DHFIRGGVGVISLWMWFYSFSLLPVATATTLNYMSSIWIAVMLFAAGWWQGNK-KFEWGL 120 H R GV SL +WF S SLLP+ATA TLNYMS +WIA+++ A G + + Sbjct: 79 SHIKRSVFGVTSLLLWFSSISLLPLATAMTLNYMSPVWIALIIGAGATLAGKAGGADRKM 138 Query: 121 AGTVALSFVGVALLMRPSLNAEQLLGGAISLASGVLSALVYLQVRKLGLLGEPEYRVVFY 180 + +SFVGV L++PS+ Q+ GG I L SGV +AL Y++VR+LG LGE E R+VFY Sbjct: 139 VTAILMSFVGVICLLQPSVGPSQMTGGMIGLVSGVFTALAYVEVRQLGDLGENEARIVFY 198 Query: 181 FSATGVLAGLIGSVVTGRVPLWHSHSWLGVLLVVMIGLTATTAQIAMTRAYRLGNTLVTA 240 FS +AG ++ G H+H+W L+V +GL AT Q AMTRAY+ GNTL+TA Sbjct: 199 FSLVSSIAGGAWMLIAGA----HAHTWQSAWLLVAVGLLATLGQTAMTRAYKRGNTLLTA 254 Query: 241 NLQYTGIVFSSLFGVLIWNDAPGWIGWLGMAVILASGMLATYRNQKQTQAEARNVPKVDP 300 NLQYTGIVF+S +G+L+W+D + W+GMA+I+ SG++ T +Q+ A P+ Sbjct: 255 NLQYTGIVFASGWGMLLWHDHLNALSWMGMALIIGSGIVTTVMRARQS-GVAHPTPQTAV 313 Query: 301 IATEA 305 EA Sbjct: 314 SGPEA 318 >NMA1785 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily NmA Neisseria meningitidis Z2491 Length = 300 Score = 149 bits (377), Expect = 6e-36, Method: Compositional matrix adjust. Identities = 102/287 (35%), Positives = 155/287 (54%), Gaps = 10/287 (3%) Query: 5 WMLVASFLFAVMGVCVKLAGSYYT--TSEIVLCRGVIGVLFILGLIRLRGGTLRTPFPRD 62 WMLVA+ F +M V +K A + + + E+V R + + + LR T RTP ++ Sbjct: 13 WMLVAAACFTIMNVLIKEASAKFALGSGELVFWRMLFSTVALGAAAVLRRDTFRTPHWKN 72 Query: 63 HFIRGGVGVISLWMWFYSFSLLPVATATTLNYMSSIWIAVMLFAAGWWQGNKKFEWGLAG 122 H R VG ++ + FY+ + LP+AT TL+Y SSI++AV F ++ Sbjct: 73 HLNRSMVGTGAMLLLFYAVTHLPLATGVTLSYTSSIFLAVFSFLIL----KERISVYTQA 128 Query: 123 TVALSFVGVALLMRPSLNAEQLLGGAISLASGVLSALVYLQVRKLGLLGEPEYRVVFYFS 182 + L F GV LL+ PS + Q LA G +S YL+VR+L L GEP +RVVFY S Sbjct: 129 VLLLGFAGVVLLLNPSFRSGQETAALAGLAGGAMSGWAYLKVRELSLAGEPGWRVVFYLS 188 Query: 183 ATGVLAGLIGSVVTGRVPLWHSHSWLGVLLVVMIGLTATTAQIAMTRAYRLGNTLVTANL 242 TGV + + +TG WH+ S+ + + IG++A AQ++MTRAY++G+ A+L Sbjct: 189 VTGVAMSSVWATLTG----WHTLSFPSAVYLSCIGVSALIAQLSMTRAYKVGDKFTVASL 244 Query: 243 QYTGIVFSSLFGVLIWNDAPGWIGWLGMAVILASGMLATYRNQKQTQ 289 Y +VFS+L + W LGM +I+ SG+L++ R Q Sbjct: 245 SYMTVVFSALSAAFFLAEELFWQEILGMCIIILSGILSSIRPTAFKQ 291 >NMB1593 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Nme Neisseria meningitidis MC58 Length = 287 Score = 146 bits (368), Expect = 6e-35, Method: Compositional matrix adjust. Identities = 101/286 (35%), Positives = 154/286 (53%), Gaps = 10/286 (3%) Query: 6 MLVASFLFAVMGVCVKLAGSYYT--TSEIVLCRGVIGVLFILGLIRLRGGTLRTPFPRDH 63 MLVA+ F +M V +K A + + + E+V R + + + LR T RTP ++H Sbjct: 1 MLVAAACFTIMNVLIKEASAKFALGSGELVFWRMLFSTVALGAAAVLRRDTFRTPHWKNH 60 Query: 64 FIRGGVGVISLWMWFYSFSLLPVATATTLNYMSSIWIAVMLFAAGWWQGNKKFEWGLAGT 123 R VG ++ + FY+ + LP+AT TL+Y SSI++AV F ++ Sbjct: 61 LNRSMVGTGAMLLLFYAVTHLPLATGVTLSYTSSIFLAVFSFLIL----KERISVYTQAV 116 Query: 124 VALSFVGVALLMRPSLNAEQLLGGAISLASGVLSALVYLQVRKLGLLGEPEYRVVFYFSA 183 + L F GV LL+ PS + Q LA G +S YL+VR+L L GEP +RVVFY S Sbjct: 117 LLLGFAGVVLLLNPSFRSGQETAALAGLAGGAMSGWAYLKVRELSLAGEPGWRVVFYLSV 176 Query: 184 TGVLAGLIGSVVTGRVPLWHSHSWLGVLLVVMIGLTATTAQIAMTRAYRLGNTLVTANLQ 243 TGV + + +TG WH+ S+ + + IG++A AQ++MTRAY++G+ A+L Sbjct: 177 TGVAMSSVWATLTG----WHTLSFPSAVYLSCIGVSALIAQLSMTRAYKVGDKFTVASLS 232 Query: 244 YTGIVFSSLFGVLIWNDAPGWIGWLGMAVILASGMLATYRNQKQTQ 289 Y +VFS+L + W LGM +I+ SG+L++ R Q Sbjct: 233 YMTVVFSALSAAFFLGEELFWQEILGMCIIILSGILSSIRPTAFKQ 278 >PA2628 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Pae Pseudomonas aeruginosa Length = 296 Score = 102 bits (254), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 83/288 (28%), Positives = 146/288 (50%), Gaps = 18/288 (6%) Query: 8 VASFLFAVMGVCVKLAGSYYTTSEIVLCRGVIGVLFILGLIRLRG-GTLRTPFPRDHFIR 66 +++ FA+MG ++ A S +V R ++GVLF L L RG G LRT P H +R Sbjct: 23 LSALFFALMGGLIREASSTVNNETVVFFRNLVGVLFFLPLALTRGIGPLRTRRPLSHLLR 82 Query: 67 GGVGVISLWMWFYSFSLLPVATATTLNYMSSIWIAVMLFAAGWWQGNKKFEWGLAGTVAL 126 G+ ++ +FY+ + LP+ A +Y + ++ ++ A W + T+ + Sbjct: 83 TTYGLGGMYCYFYALAHLPLTDAMLFSYAAPVFTPLI---AHLWIKEPLTRRMMVATL-V 138 Query: 127 SFVGVALLMRPSLNAEQLLGGAISLASGVLSALVYLQVRKLGLLGEPEYRVVFYFSATGV 186 F+GV L+ RPS A + +AS +++A ++ +R++ EP YR+VFYF+ Sbjct: 139 GFLGVLLVARPS-GAVVAPIALVGIASSLMAACAFVSIREMSD-SEPAYRIVFYFA---- 192 Query: 187 LAGLIGSVVTGRVPL---WHSHSWLGVLLVVMIGLTATTAQIAMTRAYRLGNTLVTANLQ 243 L G++ + VPL W + +LL++ GL A+ Q+ M++AY L + V + Sbjct: 193 ---LFGTLFSA-VPLAWAWQPLNGQELLLLLGAGLFASLGQLTMSQAYALASPGVIGPIA 248 Query: 244 YTGIVFSSLFGVLIWNDAPGWIGWLGMAVILASGMLATYRNQKQTQAE 291 Y IVF+ + L W++ P LG A+I A+ ++ N+ + Sbjct: 249 YMAIVFAGVIAWLRWDELPSHTSLLGAALIFAASLIPLLGNRPAERPR 296 >SMc02371 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Sme Sinorhizobium meliloti Length = 312 Score = 95.5 bits (236), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 77/284 (27%), Positives = 126/284 (44%), Gaps = 17/284 (5%) Query: 12 LFAVMGVCVKLAGSYYTTSEIVLCRGVIGVLFILGLIRLRGG---TLRTPFPRDHFIRGG 68 +F M C+K AG T +I R ++ ILG + RG RT H +RG Sbjct: 21 VFVCMSTCIKAAGDDIPTGQITFYRSAFAMVPILGFLACRGALRDAFRTTDITGHLVRGF 80 Query: 69 VGVISLWMWFYSFSLLPVATATTLNYMSSIWIAVMLFAAGWWQGNKKFEW-----GLAGT 123 VG++++ FY LP+ A + Y + +AV A + + + W GLAG Sbjct: 81 VGILAMSCGFYGLVHLPLPEAIAIGYAMPL-LAVAFAAIFLGEIVRLYRWSAVFVGLAGV 139 Query: 124 VALSFVGVALLMRPSLNAEQLLGGAISLASGVLSALVYLQVRKLGLLGEPEYRVVFYFSA 183 +++ + L + + +G L S L A + VRKL + E + +V YFS Sbjct: 140 FIITWPRLTLFNEGGFGSAEAMGAVAVLLSAALGATAMVLVRKL-VQKERTHTIVLYFS- 197 Query: 184 TGVLAGLIGSVVTGRVPL-WHSHSWLGVLLVVMIGLTATTAQIAMTRAYRLGNTLVTANL 242 L+ + S+ T +P W SW +L+ + G QI +T +YR + A Sbjct: 198 ---LSAAVFSLAT--LPFGWSELSWQAFVLLTIAGFCGGVGQILLTESYRHADMSTIAPF 252 Query: 243 QYTGIVFSSLFGVLIWNDAPGWIGWLGMAVILASGMLATYRNQK 286 +YT IV + G ++ D P G A+++ +G+ YR + Sbjct: 253 EYTSIVLGIVIGYFLFGDVPTATMLAGTAIVVGAGIFIIYREHR 296