BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.3713.p (270 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2684 [E] COG0345 Pyrroline-5-carboxylate reductase Rso Ralsto... 284 1e-76 PA0393 [E] COG0345 Pyrroline-5-carboxylate reductase Pae Pseudom... 221 1e-57 NMA0215 [E] COG0345 Pyrroline-5-carboxylate reductase NmA Neisse... 200 2e-51 NMB0055 [E] COG0345 Pyrroline-5-carboxylate reductase Nme Neisse... 195 9e-50 HI0307 [E] COG0345 Pyrroline-5-carboxylate reductase Hin Haemoph... 181 2e-45 >RSc2684 [E] COG0345 Pyrroline-5-carboxylate reductase Rso Ralstonia solanacearum Length = 274 Score = 284 bits (727), Expect = 1e-76, Method: Compositional matrix adjust. Identities = 149/269 (55%), Positives = 186/269 (69%) Query: 1 VKIAFIGGGNMASALIGGLVGKVAAAQDIHVVDLNADALQSLQDKFGVATAQTIDGAIAS 60 +K FIGGGNMASALIGGLV + A +I VVD A +G T +A Sbjct: 5 LKFGFIGGGNMASALIGGLVSRGAPGANIVVVDPTEPARAHAAQTWGATTIAAPGAELAD 64 Query: 61 VDVVVLAVKPQQMREVVATLKPFIGAQLIVSIAAGIRMVDLSRWLDGHQAIVRAMPNTPA 120 DV+VLAVKPQQMREV A L P + L++S+AAGIR+ DLSRWL GH +VRAMPNTPA Sbjct: 65 RDVIVLAVKPQQMREVCAQLAPHLRDSLVLSVAAGIRIQDLSRWLGGHARVVRAMPNTPA 124 Query: 121 LIGRGISGVVPHEQVSTLQRAQADTILKAVGETLWLAQEAQLDAVTAVSGSGPAYVFYFL 180 L G G++G+ + R A I AVG+++W+ EAQ+DAVTA+SGSGPAYVFYF+ Sbjct: 125 LSGMGMTGLAARAGLGGTDRDIASAIANAVGKSVWVPDEAQIDAVTAISGSGPAYVFYFI 184 Query: 181 EAMEQAAAQLGLSRQEGLELAKATFAGATELARRSEESVAILRERVTSKGGTTYAALTSL 240 EAM+Q A +LGLS + G LA TF GA LA +S E V +LRERVTSKGGTTYAALT++ Sbjct: 185 EAMQQVALELGLSPEAGRLLAAETFIGAATLAEQSSEPVEVLRERVTSKGGTTYAALTAM 244 Query: 241 EQSGVKAAIVTALQAAATRSKELGDEFGQ 269 + +G+K A V A+ AAA R K +G+EFG+ Sbjct: 245 DAAGIKPAFVRAMHAAAARGKAMGEEFGR 273 >PA0393 [E] COG0345 Pyrroline-5-carboxylate reductase Pae Pseudomonas aeruginosa Length = 273 Score = 221 bits (564), Expect = 1e-57, Method: Compositional matrix adjust. Identities = 129/269 (47%), Positives = 165/269 (61%), Gaps = 1/269 (0%) Query: 2 KIAFIGGGNMASALIGGLVGKVAAAQDIHVVDLNADALQSLQDKFGVATAQTIDGAIASV 61 +IAFIG GNMA++LIGGL + A I D A+ + +F + ++ A+A Sbjct: 5 RIAFIGAGNMAASLIGGLRAQGVPAAQIRASDPGAEQRAKIAGEFAIDVVESNAEAVADA 64 Query: 62 DVVVLAVKPQQMREVVATLKPFIGA-QLIVSIAAGIRMVDLSRWLDGHQAIVRAMPNTPA 120 DVVVL+VKPQ M+ V L P + QLIVSIAAGI L WL + +VR MPNTPA Sbjct: 65 DVVVLSVKPQAMKAVCQALAPALKPEQLIVSIAAGIPCASLEAWLGQPRPVVRCMPNTPA 124 Query: 121 LIGRGISGVVPHEQVSTLQRAQADTILKAVGETLWLAQEAQLDAVTAVSGSGPAYVFYFL 180 L+ +G SG+ + QVS Q QA +L AVG LWL EAQ+DAVTAVSGSGPAY F + Sbjct: 125 LLRQGASGLYANAQVSAAQCEQAGQLLSAVGIALWLDDEAQIDAVTAVSGSGPAYFFLLM 184 Query: 181 EAMEQAAAQLGLSRQEGLELAKATFAGATELARRSEESVAILRERVTSKGGTTYAALTSL 240 +AM A +LGLSR+ L T GA ++A SE A LR RVTS GTT AA+ S Sbjct: 185 QAMTDAGEKLGLSRETASRLTLQTALGAAQMALSSEVEPAELRRRVTSPNGTTEAAIKSF 244 Query: 241 EQSGVKAAIVTALQAAATRSKELGDEFGQ 269 + +G +A + AL AA+ RS EL ++ GQ Sbjct: 245 QANGFEALVEQALNAASQRSAELAEQLGQ 273 >NMA0215 [E] COG0345 Pyrroline-5-carboxylate reductase NmA Neisseria meningitidis Z2491 Length = 263 Score = 200 bits (509), Expect = 2e-51, Method: Compositional matrix adjust. Identities = 111/267 (41%), Positives = 164/267 (61%), Gaps = 5/267 (1%) Query: 1 VKIAFIGGGNMASALIGGLVGKVAAAQDIHVVDLNADALQSLQDKFGVATAQTIDGAIAS 60 + + F+GGGNMA+A+ GGLV + IH+ + A+ + L + GV T+ T+ + S Sbjct: 1 MNVYFLGGGNMAAAVAGGLVKQ--GGYRIHIANRGAEKRERLGKELGVETSATLP-ELHS 57 Query: 61 VDVVVLAVKPQQMREVVATLKPFIGAQLIVSIAAGIRMVDLSRWLDGHQAIVRAMPNTPA 120 DV++LAVKPQ M ++ L++S+AAG+ + LSR+L G + IVR MPNTP Sbjct: 58 DDVLILAVKPQDMEAACKNIR--TNGALVLSVAAGLSVDTLSRYLGGTRRIVRVMPNTPG 115 Query: 121 LIGRGISGVVPHEQVSTLQRAQADTILKAVGETLWLAQEAQLDAVTAVSGSGPAYVFYFL 180 IG G+SG+ +VS R AD I+K+VG T+WL EAQ+ ++T +SGSGPAYVFY L Sbjct: 116 KIGLGVSGMFAEAEVSETDRRIADRIMKSVGLTVWLEDEAQMHSITGISGSGPAYVFYLL 175 Query: 181 EAMEQAAAQLGLSRQEGLELAKATFAGATELARRSEESVAILRERVTSKGGTTYAALTSL 240 +A++ AA + G E L+ ATF GA LA ++ E L++ VTSKGGTT+ A+ + Sbjct: 176 DALQNAAIRQGFDMAEARALSLATFKGAVALAEQTGEDFEKLQKNVTSKGGTTHEAVEAF 235 Query: 241 EQSGVKAAIVTALQAAATRSKELGDEF 267 + V AI + A RS+E+ ++ Sbjct: 236 RRHRVAEAISEGVCACVRRSQEMERQY 262 >NMB0055 [E] COG0345 Pyrroline-5-carboxylate reductase Nme Neisseria meningitidis MC58 Length = 263 Score = 195 bits (496), Expect = 9e-50, Method: Compositional matrix adjust. Identities = 108/267 (40%), Positives = 163/267 (61%), Gaps = 5/267 (1%) Query: 1 VKIAFIGGGNMASALIGGLVGKVAAAQDIHVVDLNADALQSLQDKFGVATAQTIDGAIAS 60 + + F+GGGNMA+A+ GGLV + I++ + A+ + L+ + GV T+ T+ + S Sbjct: 1 MNVYFLGGGNMAAAVAGGLVKQ--GGYRIYIANRGAEKRERLEKELGVETSATLP-ELHS 57 Query: 61 VDVVVLAVKPQQMREVVATLKPFIGAQLIVSIAAGIRMVDLSRWLDGHQAIVRAMPNTPA 120 DV++LAVKPQ M ++ L++S+AAG+ + LSR+L G + IVR MPNTP Sbjct: 58 DDVLILAVKPQDMEAACKNIR--TNGALVLSVAAGLSVGTLSRYLGGTRRIVRVMPNTPG 115 Query: 121 LIGRGISGVVPHEQVSTLQRAQADTILKAVGETLWLAQEAQLDAVTAVSGSGPAYVFYFL 180 IG G+SG+ +VS R AD I+K+VG T+WL E ++ +T +SGSGPAYVFY L Sbjct: 116 KIGLGVSGMYAEAEVSETDRRIADRIMKSVGLTVWLDDEEKMHGITGISGSGPAYVFYLL 175 Query: 181 EAMEQAAAQLGLSRQEGLELAKATFAGATELARRSEESVAILRERVTSKGGTTYAALTSL 240 +A++ AA + G E L+ ATF GA LA ++ E L++ VTSKGGTT+ A+ + Sbjct: 176 DALQNAAIRQGFDMAEARALSLATFKGAVALAEQTGEDFEKLQKNVTSKGGTTHEAVEAF 235 Query: 241 EQSGVKAAIVTALQAAATRSKELGDEF 267 + V AI + A RS+E+ ++ Sbjct: 236 RRHRVAEAISEGVCACVRRSQEMERQY 262 >HI0307 [E] COG0345 Pyrroline-5-carboxylate reductase Hin Haemophilus influenzae Length = 271 Score = 181 bits (459), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 109/267 (40%), Positives = 158/267 (59%), Gaps = 3/267 (1%) Query: 3 IAFIGGGNMASALIGGLVGKVAAAQDIHVVDLNADALQSLQDKFGVATAQTIDGAIASVD 62 IAFIGGGNMA A+I GL+ + A+ I V D N + ++ VAT++ G+ + Sbjct: 6 IAFIGGGNMAQAIILGLLKQGYPAEQIIVNDPNEEK-RAFFANLDVATSENNVGSAIKAE 64 Query: 63 VVVLAVKPQQMREVVATLKPF-IGAQLIVSIAAGIRMVDLSRWLDGHQAIVRAMPNTPAL 121 VV+LAVKPQ M EV + L +L++SIAAGI L+ + ++IVR MPNTPAL Sbjct: 65 VVLLAVKPQMMAEVCSPLSAVDFSDKLLISIAAGISTERLNALIPSVKSIVRVMPNTPAL 124 Query: 122 IGRGISGVVPHEQVSTLQRAQADTILKAVGETLWLAQEAQLDAVTAVSGSGPAYVFYFLE 181 +G G++G+ + S R A +L AVG T+W+ E Q+ AVTA SGS PAY F LE Sbjct: 125 VGEGMAGLFAPKNTSENYRTFAQDLLGAVGRTVWVNDETQMHAVTAASGSSPAYFFLMLE 184 Query: 182 AMEQAAAQLGLSRQEGLELAKATFAGATELARRSEE-SVAILRERVTSKGGTTYAALTSL 240 AM++A ++ + + EL + + GA ++ + + +++ LRE VTSKGGTT AAL Sbjct: 185 AMQKALIKMNIDEKTARELVQQSMLGAAKMVTENPQIALSTLRENVTSKGGTTAAALAVF 244 Query: 241 EQSGVKAAIVTALQAAATRSKELGDEF 267 + I A+QA +RS+E+ F Sbjct: 245 DAQHFNQTIEQAMQACLSRSQEMETLF 271