BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.3657.p (436 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA5370 [GEPR] COG0477 Permeases of the major facilitator superfa... 517 e-146 YPO0465 [GEPR] COG0477 Permeases of the major facilitator superf... 474 e-133 AGc3904 [GEPR] COG0477 Permeases of the major facilitator superf... 431 e-120 BMEI0353 [GEPR] COG0477 Permeases of the major facilitator super... 425 e-118 Cj0250c [GEPR] COG0477 Permeases of the major facilitator superf... 357 2e-98 >PA5370 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 438 Score = 517 bits (1332), Expect = e-146, Method: Compositional matrix adjust. Identities = 257/417 (61%), Positives = 317/417 (76%) Query: 16 HRPLTSSDYRTLGLSALGGTLEFYDFVIYVFFAAVVGKLFFPADMPEWLRMLQTFGIFAA 75 RPLT SDY+TL LSALGG LEFYDF+I+VFFA VVGKLFFPADMPEWLR LQTFG+FAA Sbjct: 12 QRPLTRSDYKTLSLSALGGALEFYDFIIFVFFATVVGKLFFPADMPEWLRQLQTFGLFAA 71 Query: 76 GYLARPVGGIIIAHYGDVIGRKRMFTLSIFLMAVPTLVIGLLPTYASIGVAAPILLLLMR 135 GYLARP+GG+I+AH+GD++GRKRMFTLSIF+MAVPTL++GLLPTYA IG+ AP+ LLL+R Sbjct: 72 GYLARPLGGVIMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLLPTYAQIGIWAPLALLLLR 131 Query: 136 TLQGAAIGGEMPGAWVFVAEHVPANRYSFGVGSLTAGITGGILLGSLMGIFINSVYQPAE 195 +QGAAIGGE+PGAWVFVAEHVPA + G+LT+G+T GILLGSL+ INS Y E Sbjct: 132 VIQGAAIGGEVPGAWVFVAEHVPARHVGYACGTLTSGLTAGILLGSLVATAINSFYSATE 191 Query: 196 VAAYAWRIPFLLGGVFGLVSVYLRRYLEETPVFRELAARRKQSHELPLKTVLREHRGASL 255 V YAWRIPFLLGGVFGL SVYLRR+L ETPVF EL R+ + E+PLK V+R+HRGA L Sbjct: 192 VQDYAWRIPFLLGGVFGLFSVYLRRWLHETPVFAELQQRKALAEEVPLKAVVRDHRGAVL 251 Query: 256 LTAGMTWCLSGAVVVVILMTPSYLQTVHHLPAKLVMQANCAGTLMLTIGCLLIGWLCDRI 315 ++ +TW LS A+VVVILMTP+ LQ+V+ A ++AN + LT+GC++ G + DR Sbjct: 252 VSMLLTWVLSAAIVVVILMTPTVLQSVYGFDAATALKANSLAIVCLTLGCIVAGRMADRY 311 Query: 316 GTRASMILGWGGLGLSSWWFYGQLPGSPESLIWGYALVGLFVGSIALTPIVSTRAFPPPV 375 G + + G L L SW FYG L P+ L YAL G FVG + P V AFPP V Sbjct: 312 GAGLTFVAGSVLLALVSWSFYGNLKAHPDWLFPLYALTGFFVGIVGAVPYVMVNAFPPVV 371 Query: 376 RFTGLSFAYNMAYAIFGGLTPVLISLWIKADPQGPALYVIGLSILGVLLAFVPMSSK 432 RF+GLSF+YN+AYAIFGGLTP+ ++L +K P GPA YV+ L ++G L+ ++ K Sbjct: 372 RFSGLSFSYNLAYAIFGGLTPMAVALLLKQSPMGPAYYVVTLCLVGFLVGLYLLAQK 428 >YPO0465 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 462 Score = 474 bits (1221), Expect = e-133, Method: Compositional matrix adjust. Identities = 232/411 (56%), Positives = 301/411 (73%) Query: 4 SAEFTGALNESQHRPLTSSDYRTLGLSALGGTLEFYDFVIYVFFAAVVGKLFFPADMPEW 63 S++ + +R L DY+TL L+ALGG LEFYDF+I+VFFAAV+G LFFPADMPEW Sbjct: 17 SSQHHVDQQHNHNRRLNKQDYKTLTLAALGGALEFYDFIIFVFFAAVIGDLFFPADMPEW 76 Query: 64 LRMLQTFGIFAAGYLARPVGGIIIAHYGDVIGRKRMFTLSIFLMAVPTLVIGLLPTYASI 123 LR +QTFGIFAAGYLARP+GGII+AH+GD++GRK+MFTLSI LMA+PTL IG+LPTYA+I Sbjct: 77 LRQVQTFGIFAAGYLARPLGGIIMAHFGDLVGRKKMFTLSILLMALPTLAIGMLPTYATI 136 Query: 124 GVAAPILLLLMRTLQGAAIGGEMPGAWVFVAEHVPANRYSFGVGSLTAGITGGILLGSLM 183 G+ AP+LLLLMR LQGAAIGGE+PGAWVFVAEHVP R G+LTAG+T GILLGSL+ Sbjct: 137 GITAPLLLLLMRVLQGAAIGGEVPGAWVFVAEHVPRKRIGIACGTLTAGLTAGILLGSLV 196 Query: 184 GIFINSVYQPAEVAAYAWRIPFLLGGVFGLVSVYLRRYLEETPVFRELAARRKQSHELPL 243 +N+ + WRIPF LGG+FGL ++YLRR+L+ETP+F+E+ AR+ + ELPL Sbjct: 197 ATVMNTTLGHQAILEGGWRIPFFLGGIFGLFAMYLRRWLQETPIFKEMQARKTLAEELPL 256 Query: 244 KTVLREHRGASLLTAGMTWCLSGAVVVVILMTPSYLQTVHHLPAKLVMQANCAGTLMLTI 303 K+V+ H+ +++ +TW LS +VVVILMTP+YLQ ++P +L +QAN + L I Sbjct: 257 KSVVVNHKKEVVVSMLLTWLLSAGIVVVILMTPTYLQKQFNVPPELALQANSLAIIALVI 316 Query: 304 GCLLIGWLCDRIGTRASMILGWGGLGLSSWWFYGQLPGSPESLIWGYALVGLFVGSIALT 363 GC++ G DR G + I+G L +S+W FY +P L Y L G VG + Sbjct: 317 GCVVAGLAIDRFGASKTFIVGSLMLAMSTWSFYHTNLTNPSQLFPHYMLAGFCVGIVGAV 376 Query: 364 PIVSTRAFPPPVRFTGLSFAYNMAYAIFGGLTPVLISLWIKADPQGPALYV 414 P V RAFP VRFTG+SF+YN+AYAIFGGLTP+L++LW+K+ PA Y+ Sbjct: 377 PYVMVRAFPAEVRFTGISFSYNVAYAIFGGLTPILVTLWMKSSAMAPAYYM 427 >AGc3904 [GEPR] COG0477 Permeases of the major facilitator superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 443 Score = 431 bits (1107), Expect = e-120, Method: Compositional matrix adjust. Identities = 216/404 (53%), Positives = 289/404 (71%) Query: 17 RPLTSSDYRTLGLSALGGTLEFYDFVIYVFFAAVVGKLFFPADMPEWLRMLQTFGIFAAG 76 RPL S D+RTLGLSALGG LEFYDF+I+VFFA V+G LFFP +MP+WL M+QTFGIFAAG Sbjct: 11 RPLNSQDFRTLGLSALGGALEFYDFIIFVFFATVIGHLFFPPEMPDWLVMIQTFGIFAAG 70 Query: 77 YLARPVGGIIIAHYGDVIGRKRMFTLSIFLMAVPTLVIGLLPTYASIGVAAPILLLLMRT 136 YL RP+GGI++AHYGD GRKR+F SI LMA+ TL + L+PTYA+IGVAAPILL+++R Sbjct: 71 YLVRPLGGIVLAHYGDRYGRKRVFAFSILLMALSTLGMALMPTYATIGVAAPILLIILRM 130 Query: 137 LQGAAIGGEMPGAWVFVAEHVPANRYSFGVGSLTAGITGGILLGSLMGIFINSVYQPAEV 196 LQGAAIGGE+PGAW FVAEHVP R G LT+G++ GI+LGSL+ INS++ P +V Sbjct: 131 LQGAAIGGEVPGAWTFVAEHVPFRRVGLACGFLTSGLSFGIMLGSLIAFAINSLFTPEDV 190 Query: 197 AAYAWRIPFLLGGVFGLVSVYLRRYLEETPVFRELAARRKQSHELPLKTVLREHRGASLL 256 A YAWRIPFLLGGVFGL++VYLRR+LEETP++ E+ + + +LPL VL+ HR ++ Sbjct: 191 AGYAWRIPFLLGGVFGLIAVYLRRWLEETPIYMEMKKSKSLTDKLPLGLVLKHHRRGVII 250 Query: 257 TAGMTWCLSGAVVVVILMTPSYLQTVHHLPAKLVMQANCAGTLMLTIGCLLIGWLCDRIG 316 +A +TW LS A+VV LMT ++LQ ++ + GTL L G ++ G L DR+G Sbjct: 251 SALLTWVLSAAIVVTTLMTATFLQKLYGYTPTQALAGTSFGTLFLIFGVIIAGALIDRVG 310 Query: 317 TRASMILGWGGLGLSSWWFYGQLPGSPESLIWGYALVGLFVGSIALTPIVSTRAFPPPVR 376 + + G++++ FY S E++ Y ++GL VG P V RAFP VR Sbjct: 311 SGIFFMGASIFFGIATFTFYSYAGTSLETMFVLYGVMGLSVGMAGAVPYVMVRAFPASVR 370 Query: 377 FTGLSFAYNMAYAIFGGLTPVLISLWIKADPQGPALYVIGLSIL 420 F+GLSFAYN++YA+FGGLTP+ ++ + +P A Y++ ++ L Sbjct: 371 FSGLSFAYNVSYAVFGGLTPIGVTTALAINPMAHAWYLVFIAFL 414 >BMEI0353 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 503 Score = 425 bits (1093), Expect = e-118, Method: Compositional matrix adjust. Identities = 216/424 (50%), Positives = 292/424 (68%), Gaps = 5/424 (1%) Query: 2 TTSAEFTGALNESQH-----RPLTSSDYRTLGLSALGGTLEFYDFVIYVFFAAVVGKLFF 56 T S E + + H RPL D+RTLGLSALGG LEFYDF+I+VFFA+V+G LFF Sbjct: 46 TQSEESESMASTNLHTGNSPRPLNRQDFRTLGLSALGGALEFYDFIIFVFFASVIGHLFF 105 Query: 57 PADMPEWLRMLQTFGIFAAGYLARPVGGIIIAHYGDVIGRKRMFTLSIFLMAVPTLVIGL 116 P DMP+WL ++QTFGIFAAGYL RPVGGI++AH+GD GRKR+F S+FLM++ TL + Sbjct: 106 PPDMPDWLVLIQTFGIFAAGYLVRPVGGIVLAHFGDKFGRKRVFAFSVFLMSISTLAMAA 165 Query: 117 LPTYASIGVAAPILLLLMRTLQGAAIGGEMPGAWVFVAEHVPANRYSFGVGSLTAGITGG 176 LPTYA++GV APILL++ R LQGAAIGGE+PGAW FVAEHVPANR G L +G+T G Sbjct: 166 LPTYATLGVGAPILLIVFRMLQGAAIGGEVPGAWTFVAEHVPANRVGMACGFLCSGLTLG 225 Query: 177 ILLGSLMGIFINSVYQPAEVAAYAWRIPFLLGGVFGLVSVYLRRYLEETPVFRELAARRK 236 I++GSL+ IN ++ P E++AYAWRIPF +GG+FGL++VYLRR+L ETP+F E+ R Sbjct: 226 IMIGSLIATAINWIFTPEELSAYAWRIPFFIGGIFGLLAVYLRRWLAETPIFTEMKNSRL 285 Query: 237 QSHELPLKTVLREHRGASLLTAGMTWCLSGAVVVVILMTPSYLQTVHHLPAKLVMQANCA 296 +LPL TVLR H +++ +TW LS +VV LMT ++LQ ++ + A Sbjct: 286 LKDKLPLGTVLRNHMHGVVISVLLTWILSAGIVVTTLMTATFLQKLYGYTPLQSLAATSF 345 Query: 297 GTLMLTIGCLLIGWLCDRIGTRASMILGWGGLGLSSWWFYGQLPGSPESLIWGYALVGLF 356 GTL L G + G + DRIG+ + G++++ FY S L YA++GL Sbjct: 346 GTLFLMFGTVSAGAIVDRIGSGRFFAVAGIFFGVATFVFYTYAAVSLPVLFALYAVMGLS 405 Query: 357 VGSIALTPIVSTRAFPPPVRFTGLSFAYNMAYAIFGGLTPVLISLWIKADPQGPALYVIG 416 VG + P V RAFP PVRF+GLSF+YN++YA+FGGLTPV+++ + +P A Y++ Sbjct: 406 VGMVGAAPYVMVRAFPAPVRFSGLSFSYNVSYAVFGGLTPVIVTSLLAVNPMAHAWYLVF 465 Query: 417 LSIL 420 +++L Sbjct: 466 IAVL 469 >Cj0250c [GEPR] COG0477 Permeases of the major facilitator superfamily Cje Campylobacter jejuni Length = 436 Score = 357 bits (917), Expect = 2e-98, Method: Compositional matrix adjust. Identities = 181/423 (42%), Positives = 266/423 (62%), Gaps = 14/423 (3%) Query: 17 RPLTSSDYRTLGLSALGGTLEFYDFVIYVFFAAVVGKLFFPADMPEWLRMLQTFGIFAAG 76 + L D + LGLS+LGGTLEFYDF+I+VFFA + FFP D+ + +M T+GIFAAG Sbjct: 3 KTLNQKDIKVLGLSSLGGTLEFYDFIIFVFFANYISTNFFPKDLSSFWQMFNTYGIFAAG 62 Query: 77 YLARPVGGIIIAHYGDVIGRKRMFTLSIFLMAVPTLVIGLLPTYASIGVAAPILLLLMRT 136 YLARP+GG+I+AH+GD GRKRMF +SI LM +PT + +P Y SIG +LL+ +R Sbjct: 63 YLARPLGGVILAHFGDKFGRKRMFMISILLMVIPTFTLAFIPNYESIGFLCIVLLVFIRI 122 Query: 137 LQGAAIGGEMPGAWVFVAEHVPANRYSFGVGSLTAGITGGILLGSLMGIFINSVYQPAEV 196 QG AIGGE+PGAWVFV EH P + +G LTA + GGILLGSL+ + +N +Y E+ Sbjct: 123 CQGIAIGGELPGAWVFVYEHAPQGQKRTYLGILTASVVGGILLGSLVFLIMNKIYTQEEL 182 Query: 197 AAYAWRIPFLLGGVFGLVSVYLRRYLEETPVFRELAARRKQSHELPLKTVLREHRGASLL 256 +AWRIPF LGG+FG++S YLR++L ETPVF ++ + K + PLK V ++ + +L Sbjct: 183 HEWAWRIPFFLGGIFGIISAYLRKFLRETPVFEQM-KKDKALEKFPLKEVFKKAKMGIVL 241 Query: 257 TAGMTWCLSGAVVVVILMTPSYLQTVHHLPAKLVMQANCAGTLMLTIGCLLIGWLCDRIG 316 + +TW L+G +VV+IL+ PSY+ + + + G L++ +GC++ G L D+IG Sbjct: 242 SMMITWVLTGCIVVMILLMPSYMAKILQINTSIQTYLQIGGILLICLGCIISGILADKIG 301 Query: 317 TRASMILGWGGLGLSSWWFYGQL--PGSPESLIWG-YALVGLFVGSIALTPIVSTRAFPP 373 S + G++S ++ L + +L+ Y LV F G + P++ + F Sbjct: 302 VIKSCVFFSVFFGIASLLYFNTLYRQNADFNLVACLYLLVCFFSGVMNFCPLIMSEVFDA 361 Query: 374 PVRFTGLSFAYNMAYAIFGGLTPVLISLWIKADPQGP---------ALYVIGLSILGVLL 424 ++F+GLSF+YN+AYAI GGLTP L + ++ + LYV L+I+ +L Sbjct: 362 KIKFSGLSFSYNIAYAIAGGLTPQL-AFFLHSFALNNLSNFWRFSLGLYVFFLAIIALLC 420 Query: 425 AFV 427 AF+ Sbjct: 421 AFI 423