BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.3652.p (295 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value DRA0364 [IQR] COG1028 Dehydrogenases with different specificitie... 353 3e-97 PA2142 [IQR] COG1028 Dehydrogenases with different specificities... 347 3e-95 BH1511 [IQR] COG1028 Dehydrogenases with different specificities... 345 5e-95 alr5182 [IQR] COG1028 Dehydrogenases with different specificitie... 345 8e-95 BS_yhdF [IQR] COG1028 Dehydrogenases with different specificitie... 340 2e-93 >DRA0364 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Dra Deinococcus radiodurans Length = 390 Score = 353 bits (905), Expect = 3e-97, Method: Compositional matrix adjust. Identities = 173/289 (59%), Positives = 220/289 (76%), Gaps = 1/289 (0%) Query: 7 EDSMSDTRPEGVPAQHQAHQPGSEQQMQPRPHSAPAGEPGR-RLAGKVALITGGDSGIGR 65 E + ++ P+ VPA+ Q QPGSE +M P G +L GKVALI+GGDSGIGR Sbjct: 101 ETAATENMPQEVPAETQEQQPGSEAEMSLAPVVIRDDYRGSDKLKGKVALISGGDSGIGR 160 Query: 66 AVALAYAREGARLAIVYLDEEEDARQTQQQVQGLDAPCLLLPGDVGSPEFCRSAVRAVME 125 AVA+ +AREGA +AI+YLDE +DAR T + VQ L++ GD+G P+FC+ AV VM+ Sbjct: 161 AVAVHFAREGADVAILYLDEHQDARDTLKMVQAEGRQGLIIAGDIGDPKFCQDAVAQVMK 220 Query: 126 AYGRLDVLVNNAAQQYPAKSIEQISQEQLEHTFRTNIFSMFYMVKEAMPFLTRGARIINT 185 G+LD+LVNNAA+Q+P +++ I+ EQLE TFRTNIF MFY+ + A+P L +GA I+NT Sbjct: 221 ELGKLDILVNNAAEQHPQENLTDITPEQLERTFRTNIFGMFYLTQAALPHLQKGAVIVNT 280 Query: 186 TSVTAYRGSKHLVDYAATKGTIVAFTRSLSQQLAAAGIHVNAVAPGPIWTPLIPSSFSEE 245 TSVTAY+GS L+DY++TKG I+AFTRSLSQ LA GI VNAVAPGPIWTPLIPS+F ++ Sbjct: 281 TSVTAYKGSPELLDYSSTKGAILAFTRSLSQNLADKGIRVNAVAPGPIWTPLIPSTFDQK 340 Query: 246 EVASFGKNVPLGRPGQPDEVAPAYVFLATEGASYMTGQVLHPNGGEIVN 294 VA GK PL RPGQP EVAP+YVFLA+E +SY+TGQVLHPNGG++VN Sbjct: 341 RVAEHGKKTPLERPGQPAEVAPSYVFLASEDSSYITGQVLHPNGGDVVN 389 >PA2142 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Pae Pseudomonas aeruginosa Length = 286 Score = 347 bits (889), Expect = 3e-95, Method: Compositional matrix adjust. Identities = 165/286 (57%), Positives = 211/286 (73%), Gaps = 2/286 (0%) Query: 10 MSDTRPEGVPAQHQAHQPGSEQQMQPRPHSAPAG-EPGRRLAGKVALITGGDSGIGRAVA 68 MS+ R + +PAQHQ +PG E QMQP+P A P +L GKVAL+TGGDSGIGRAVA Sbjct: 1 MSEQR-QTLPAQHQDQRPGHESQMQPKPEFVSADYRPAAKLEGKVALVTGGDSGIGRAVA 59 Query: 69 LAYAREGARLAIVYLDEEEDARQTQQQVQGLDAPCLLLPGDVGSPEFCRSAVRAVMEAYG 128 +A+ARE A + +VYLDE EDA +T++ ++ L CL GDV FCR V + + +G Sbjct: 60 VAFAREKADVVLVYLDENEDAAKTREIIESLGRQCLAFAGDVADAGFCRQVVDTLRQKWG 119 Query: 129 RLDVLVNNAAQQYPAKSIEQISQEQLEHTFRTNIFSMFYMVKEAMPFLTRGARIINTTSV 188 RLDVLVNNA +Q+P +E IS+EQ E TFRTNIF MF + K A+P + +G IINTTS+ Sbjct: 120 RLDVLVNNAGEQHPQARLEDISEEQWEKTFRTNIFGMFQLTKAALPLMGKGGAIINTTSI 179 Query: 189 TAYRGSKHLVDYAATKGTIVAFTRSLSQQLAAAGIHVNAVAPGPIWTPLIPSSFSEEEVA 248 TAY+G+ L+DY++TKG I +FTRSLS L GI VNAVAPGPIWTPLIPS+FS E+VA Sbjct: 180 TAYKGNPQLIDYSSTKGAITSFTRSLSMNLVNRGIRVNAVAPGPIWTPLIPSTFSAEKVA 239 Query: 249 SFGKNVPLGRPGQPDEVAPAYVFLATEGASYMTGQVLHPNGGEIVN 294 FG + P+GRPGQP+E+A +YV+LA +SY++GQVLH NGG +VN Sbjct: 240 HFGADTPMGRPGQPEELAASYVYLACNDSSYVSGQVLHVNGGTVVN 285 >BH1511 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Bha Bacillus halodurans Length = 287 Score = 345 bits (886), Expect = 5e-95, Method: Compositional matrix adjust. Identities = 167/286 (58%), Positives = 211/286 (73%), Gaps = 1/286 (0%) Query: 10 MSDTRPEGVPAQHQAHQPGSEQQMQPRPHSAPAGEPGR-RLAGKVALITGGDSGIGRAVA 68 M+ P P QHQ QPG EQ+M PRP A G +L+GKVALITGGDSGIGRAVA Sbjct: 1 MTKQYPSSQPPQHQMKQPGIEQEMNPRPVFDRADYRGSGKLSGKVALITGGDSGIGRAVA 60 Query: 69 LAYAREGARLAIVYLDEEEDARQTQQQVQGLDAPCLLLPGDVGSPEFCRSAVRAVMEAYG 128 +A+A+EGA++AI YLDE DA +T+Q V+ + C LLPGDVG C+ V+ + +G Sbjct: 61 VAFAKEGAKVAISYLDEHGDANETKQYVEQIGGVCHLLPGDVGEEAICQQIVQETVNQFG 120 Query: 129 RLDVLVNNAAQQYPAKSIEQISQEQLEHTFRTNIFSMFYMVKEAMPFLTRGARIINTTSV 188 RLD++VNNAA+Q+P +E I QLE TFRTN+FS FY K A+P L +GA IINTTS+ Sbjct: 121 RLDIVVNNAAEQHPQAGLEAIDSTQLEQTFRTNVFSFFYTTKAALPHLQQGASIINTTSI 180 Query: 189 TAYRGSKHLVDYAATKGTIVAFTRSLSQQLAAAGIHVNAVAPGPIWTPLIPSSFSEEEVA 248 TAY+GSK L+DYA+TKG IVA TRSLS+ + GI VN VAPGPIWTPLIP+SF ++VA Sbjct: 181 TAYQGSKDLIDYASTKGAIVALTRSLSESIVGQGIRVNGVAPGPIWTPLIPASFDAQKVA 240 Query: 249 SFGKNVPLGRPGQPDEVAPAYVFLATEGASYMTGQVLHPNGGEIVN 294 FG + P+ R GQP+E+A AYV+LA++ +SY++GQVLH NGG IVN Sbjct: 241 QFGSDTPMKRAGQPEELAAAYVYLASDDSSYVSGQVLHVNGGVIVN 286 >alr5182 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Nos Nostoc sp. PCC 7120 Length = 285 Score = 345 bits (885), Expect = 8e-95, Method: Compositional matrix adjust. Identities = 162/268 (60%), Positives = 211/268 (78%), Gaps = 1/268 (0%) Query: 28 GSEQQMQPRPHSAPAGEPGR-RLAGKVALITGGDSGIGRAVALAYAREGARLAIVYLDEE 86 G+E +MQP+P + A G +L KVALITGGDSGIGRAVA+AYA+EGA +A VYL E Sbjct: 17 GTESKMQPKPQADDAQYRGSGKLKDKVALITGGDSGIGRAVAIAYAKEGADVAFVYLSEH 76 Query: 87 EDARQTQQQVQGLDAPCLLLPGDVGSPEFCRSAVRAVMEAYGRLDVLVNNAAQQYPAKSI 146 +DA +T+ V+ + + GD+ FC+ A++ ++ +G+LD+L+NNAA+Q+P +SI Sbjct: 77 DDAEETKNLVEEQGRRAVSIAGDITDEAFCQRAIQQTVDEFGKLDILINNAAEQHPQESI 136 Query: 147 EQISQEQLEHTFRTNIFSMFYMVKEAMPFLTRGARIINTTSVTAYRGSKHLVDYAATKGT 206 E I++EQLE TFRTNIFSMFY+ K A+ L +G+ IINTTSVTAY+GS L+DY++TKG Sbjct: 137 EDITKEQLERTFRTNIFSMFYLTKAAIKHLKKGSAIINTTSVTAYKGSPQLLDYSSTKGA 196 Query: 207 IVAFTRSLSQQLAAAGIHVNAVAPGPIWTPLIPSSFSEEEVASFGKNVPLGRPGQPDEVA 266 IVAFTRSLSQ L + GI VNAVAPGPIWTPLIPS+F E+V +FGK VP+ R GQP+EVA Sbjct: 197 IVAFTRSLSQNLISKGIRVNAVAPGPIWTPLIPSTFPAEKVETFGKQVPMQRAGQPEEVA 256 Query: 267 PAYVFLATEGASYMTGQVLHPNGGEIVN 294 P+YVFLA++ +SYM+GQVLHPNGGE+VN Sbjct: 257 PSYVFLASDDSSYMSGQVLHPNGGEVVN 284 >BS_yhdF [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Bsu Bacillus subtilis Length = 289 Score = 340 bits (872), Expect = 2e-93, Method: Compositional matrix adjust. Identities = 162/285 (56%), Positives = 210/285 (73%), Gaps = 1/285 (0%) Query: 12 DTRPEGVPAQHQAHQPGSEQQMQPRPHSAPAGEPGR-RLAGKVALITGGDSGIGRAVALA 70 D + EG QHQ QPG E +M P P S G +L GKVA+ITGGDSGIGRA A+A Sbjct: 5 DRQTEGQEPQHQDRQPGIESKMNPLPLSEDEDYRGSGKLKGKVAIITGGDSGIGRAAAIA 64 Query: 71 YAREGARLAIVYLDEEEDARQTQQQVQGLDAPCLLLPGDVGSPEFCRSAVRAVMEAYGRL 130 +A+EGA ++I+YLDE DA +T+++++ + CLL+PGDVG C AV+ ++ +G+L Sbjct: 65 FAKEGADISILYLDEHSDAEETRKRIEKENVRCLLIPGDVGDENHCEQAVQQTVDHFGKL 124 Query: 131 DVLVNNAAQQYPAKSIEQISQEQLEHTFRTNIFSMFYMVKEAMPFLTRGARIINTTSVTA 190 D+LVNNAA+Q+P SI IS EQLE TFRTNIFSMF+M K+A+P L G IINTTS+TA Sbjct: 125 DILVNNAAEQHPQDSILNISTEQLEKTFRTNIFSMFHMTKKALPHLQEGCAIINTTSITA 184 Query: 191 YRGSKHLVDYAATKGTIVAFTRSLSQQLAAAGIHVNAVAPGPIWTPLIPSSFSEEEVASF 250 Y G L+DY++TKG IV+FTRS+++ LA GI VNAVAPGPIWTPLIP++F EE+V Sbjct: 185 YEGDTALIDYSSTKGAIVSFTRSMAKSLADKGIRVNAVAPGPIWTPLIPATFPEEKVKQH 244 Query: 251 GKNVPLGRPGQPDEVAPAYVFLATEGASYMTGQVLHPNGGEIVNT 295 G + P+GRPGQP E A AYV LA++ +SYMTGQ +H NGG ++T Sbjct: 245 GLDTPMGRPGQPVEHAGAYVLLASDESSYMTGQTIHVNGGRFIST 289