BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.3604.p (881 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc0901 [L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, ... 1451 0.0 NMB1384 [L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, ... 1055 0.0 PA3168 [L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, t... 1055 0.0 YPO1216 [L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, ... 1054 0.0 STM2272 [L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, ... 1053 0.0 >RSc0901 [L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit Rso Ralstonia solanacearum Length = 885 Score = 1451 bits (3755), Expect = 0.0, Method: Compositional matrix adjust. Identities = 709/888 (79%), Positives = 781/888 (87%), Gaps = 17/888 (1%) Query: 1 MDQFAKETIPISLEEEMRKSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMHEMNNVWN 60 MDQFAKET+P+SLEEEMR SYL YAMSVIVGRALPDVRDGLKPVHRRVLYAMHE+NN WN Sbjct: 1 MDQFAKETLPVSLEEEMRSSYLAYAMSVIVGRALPDVRDGLKPVHRRVLYAMHELNNDWN 60 Query: 61 RPFVKCARVVGEVMGKYHPHGDASIYDTLVRMAQDFSLRYTLVDGQGNFGSIDGDGAAAM 120 RP+ K AR+VG+V+GKYHPHGD+++YDT+VRMAQDFSLRY LVDGQGNFGS+DGD AAAM Sbjct: 61 RPYKKSARIVGDVIGKYHPHGDSAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDNAAAM 120 Query: 121 RYTECRLDKISNELLADIEKETVDFVPNYDGKEKEPSVLPTRIPNLLVNGSSGIAVGMAT 180 RYTE RL KI++ELLADI+KETVDF PNYDG E EPS+LP RIPNLL+NGSSGIAVGMAT Sbjct: 121 RYTEIRLSKIAHELLADIDKETVDFEPNYDGSETEPSILPARIPNLLINGSSGIAVGMAT 180 Query: 181 NIPPHNITEVINGALHLLANEHCTIDELIELVPAPDFPTGGIIYGVSGVRDGYRTGRGRV 240 NIPPHN+ EV++G LHLL N T+DELIEL+PAPDFPT GIIYG+SGVR+GYRTGRGRV Sbjct: 181 NIPPHNLREVVDGCLHLLRNPDATVDELIELIPAPDFPTAGIIYGISGVREGYRTGRGRV 240 Query: 241 VMRAKTHFEEYGREGRIAIIVDELPYQVNKKALLERIAELVRDKKLEGISDLRDESDKSG 300 VMRAKTHFE+ R R AIIVDELPYQVNK+ LLERIAELV +K++EGISD+RDESDKSG Sbjct: 241 VMRAKTHFEDIDRGQRQAIIVDELPYQVNKRTLLERIAELVTEKRIEGISDIRDESDKSG 300 Query: 301 MRVVIELKRGEVPEVVLNNLYKQTQLQDTFGMNMVALVDGQPRLLNLKQLLECFLSHRRE 360 MRVVIELKRGEVPEVVLNNLYK TQLQDTFGMNMVALVDGQPRLLNL+Q+LECFL HRRE Sbjct: 301 MRVVIELKRGEVPEVVLNNLYKNTQLQDTFGMNMVALVDGQPRLLNLRQMLECFLLHRRE 360 Query: 361 VVTRRTVFELRKARERGHVLEGLAVALANIDDFIAIIRAAPTPPIAKAELMSKSWDSSMV 420 VVTRRTVF+LRKARERGH+LEGLAVALANID+FIAII+AAPTPPIAK ELM ++WDS +V Sbjct: 361 VVTRRTVFDLRKARERGHILEGLAVALANIDEFIAIIKAAPTPPIAKQELMGRNWDSGLV 420 Query: 421 REMLARAGEANEGGIEAFRPESLPAHYGIQSDGLYKLSDEQAQEILQMRLQRLTGLEQDK 480 REML+RA GG A+RPE L +G+Q GLYKLSD QAQEILQMRLQRLTGLEQDK Sbjct: 421 REMLSRAESDTVGGRAAYRPEGLLPVFGMQEGGLYKLSDTQAQEILQMRLQRLTGLEQDK 480 Query: 481 IVNEYKDVMAQIADLLDILSKPARVTAIITDELNAAKNDFGIGAKDERRSTIEHNATDLA 540 IV EY++VMAQIADLLDIL++P R+TAII +EL + +FG DERRS IEHNAT+L Sbjct: 481 IVQEYREVMAQIADLLDILARPERITAIIVEELTLIRAEFG----DERRSQIEHNATELD 536 Query: 541 TEDLITPQDMVVTLSHTGYMKSQPVSEYRAQKRGGRGKQAMATKDDDWIDQLFIANTHDY 600 TEDLITPQD+VVTLSH+GYMKSQP+SEYRAQKRGGRGKQA ATK+DDWID LF+ANTHDY Sbjct: 537 TEDLITPQDLVVTLSHSGYMKSQPISEYRAQKRGGRGKQAAATKEDDWIDTLFVANTHDY 596 Query: 601 ILCFSNRGRLYWLKVWEVPQGSRNSRGKPIVNMFPLQDGEKITVILPVSGANRSFPDDRY 660 ILCFSNRGRLYWLKVWEVPQGSRNSRG+PIVNMFPL GEKI VILPV + F + + Sbjct: 597 ILCFSNRGRLYWLKVWEVPQGSRNSRGRPIVNMFPLSPGEKINVILPV----KQFDEQHF 652 Query: 661 VFMATSLGTVKKTPLSDFSNPRKAGIIAVDLDEGDFLIGAALTDGQHDVMLFSDGGKAVR 720 VFMATS GTVKKT L++FSNPRKAGIIAVDLD+GDFLIGA +TDGQHDVMLFSD GKAVR Sbjct: 653 VFMATSKGTVKKTALTEFSNPRKAGIIAVDLDDGDFLIGADITDGQHDVMLFSDAGKAVR 712 Query: 721 FDENDVRPMGRTARGVRGMNLEETQQVIALLVA------ENEQQ---SVLTATENGFGKR 771 FDENDVRPMGR ARGVRGMNLEE QQVIA+LVA E EQ SVLTATENG+GKR Sbjct: 713 FDENDVRPMGRQARGVRGMNLEEGQQVIAMLVAPAETAGEGEQAVAGSVLTATENGYGKR 772 Query: 772 TPITEYTRHGRGTKGMIAIQTSERNGKVVAATLVDSSDEIMLITTGGVLIRTRVSEIREM 831 TPI+EYTRHGRGTKGMIAIQTSERNGKVVAA LV DEIMLITTGGVLIRTRV EIREM Sbjct: 773 TPISEYTRHGRGTKGMIAIQTSERNGKVVAAALVAPEDEIMLITTGGVLIRTRVDEIREM 832 Query: 832 GRATQGVTLIAVEDGTKLSGLQRVVESDVEDVIESEGTEAAGGETPAA 879 GRATQGVTLIAV +G KLSGLQRVVESD E ++G + GE P A Sbjct: 833 GRATQGVTLIAVGEGNKLSGLQRVVESDAEGEDAADGGPESDGEAPDA 880 >NMB1384 [L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit Nme Neisseria meningitidis MC58 Length = 916 Score = 1055 bits (2728), Expect = 0.0, Method: Compositional matrix adjust. Identities = 533/902 (59%), Positives = 672/902 (74%), Gaps = 56/902 (6%) Query: 3 QFAKETIPISLEEEMRKSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMHEMNNVWNRP 62 +FA ET+P+SLE+EMRKSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMHE+ N WN Sbjct: 11 KFALETLPVSLEDEMRKSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMHELKNNWNAA 70 Query: 63 FVKCARVVGEVMGKYHPHGDASIYDTLVRMAQDFSLRYTLVDGQGNFGSIDGDGAAAMRY 122 + K AR+VG+V+GKYHPHGD ++YDT+VRMAQ+F++RY L+DGQGNFGS+DG AAAMRY Sbjct: 71 YKKSARIVGDVIGKYHPHGDTAVYDTIVRMAQNFAMRYVLIDGQGNFGSVDGLAAAAMRY 130 Query: 123 TECRLDKISNELLADIEKETVDFVPNYDGKEKEPSVLPTRIPNLLVNGSSGIAVGMATNI 182 TE R+ KIS+E+LADIE+ETV+F PNYDG E EP VLPTR P LLVNGSSGIAVGMATNI Sbjct: 131 TEIRMAKISHEMLADIEEETVNFGPNYDGSEHEPLVLPTRFPTLLVNGSSGIAVGMATNI 190 Query: 183 PPHNITEVINGALHLLANEHCTIDELIELVPAPDFPTGGIIYGVSGVRDGYRTGRGRVVM 242 PPHN+++ +N L LL IDELI+++ APDFPTG IYG+SGVR+GY+TGRGRVVM Sbjct: 191 PPHNLSDTVNACLRLLDAPDTEIDELIDIIQAPDFPTGATIYGLSGVREGYKTGRGRVVM 250 Query: 243 RAKTHFEEYGREG-RIAIIVDELPYQVNKKALLERIAELVRDKKLEGISDLRDESDKSGM 301 R KTH E GR G R AI++DE+PYQVNK L+E+I +LVR+K LEGIS+LRDESDKSGM Sbjct: 251 RGKTHIEPIGRNGEREAIVIDEIPYQVNKAKLVEKIGDLVREKTLEGISELRDESDKSGM 310 Query: 302 RVVIELKRGEVPEVVLNNLYKQTQLQDTFGMNMVALVDGQPRLLNLKQLLECFLSHRREV 361 RVVIELKR E EVVLN LYK T LQD+FG+NMV LVDGQPRLLNLKQ+L FL HRREV Sbjct: 311 RVVIELKRNENAEVVLNQLYKLTPLQDSFGINMVVLVDGQPRLLNLKQILSEFLRHRREV 370 Query: 362 VTRRTVFELRKARERGHVLEGLAVALANIDDFIAIIRAAPTPPIAKAELMSKSWDSSMVR 421 VTRRT+F L+KAR GH+ EG AVAL+NID+ I +I+ +P AK +L+++ W SS+V Sbjct: 371 VTRRTLFRLKKARHEGHIAEGKAVALSNIDEIIKLIKESPNAAEAKDKLLARPWRSSLVE 430 Query: 422 EMLARAGEANEGGIEAFRPESLPAHYGIQSDGLYKLSDEQAQEILQMRLQRLTGLEQDKI 481 EML R+G +E RPE L A+ G++ G Y LS+ QA IL+M L+ LTGL+Q++I Sbjct: 431 EMLTRSGL----DLEMMRPEGLAANIGLKEQGYY-LSEIQADAILRMSLRNLTGLDQEEI 485 Query: 482 VNEYKDVMAQIADLLDILSKPARVTAIITDELNAAKNDFGIGAKDERRSTIEHNATDLAT 541 V YK++M +I D +DILSKP R+T II DEL K ++G DERRS I D+A Sbjct: 486 VESYKNLMGKIIDFVDILSKPERITQIIRDELEEIKTNYG----DERRSEINPFGGDIAD 541 Query: 542 EDLITPQDMVVTLSHTGYMKSQPVSEYRAQKRGGRGKQAMATKDDDWIDQLFIANTHDYI 601 EDLI ++MVVTL+H GY+K+QP ++Y+AQ+RGGRGKQA ATKD+D+I+ LF+ANTHDY+ Sbjct: 542 EDLIPQREMVVTLTHGGYIKTQPTTDYQAQRRGGRGKQAAATKDEDFIETLFVANTHDYL 601 Query: 602 LCFSNRGRLYWLKVWEVPQGSRNSRGKPIVNMFPLQDGEKITVILPVSGANRSFPDDRYV 661 +CF+N G+ +W+KV+++P+G RNSRG+PI N+ L++GEK++ IL V R FP+D+YV Sbjct: 602 MCFTNLGKCHWIKVYKLPEGGRNSRGRPINNVIQLEEGEKVSAILAV----REFPEDQYV 657 Query: 662 FMATSLGTVKKTPLSDFSNPRKAGIIAVDLDEGDFLIGAALTDGQHDVMLFSDGGKAVRF 721 F AT+ G VKK LS F N R GI A+ L EGD+L+GAA T G D+MLFS+ GKA+RF Sbjct: 658 FFATAQGMVKKVQLSAFKNVRAQGIKAIALKEGDYLVGAAQTGGADDIMLFSNLGKAIRF 717 Query: 722 DE------ND--------------------------------VRPMGRTARGVRGMNLEE 743 +E ND VRP GR + G+RGM L Sbjct: 718 NEYWEKSGNDEAEDADIETEISDGIEDETADSENALPSGKHGVRPSGRGSGGLRGMRLPA 777 Query: 744 TQQVIALLVAENEQQ----SVLTATENGFGKRTPITEYTRHGRGTKGMIAIQTSERNGKV 799 ++++L+ E + VLTAT NG+GKRTPI +Y+R +G +G IAI T ERNG + Sbjct: 778 DGKIVSLITFAPETEESGLQVLTATANGYGKRTPIADYSRKNKGGQGNIAINTGERNGDL 837 Query: 800 VAATLVDSSDEIMLITTGGVLIRTRVSEIREMGRATQGVTLIAVEDGTKLSGLQRVVESD 859 VAATLV +D++MLIT+GGVLIRT+V +IRE GRA GV LI +++G L L+RV E + Sbjct: 838 VAATLVGETDDLMLITSGGVLIRTKVEQIRETGRAAAGVKLINLDEGETLVSLERVAEDE 897 Query: 860 VE 861 E Sbjct: 898 SE 899 >PA3168 [L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit Pae Pseudomonas aeruginosa Length = 923 Score = 1055 bits (2727), Expect = 0.0, Method: Compositional matrix adjust. Identities = 524/919 (57%), Positives = 680/919 (73%), Gaps = 55/919 (5%) Query: 1 MDQFAKETIPISLEEEMRKSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMHEMNNVWN 60 M + AKE +P+++E+E+++SYLDYAMSVIVGRALPD RDGLKPVHRRVLYAM E+ N WN Sbjct: 1 MGELAKEILPVNIEDELKQSYLDYAMSVIVGRALPDARDGLKPVHRRVLYAMSELGNDWN 60 Query: 61 RPFVKCARVVGEVMGKYHPHGDASIYDTLVRMAQDFSLRYTLVDGQGNFGSIDGDGAAAM 120 +P+ K ARVVG+V+GKYHPHGD ++YDT+VRMAQ FSLRY LVDGQGNFGS+DGD AAAM Sbjct: 61 KPYKKSARVVGDVIGKYHPHGDTAVYDTIVRMAQPFSLRYMLVDGQGNFGSVDGDNAAAM 120 Query: 121 RYTECRLDKISNELLADIEKETVDFVPNYDGKEKEPSVLPTRIPNLLVNGSSGIAVGMAT 180 RYTE R+ K+++ELLAD+EKETVD+VPNYDG E+ P+V+PT+IPNLLVNGSSGIAVGMAT Sbjct: 121 RYTEVRMAKLAHELLADLEKETVDWVPNYDGTEQIPAVMPTKIPNLLVNGSSGIAVGMAT 180 Query: 181 NIPPHNITEVINGALHLLANEHCTIDELIELVPAPDFPTGGIIYGVSGVRDGYRTGRGRV 240 NIPPHN+ EVI+G L L+ N T+DEL++ +P PDFPT GII G +G+ + YRTGRGR+ Sbjct: 181 NIPPHNLGEVIDGCLALMDNPDLTVDELMQYIPGPDFPTAGIINGRAGIIEAYRTGRGRI 240 Query: 241 VMRAKTHFEEYGR-EGRIAIIVDELPYQVNKKALLERIAELVRDKKLEGISDLRDESDKS 299 +RA+ EE + GR II+ ELPYQ+NK L+E+IAELV++KK+EGIS+LRDESDK Sbjct: 241 YIRARAVVEEMEKGGGREQIIITELPYQLNKARLIEKIAELVKEKKIEGISELRDESDKD 300 Query: 300 GMRVVIELKRGEVPEVVLNNLYKQTQLQDTFGMNMVALVDGQPRLLNLKQLLECFLSHRR 359 GMRVVIEL+RGEV EVVLNNLY QTQLQ FG+N+VALVDGQPR LNLK +LE F+ HRR Sbjct: 301 GMRVVIELRRGEVGEVVLNNLYAQTQLQSVFGINVVALVDGQPRTLNLKDMLEVFVRHRR 360 Query: 360 EVVTRRTVFELRKARERGHVLEGLAVALANIDDFIAIIRAAPTPPIAKAELMSKSWDSSM 419 EVVTRRTV+ELRKARERGH+LEG AVAL+NID I +I+++PTP AK L++ +W+SS Sbjct: 361 EVVTRRTVYELRKARERGHILEGQAVALSNIDPVIELIKSSPTPAEAKERLIATAWESSA 420 Query: 420 VREMLARAGEANEGGIEAFRPESLPAHYGIQSDGLYKLSDEQAQEILQMRLQRLTGLEQD 479 V M+ RA G +A RPE L YG++ DG Y LS EQAQ IL++RL RLTGLE + Sbjct: 421 VEAMVERA------GADACRPEDLDPQYGLR-DGKYYLSPEQAQAILELRLHRLTGLEHE 473 Query: 480 KIVNEYKDVMAQIADLLDILSKPARVTAIITDELNAAKNDFGIGAKDERRSTIEHNATDL 539 K+++EY++++ I +L+ IL+ PAR+ +I +EL A K +FG D RR+ I + DL Sbjct: 474 KLLSEYQEILNLIGELIRILTNPARLMEVIREELEAVKAEFG----DARRTEIVASQVDL 529 Query: 540 ATEDLITPQDMVVTLSHTGYMKSQPVSEYRAQKRGGRGKQAMATKDDDWIDQLFIANTHD 599 DLIT +D VVT+SH GY KSQP++ Y+AQ+RGG+GK A KD+D+I+ L +AN+H Sbjct: 530 TIADLITEEDRVVTISHGGYAKSQPLAAYQAQRRGGKGKSATGMKDEDYIEHLLVANSHA 589 Query: 600 YILCFSNRGRLYWLKVWEVPQGSRNSRGKPIVNMFPLQDGEKITVILPV--------SGA 651 +L FS++G++YWL+ +E+P+ SR +RG+P+VN+ PL +GE+IT +L + GA Sbjct: 590 TLLLFSSKGKVYWLRTFEIPEASRTARGRPLVNLLPLDEGERITAMLQIDLEALQQNGGA 649 Query: 652 NRSF-------------------------------PDDRYVFMATSLGTVKKTPLSDFSN 680 + P Y+FMAT+ GTVKKTPL FS Sbjct: 650 DDDLDEAEGAVLEGEVVEAAEVEEVEGETAELVAEPTGAYIFMATAFGTVKKTPLVQFSR 709 Query: 681 PRKAGIIAVDLDEGDFLIGAALTDGQHDVMLFSDGGKAVRFDENDVRPMGRTARGVRGMN 740 PR +G+IA+ L+EGD LI AA+TDG +VMLFS GK +RF E+ VR MGR ARGVRGM Sbjct: 710 PRSSGLIALKLEEGDTLIAAAITDGAKEVMLFSSAGKVIRFAESVVRIMGRNARGVRGMR 769 Query: 741 LEETQQVIALLVAENEQQSVLTATENGFGKRTPITEYTRHGRGTKGMIAIQTSERNGKVV 800 L + QQ+I++L+ E+ Q +LTA+E GFGKRTP++++ R GRG +G+IA+ T+ERNG ++ Sbjct: 770 LGKGQQLISMLIPESGAQ-ILTASERGFGKRTPLSKFPRRGRGGQGVIAMVTNERNGALI 828 Query: 801 AATLVDSSDEIMLITTGGVLIRTRVSEIREMGRATQGVTLIAVEDGTKLSGLQRVVE--- 857 AA V +EIMLI+ G L+RTRV E+ GR TQGVTLI + L GL+RV E Sbjct: 829 AAVQVQEGEEIMLISDQGTLVRTRVDEVSLSGRNTQGVTLIKLASDEVLVGLERVQEPSG 888 Query: 858 SDVEDVIESEGTEAAGGET 876 D ED+ E E + GE+ Sbjct: 889 GDDEDLPEGEEAAESLGES 907 >YPO1216 [L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit Ype Yersinia pestis Length = 891 Score = 1054 bits (2725), Expect = 0.0, Method: Compositional matrix adjust. Identities = 518/864 (59%), Positives = 663/864 (76%), Gaps = 16/864 (1%) Query: 1 MDQFAKETIPISLEEEMRKSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMHEMNNVWN 60 M A+E P+++EEE++ SYLDYAMSVIVGRALPDVRDGLKPVHRRVL+AM+ + N WN Sbjct: 1 MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNVLGNDWN 60 Query: 61 RPFVKCARVVGEVMGKYHPHGDASIYDTLVRMAQDFSLRYTLVDGQGNFGSIDGDGAAAM 120 +P+ K ARVVG+V+GKYHPHGD+++YDT+VRMAQ FSLRY LVDGQGNFGS+DGD AAAM Sbjct: 61 KPYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSVDGDSAAAM 120 Query: 121 RYTECRLDKISNELLADIEKETVDFVPNYDGKEKEPSVLPTRIPNLLVNGSSGIAVGMAT 180 RYTE R+ KI++ELLAD+EK+TVDFVPNYDG E+ P+V+PTRIPNLLVNGSSGIAVGMAT Sbjct: 121 RYTEIRMSKIAHELLADLEKDTVDFVPNYDGTEQIPAVMPTRIPNLLVNGSSGIAVGMAT 180 Query: 181 NIPPHNITEVINGALHLLANEHCTIDELIELVPAPDFPTGGIIYGVSGVRDGYRTGRGRV 240 NIPPHN++EVI+G L + +E+ +I+ L+E +P PDFPT II G G+ + YRTGRG+V Sbjct: 181 NIPPHNLSEVIDGCLAYIEDENISIEGLMEYIPGPDFPTAAIINGRRGIEEAYRTGRGKV 240 Query: 241 VMRAKTHFEEYGREGRIAIIVDELPYQVNKKALLERIAELVRDKKLEGISDLRDESDKSG 300 +RA+ E + GR IIV E+PYQVNK L+E+IAELV++K++EGIS LRDESDK G Sbjct: 241 YIRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDG 300 Query: 301 MRVVIELKRGEVPEVVLNNLYKQTQLQDTFGMNMVALVDGQPRLLNLKQLLECFLSHRRE 360 MR+VIE+KR V EVVLNNLY TQLQ TFG+NMVAL GQP+LLNLK +L F+ HRRE Sbjct: 301 MRIVIEIKRDAVGEVVLNNLYSLTQLQVTFGINMVALSQGQPKLLNLKDILVAFVRHRRE 360 Query: 361 VVTRRTVFELRKARERGHVLEGLAVALANIDDFIAIIRAAPTPPIAKAELMSKSWDSSMV 420 VVTRRT+FELRKAR+R H+LE LA+ALANID I +IR A TP AKA L++ W+ V Sbjct: 361 VVTRRTIFELRKARDRAHILEALAIALANIDPIIELIRRASTPAEAKAGLIASPWELGNV 420 Query: 421 REMLARAGEANEGGIEAFRPESLPAHYGIQSDGLYKLSDEQAQEILQMRLQRLTGLEQDK 480 ML RAG+ +A RPE L A +GI+ DG Y L+++QAQ IL +RLQ+LTGLE +K Sbjct: 421 ASMLERAGD------DAARPEWLEAEFGIR-DGKYYLTEQQAQAILDLRLQKLTGLEHEK 473 Query: 481 IVNEYKDVMAQIADLLDILSKPARVTAIITDELNAAKNDFGIGAKDERRSTIEHNATDLA 540 +++EYK+++ I +L+ IL P R+ +I +EL A K + D RR+ I N +D+ Sbjct: 474 LLDEYKELLTLIGELIFILENPDRLMEVIREELVAIKEQY----NDLRRTEITANTSDIN 529 Query: 541 TEDLITPQDMVVTLSHTGYMKSQPVSEYRAQKRGGRGKQAMATKDDDWIDQLFIANTHDY 600 EDLI +D+VVTLSH GY+K QP+S+Y AQ+RGG+GK A K++D+ID+L +ANTHD Sbjct: 530 IEDLINQEDVVVTLSHQGYVKYQPLSDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDT 589 Query: 601 ILCFSNRGRLYWLKVWEVPQGSRNSRGKPIVNMFPLQDGEKITVILPVSGANRSFPDDRY 660 ILCFS+RGRLYW+KV+++P+ SR +RG+PIVN+ PL+ E+IT ILPV R + + + Sbjct: 590 ILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEPNERITAILPV----REYEEGCH 645 Query: 661 VFMATSLGTVKKTPLSDFSNPRKAGIIAVDLDEGDFLIGAALTDGQHDVMLFSDGGKAVR 720 VFMAT+ GTVKKT L++FS PR AGIIAV+L+EGD LIG LTDG ++VMLFS GK VR Sbjct: 646 VFMATASGTVKKTALTEFSRPRSAGIIAVNLNEGDELIGVDLTDGSNEVMLFSALGKVVR 705 Query: 721 FDENDVRPMGRTARGVRGMNLEETQQVIALLVAENEQQSVLTATENGFGKRTPITEYTRH 780 F E VR MGRTA GVRG+NL +VI+L++ + + +LT TENG+GKRT + EY Sbjct: 706 FPEGQVRSMGRTATGVRGINLNGDDRVISLIIPRGDGE-ILTVTENGYGKRTAVAEYPTK 764 Query: 781 GRGTKGMIAIQTSERNGKVVAATLVDSSDEIMLITTGGVLIRTRVSEIREMGRATQGVTL 840 R T+G+I+I+ SERNGKVV A V +D+IM+IT G L+RTRVSE+ +GR TQGVTL Sbjct: 765 SRATQGVISIKVSERNGKVVGAVQVAPTDQIMMITDAGTLVRTRVSEVSVVGRNTQGVTL 824 Query: 841 IAVEDGTKLSGLQRVVESDVEDVI 864 I + + GLQRV E + +D I Sbjct: 825 IRTAEDEHVVGLQRVAEPEEDDDI 848 >STM2272 [L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit Sty Salmonella typhimurium LT2 Length = 878 Score = 1053 bits (2723), Expect = 0.0, Method: Compositional matrix adjust. Identities = 522/879 (59%), Positives = 666/879 (75%), Gaps = 17/879 (1%) Query: 1 MDQFAKETIPISLEEEMRKSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMHEMNNVWN 60 M A+E P+++EEE++ SYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAM+ + N WN Sbjct: 1 MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWN 60 Query: 61 RPFVKCARVVGEVMGKYHPHGDASIYDTLVRMAQDFSLRYTLVDGQGNFGSIDGDGAAAM 120 + + K ARVVG+V+GKYHPHGD+++YDT+VRMAQ FSLRY LVDGQGNFGSIDGD AAAM Sbjct: 61 KAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAM 120 Query: 121 RYTECRLDKISNELLADIEKETVDFVPNYDGKEKEPSVLPTRIPNLLVNGSSGIAVGMAT 180 RYTE RL KI++EL+AD+EKETVDFV NYDG EK P V+PT+IPNLLVNGSSGIAVGMAT Sbjct: 121 RYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPDVMPTKIPNLLVNGSSGIAVGMAT 180 Query: 181 NIPPHNITEVINGALHLLANEHCTIDELIELVPAPDFPTGGIIYGVSGVRDGYRTGRGRV 240 NIPPHN+TEVING L + NE +I+ L+E +P PDFPT II G G+ + YRTGRG+V Sbjct: 181 NIPPHNLTEVINGCLAYIDNEDISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKV 240 Query: 241 VMRAKTHFEEYGREGRIAIIVDELPYQVNKKALLERIAELVRDKKLEGISDLRDESDKSG 300 +RA+ E + GR IIV E+PYQVNK L+E+IAELV+DK++EGIS LRDESDK G Sbjct: 241 YIRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKDKRVEGISALRDESDKDG 300 Query: 301 MRVVIELKRGEVPEVVLNNLYKQTQLQDTFGMNMVALVDGQPRLLNLKQLLECFLSHRRE 360 MR+VIE+KR V EVVLNNLY QTQLQ +FG+NMVAL GQP+++NLK ++ F+ HRRE Sbjct: 301 MRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIISAFVRHRRE 360 Query: 361 VVTRRTVFELRKARERGHVLEGLAVALANIDDFIAIIRAAPTPPIAKAELMSKSWDSSMV 420 VVTRRT+FELRKAR+R H+LE LA+ALANID I +IR APTP AKA L+S+ WD V Sbjct: 361 VVTRRTIFELRKARDRAHILEALAIALANIDPIIELIRRAPTPAEAKAALISRPWDLGNV 420 Query: 421 REMLARAGEANEGGIEAFRPESLPAHYGIQSDGLYKLSDEQAQEILQMRLQRLTGLEQDK 480 ML RAG+ +A RPE L +G++ DG Y L+++QAQ IL +RLQ+LTGLE +K Sbjct: 421 AAMLERAGD------DAARPEWLEPEFGVR-DGQYYLTEQQAQAILDLRLQKLTGLEHEK 473 Query: 481 IVNEYKDVMAQIADLLDILSKPARVTAIITDELNAAKNDFGIGAKDERRSTIEHNATDLA 540 +++EYK+++ QIA+LL IL R+ +I +E+ ++ FG DERR+ I N+ D+ Sbjct: 474 LLDEYKELLEQIAELLHILGSADRLMEVIREEMELIRDQFG----DERRTEITANSADIN 529 Query: 541 TEDLITPQDMVVTLSHTGYMKSQPVSEYRAQKRGGRGKQAMATKDDDWIDQLFIANTHDY 600 EDLI+ +D+VVTLSH GY+K QP+++Y AQ+RGG+GK A K++D+ID+L +ANTHD Sbjct: 530 IEDLISQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDT 589 Query: 601 ILCFSNRGRLYWLKVWEVPQGSRNSRGKPIVNMFPLQDGEKITVILPVSGANRSFPDDRY 660 ILCFS+RGRLYW+KV+++P+ SR +RG+PIVN+ PL+ E+IT ILPV R + + Sbjct: 590 ILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEANERITAILPV----REYEEGVN 645 Query: 661 VFMATSLGTVKKTPLSDFSNPRKAGIIAVDLDEGDFLIGAALTDGQHDVMLFSDGGKAVR 720 VFMAT+ GTVKKT L++FS PR AGIIAV+L++GD LIG LT G +VMLFS GK VR Sbjct: 646 VFMATASGTVKKTALTEFSRPRSAGIIAVNLNDGDELIGVDLTSGSDEVMLFSAAGKVVR 705 Query: 721 FDENDVRPMGRTARGVRGMNLEETQQVIALLVAENEQQSVLTATENGFGKRTPITEYTRH 780 F E+ VR MGRTA GVRG+ L +V++L++ E ++LT T+NG+GKRT EY Sbjct: 706 FKEDAVRAMGRTATGVRGIKLAGDDKVVSLIIPRGE-GAILTVTQNGYGKRTAADEYPTK 764 Query: 781 GRGTKGMIAIQTSERNGKVVAATLVDSSDEIMLITTGGVLIRTRVSEIREMGRATQGVTL 840 R T+G+I+I+ +ERNG VV A VD D+IM+IT G L+RTRVSEI +GR TQGV L Sbjct: 765 SRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSEISVVGRNTQGVIL 824 Query: 841 IAVEDGTKLSGLQRVVES-DVEDVIESEGTEAAGGETPA 878 I + + GLQRV E D E++ +G+ A G E A Sbjct: 825 IRTAEDENVVGLQRVAEPVDDEELDAIDGSVAEGDEDIA 863