BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.3722.p (256 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value aq_1716 [IQR] COG1028 Dehydrogenases with different specificitie... 199 4e-51 TM1724 [IQR] COG1028 Dehydrogenases with different specificities... 181 2e-45 lin1921 [IQR] COG1028 Dehydrogenases with different specificitie... 178 1e-44 CAC3574 [IQR] COG1028 Dehydrogenases with different specificitie... 177 2e-44 AGl126 [IQR] COG1028 Dehydrogenases with different specificities... 177 2e-44 >aq_1716 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Aae Aquifex aeolicus Length = 248 Score = 199 bits (507), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 102/242 (42%), Positives = 154/242 (63%), Gaps = 2/242 (0%) Query: 9 RVALVTGGAMGIGASISQQLAARGHTVLVADINLEAAASTAQALVAA-GHRAAPVQMDLG 67 +V+LVTG GIG +I+++LA+ G TV++ + E A + A+ + G +A V+M+L Sbjct: 8 KVSLVTGSTRGIGRAIAEKLASAGSTVIITGTSGERAKAVAEEIANKYGVKAHGVEMNLL 67 Query: 68 SADSIASAFADIEKDHGRCDVLVNNAGVARTYCFLDYPLENWLLTMNVNVTGVMLAGQHA 127 S +SI AF +I D+LVNNAG+ R FL L +W + VN+TG L Q++ Sbjct: 68 SEESINKAFEEIYNLVDGIDILVNNAGITRDKLFLRMSLLDWEEVLKVNLTGTFLVTQNS 127 Query: 128 ARLMVKQRWGRIVNISSISGLRAGAGRTAYGTSKAAVIALTRQMAIELAQHGITVNSVAP 187 R M+KQRWGRIVNISS+ G G+ Y T+KA +I T+ +A ELA + VN+VAP Sbjct: 128 LRKMIKQRWGRIVNISSVVGFTGNVGQVNYSTTKAGLIGFTKSLAKELAPRNVLVNAVAP 187 Query: 188 GPVETQMTQAMHSEQTRESYYRLVPMHRYGTTDEIASAVCYLAADESSYITGHVLPVDGG 247 G +ET MT A+ SE+ ++ Y +P+ R+G+ +E+A+ V +L ++ +SYITG V+ V+GG Sbjct: 188 GFIETDMT-AVLSEEIKQKYKEQIPLGRFGSPEEVANVVLFLCSELASYITGEVIHVNGG 246 Query: 248 FM 249 Sbjct: 247 MF 248 >TM1724 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Tma Thermotoga maritima Length = 246 Score = 181 bits (458), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 94/241 (39%), Positives = 138/241 (57%), Gaps = 1/241 (0%) Query: 9 RVALVTGGAMGIGASISQQLAARGHTVLVADINLEAAASTAQALVAAGHRAAPVQMDLGS 68 +V L+TG A GIG + + A G TV+ DI+ E S + + P +++ Sbjct: 6 KVCLITGAASGIGKATTLLFAQEGATVIAGDISKENLDSLVKEAEGLPGKVDPYVLNVTD 65 Query: 69 ADSIASAFADIEKDHGRCDVLVNNAGVARTYCFLDYPLENWLLTMNVNVTGVMLAGQHAA 128 D I + + +GR DVLVNNAG+ R + E+W +NVN+ GV Q Sbjct: 66 RDQIKEVVEKVVQKYGRIDVLVNNAGITRDALLVRMKEEDWDAVINVNLKGVFNVTQMVV 125 Query: 129 RLMVKQRWGRIVNISSISGLRAGAGRTAYGTSKAAVIALTRQMAIELAQHGITVNSVAPG 188 M+KQR G IVN+SS+ G+ G+T Y SKA VI +T+ A ELA I VN+VAPG Sbjct: 126 PYMIKQRNGSIVNVSSVVGIYGNPGQTNYAASKAGVIGMTKTWAKELAGRNIRVNAVAPG 185 Query: 189 PVETQMTQAMHSEQTRESYYRLVPMHRYGTTDEIASAVCYLAADESSYITGHVLPVDGGF 248 +ET MT+ + E+ RE+ +P+ R+G +E+A + +LA+DESSY+TG V+ +DGG Sbjct: 186 FIETPMTEKL-PEKARETALSRIPLGRFGKPEEVAQVILFLASDESSYVTGQVIGIDGGL 244 Query: 249 M 249 + Sbjct: 245 V 245 >lin1921 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Lin Listeria innocua Length = 247 Score = 178 bits (451), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 96/242 (39%), Positives = 147/242 (60%), Gaps = 2/242 (0%) Query: 9 RVALVTGGAMGIGASISQQLAARGHTVLVA-DINLEAAASTAQALVAAGHRAAPVQMDLG 67 +VA+VTGG+ GIG I+ +LA G + + + EAA TA+ + G ++ ++ Sbjct: 6 KVAVVTGGSRGIGRDIAIKLAKEGANIFFNYNGSPEAAEETAKLVAEHGVEVEAMKANVA 65 Query: 68 SADSIASAFADIEKDHGRCDVLVNNAGVARTYCFLDYPLENWLLTMNVNVTGVMLAGQHA 127 A+ + + F + GR D+LVNNAG+ R + + W +N+N+ G L + Sbjct: 66 IAEDVDAFFKQAIERFGRIDILVNNAGITRDNLLMRMKEDEWDDVININLKGTFLCTKAV 125 Query: 128 ARLMVKQRWGRIVNISSISGLRAGAGRTAYGTSKAAVIALTRQMAIELAQHGITVNSVAP 187 +R M+KQR G+I+N++S+ GL AG+ Y SKA VI LT+ A ELA GI VN+VAP Sbjct: 126 SRTMMKQRAGKIINMASVVGLIGNAGQANYVASKAGVIGLTKTTARELAPRGINVNAVAP 185 Query: 188 GPVETQMTQAMHSEQTRESYYRLVPMHRYGTTDEIASAVCYLAADESSYITGHVLPVDGG 247 G + T+MT + ++T+E+ +P+ YGTT++IA+AV +LA+D S YITG L VDGG Sbjct: 186 GFITTEMTDKLD-DKTKEAMLAQIPLGAYGTTEDIANAVLFLASDASKYITGQTLSVDGG 244 Query: 248 FM 249 + Sbjct: 245 MV 246 >CAC3574 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cac Clostridium acetobutylicum Length = 249 Score = 177 bits (449), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 93/245 (37%), Positives = 150/245 (61%), Gaps = 8/245 (3%) Query: 9 RVALVTGGAMGIGASISQQLAARGHTVLVADINLEAAASTAQALVAA----GHRAAPVQM 64 +VA+VTG G+G +I+ +LAA G ++V N ++ + Q L+ G +A V+ Sbjct: 8 KVAVVTGAGRGLGRAIALKLAAEGANLVV---NYRSSEAETQKLIKEIEELGSKAVAVKA 64 Query: 65 DLGSADSIASAFADIEKDHGRCDVLVNNAGVARTYCFLDYPLENWLLTMNVNVTGVMLAG 124 D+ D + ++G D+LVNNAG+ + L E++ +NVN+ G Sbjct: 65 DISKYDEAETIIKKALDEYGTVDILVNNAGITKDNLLLRMKEEDFDSVINVNLKGAFNCI 124 Query: 125 QHAARLMVKQRWGRIVNISSISGLRAGAGRTAYGTSKAAVIALTRQMAIELAQHGITVNS 184 +H +R+M+K++ G+I+NISS+ GL AG+ Y +KA +I +T+ +A ELA GITVN+ Sbjct: 125 KHTSRVMLKKKSGKIINISSVIGLIGNAGQVNYAAAKAGIIGMTKSVAKELASRGITVNA 184 Query: 185 VAPGPVETQMTQAMHSEQTRESYYRLVPMHRYGTTDEIASAVCYLAADESSYITGHVLPV 244 VAPG +++ MT A+ +Q RES VP+++ G +++A+ V +LA+D SSYITG V+ V Sbjct: 185 VAPGIIKSDMTDALTDKQ-RESIVAAVPLNKVGEAEDVANLVLFLASDLSSYITGQVINV 243 Query: 245 DGGFM 249 DGG + Sbjct: 244 DGGMV 248 >AGl126 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 259 Score = 177 bits (448), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 111/259 (42%), Positives = 153/259 (59%), Gaps = 8/259 (3%) Query: 1 MNQHDSGARVAL-VTGGAMGIGASISQQLAARGHTVLVADINLEAAASTAQALVAAGHRA 59 M +G + A+ +TGGA GIG S +Q L ARG + D+ EA + L R Sbjct: 1 MTHEKTGTKGAVAITGGASGIGFSTAQLLMARGWQPWLLDLKREALDIACEKLGIDLWRG 60 Query: 60 APVQMDLGSADSIASAFADIEK---DHGRCDV-LVNNAGVARTYCFLDYPLENWLLTMNV 115 + D+ SI AFA + DH V +VN+AG+ +D +E + ++V Sbjct: 61 --IVCDVADEASIEMAFAALTANGADHAVDLVAVVNSAGIGIDKLSVDTSVEEFRRIVDV 118 Query: 116 NVTGVMLAGQHAARLMVKQRW-GRIVNISSISGLRAGAGRTAYGTSKAAVIALTRQMAIE 174 N+ G + AAR +++ G IVNISS+SG+ GR+AYG SK V LT MA E Sbjct: 119 NLVGSFAVARAAARYWLERDVAGSIVNISSVSGMCGNRGRSAYGASKGGVNLLTMVMANE 178 Query: 175 LAQHGITVNSVAPGPVETQMTQAMHSEQTRESYYRLVPMHRYGTTDEIASAVCYLAADES 234 L Q GI VN++APGPV+T +TQA+H+E R+ ++ VPMHRYG TDEIASAV +L +D++ Sbjct: 179 LGQSGIRVNAIAPGPVDTPLTQAVHTENVRDQWHSRVPMHRYGRTDEIASAVAFLVSDDA 238 Query: 235 SYITGHVLPVDGGFMAGGV 253 SYI G VL VDGGF+ G+ Sbjct: 239 SYINGQVLAVDGGFITAGL 257