BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.3697.p (420 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value mlr7407 [GEPR] COG0477 Permeases of the major facilitator superf... 330 3e-90 Rv2994 [GEPR] COG0477 Permeases of the major facilitator superfa... 113 8e-25 MT3072 [GEPR] COG0477 Permeases of the major facilitator superfa... 111 4e-24 PA0811 [GEPR] COG0477 Permeases of the major facilitator superfa... 78 3e-14 AGl2008 [GEPR] COG0477 Permeases of the major facilitator superf... 66 1e-10 >mlr7407 [GEPR] COG0477 Permeases of the major facilitator superfamily Mlo Mesorhizobium loti Length = 430 Score = 330 bits (847), Expect = 3e-90, Method: Compositional matrix adjust. Identities = 222/410 (54%), Positives = 270/410 (65%), Gaps = 12/410 (2%) Query: 12 ASTPSSSLSASAHRWKVLAAGVAANASFSAVFSGIPVTSLVLRSDYHLSNAQLGLALGLL 71 A+ P+ + + HRWKVL GVAANASFSA FSGIP T++VLR YHLSNA+LGLALG+L Sbjct: 20 AAAPAGRVFSPGHRWKVLGIGVAANASFSATFSGIPATAVVLRQGYHLSNAELGLALGVL 79 Query: 72 SLGVALGELPWGLLTDRLGDRKVLLVGLLGTSVALGLLMLLARPGRGADAAYLWLCGGLM 131 LGVAL ELPWGLLTDR GDR+VLL+GL T+ L + +L P R + L L+ Sbjct: 80 GLGVALSELPWGLLTDRWGDRRVLLIGLGATAAWLLAMAMLVVPTRSGVPDVMLLSASLL 139 Query: 132 LAGLLGGSVNGASGRAIMGWFADGERGLAMSIRQTAVPLGGGIGALLLPLLAAQAGFAAV 191 GLLGGSVNG+SGRAIMGWF + ERG AMSIRQTAVPLGGG+GAL+LP LA GF+AV Sbjct: 140 FTGLLGGSVNGSSGRAIMGWFRENERGFAMSIRQTAVPLGGGLGALVLPSLALAFGFSAV 199 Query: 192 FGLLMSWCLASVGLVLWWLREPPLQLHARLAATSATPALRNAMVWRLALGIGLLCAPQVA 251 F LL S WL EPP H +A + LRN VWR+A IGLLC PQVA Sbjct: 200 FTLLAGASALSALFAWRWLHEPPAAAHVAASAAAGPAPLRNIEVWRIATAIGLLCFPQVA 259 Query: 252 LISFGGIFLHEVGQAGLLLISVLLTLVQIGAAITRIASGRWTDRRGQRRDYLRGCALASA 311 +++F +FLH+ G + IS L VQIGA + R+ SGR+TDR G RR +LR C+ S Sbjct: 260 VLTFASVFLHDFVGLGTVAISASLAAVQIGAMVMRVWSGRFTDRHGNRRQFLRSCSALSG 319 Query: 312 ILFAALGALSLLS---------LHAALPWLSLLLVSAGVVVSAWHGVAYTELAVVAGPSQ 362 + F+ L + L L A LP +L+ AG+ VSAWHGVAYTELA +AG Sbjct: 320 LAFSVLWLMVLAGSAVPGGQSFLIAVLP---FVLIVAGISVSAWHGVAYTELATLAGAGH 376 Query: 363 VGTALGLGNSCVFLVFFLTAQAVPLLLHWQGWPAVWLGTALVALLVFPLF 412 VGTAL L N+ VF+ FFL A+P LLH WP VWL +L AL+ +P+F Sbjct: 377 VGTALSLANTFVFVGFFLVPVAIPGLLHLWSWPGVWLSASLCALIAWPIF 426 >Rv2994 [GEPR] COG0477 Permeases of the major facilitator superfamily Mtu Mycobacterium tuberculosis H37Rv Length = 445 Score = 113 bits (283), Expect = 8e-25, Method: Compositional matrix adjust. Identities = 120/403 (29%), Positives = 186/403 (46%), Gaps = 30/403 (7%) Query: 25 RWKVLAAGVAANASFSAVFSGIPVTSLVLRSDYHLSNAQLGLALGLLSLGVALGELPWGL 84 RW ++ + AS +G+ L + + GL + S G+ + WG Sbjct: 11 RWAIMIVSLGVTASSFLFINGVAFLIPRLENARGTPLSHAGLLASMPSWGLVVTMFAWGY 70 Query: 85 LTDRLGDRKVLLVGLLGTSVALGLLMLLARPGRGADAAYLWLCGGLMLAGLLGGSVNGAS 144 L D +G+R V+ VG T+ A + + LW+ L L G+ G N A Sbjct: 71 LLDHVGERMVMAVGSALTAAAAYAAASVH--------SLLWIGVFLFLGGMAAGGCNSAG 122 Query: 145 GRAIMGWFADGERGLAMSIRQTAVPLGGGIGALLLPLLAAQAGFAAVFGLLMSWCLASVG 204 GR + GWF +RGLAM IRQTA PLG GAL++P LA + A + + LA+V Sbjct: 123 GRLVSGWFPPQQRGLAMGIRQTAQPLGIASGALVIPELAERGVHAGLMFPAVVCTLAAVA 182 Query: 205 LVLWWLREPPLQLHARLAATS-ATPALRNAMVWRLALGIGLLCAPQVALISFGGIFL--H 261 VL + +PP + + + A+P ++++WR+ LL PQ ++F ++L H Sbjct: 183 SVL-GIVDPPRKSRTKASEQELASPYRGSSILWRIHAASALLMMPQTVTVTFMLVWLINH 241 Query: 262 E---VGQAGLLLISVLLTLVQIGAAITRIASGRWTDRRGQRRDYLRGCALASAILFAALG 318 V QAG VL+T+ Q+ A+ R+A GRW+D G R +R A A+A L Sbjct: 242 HGWSVAQAG-----VLVTISQLLGALGRVAVGRWSDHVGSRMRPVRLIAAAAAATLFLLA 296 Query: 319 ALSLLSLHAALPWLSLLLVSAGVVVSAWHGVAYTELAVVAGPSQVGTALGLGNSCVFLVF 378 A+ + + LL+++ V+ +G+ T + AGP G ALG+ N+ L Sbjct: 297 AVD----NEGSRYDVLLMIAISVIAVLDNGLEATAITEYAGPYWSGRALGIQNTTQRL-- 350 Query: 379 FLTAQAVPL---LLHWQGWPAVWLGTALVALLVFPLFPALVKP 418 + A PL L+ +P W + L PL P + P Sbjct: 351 -MAAAGPPLFGSLITTAAYPTAWALCGVFPLAAVPLVPVRLLP 392 >MT3072 [GEPR] COG0477 Permeases of the major facilitator superfamily MtC Mycobacterium tuberculosis CDC1551 Length = 445 Score = 111 bits (277), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 119/403 (29%), Positives = 185/403 (45%), Gaps = 30/403 (7%) Query: 25 RWKVLAAGVAANASFSAVFSGIPVTSLVLRSDYHLSNAQLGLALGLLSLGVALGELPWGL 84 RW ++ + AS +G+ L + + GL + S G+ + WG Sbjct: 11 RWAIMIVSLGVTASSFLFINGVAFLIPRLENARGTPLSHAGLLASMPSWGLVVTMFAWGY 70 Query: 85 LTDRLGDRKVLLVGLLGTSVALGLLMLLARPGRGADAAYLWLCGGLMLAGLLGGSVNGAS 144 L D +G+R V+ VG T+ A + + LW+ L L G+ G N A Sbjct: 71 LLDHVGERMVMAVGSALTAAAAYAAASVH--------SLLWIGVFLFLGGMAAGGCNSAG 122 Query: 145 GRAIMGWFADGERGLAMSIRQTAVPLGGGIGALLLPLLAAQAGFAAVFGLLMSWCLASVG 204 GR + GWF +RGLAM IRQTA PLG GAL++P LA + A + + LA+V Sbjct: 123 GRLVSGWFPPQQRGLAMGIRQTAQPLGIASGALVIPELAERGVHAGLMFPAVVCTLAAVA 182 Query: 205 LVLWWLREPPLQLHARLAATS-ATPALRNAMVWRLALGIGLLCAPQVALISFGGIFL--H 261 VL + +PP + + + A+P ++++WR+ LL PQ ++F ++L H Sbjct: 183 SVL-GIVDPPRKSRTKASEQELASPYRGSSILWRIHAASALLMMPQTVTVTFMLVWLINH 241 Query: 262 E---VGQAGLLLISVLLTLVQIGAAITRIASGRWTDRRGQRRDYLRGCALASAILFAALG 318 V QAG VL+T+ Q+ A+ R+A GRW+D G R +R A A+A L Sbjct: 242 HGWSVAQAG-----VLVTISQLLGALGRVAVGRWSDHVGSRMRPVRLIAAAAAATLFLLA 296 Query: 319 ALSLLSLHAALPWLSLLLVSAGVVVSAWHGVAYTELAVVAGPSQVGTALGLGNSCVFLVF 378 A+ + + LL+++ V+ +G+ + AGP G ALG+ N+ L Sbjct: 297 AVD----NEGSRYDVLLMIAISVIAVLDNGLEAAAITEYAGPYWSGRALGIQNTTQRL-- 350 Query: 379 FLTAQAVPL---LLHWQGWPAVWLGTALVALLVFPLFPALVKP 418 + A PL L+ +P W + L PL P + P Sbjct: 351 -MAAAGPPLFGSLITTAAYPTAWALCGVFPLAAVPLVPVRLLP 392 >PA0811 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 415 Score = 78.2 bits (191), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 89/312 (28%), Positives = 144/312 (46%), Gaps = 38/312 (12%) Query: 8 SAPLASTPSSSLSASAHRWKVLAAGVAANASFSAVFSGIPVTSLVLRSDYHLSNAQLGLA 67 +A LA+ P+ +RW +L A A GI ++ +++D LS+ Q+GL Sbjct: 2 TAALAANPTQR-----YRWVILLIATFAQACACFFVQGIGAIAVFVQNDLQLSSLQIGLL 56 Query: 68 LGLLSLGVALGELPWGLLTDRLGDRKVLLVGLLGTSVALGLLMLLARPGRGADAAYLWLC 127 + L +G L G L DR +R L+VGL VAL L L YL + Sbjct: 57 VSAAQLVPIVGLLVAGELLDRYSER--LVVGLGTLIVALALCASLWA------TDYLTIL 108 Query: 128 GGLMLAGLLGGSVNGASGRAIMGWFADGERGLAMSIRQTAVPLGGGIGALLLPLLAAQAG 187 L++ G + +++ WFA + G AM IRQ +PLGG + A LLP LA G Sbjct: 109 LFLVVVGAGYSTAQPGGSKSVSRWFAKTQLGFAMGIRQAGLPLGGALSAALLPYLAGVYG 168 Query: 188 FAAVF--GLLMSWCLASVGLVLWWLREPPLQ---------------LHARLAATSATPAL 230 + + F G L+++ L ++ +L++ R PP + +RLA + PA+ Sbjct: 169 WRSAFLAGGLVAF-LGALAFMLFY-RTPPDAPAPGANPAERDLGAVVKSRLAMIT-DPAM 225 Query: 231 RNAMVWRLALGIGLLCAPQVALISFGGIFLHEVGQAGLLLISVLLTLVQIGAAITRIASG 290 +N + +A L + Q ++ F ++LHE + G+ + + LL + Q RI Sbjct: 226 KNIVCSGVA-----LISVQYGILVFTVLYLHETLEIGIGMAATLLFVAQGSGVAGRILLA 280 Query: 291 RWTDRRGQRRDY 302 W+DR R + Sbjct: 281 AWSDRCRAGRYF 292 >AGl2008 [GEPR] COG0477 Permeases of the major facilitator superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 418 Score = 66.2 bits (160), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 64/207 (30%), Positives = 95/207 (45%), Gaps = 25/207 (12%) Query: 15 PSSSLSASAHRWKVLAAGVAANASFSAVFSGIPVTSLVLRSDYHLSNAQLGLALGLLSLG 74 P + +A H W VLA V + S V GI + R + +S A LA+ +++ G Sbjct: 10 PGPAPAADPHIWAVLAVAVGTQTAGSFVSQGIYILVPFWREAFGVSLASASLAVTVMN-G 68 Query: 75 VALGEL-PWGLLTDRLGDRKVLLVGLLGTSVALGLLMLLARPGRGADAAYLWLCGGLMLA 133 V + + G D G+R+++ + +LG ++A+ A L L+ Sbjct: 69 VQIATMFTLGRAIDIHGERRIVGIAMLGMAIAMACAATFANS----------LPALLVCI 118 Query: 134 GLLGGS---VNGASGRAIMGWFADGERGLAMSIRQTAVPLGGGIGALLLPLLAAQAGFAA 190 LGG+ V RAIM WF +RG+A RQ AVP G I A LLP +A + G+ A Sbjct: 119 AFLGGTYAAVQPGGTRAIMRWFPPAKRGIATGFRQAAVPFGTMIAAALLPFMAVRYGWHA 178 Query: 191 VFGLLMSWCLASVGLV---LWW--LRE 212 +W A V +V L+W RE Sbjct: 179 A-----AWLCAGVSIVGAALFWGLYRE 200