BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.3671.p (322 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BS_yoaV [GER] COG0697 Permeases of the drug/metabolite transport... 95 2e-19 yijE [GER] COG0697 Permeases of the drug/metabolite transporter ... 67 5e-11 ZyijE [GER] COG0697 Permeases of the drug/metabolite transporter... 66 1e-10 ECs4872 [GER] COG0697 Permeases of the drug/metabolite transport... 66 1e-10 PA2101 [GER] COG0697 Permeases of the drug/metabolite transporte... 65 3e-10 >BS_yoaV [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Bsu Bacillus subtilis Length = 292 Score = 95.1 bits (235), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 75/294 (25%), Positives = 141/294 (47%), Gaps = 11/294 (3%) Query: 30 LLAVVLAICIWGGNWPVMKFGSQFIPPLWFAASRFLSAAILSFVIAAALGKLRLPTRQEW 89 +L ++ IWG W MK G IPPL F+ R A+ F+I K +L ++E Sbjct: 5 MLGIISVTLIWGYTWVAMKVGIHDIPPLLFSGLRLFIGAVPLFLILFIQRK-KLSIQKEH 63 Query: 90 PVVAGVGVLQMGL-FTALVTGALHFVMPGRASLIAYATSIWVVPGAALVLKHKLSTQQSL 148 + L MGL + ++T + FV G+ S++ Y I+V + L K++ +++ Sbjct: 64 LKSYIIMSLLMGLGYMGILTYGMQFVDSGKTSVLVYTMPIFVTVISHFSLNEKMNVYKTM 123 Query: 149 ATVCSYAGMAVIVLPALLHADMHSMIGYLMLGAASLSWAM-NI---LQIKLTPGVKLDFD 204 VC G+ I +L+ D ++ G L + A+LSW + N+ LQ K + ++ Sbjct: 124 GLVCGLFGLLFIFGKEMLNIDQSALFGELCVLVAALSWGIANVFSKLQFKHIDIIHMN-- 181 Query: 205 LLPWQTLVAAVPLSLLALVVDGAPTFLANPHSWGVIAYTGPLATALTFLIVLQMTQRLSP 264 W ++ AV L + + + + P+ + + + G L+T TF++ + ++ Sbjct: 182 --AWHLMMGAVMLLVFSFIFEAVPSAEWTYQAVWSLLFNGLLSTGFTFVVWFWVLNQIQA 239 Query: 265 VTVSVCMLGVPVVGLTLSSLIFGEQLSGDLLLGMGLLCLGLVLPALPALATRRV 318 S+ ++ VPV+ L L EQ++ +++LG L+C G+ + + R+V Sbjct: 240 SKASMALMFVPVLALFFGWLQLHEQITINIILGALLICCGIFMNTF-TFSRRKV 292 >yijE [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Eco Escherichia coli K12 Length = 312 Score = 67.0 bits (162), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 74/259 (28%), Positives = 120/259 (46%), Gaps = 18/259 (6%) Query: 39 IWGGNWPVMKFGSQFIPPLWFAASRFLSAAILSFVIAAALGKLRLPTRQEWPVVAGVGVL 98 IW +W MK + +I F A R + A++ F++ G+ PT ++ + + +L Sbjct: 32 IWSYSWIFMKQVTSYIGAFDFTALRCIFGALVLFIVLLLRGRGMRPTPFKYTL--AIALL 89 Query: 99 QMGLFTALVTGALHFVMPGRASLIAYATSIWVVPGAALVLKHKLSTQQSLATVCSYAGMA 158 Q L AL G+ ++++Y WVV AAL L +L Q A + + G+ Sbjct: 90 QTCGMVGLAQWALVSGGAGKVAILSYTMPFWVVIFAALFLGERLRRGQYFAILIAAFGLF 149 Query: 159 VIVLPALLHADMHSMIGYLMLGAASLSWAMNILQIKLTPGVKLDFDLLP---WQTLVAAV 215 +++ P L D SM ++ + +SW + + K DLL WQ L AA+ Sbjct: 150 LVLQPWQL--DFSSMKSAMLAILSGVSWGASAIVAKRLYARHPRVDLLSLTSWQMLYAAL 207 Query: 216 PLSLLALVV-----DGAPTFLANPHSWGVIAYTGPLATALTFLIVLQMTQRLSPVTVSVC 270 +S++AL+V D PT W +AY+ LATAL + + L + + L S+ Sbjct: 208 VMSVVALLVPQREIDWQPTVF-----WA-LAYSAILATALAWSLWLFVLKNLPASIASLS 261 Query: 271 MLGVPVVGLTLSSLIFGEQ 289 L VPV G+ S + GE Sbjct: 262 TLAVPVCGVLFSWWLLGEN 280 >ZyijE [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 312 Score = 66.2 bits (160), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 80/291 (27%), Positives = 133/291 (45%), Gaps = 21/291 (7%) Query: 39 IWGGNWPVMKFGSQFIPPLWFAASRFLSAAILSFVIAAALGKLRLPTRQEWPVVAGVGVL 98 IW +W MK + +I F A R + A++ F++ G+ PT ++ + + +L Sbjct: 32 IWSYSWIFMKQVTSYIGAFDFTALRCIFGALVLFIVLLLRGRGMRPTPFKYTL--AIALL 89 Query: 99 QMGLFTALVTGALHFVMPGRASLIAYATSIWVVPGAALVLKHKLSTQQSLATVCSYAGMA 158 Q L AL G+ ++++Y WVV AA+ L +L Q A + + G+ Sbjct: 90 QTCGMVGLAQWALVSGGAGKVAILSYTMPFWVVIFAAVFLGERLRRGQYFAILIAAFGLF 149 Query: 159 VIVLPALLHADMHSMIGYLMLGAASLSWAMNILQIKLTPGVKLDFDLLP---WQTLVAAV 215 +++ P L D SM ++ + +SW + + K DLL WQ L AA+ Sbjct: 150 LVLQPWQL--DFSSMKSAMLAILSGVSWGASAIVAKRLYARHPRVDLLSLTSWQMLYAAL 207 Query: 216 PLSLLALVV-----DGAPTFLANPHSWGVIAYTGPLATALTFLIVLQMTQRLSPVTVSVC 270 +S++AL+V D PT W +AY+ LATAL + + L + + L S+ Sbjct: 208 VMSVVALLVPQREIDWQPTVF-----WA-LAYSAILATALAWSLWLFVLKNLPASIASLS 261 Query: 271 MLGVPVVGLTLSSLIFGEQLSGDLLLGMGLLCLGLVL---PALPALATRRV 318 L VPV G+ S + GE G+ L+ L L L A++ +R+ Sbjct: 262 TLAVPVCGVLFSWWLLGENPGAVEXSGIVLIVLALALVSRKKKEAVSVKRI 312 >ECs4872 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Ecs Escherichia coli O157:H7 Length = 312 Score = 65.9 bits (159), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 73/259 (28%), Positives = 120/259 (46%), Gaps = 18/259 (6%) Query: 39 IWGGNWPVMKFGSQFIPPLWFAASRFLSAAILSFVIAAALGKLRLPTRQEWPVVAGVGVL 98 IW +W MK + +I F A R + A++ F++ G+ PT ++ + + +L Sbjct: 32 IWSYSWIFMKQVTSYIGAFDFTALRCIFGALVLFIVLLLRGRGMRPTPFKYTL--AIALL 89 Query: 99 QMGLFTALVTGALHFVMPGRASLIAYATSIWVVPGAALVLKHKLSTQQSLATVCSYAGMA 158 Q L AL G+ ++++Y WVV AA+ L +L Q A + + G+ Sbjct: 90 QTCGMVGLAQWALVSGGAGKVAILSYTMPFWVVIFAAVFLGERLRRGQYFAILIAAFGLF 149 Query: 159 VIVLPALLHADMHSMIGYLMLGAASLSWAMNILQIKLTPGVKLDFDLLP---WQTLVAAV 215 +++ P L D SM ++ + +SW + + K DLL WQ L AA+ Sbjct: 150 LVLQPWQL--DFSSMKSAMLAILSGVSWGASAIVAKRLYARHPRVDLLSLTSWQMLYAAL 207 Query: 216 PLSLLALVV-----DGAPTFLANPHSWGVIAYTGPLATALTFLIVLQMTQRLSPVTVSVC 270 +S++AL+V D PT W +AY+ LATAL + + L + + L S+ Sbjct: 208 VMSVVALLVPQREIDWQPTVF-----WA-LAYSAILATALAWSLWLFVLKNLPASIASLS 261 Query: 271 MLGVPVVGLTLSSLIFGEQ 289 L VPV G+ S + GE Sbjct: 262 TLAVPVCGVLFSWWLLGEN 280 >PA2101 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Pae Pseudomonas aeruginosa Length = 296 Score = 64.7 bits (156), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 72/289 (24%), Positives = 131/289 (45%), Gaps = 23/289 (7%) Query: 35 LAICI-WGGNWPVMKFGSQFIPPLWFAASRFLSAAILSFVIAAALGKLRLPTRQE---WP 90 L +CI WG W +K + +PPL +AA L F+IA L L R E +P Sbjct: 11 LVVCISWGTTWLGIKIAVESVPPL--------TAAGLRFLIAFPLFLLFARLRHETIFFP 62 Query: 91 --VVAGVGVLQMGLFTA---LVTGALHFVMPGRASLIAYATSIWVVPGAALVLKHKLSTQ 145 ++A + +G F+ L+ +V G +L+ + ++++ +A+ L+ ++ Sbjct: 63 RRLLAFFVFVTLGYFSVPYYLLNYGEQYVASGLTALLFSSMPVFILIFSAIFLRERIYLS 122 Query: 146 QSLATVCSYAGMAVIVLPALLHADMHSMIGYLMLGAASLSWAMNILQIKLTPGVKLDFDL 205 Q L + + +I+ LH D ++G L A L+ M+ L +T D + Sbjct: 123 QILGIAIGFGSLFMIIRSQGLHLDYTELLGVL---AILLAAIMHALSYVITKRQGADIGV 179 Query: 206 LPWQTL---VAAVPLSLLALVVDGAPTFLANPHSWGVIAYTGPLATALTFLIVLQMTQRL 262 + + TL +A + L + LV++ SW + Y G +A+ F++ + +RL Sbjct: 180 ITFNTLPIGIAGLGLFMAGLVMEHPNLSAVTSRSWAALIYLGLVASVGGFIVYFFLLKRL 239 Query: 263 SPVTVSVCMLGVPVVGLTLSSLIFGEQLSGDLLLGMGLLCLGLVLPALP 311 SPV +S + PV + + + G +S +L+ LL G + LP Sbjct: 240 SPVVLSFVFIIFPVFAVIIGAWYEGVAISRELIGFTVLLLAGFAITKLP 288