BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.3285.p (414 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value YPO1932 [GEPR] COG0477 Permeases of the major facilitator superf... 443 e-124 PA2114 [GEPR] COG0477 Permeases of the major facilitator superfa... 434 e-121 RSp0234 [GEPR] COG0477 Permeases of the major facilitator superf... 385 e-106 PM0835 [GEPR] COG0477 Permeases of the major facilitator superfa... 229 9e-60 HI1104 [GEPR] COG0477 Permeases of the major facilitator superfa... 202 1e-51 >YPO1932 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 409 Score = 443 bits (1140), Expect = e-124, Method: Compositional matrix adjust. Identities = 216/407 (53%), Positives = 293/407 (71%) Query: 2 WLQETTTSERRTLTATFTGYAVDGFDYMIYTFLIPTLLAAWSMSKAEAGYIATGALLTSA 61 W + +ER+T A F G+A+D D+M++TF+I TL+A W + +AG ++T LL SA Sbjct: 3 WFSDLNQTERKTFIAAFGGWALDALDFMVFTFVIATLMALWQIDAGQAGMLSTVTLLFSA 62 Query: 62 VGGWAAGVLADRYGRVRVLQWTVLWFALFTFLSGFTNSFGQLFFTRAMQGFGMGGEWAVG 121 +GGW AG+LADRYGRVR+LQ T+LWF+L T L GF +F +F RA+QG G GGEWAVG Sbjct: 63 IGGWGAGILADRYGRVRILQITILWFSLCTVLIGFAQNFEHVFILRALQGLGFGGEWAVG 122 Query: 122 SVLIAETISARHRGKASGLVQSSWAVGWAASALAFWGIYAVLPPEMAWKVLFWIGILPAL 181 SVL+ E + A HRGKA G VQS WA+GW A+AL + +++VL E AW+ LFWIG+LPAL Sbjct: 123 SVLMGEIVRAEHRGKAVGTVQSGWAIGWGAAALLYTLMFSVLSEEWAWRALFWIGVLPAL 182 Query: 182 LTLYIRRTLHEPEIYLATQARLRQSGQRGNFLRIFHRDLLRTTLLASLLATGMQGAYYSV 241 L LYIR+ + EP ++L ++ + +R + IF LL+TT+LASLL TG+QG YY++ Sbjct: 183 LVLYIRKNVPEPALFLKSRHEQQAKDRRVSSFAIFSPALLKTTVLASLLCTGVQGGYYAI 242 Query: 242 TTWLPTFLKTERHLSVLGTSTYLLVLIGGSFCGYLTSAWLSDTIGRRRCFMFFAVMGIVL 301 TTWLPTFLK ER+LSV+GT YL+V+I GSF GY+ A+L+D +GRR + F+++ + Sbjct: 243 TTWLPTFLKLERNLSVIGTGGYLMVIIFGSFVGYICGAYLTDKLGRRANLIIFSLLSCIT 302 Query: 302 VLSYTQMVITDAWMLALGFVLGFFLSGIFAGMGAYLSELFPSDVRGSGQGFCYNVGRALG 361 + +YTQ+ +T+ ML LGF LGF SGIF+GMGA+L+ELFPS VR +GQGF Y+ GRA+G Sbjct: 303 IFAYTQLTLTNTQMLVLGFPLGFSASGIFSGMGAFLTELFPSAVRATGQGFTYSFGRAVG 362 Query: 362 AICPALVGYLGNSLPLGQTIGWVAAACYALVILACLALPETRGKELE 408 A+ P LVGYL S L IG A + Y +V++ L LPET+ K+LE Sbjct: 363 ALFPGLVGYLSQSSSLAFAIGVFAGSAYCIVLVMSLLLPETKNKQLE 409 >PA2114 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 423 Score = 434 bits (1116), Expect = e-121, Method: Compositional matrix adjust. Identities = 221/407 (54%), Positives = 282/407 (69%), Gaps = 1/407 (0%) Query: 2 WLQETTTSERRTLTATFTGYAVDGFDYMIYTFLIPTLLAAWSMSKAEAGYIATGALLTSA 61 W + ERR + GY +DG D + +F+IPTL+A W + EAG+I T LL SA Sbjct: 17 WYRALDKQERRAFWSCKIGYGLDGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASA 76 Query: 62 VGGWAAGVLADRYGRVRVLQWTVLWFALFTFLSGFTNSFGQLFFTRAMQGFGMGGEWAVG 121 GGW AG+L+DR GRV LQ TVLWFA FTFL G ++ QL R + GFG GGEW G Sbjct: 77 AGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGFGGEWTAG 136 Query: 122 SVLIAETISARHRGKASGLVQSSWAVGWAASALAFWGIYAVLPPEMAWKVLFWIGILPAL 181 +VLI E I AR RGKA GLVQS WA+GW +A+ + ++++LPPE AW+ LF +G+LPAL Sbjct: 137 AVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLPPEEAWRALFMLGLLPAL 196 Query: 182 LTLYIRRTLHEPEIYLATQARLRQSGQRGNFLRIFHRDLLRTTLLASLLATGMQGAYYSV 241 L +RR + EPEIY + R Q + +F IF +L TL ASLL TG G YY++ Sbjct: 197 FVLVVRRLVKEPEIYREARQR-NQGADKVSFYEIFAPGMLSITLRASLLTTGALGGYYAI 255 Query: 242 TTWLPTFLKTERHLSVLGTSTYLLVLIGGSFCGYLTSAWLSDTIGRRRCFMFFAVMGIVL 301 T WLPTFLKTER L+VLGTS YL ++I GS+ GY+ SA+L+D IGR++ F+ FAV + Sbjct: 256 TAWLPTFLKTERGLTVLGTSGYLAMVILGSYVGYVVSAFLTDLIGRKKNFVLFAVGSFTV 315 Query: 302 VLSYTQMVITDAWMLALGFVLGFFLSGIFAGMGAYLSELFPSDVRGSGQGFCYNVGRALG 361 VL YTQ+ +++ ML LGF LGFF SGIF+GMG++L+ELFP+ +RGSGQGFCYN GRA+ Sbjct: 316 VLLYTQLPVSNGAMLWLGFPLGFFASGIFSGMGSFLTELFPTRIRGSGQGFCYNAGRAIA 375 Query: 362 AICPALVGYLGNSLPLGQTIGWVAAACYALVILACLALPETRGKELE 408 A+ P L+G LG L LG IG AA Y +VILA L+LPETRGK+LE Sbjct: 376 ALFPMLIGMLGQKLSLGLGIGAFAAVSYGVVILAALSLPETRGKQLE 422 >RSp0234 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 416 Score = 385 bits (988), Expect = e-106, Method: Compositional matrix adjust. Identities = 207/414 (50%), Positives = 272/414 (65%), Gaps = 4/414 (0%) Query: 2 WLQETTTSERRTLTATFTGYAVDGFDYMIYTFLIPTLLAAWSMSKAEAGYIATGALLTSA 61 W +E + E+RT A F G+A+D D +++ +IPT++AAW + K EAG ++ L+ SA Sbjct: 4 WFKEISAGEKRTFWACFGGWALDALDVQMFSLVIPTIIAAWHIGKTEAGLVSGITLVASA 63 Query: 62 VGGWAAGVLADRYGRVRVLQWTVLWFALFTFLSGFTNSFGQLFFTRAMQGFGMGGEWAVG 121 +GGW AG + DR GRVR LQ TV WF+L TF S F +F Q +A+QGFG GGEWA G Sbjct: 64 LGGWIAGAMTDRLGRVRTLQITVAWFSLATFASAFAQNFEQFLALKAVQGFGFGGEWAAG 123 Query: 122 SVLIAETISARHRGKASGLVQSSWAVGWAASALAFWGIYAVLPPEMAWKVLFWIGILPAL 181 +VL+AE+I A HRGKA G VQS+WAVGW A+ L + Y+++ P++AW+V+F G+LPAL Sbjct: 124 AVLMAESIRASHRGKAMGTVQSAWAVGWGAAVLLYALTYSLVEPDLAWRVMFAAGVLPAL 183 Query: 182 LTLYIRRTLHEPEIYLATQARLRQSG---QRGNFLRIFHRDLLRTTLLASLLATGMQGAY 238 L +YIRR + EP +A G R L IF +LR TL+ +LL G G Y Sbjct: 184 LIIYIRRGVQEPA-PAGAKAEAGPDGMPVSRFPLLDIFRPRVLRMTLIGALLGVGAHGGY 242 Query: 239 YSVTTWLPTFLKTERHLSVLGTSTYLLVLIGGSFCGYLTSAWLSDTIGRRRCFMFFAVMG 298 Y++ TWLPT+LKTERHLSVLGT YL V+I +CG + SAWL D IGRR + F+ Sbjct: 243 YALMTWLPTYLKTERHLSVLGTGGYLAVIIFAFWCGCVASAWLLDVIGRRGNILLFSCCC 302 Query: 299 IVLVLSYTQMVITDAWMLALGFVLGFFLSGIFAGMGAYLSELFPSDVRGSGQGFCYNVGR 358 +V VL Y + ++D ML LGF LGFF +GI A MGA +EL+P VRG+G GFCYN GR Sbjct: 303 VVTVLVYLLVPLSDGAMLVLGFPLGFFAAGIPASMGALFNELYPHGVRGTGVGFCYNFGR 362 Query: 359 ALGAICPALVGYLGNSLPLGQTIGWVAAACYALVILACLALPETRGKELEAAVA 412 + A P LVG + S+ LG IG AA Y++V +A L LPETRG++L A A Sbjct: 363 VVSAAFPVLVGKMSASMSLGTAIGIDAAIAYSIVAVAVLMLPETRGRDLAAVTA 416 >PM0835 [GEPR] COG0477 Permeases of the major facilitator superfamily Pmu Pasteurella multocida Length = 405 Score = 229 bits (584), Expect = 9e-60, Method: Compositional matrix adjust. Identities = 138/400 (34%), Positives = 216/400 (54%), Gaps = 8/400 (2%) Query: 12 RTLTATFTGYAVDGFDYMIYTFLIPTLLAAWSMSKAEAGYIATGALLTSAVGGWAAGVLA 71 + L + GYA+DGFD +I F++ + A +++ A++G + T L+ + GG G L+ Sbjct: 11 KALLGSAVGYAMDGFDLLILGFMLSAISADLALTPAQSGSLVTWTLIGAVAGGIIFGALS 70 Query: 72 DRYGRVRVLQWTVLWFALFTFLSGFTNSFGQLFFTRAMQGFGMGGEWAVGSVLIAETISA 131 D+YGRVRVL WT++ FA+FT L F + L R + G G+GGE+ +G L AE A Sbjct: 71 DKYGRVRVLTWTIVLFAVFTGLCAFAQGYWDLLIYRTIAGIGLGGEFGIGMALAAEAWPA 130 Query: 132 RHRGKASGLVQSSWAVGWAASALAFWGIYAVLPPEMAWKVLFWIGILPALLTLYIRRTLH 191 RHR KAS V A+GW L + +L P + W+ +F +GI PA + Y+R LH Sbjct: 131 RHRAKASSYV----ALGWQVGVLGAALLTPLLLPHIGWRGMFLVGIFPAFVAWYLRAKLH 186 Query: 192 EPEIYLATQARL-RQSGQRGNFLRIFHRDLLRTTLLASLLA-TGMQG-AYYSVTTWLPTF 248 EPEI++ Q L RQ R R+ +D + A ++ T +Q YY + W+P F Sbjct: 187 EPEIFVKKQTALERQKTSRLEPFRLLIKDKATAKISAGIVVLTSVQNFGYYGIMIWMPNF 246 Query: 249 LKTERHLSVLGTSTYLLVLIGGSFCGYLTSAWLSDTIGRRRCFMFFAVMGIVLVLSYTQM 308 L + S+ + + V I G G L+D IGR+ F+ F ++ + +Y+QM Sbjct: 247 LSKQLGFSLTKSGVWTAVTICGMMFGIWLFGQLADRIGRKPSFLLFQFGAVISIFTYSQM 306 Query: 309 VITDAWMLALGFVLGFFLSGIFAGMGAYLSELFPSDVRGSGQGFCYNVGRALGAICPALV 368 +ML G VLG F++G+ G GA +SE +P+ R + Q +N+GRA+G P +V Sbjct: 307 S-DPTYMLFAGAVLGMFVNGMMGGYGALMSEAYPTQARATAQNVLFNLGRAVGGFGPIVV 365 Query: 369 GYLGNSLPLGQTIGWVAAACYALVILACLALPETRGKELE 408 G L ++ I ++A+ +I +PE +GK+L+ Sbjct: 366 GALVSTYSFQLAIAFLASIYIIDMIATIFLIPELKGKQLD 405 >HI1104 [GEPR] COG0477 Permeases of the major facilitator superfamily Hin Haemophilus influenzae Length = 407 Score = 202 bits (514), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 135/403 (33%), Positives = 215/403 (53%), Gaps = 12/403 (2%) Query: 12 RTLTATFTGYAVDGFDYMIYTFLIPTLLAAWSMSKAEAGYIATGALLTSAVGGWAAGVLA 71 + L + GY +DGFD +I F++ + A +++ A+ G + T L+ + GG G L+ Sbjct: 11 KALIGSAVGYGMDGFDLLILGFMLSAISADLNLTPAQGGSLVTWTLIGAVFGGILFGALS 70 Query: 72 DRYGRVRVLQWTVLWFALFTFLSGFTNSFGQLFFTRAMQGFGMGGEWAVGSVLIAETISA 131 D+YGRVRVL WT+L FA+FT L + L R + G G+GGE+ +G L AE A Sbjct: 71 DKYGRVRVLTWTILLFAVFTGLCAIAQGYWDLLIYRTIAGIGLGGEFGIGMALAAEAWPA 130 Query: 132 RHRGKASGLVQSSWAVGWAASALAFWGIYAVLPPEMAWKVLFWIGILPALLTLYIRRTLH 191 RHR KA+ V A+GW L + +L P + W+ +F +GI PA + ++R LH Sbjct: 131 RHRAKAASYV----ALGWQVGVLGAALLTPLLLPHIGWRGMFLVGIFPAFVAWFLRSHLH 186 Query: 192 EPEIYLATQARLRQSGQRGNFLRIFH---RDLLRTTL-LASLLATGMQG-AYYSVTTWLP 246 EPEI+ Q L + LR F +D + + L ++ T +Q YY + WLP Sbjct: 187 EPEIFTQKQTALSTQSSFTDKLRSFQLLIKDKATSKISLGIVVLTSVQNFGYYGIMIWLP 246 Query: 247 TFLKTERHLSVLGTSTYLLVLIGGSFCGYLTSAWLSDTIGRRRCFMFFAVMGIVLVLSYT 306 FL + S+ + + V + G G L+D IGR+ F+ F + ++ ++ Y+ Sbjct: 247 NFLSKQLGFSLTKSGLWTAVTVCGMMAGIWIFGQLADRIGRKPSFLLFQLGAVISIVVYS 306 Query: 307 QMVITDAWMLALGFVLGFFLSGIFAGMGAYLSELFPSDVRGSGQGFCYNVGRALGAICPA 366 Q+ D +LA G LG F++G+ G GA ++E +P++ R + Q +N+GRA+G P Sbjct: 307 QLTDPDIMLLA-GAFLGMFVNGMLGGYGALMAEAYPTEARATAQNVLFNIGRAVGGFGPV 365 Query: 367 LVGYLGNSLPLGQTIGWVAAACYALVILACLAL-PETRGKELE 408 +VG + + QT + A Y + +LA + L PE +GK L+ Sbjct: 366 VVGSVVLAYSF-QTAIALLAIIYVIDMLATIFLIPELKGKALD 407