BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.3459.p (304 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2187 [GER] COG0697 Permeases of the drug/metabolite transport... 361 1e-99 BS_ycbK [GER] COG0697 Permeases of the drug/metabolite transport... 107 3e-23 DR0512 [GER] COG0697 Permeases of the drug/metabolite transporte... 65 2e-10 BS_yoaV [GER] COG0697 Permeases of the drug/metabolite transport... 63 1e-09 RSc1002 [GER] COG0697 Permeases of the drug/metabolite transport... 62 2e-09 >RSc2187 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Rso Ralstonia solanacearum Length = 308 Score = 361 bits (927), Expect = 1e-99, Method: Compositional matrix adjust. Identities = 199/308 (64%), Positives = 240/308 (77%), Gaps = 7/308 (2%) Query: 1 MTAATSHS--TPRQAFLGGLLLAIVGAIFFSAKAIVAKLMYRYQVDAVMVITLRMVFSFP 58 MT A+S S + R A GGLLLA VGA+ FSAKAIVAKLMYRYQ+DAVMVITLRM+ + P Sbjct: 1 MTTASSASPASTRPADAGGLLLASVGAVLFSAKAIVAKLMYRYQIDAVMVITLRMLLAAP 60 Query: 59 MFAAVAIWKARTQPPLARADYLRILVLGLMGYYLSSFLDFLGLQYISAGLERLILFLTPS 118 +F A+ W++R PLA AD RI+ LGL+GYYLSSFLDFLGLQYI+AGLERLILFLTPS Sbjct: 61 LFMAMGWWQSRRAAPLAPADRWRIVGLGLIGYYLSSFLDFLGLQYITAGLERLILFLTPS 120 Query: 119 FVMLIAFFFFKRKVGAIEWGALLVSYFGTVLVLQHDLHTGGSEVILGSALVLGSALSYSI 178 FV+LI FKR++ ++W ++ ++Y G V+V HDL GG V LG LVL SALSY I Sbjct: 121 FVLLITATVFKRRITGLQWLSMAIAYAGIVMVFAHDLGLGGRHVWLGGGLVLASALSYGI 180 Query: 179 YLIGSGELVRRVGAVRLVAYAMCVSSVACVIQFFILRPPAELLTQVAP--VYQLSLFNAV 236 YL+ SGELVRRVG++RLVAYAMCVS+VAC++QFF+LRP + L V P VY LS N+V Sbjct: 181 YLLASGELVRRVGSMRLVAYAMCVSTVACMVQFFVLRPVSAL---VLPWQVYGLSAINSV 237 Query: 237 FCTVLPVFLTMVAVARIGAPTAAQAGLVGPVSTLFMGAVLLDEPITAIQLLGTALVLAGM 296 FCTV PV LTM+AVAR+GAP A+QAG++GPVSTL +G LL EPIT Q+ G+ALVLAGM Sbjct: 238 FCTVAPVTLTMMAVARVGAPVASQAGMIGPVSTLLLGWWLLGEPITLWQVGGSALVLAGM 297 Query: 297 WLLSRKKR 304 LLSR+ Sbjct: 298 ALLSRRGN 305 >BS_ycbK [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Bsu Bacillus subtilis Length = 312 Score = 107 bits (267), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 94/307 (30%), Positives = 157/307 (51%), Gaps = 22/307 (7%) Query: 4 ATSHSTPRQAFLGGLLLAIVGAIFFSAKAIVAKLMYRYQVDAVMVITLRMVFSFPMFAAV 63 A S R+A G + L ++G + F++K+I K Y+ + V+ R + + P+F + Sbjct: 3 AEEQSKIREAAAGTIFL-LIGTVCFASKSIWIKWAYQMGAEPDAVLLYRQLLAVPLFWLI 61 Query: 64 -AIWKARTQPPLARADYLRILVLGLMGYYLSSFLDFLGLQYISAGLERLILFLTPSFVML 122 I++ + D + G+ ++LS LDF+GL ++SA +ER++L P FV Sbjct: 62 FLIYRPPMPDGKKKGDLWKACGAGVFCFFLSPLLDFIGLNHVSAMVERILLMSYPLFV-- 119 Query: 123 IAFFFF----KRKVGAI-EWGALLVSYFGTVLVLQHDLHTGGSEVILGSALVLGSALSYS 177 F F RK+ +I + A+L FG L L ++G+ +L S+ Y+ Sbjct: 120 ---FGFTACRDRKMSSIQDLFAVLAVMFGLFLALGGWNAELFQANMIGAVFILLSSAVYA 176 Query: 178 IYLIGSGELVRRVGAVRLVAYAMCVSSVACVIQFFILRPPAELLTQVAPVYQLSLFN--- 234 YL+ SG LV ++G +RL AY M + A ++ + ++ A + T +A Y LS++ Sbjct: 177 GYLVLSGHLVHQIGGIRLNAYGMTAAGAAMML-YTGIKSAAGMNTPMA-AYPLSMYGLFA 234 Query: 235 --AVFCTVLPVFLTMVAVARIGAPTAAQAGLVGPVSTLFMGAVLLDEPITAIQLLGTA-- 290 AV TV+P L + + RIGA AA + GP+ T+F GA+ L E + IQ++G Sbjct: 235 VIAVVTTVIPFVLMLEGIKRIGAQRAAAISMAGPILTIFYGALFLGERLGLIQVIGCGGV 294 Query: 291 -LVLAGM 296 V+ GM Sbjct: 295 FFVITGM 301 >DR0512 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Dra Deinococcus radiodurans Length = 301 Score = 64.7 bits (156), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 74/268 (27%), Positives = 120/268 (44%), Gaps = 20/268 (7%) Query: 38 MYRYQVDAVMVITLRMVFSFPMFAAVAIWKARTQPPLARADYLRILVLGLMGYYLSSFLD 97 +YR+ V +V ++ + V P+ A +W+ I VL + G L L Sbjct: 51 LYRFLVASVTLLLVMAVTRLPVPAPRDLWQ--------------IGVLSVAGISLYHVLL 96 Query: 98 FLGLQYISAGLERLILFLTPSFVMLIAFFFFKRKVGAIEWGALLVSYFGTVL-VLQHDLH 156 +G + + AG LI+ P L+A F + + W VS G L VL Sbjct: 97 NMGERSVPAGTASLIIAAGPVITALLAARFLGESLNPLGWLGTAVSLGGVALIVLGQGQG 156 Query: 157 TGGSEVILGSALVLGSALSYSIYLIGSGELVRRVGAVRLVAYAMCVSSVACVIQFFILRP 216 G S G+ LVLG+A S+Y + ++ RVG++R +++ + +V ++ F+ Sbjct: 157 LGFSA---GALLVLGAAFFTSLYFVFQKGVLARVGSLRFTVWSLILGTVPLLV--FLPGF 211 Query: 217 PAELLTQVAPVYQLSLFNAVFCTVLPVFLTMVAVARIGAPTAAQAGLVGPVSTLFMGAVL 276 EL P + L+ VF + L A++R+GA + V PV L M L Sbjct: 212 GTELRAAPLPAHLAVLYLGVFPSALAYLTWTFAISRVGAGVTSSFLYVSPVFALLMAWAL 271 Query: 277 LDEPITAIQLLGTALVLAGMWLLSRKKR 304 L E A+ LLG + LAG+ L++ + R Sbjct: 272 LGEVPGAVTLLGGVIALAGVLLVNTRGR 299 >BS_yoaV [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Bsu Bacillus subtilis Length = 292 Score = 62.8 bits (151), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 54/210 (25%), Positives = 99/210 (47%), Gaps = 9/210 (4%) Query: 100 GLQYISAGLERLILFLTPSFVMLIAFFFFKRKVGAIEWGALLVSYFGTVLVLQHDLHTGG 159 G+Q++ +G ++++ P FV +I+ F K+ + L+ FG + + ++ Sbjct: 85 GMQFVDSGKTSVLVYTMPIFVTVISHFSLNEKMNVYKTMGLVCGLFGLLFIFGKEMLNID 144 Query: 160 SEVILGSALVLGSALSYSIYLIGSGELVRRVGAVRLVAYAMCVSSVACVIQFFILR--PP 217 + G VL +ALS+ I + S + + + + A+ + + +V ++ FI P Sbjct: 145 QSALFGELCVLVAALSWGIANVFSKLQFKHIDIIHMNAWHLMMGAVMLLVFSFIFEAVPS 204 Query: 218 AELLTQVAPVYQLSLFNAVFCTVLPVFLTMVAVARIGAPTAAQAGLVGPVSTLFMGAVLL 277 AE Q V+ L LFN + T + + +I A A+ A + PV LF G + L Sbjct: 205 AEWTYQ--AVWSL-LFNGLLSTGFTFVVWFWVLNQIQASKASMALMFVPVLALFFGWLQL 261 Query: 278 DEPITAIQLLGTALVLAGMWL----LSRKK 303 E IT +LG L+ G+++ SR+K Sbjct: 262 HEQITINIILGALLICCGIFMNTFTFSRRK 291 >RSc1002 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Rso Ralstonia solanacearum Length = 312 Score = 61.6 bits (148), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 89/296 (30%), Positives = 129/296 (43%), Gaps = 21/296 (7%) Query: 17 GLLLAIVGAIFFSAKAIVAKLMYRYQVDAVMVITLRMVFSFPMFAAVAIWKART--QPPL 74 G+LL V A F A AI Y D V ++ +R FS A A+ + R PP Sbjct: 20 GVLLIAVSAASFGAMAIFTHYAYASGADTVGLLAVR--FSLAALALTAVMRVRRIGLPPW 77 Query: 75 ARADYLRILVLGLMGYYLSSFLDFLGLQYISAGLERLILFLTPSFVMLIAFFFFKRKVGA 134 R L +G +GY SF F L Y A L L+L+L P FV ++A F ++ Sbjct: 78 PRVAGLA--AMGGIGYAGQSFAFFTALHYAPASLVALLLYLYPMFVTVLAAVFLHERLTP 135 Query: 135 IEWGALLVSYFGTVLVLQHDLHTGGSE--VILGSALVLGSALSYSIYLIGSGELVRRVGA 192 AL++ G L + GGS V+LG A +A+ YS+Y+ + R V Sbjct: 136 AALLALVLCSVGAGLTVGGAGLAGGSATGVVLGVA----AAVIYSVYITVGARVTRGVDP 191 Query: 193 V---RLVAYAMCVSSVACVIQFFILRPPAELLTQVAPVYQLSLFNAVFCTVLPVFLTMVA 249 + L+ A V + R P + +L A TV+ + Sbjct: 192 IACTTLICTAAAVVYAGAAVAGVPARFPGSVAGWA-----AALAIAGLSTVIAILAFFAG 246 Query: 250 VARIGAPTAAQAGLVGPVSTLFMGAVLLDEPITAIQLLGTALVLAG-MWLLSRKKR 304 + R+GA A+ + PV T+ + A+LL E I A Q+ G AL+LAG +WL R Sbjct: 247 LQRLGAAQASMLSTLEPVVTVALAALLLGESIGAAQMAGGALILAGVLWLTRADAR 302