BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.3412.p (427 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value arsB [P] COG1055 Na+/H+ antiporter NhaD and related arsenite per... 607 e-173 ZarsB [P] COG1055 Na+/H+ antiporter NhaD and related arsenite pe... 607 e-173 ECs4374 [P] COG1055 Na+/H+ antiporter NhaD and related arsenite ... 607 e-173 YPO3347 [P] COG1055 Na+/H+ antiporter NhaD and related arsenite ... 587 e-167 PA2278 [P] COG1055 Na+/H+ antiporter NhaD and related arsenite p... 578 e-165 >arsB [P] COG1055 Na+/H+ antiporter NhaD and related arsenite permeases Eco Escherichia coli K12 Length = 436 Score = 607 bits (1565), Expect = e-173, Method: Compositional matrix adjust. Identities = 312/419 (74%), Positives = 367/419 (87%) Query: 7 IFLLTLMFVIWQPKGLGIGWSACAGAAVALAAGVIHLSDIPVVWHIVWNATATFIAIIII 66 IF+LT++ VIWQPKGLGIGWSA GA +AL GV+H DIPVVW+IVWNATA FIA+III Sbjct: 14 IFVLTIVLVIWQPKGLGIGWSATLGAVLALVTGVVHPGDIPVVWNIVWNATAAFIAVIII 73 Query: 67 SLLLDKAGFFEWAALHVARWGGGRGHLLFVLLVLLGAAVSALFANDGAALILTPIVIAML 126 SLLLD++GFFEWAALHV+RWG GRG LLF +VLLGAAV+ALFANDGAALILTPIVIAML Sbjct: 74 SLLLDESGFFEWAALHVSRWGNGRGRLLFTWIVLLGAAVAALFANDGAALILTPIVIAML 133 Query: 127 LALRFSPQATLAFVMAAGFIADTASLPLVVSNLVNIVSADFFKIGFAQYASIMIPVDMVS 186 LAL FS TLAFVMAAGFIADTASLPL+VSNLVNIVSADFF +GF +YAS+M+PVD+ + Sbjct: 134 LALGFSKGTTLAFVMAAGFIADTASLPLIVSNLVNIVSADFFGLGFREYASVMVPVDIAA 193 Query: 187 IVATLIVLFIYFRRDIPQHYDLTQLQEAAAAIQDRATFVAGWWVLALLLVGFFWLEDMGV 246 IVATL++L +YFR+DIPQ+YD+ L+ A AI+D ATF GW VL LLLVGFF LE +G+ Sbjct: 194 IVATLVMLHLYFRKDIPQNYDMALLKSPAEAIKDPATFKTGWVVLLLLLVGFFVLEPLGI 253 Query: 247 PISAVAAAGAVILLAVAGKGQVISTREVIKGAPWQVVFFSLGMYLVVYGLRNAGLTDHLT 306 P+SA+AA GA+IL VA +G I+T +V++GAPWQ+V FSLGMYLVVYGLRNAGLT++L+ Sbjct: 254 PVSAIAAVGALILFVVAKRGHAINTGKVLRGAPWQIVIFSLGMYLVVYGLRNAGLTEYLS 313 Query: 307 GVLNGLAEHGVWSAALGTGFLTALLSSIMNNMPTVLVGALSIEATTAQGVVKEAMIYANV 366 GVLN LA++G+W+A LGTGFLTA LSSIMNNMPTVLVGALSI+ +TA GV+KEAM+YANV Sbjct: 314 GVLNVLADNGLWAATLGTGFLTAFLSSIMNNMPTVLVGALSIDGSTASGVIKEAMVYANV 373 Query: 367 IGSDLGPKITPIGSLATLLWLHVLDQKNIHISWGYYFRVGALLTLPVLLITLSALAIRL 425 IG DLGPKITPIGSLATLLWLHVL QKN+ ISWGYYFR G ++TLPVL +TL+ALA+RL Sbjct: 374 IGCDLGPKITPIGSLATLLWLHVLSQKNMTISWGYYFRTGIIMTLPVLFVTLAALALRL 432 >ZarsB [P] COG1055 Na+/H+ antiporter NhaD and related arsenite permeases EcZ Escherichia coli O157:H7 EDL933 Length = 429 Score = 607 bits (1565), Expect = e-173, Method: Compositional matrix adjust. Identities = 312/419 (74%), Positives = 367/419 (87%) Query: 7 IFLLTLMFVIWQPKGLGIGWSACAGAAVALAAGVIHLSDIPVVWHIVWNATATFIAIIII 66 IF+LT++ VIWQPKGLGIGWSA GA +AL GV+H DIPVVW+IVWNATA FIA+III Sbjct: 7 IFVLTIVLVIWQPKGLGIGWSATLGAVLALVTGVVHPGDIPVVWNIVWNATAAFIAVIII 66 Query: 67 SLLLDKAGFFEWAALHVARWGGGRGHLLFVLLVLLGAAVSALFANDGAALILTPIVIAML 126 SLLLD++GFFEWAALHV+RWG GRG LLF +VLLGAAV+ALFANDGAALILTPIVIAML Sbjct: 67 SLLLDESGFFEWAALHVSRWGNGRGRLLFTWIVLLGAAVAALFANDGAALILTPIVIAML 126 Query: 127 LALRFSPQATLAFVMAAGFIADTASLPLVVSNLVNIVSADFFKIGFAQYASIMIPVDMVS 186 LAL FS TLAFVMAAGFIADTASLPL+VSNLVNIVSADFF +GF +YAS+M+PVD+ + Sbjct: 127 LALGFSKGTTLAFVMAAGFIADTASLPLIVSNLVNIVSADFFGLGFREYASVMVPVDIAA 186 Query: 187 IVATLIVLFIYFRRDIPQHYDLTQLQEAAAAIQDRATFVAGWWVLALLLVGFFWLEDMGV 246 IVATL++L +YFR+DIPQ+YD+ L+ A AI+D ATF GW VL LLLVGFF LE +G+ Sbjct: 187 IVATLVMLHLYFRKDIPQNYDMALLKSPAEAIKDPATFKTGWVVLLLLLVGFFVLEPLGI 246 Query: 247 PISAVAAAGAVILLAVAGKGQVISTREVIKGAPWQVVFFSLGMYLVVYGLRNAGLTDHLT 306 P+SA+AA GA+IL VA +G I+T +V++GAPWQ+V FSLGMYLVVYGLRNAGLT++L+ Sbjct: 247 PVSAIAAVGALILFVVAKRGHAINTGKVLRGAPWQIVIFSLGMYLVVYGLRNAGLTEYLS 306 Query: 307 GVLNGLAEHGVWSAALGTGFLTALLSSIMNNMPTVLVGALSIEATTAQGVVKEAMIYANV 366 GVLN LA++G+W+A LGTGFLTA LSSIMNNMPTVLVGALSI+ +TA GV+KEAM+YANV Sbjct: 307 GVLNVLADNGLWAATLGTGFLTAFLSSIMNNMPTVLVGALSIDGSTASGVIKEAMVYANV 366 Query: 367 IGSDLGPKITPIGSLATLLWLHVLDQKNIHISWGYYFRVGALLTLPVLLITLSALAIRL 425 IG DLGPKITPIGSLATLLWLHVL QKN+ ISWGYYFR G ++TLPVL +TL+ALA+RL Sbjct: 367 IGCDLGPKITPIGSLATLLWLHVLSQKNMTISWGYYFRTGIIMTLPVLFVTLAALALRL 425 >ECs4374 [P] COG1055 Na+/H+ antiporter NhaD and related arsenite permeases Ecs Escherichia coli O157:H7 Length = 429 Score = 607 bits (1565), Expect = e-173, Method: Compositional matrix adjust. Identities = 312/419 (74%), Positives = 367/419 (87%) Query: 7 IFLLTLMFVIWQPKGLGIGWSACAGAAVALAAGVIHLSDIPVVWHIVWNATATFIAIIII 66 IF+LT++ VIWQPKGLGIGWSA GA +AL GV+H DIPVVW+IVWNATA FIA+III Sbjct: 7 IFVLTIVLVIWQPKGLGIGWSATLGAVLALVTGVVHPGDIPVVWNIVWNATAAFIAVIII 66 Query: 67 SLLLDKAGFFEWAALHVARWGGGRGHLLFVLLVLLGAAVSALFANDGAALILTPIVIAML 126 SLLLD++GFFEWAALHV+RWG GRG LLF +VLLGAAV+ALFANDGAALILTPIVIAML Sbjct: 67 SLLLDESGFFEWAALHVSRWGNGRGRLLFTWIVLLGAAVAALFANDGAALILTPIVIAML 126 Query: 127 LALRFSPQATLAFVMAAGFIADTASLPLVVSNLVNIVSADFFKIGFAQYASIMIPVDMVS 186 LAL FS TLAFVMAAGFIADTASLPL+VSNLVNIVSADFF +GF +YAS+M+PVD+ + Sbjct: 127 LALGFSKGTTLAFVMAAGFIADTASLPLIVSNLVNIVSADFFGLGFREYASVMVPVDIAA 186 Query: 187 IVATLIVLFIYFRRDIPQHYDLTQLQEAAAAIQDRATFVAGWWVLALLLVGFFWLEDMGV 246 IVATL++L +YFR+DIPQ+YD+ L+ A AI+D ATF GW VL LLLVGFF LE +G+ Sbjct: 187 IVATLVMLHLYFRKDIPQNYDMALLKSPAEAIKDPATFKTGWVVLLLLLVGFFVLEPLGI 246 Query: 247 PISAVAAAGAVILLAVAGKGQVISTREVIKGAPWQVVFFSLGMYLVVYGLRNAGLTDHLT 306 P+SA+AA GA+IL VA +G I+T +V++GAPWQ+V FSLGMYLVVYGLRNAGLT++L+ Sbjct: 247 PVSAIAAVGALILFVVAKRGHAINTGKVLRGAPWQIVIFSLGMYLVVYGLRNAGLTEYLS 306 Query: 307 GVLNGLAEHGVWSAALGTGFLTALLSSIMNNMPTVLVGALSIEATTAQGVVKEAMIYANV 366 GVLN LA++G+W+A LGTGFLTA LSSIMNNMPTVLVGALSI+ +TA GV+KEAM+YANV Sbjct: 307 GVLNVLADNGLWAATLGTGFLTAFLSSIMNNMPTVLVGALSIDGSTASGVIKEAMVYANV 366 Query: 367 IGSDLGPKITPIGSLATLLWLHVLDQKNIHISWGYYFRVGALLTLPVLLITLSALAIRL 425 IG DLGPKITPIGSLATLLWLHVL QKN+ ISWGYYFR G ++TLPVL +TL+ALA+RL Sbjct: 367 IGCDLGPKITPIGSLATLLWLHVLSQKNMTISWGYYFRTGIIMTLPVLFVTLAALALRL 425 >YPO3347 [P] COG1055 Na+/H+ antiporter NhaD and related arsenite permeases Ype Yersinia pestis Length = 429 Score = 587 bits (1514), Expect = e-167, Method: Compositional matrix adjust. Identities = 310/419 (73%), Positives = 365/419 (87%) Query: 7 IFLLTLMFVIWQPKGLGIGWSACAGAAVALAAGVIHLSDIPVVWHIVWNATATFIAIIII 66 IF+LT++ VIWQPKGLGIGWSA GA +AL GV+H+SDIPVVW IVWNATATFIAIIII Sbjct: 7 IFILTIVLVIWQPKGLGIGWSAMLGAGLALLTGVVHVSDIPVVWQIVWNATATFIAIIII 66 Query: 67 SLLLDKAGFFEWAALHVARWGGGRGHLLFVLLVLLGAAVSALFANDGAALILTPIVIAML 126 SLLLD++GFFEWAALHVARWG G G LF ++LLGAAV+ALFANDGAALILTPIVIAML Sbjct: 67 SLLLDESGFFEWAALHVARWGNGHGRRLFTYIILLGAAVAALFANDGAALILTPIVIAML 126 Query: 127 LALRFSPQATLAFVMAAGFIADTASLPLVVSNLVNIVSADFFKIGFAQYASIMIPVDMVS 186 LAL F ATLAFVMAAGFIADTASLPL+VSNLVNIVSADFF +GF +YA++M+PV++V+ Sbjct: 127 LALGFGRGATLAFVMAAGFIADTASLPLIVSNLVNIVSADFFNLGFTEYAAVMVPVNLVA 186 Query: 187 IVATLIVLFIYFRRDIPQHYDLTQLQEAAAAIQDRATFVAGWWVLALLLVGFFWLEDMGV 246 ++ATL +L ++FR+DIP YDL+ L+ AAI+D TF GW VLALLL+GFF LE +GV Sbjct: 187 VIATLAMLHLFFRKDIPAVYDLSLLKAPQAAIRDMNTFKTGWLVLALLLIGFFALEPLGV 246 Query: 247 PISAVAAAGAVILLAVAGKGQVISTREVIKGAPWQVVFFSLGMYLVVYGLRNAGLTDHLT 306 P+S VAA GA+ILLAVA KG I+T +V++GAPWQ+V FSLGMYLVVYGLRNAGLT +++ Sbjct: 247 PVSLVAAVGALILLAVAKKGHAINTGKVLRGAPWQIVIFSLGMYLVVYGLRNAGLTHYIS 306 Query: 307 GVLNGLAEHGVWSAALGTGFLTALLSSIMNNMPTVLVGALSIEATTAQGVVKEAMIYANV 366 +LN L E G+W++ LGTGFLTA LSSIMNN+PTVLVGALSIE +TA G++KEAMIYANV Sbjct: 307 ALLNRLGEQGLWASTLGTGFLTAFLSSIMNNLPTVLVGALSIEGSTATGLIKEAMIYANV 366 Query: 367 IGSDLGPKITPIGSLATLLWLHVLDQKNIHISWGYYFRVGALLTLPVLLITLSALAIRL 425 IGSDLGPKIT IGSLATLLWLHVL QKN+ I+WGYYFRVG ++TLPVLL+TLSALA+RL Sbjct: 367 IGSDLGPKITLIGSLATLLWLHVLSQKNMTITWGYYFRVGIIMTLPVLLVTLSALALRL 425 >PA2278 [P] COG1055 Na+/H+ antiporter NhaD and related arsenite permeases Pae Pseudomonas aeruginosa Length = 427 Score = 578 bits (1491), Expect = e-165, Method: Compositional matrix adjust. Identities = 303/413 (73%), Positives = 354/413 (85%) Query: 1 VLSALVIFLLTLMFVIWQPKGLGIGWSACAGAAVALAAGVIHLSDIPVVWHIVWNATATF 60 +L A IFL TL+ VIWQP+GLGIGWSA GA +ALA G + DIP VW+IVWNATATF Sbjct: 1 MLIAFAIFLFTLVLVIWQPRGLGIGWSASIGALLALALGSVAPGDIPTVWNIVWNATATF 60 Query: 61 IAIIIISLLLDKAGFFEWAALHVARWGGGRGHLLFVLLVLLGAAVSALFANDGAALILTP 120 IA+I+ISLLLD+AGFFEWAALHVARW GG G LF VLLGAAVSALFANDGAALILTP Sbjct: 61 IAVIVISLLLDEAGFFEWAALHVARWAGGDGRRLFAFCVLLGAAVSALFANDGAALILTP 120 Query: 121 IVIAMLLALRFSPQATLAFVMAAGFIADTASLPLVVSNLVNIVSADFFKIGFAQYASIMI 180 IV++MLLALRFSP ATLAFVMAAGFIAD+ASLPLVVSNLVNIVSAD+F +GF +YA++M+ Sbjct: 121 IVMSMLLALRFSPAATLAFVMAAGFIADSASLPLVVSNLVNIVSADYFGLGFGEYAAVML 180 Query: 181 PVDMVSIVATLIVLFIYFRRDIPQHYDLTQLQEAAAAIQDRATFVAGWWVLALLLVGFFW 240 PV++VS+ +L+VLF+YFRRD+P Y L QL+ AAI+DRATFV G W+L +LL G F Sbjct: 181 PVNLVSVATSLLVLFLYFRRDLPPVYALEQLKPPRAAIRDRATFVVGGWMLLVLLAGLFA 240 Query: 241 LEDMGVPISAVAAAGAVILLAVAGKGQVISTREVIKGAPWQVVFFSLGMYLVVYGLRNAG 300 LE +GVP+SAVAAA A +LLAVAG+G+VISTR V++ APWQ+V FSLGMYLVVYGL+NAG Sbjct: 241 LEPLGVPVSAVAAACAALLLAVAGRGRVISTRRVLREAPWQIVVFSLGMYLVVYGLKNAG 300 Query: 301 LTDHLTGVLNGLAEHGVWSAALGTGFLTALLSSIMNNMPTVLVGALSIEATTAQGVVKEA 360 LTD L +LN LAEHGVW+AALGTG L+A LSS+MNNMP++L+GALSI+A+ G V+EA Sbjct: 301 LTDLLAQLLNRLAEHGVWAAALGTGLLSAALSSVMNNMPSMLLGALSIQASDTAGAVREA 360 Query: 361 MIYANVIGSDLGPKITPIGSLATLLWLHVLDQKNIHISWGYYFRVGALLTLPV 413 MIYANVIG DLGPKITPIGSLATLLWLHVL +K + I+WGYYFRVGALLTLPV Sbjct: 361 MIYANVIGCDLGPKITPIGSLATLLWLHVLARKGMRITWGYYFRVGALLTLPV 413