BLASTP 2.2.21 [Jun-14-2009]

Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0001.3406.p         (164 letters)

Database: COGmodified 
           192,987 sequences; 59,019,183 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

RSc0946 [H] COG0262 Dihydrofolate reductase Rso Ralstonia solana...   181   4e-46
BS_dfrA [H] COG0262 Dihydrofolate reductase Bsu Bacillus subtilis     158   4e-39
BH3450 [H] COG0262 Dihydrofolate reductase Bha Bacillus halodurans    141   5e-34
lin1987 [H] COG0262 Dihydrofolate reductase Lin Listeria innocua      138   6e-33
BMEI0609 [H] COG0262 Dihydrofolate reductase Bme Brucella melite...   136   2e-32

>RSc0946 [H] COG0262 Dihydrofolate reductase Rso Ralstonia solanacearum
          Length = 167

 Score =  181 bits (460), Expect = 4e-46,   Method: Compositional matrix adjust.
 Identities = 97/158 (61%), Positives = 108/158 (68%), Gaps = 2/158 (1%)

Query: 8   LTIIVATDLNNGIGIRNTLPWHLPEDLAHFKRTTSGHTILMGRKTFESIGRPLPNRRNIV 67
           LT+IVA   N  IG  NTLPW LPEDLAHFKRTT G  I+MGRKT+ESIGRPLP RRNIV
Sbjct: 4   LTLIVARARNGVIGRDNTLPWRLPEDLAHFKRTTMGAPIVMGRKTYESIGRPLPGRRNIV 63

Query: 68  ITRNALWQHSGVETTGSLAQAAALA-GAAPAFIIGGAQVYAEALPLVDRLIITRIARAFE 126
           +TR+A     G E   SL  A  L  G    F+IGGAQ+YA+ALP  DRLI+T I   FE
Sbjct: 64  VTRSAKLALPGCEIAHSLEDAQRLCIGVEQIFLIGGAQLYADALPSADRLIVTEIDADFE 123

Query: 127 CDAFFPAIDEELWQETAREQHHAET-SGLDYAFVTYER 163
            DA FPA D  +W E ARE HHA   +  DYAFVTYER
Sbjct: 124 GDAHFPAPDPAVWHEVARETHHAAAPNDFDYAFVTYER 161


>BS_dfrA [H] COG0262 Dihydrofolate reductase Bsu Bacillus subtilis
          Length = 168

 Score =  158 bits (400), Expect = 4e-39,   Method: Compositional matrix adjust.
 Identities = 76/159 (47%), Positives = 98/159 (61%), Gaps = 2/159 (1%)

Query: 8   LTIIVATDLNNGIGIRNTLPWHLPEDLAHFKRTTSGHTILMGRKTFESIGRPLPNRRNIV 67
           ++ I A D N  IG  N LPWHLP DLA+FK+ TSGH+I+MGRKTFESIGRPLPNR+NIV
Sbjct: 2   ISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGRKTFESIGRPLPNRKNIV 61

Query: 68  ITRNALWQHSGVETTGSLAQAAAL-AGAAPAFIIGGAQVYAEALPLVDRLIITRIARAFE 126
           +T     +  G     SL     + +G    F+IGGAQ+Y +  P  DRL +T+I   FE
Sbjct: 62  VTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYTDLFPYADRLYMTKIHHEFE 121

Query: 127 CDAFFPAIDEELWQETAREQ-HHAETSGLDYAFVTYERR 164
            D  FP  DE  W+  + EQ    E +  DY F+ YE++
Sbjct: 122 GDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK 160


>BH3450 [H] COG0262 Dihydrofolate reductase Bha Bacillus halodurans
          Length = 163

 Score =  141 bits (356), Expect = 5e-34,   Method: Compositional matrix adjust.
 Identities = 69/159 (43%), Positives = 99/159 (62%), Gaps = 2/159 (1%)

Query: 8   LTIIVATDLNNGIGIRNTLPWHLPEDLAHFKRTTSGHTILMGRKTFESIGRPLPNRRNIV 67
           ++ IVA D +  IG  N LPW LP DLAHFKR TSGHT++MGRKT+ESIG+PLPNRRN+V
Sbjct: 2   ISFIVAMDKHRLIGKENDLPWRLPADLAHFKRVTSGHTVIMGRKTYESIGKPLPNRRNVV 61

Query: 68  ITRNALWQHSGVETTGSLAQAAALAG-AAPAFIIGGAQVYAEALPLVDRLIITRIARAFE 126
           +TR+  +   GV+   S+ +A  L       F+IGG++++    P  DR+ +T I   F+
Sbjct: 62  VTRSQAYTAEGVDIVHSIDEAIRLTEHENETFVIGGSELFKAFWPHADRMYVTYIDEVFD 121

Query: 127 CDAFFPAIDEELWQETAREQHHAETSGL-DYAFVTYERR 164
            D +FP ID + W+  + E    +   +  + F  YER+
Sbjct: 122 GDTYFPEIDGQEWELVSVEAGTIDEKNVYPHEFRVYERQ 160


>lin1987 [H] COG0262 Dihydrofolate reductase Lin Listeria innocua
          Length = 160

 Score =  138 bits (347), Expect = 6e-33,   Method: Compositional matrix adjust.
 Identities = 67/158 (42%), Positives = 97/158 (61%), Gaps = 2/158 (1%)

Query: 8   LTIIVATDLNNGIGIRNTLPWHLPEDLAHFKRTTSGHTILMGRKTFESIGRPLPNRRNIV 67
           +  + A D    IG  N +PWHLP DL  FK+TT+G T++MGRKT+ES+G+ LPNR+ IV
Sbjct: 2   IIFVWAQDRAGNIGKDNKMPWHLPGDLQFFKKTTTGKTLVMGRKTYESLGKALPNRKTIV 61

Query: 68  ITRNALWQHSGVETTGSLAQAAALAGAA-PAFIIGGAQVYAEALPLVDRLIITRIARAFE 126
           +TR+   Q    E   S  +  ALA    P +++GGA++Y   + + D+LI+T+I   F+
Sbjct: 62  LTRDNELQLDDAEILHSRDEVLALAETGEPIYVVGGAEIYRLFMDVADKLIVTKIDAEFD 121

Query: 127 CDAFFPAIDEELWQETAREQHHA-ETSGLDYAFVTYER 163
            D  FP +D E + E A+E H   E +  +Y F TYER
Sbjct: 122 ADTAFPEVDWENFSEVAKEPHEKDEKNKYNYTFYTYER 159


>BMEI0609 [H] COG0262 Dihydrofolate reductase Bme Brucella melitensis
          Length = 172

 Score =  136 bits (342), Expect = 2e-32,   Method: Compositional matrix adjust.
 Identities = 71/165 (43%), Positives = 97/165 (58%), Gaps = 8/165 (4%)

Query: 8   LTIIVATDLNNGIGIRNTLPWHLPEDLAHFKRTTSGHTILMGRKTFESIGRPLPNRRNIV 67
           ++I+VA   NN IG  N +PW L  DL  FK  T G  ++MGR+T++S+GRPLP R NIV
Sbjct: 6   VSIVVAASENNVIGQENDMPWRLSTDLKRFKALTLGKPVIMGRRTWQSLGRPLPGRANIV 65

Query: 68  ITRNALWQHSGVETTGSLAQAAALA-------GAAPAFIIGGAQVYAEALPLVDRLIITR 120
           ITR+A ++  G E  GSL  A ALA       G     +IGG Q+Y +A+PL DRL +TR
Sbjct: 66  ITRDADFRAEGAEVVGSLEDALALARKFAAEGGVDEICVIGGGQIYVQAMPLADRLHLTR 125

Query: 121 IARAFECDAFFPAIDEELWQETAREQHHA-ETSGLDYAFVTYERR 164
           +    E D +FP I+ + WQ  + E   A +       ++ YERR
Sbjct: 126 VLSVIEGDTYFPEINPQDWQLLSSEDVPAGDKDSYPTRYMLYERR 170