BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.3262.p (629 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc1564_1 [GEPR] COG0477 Permeases of the major facilitator supe... 475 e-133 PA3267_1 [GEPR] COG0477 Permeases of the major facilitator super... 367 e-101 VC1966_1 [GEPR] COG0477 Permeases of the major facilitator super... 348 2e-95 RP620_1 [GEPR] COG0477 Permeases of the major facilitator superf... 296 8e-80 NMB1515 [GEPR] COG0477 Permeases of the major facilitator superf... 295 2e-79 >RSc1564_1 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 434 Score = 475 bits (1223), Expect = e-133, Method: Compositional matrix adjust. Identities = 246/435 (56%), Positives = 304/435 (69%), Gaps = 8/435 (1%) Query: 1 MQKKSQFTLFAQRRFAPFFWTQFLGALNDNVFKTALLTILTYDALSWTDMDPGLLNNLIP 60 M + SQF+L QRRFAPFFWTQFLGA+NDNVFK A +++TY A + + DP LI Sbjct: 1 MSQSSQFSLLKQRRFAPFFWTQFLGAMNDNVFKVAFSSLVTYHAALFGNADPASAAFLIS 60 Query: 61 GLFILPFFLFSATSGQLADKLEKGRMARAVKLLEIVIMAIAAYGWMTHHLVLLIAAVIGM 120 +FI PF L SATSGQ+AD+++K R+ R VK LEI IMAI G+ + LL M Sbjct: 61 AIFIAPFVLLSATSGQIADRMDKARLIRLVKTLEIAIMAIGCAGFALRRVELLYLCTFLM 120 Query: 121 GIHSTLFGPVKYAYLPQQLRQDELVGGNGLIEMGTFVGILLGEILGAVLVVHKPWGLHLV 180 G+HSTLFGPVKYAYLPQ L+ ELVGGNGL+EMGTFV ILLG I G L G LV Sbjct: 121 GVHSTLFGPVKYAYLPQHLQPSELVGGNGLVEMGTFVAILLGTIGGGELANLTRNG-ELV 179 Query: 181 AGVTIGIAVL-----GWLASLRIPLSPAPVPELKVNWNPFTETVRNIGFSRRNRPVFLSL 235 GIA L GWL + +P+SPA P+L++NWNP +ET RN+ + R VFLSL Sbjct: 180 GPALTGIACLAIAVGGWLTARGVPVSPASQPDLRINWNPVSETWRNLKLASNQRAVFLSL 239 Query: 236 LGNSWFWFYGAIMLAQFPVYAKNYLHGDHGVFVLLLAVFSVGIGAGSLLCERLSGHKVEI 295 LG SW WF GA L F +A+N L GD V LLLAVFS+GIG GS+LCE+LSG VE+ Sbjct: 240 LGISWLWFVGATFLTSFFAFARNVLGGDQNVVTLLLAVFSIGIGLGSVLCEKLSGRMVEV 299 Query: 296 GLVPFGSIGLSVFGLELYFAS--QAYVTPAAMLDVAGFLAQGGSWRILGDCLGIGLFGGL 353 GLVPFGSIG++VF ++LYFAS +A V A+ VAGFL WR+L D + +FGG Sbjct: 300 GLVPFGSIGMTVFAVDLYFASHAEALVAHDALTGVAGFLQNHRHWRVLADLFLLAMFGGF 359 Query: 354 YIVPLFALIQTRCDPAHVSRTIAGMNIMNALFMVVSALVAMVLLKAGLTIPQIFLATAIM 413 Y VPL+ALIQ+RC+P H +R IA NI+NALFM+ SA++AMVL +AG TIPQ+FL T I+ Sbjct: 360 YSVPLYALIQSRCEPTHRARIIAANNILNALFMIASAVLAMVLTRAGFTIPQLFLVTGIL 419 Query: 414 NGVVAVYIFSLVPEF 428 N VVA+YI++L+PEF Sbjct: 420 NAVVAIYIYTLLPEF 434 >PA3267_1 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 428 Score = 367 bits (942), Expect = e-101, Method: Compositional matrix adjust. Identities = 222/430 (51%), Positives = 281/430 (65%), Gaps = 5/430 (1%) Query: 1 MQKKSQFTLFAQRRFAPFFWTQFLGALNDNVFKTALLTILTYDALSWTDMDPGLLNNLIP 60 M + SQF L +RRF PFF TQ LGA NDN+FK +L+ + Y LS D LL NL Sbjct: 1 MTQHSQFALLGKRRFLPFFITQLLGAFNDNIFKQSLILAILYH-LS-VSGDRSLLVNLCA 58 Query: 61 GLFILPFFLFSATSGQLADKLEKGRMARAVKLLEIVIMAIAAYGWMTHHLVLLIAAVIGM 120 LFILPFFLFSA GQ +K K + RA+KL E+ IM + A G++ L L+ A+ M Sbjct: 59 LLFILPFFLFSALGGQFGEKYNKDALMRALKLAEVGIMLVGAAGFVFGSLPLMFVALFAM 118 Query: 121 GIHSTLFGPVKYAYLPQQLRQDELVGGNGLIEMGTFVGILLGEILGAVLVVHKPWGLHLV 180 G HS LFGPVKY+ LPQ L +DELVGGN L+EMGTF+ IL G I VL+ H + + Sbjct: 119 GTHSALFGPVKYSILPQHLHEDELVGGNALVEMGTFLAILAGTIGAGVLMSHAHYAAAVA 178 Query: 181 AGVTIGIAVLGWLASLRIPLSPAPVPELKVNWNPFTETVRNIGFSRRNRP-VFLSLLGNS 239 V + +A G+LAS IP + A +P LK++WN F ++ + RP V SL+GNS Sbjct: 179 TAVVL-VAACGYLASRGIPRAAAALPGLKLDWNIFAQSWSILRLGLGQRPAVSRSLVGNS 237 Query: 240 WFWFYGAIMLAQFPVYAKNYLHGDHGVFVLLLAVFSVGIGAGSLLCERLSGHKVEIGLVP 299 WFWF GA+ L Q P +AK +LHGD V L+L VFSVGI GS+LCE+LSG KVEIGLVP Sbjct: 238 WFWFLGAVYLTQIPTFAKEWLHGDESVVTLILTVFSVGIALGSMLCEKLSGRKVEIGLVP 297 Query: 300 FGSIGLSVFGLELYFASQAYVTPAAMLDVAGFLAQGGSWRILGDCLGIGLFGGLYIVPLF 359 FGSIGL+VFG+ L++ + A D L +W +L D L IG+FGG YIVPL+ Sbjct: 298 FGSIGLTVFGILLWWHAGGIPPGEAPYDWLAVLRHHETWAVLADILFIGIFGGFYIVPLY 357 Query: 360 ALIQTRCDPAHVSRTIAGMNIMNALFMVVSALVAMVLLK-AGLTIPQIFLATAIMNGVVA 418 ALIQ R D +R IA NI+NALFMV +ALV+++ L A L+IPQ+FLA ++MN V Sbjct: 358 ALIQARTDEDKRARVIAANNILNALFMVAAALVSILFLSVAKLSIPQLFLALSLMNVAVN 417 Query: 419 VYIFSLVPEF 428 VYIF +VPEF Sbjct: 418 VYIFKIVPEF 427 >VC1966_1 [GEPR] COG0477 Permeases of the major facilitator superfamily Vch Vibrio cholerae Length = 429 Score = 348 bits (893), Expect = 2e-95, Method: Compositional matrix adjust. Identities = 197/424 (46%), Positives = 265/424 (62%), Gaps = 10/424 (2%) Query: 9 LFAQRRFAPFFWTQFLGALNDNVFKTALLTILTYDALSWTDMDPGLLNNLIPGLFILPFF 68 L +RRF P+F TQFLGA NDN+FK LL + + + L NL GLFILPFF Sbjct: 11 LLTERRFLPYFITQFLGAFNDNIFKNVLLLFVAFAGPQALPISSNLFINLAAGLFILPFF 70 Query: 69 LFSATSGQLADKLEKGRMARAVKLLEIVIMAIAAYGWMTHHLVLLIAAVIGMGIHSTLFG 128 LFSAT+G LADKLEK R R VKLLEI IM A G++T + + + MG S FG Sbjct: 71 LFSATAGVLADKLEKSRYIRWVKLLEIAIMLCGAIGFITQSYGISLFLLFLMGTQSAFFG 130 Query: 129 PVKYAYLPQQLRQDELVGGNGLIEMGTFVGILLGEILGAVLVVHKPWGLHLVAGVTIGIA 188 PVKYA LPQQL+ +ELV GN L+E GTF+ ILLG LGA L+ + A + A Sbjct: 131 PVKYALLPQQLKSEELVPGNALVETGTFLAILLGT-LGAGLIASADNAHYFAAAAVVIFA 189 Query: 189 VLGWLASLRIPLSPAPVPELKVNWNPFTETVRNIGFSRRNRPVFLSLLGNSWFWFYGAIM 248 VLG+L+S IPL+PA P L+ W P T+T + + ++R+R +F S++ SWFWF GA Sbjct: 190 VLGYLSSRAIPLAPASAPHLEFRWQPITQTKQTLRIAKRDRAIFQSIMAISWFWFLGAGY 249 Query: 249 LAQFPVYAKNYLHGDHGVFVLLLAVFSVGIGAGSLLCERLSGHKVEIGLVPFGSIGLSVF 308 L QFP + K +L+G+ LLA+FSVGI GSL C++LSGH++E+G+VP GS+G+S F Sbjct: 250 LTQFPNFTKLHLNGNEAAVSFLLALFSVGIAVGSLACDKLSGHRIEVGIVPLGSVGISFF 309 Query: 309 GLELYFASQAYVTPAAM---LDVAGFLAQGGSWRILGDCLGIGLFGGLYIVPLFALIQTR 365 G + A PA + A F+ W + L IG+FGG++IVPL+A++Q R Sbjct: 310 GYLM-----ATSIPADLPIFSTFADFVTYSALWPLFAYLLLIGVFGGVFIVPLYAMLQQR 364 Query: 366 CDPAHVSRTIAGMNIMNALFMVVSALVAMVLLKA-GLTIPQIFLATAIMNGVVAVYIFSL 424 ++ IA +NI N+LFMV SA + +V L ++IPQ+F A++N +VA+YIF Sbjct: 365 AKVTERAQVIAALNIYNSLFMVGSAALGIVCLSVLEMSIPQLFALLAVLNVLVALYIFLQ 424 Query: 425 VPEF 428 VP F Sbjct: 425 VPIF 428 >RP620_1 [GEPR] COG0477 Permeases of the major facilitator superfamily Rpr Rickettsia prowazekii Length = 423 Score = 296 bits (759), Expect = 8e-80, Method: Compositional matrix adjust. Identities = 163/424 (38%), Positives = 262/424 (61%), Gaps = 7/424 (1%) Query: 5 SQFTLFAQRRFAPFFWTQFLGALNDNVFKTALLTILTYDALSWTDMDPGLLNNLIPGLFI 64 ++ LF RRF P F Q G LNDN+ K AL+ ++TY +L + F+ Sbjct: 4 NKLYLFKDRRFLPNFIVQLFGCLNDNILKNALVILITYGISGTLSKYNNVLVLITNATFV 63 Query: 65 LPFFLFSATSGQLADKLEKGRMARAVKLLEIVIMAIAAYGWMTHHLVLLIAAVIGMGIHS 124 LPF +F++ +GQ+ADK E+ + + +K+ EI I+A A YG+ ++L++L ++ MGIHS Sbjct: 64 LPFIIFASIAGQIADKYERANLMKILKIYEIGIIAFAIYGFHHNNLLILFCSIGLMGIHS 123 Query: 125 TLFGPVKYAYLPQQLRQDELVGGNGLIEMGTFVGILLGEILGAVLVVHKPWGLHLVAGVT 184 T FGP+KY+ LP L +DEL+G NG +E GTF+GI +G I+G+ + + ++ + Sbjct: 124 TFFGPIKYSVLPDHLNKDELLGANGFVEAGTFIGIFIGTIIGSYYTISNNFIIYSL---- 179 Query: 185 IGIAVLGWLASLRIPLSPAPVPELKVNWNPFTETVRNIGFSRRNRPVFLSLLGNSWFWFY 244 I IA LG++ SL P S +K+N+N E++ I +S+ + ++L++LG SWFWF Sbjct: 180 IIIAFLGFITSLFAPKSDNANHNIKINFNIIDESISMIKYSKAKKQIYLAILGISWFWFI 239 Query: 245 GAIMLAQFPVYAKNYLHGDHGVFVLLLAVFSVGIGAGSLLCERLSGHKVEIGLVPFGSIG 304 GA +++Q P+ AK D V L LAVFS+G+G GS LC ++ +++ + + ++G Sbjct: 240 GAAIISQIPLLAKITFKADENVANLFLAVFSLGVGVGSFLCSKIFENEITVKYLFISALG 299 Query: 305 LSVFGLELYFASQ---AYVTPAAMLDVAGFLAQGGSWRILGDCLGIGLFGGLYIVPLFAL 361 +S+FG++L+FAS+ P + + FL++ +WRI+ D + + GGLYIVPLFA+ Sbjct: 300 ISIFGIDLFFASRISSVNYEPTQLKSIFVFLSKRHNWRIVIDLFFLAIIGGLYIVPLFAI 359 Query: 362 IQTRCDPAHVSRTIAGMNIMNALFMVVSALVAMVLLKAGLTIPQIFLATAIMNGVVAVYI 421 +Q +PAH SR IA N++N++FMV S ++ +L TIP I L ++ N VV +YI Sbjct: 360 LQHYANPAHRSRIIAANNLINSIFMVGSTIILSLLFYLNFTIPWIILFISLANIVVTIYI 419 Query: 422 FSLV 425 + L+ Sbjct: 420 YRLI 423 >NMB1515 [GEPR] COG0477 Permeases of the major facilitator superfamily Nme Neisseria meningitidis MC58 Length = 436 Score = 295 bits (755), Expect = 2e-79, Method: Compositional matrix adjust. Identities = 176/428 (41%), Positives = 258/428 (60%), Gaps = 5/428 (1%) Query: 3 KKSQFTLFAQRRFAPFFWTQFLGALNDNVFKTALLTILTYDALSWTDMDP-GLLNNLIPG 61 KK L RRFAP F TQFLGA NDNVFKTAL ++ + L P G + NL Sbjct: 4 KKGGLGLVKSRRFAPLFATQFLGAFNDNVFKTALFVMIGFYGLGQNGFLPAGQMLNLGAL 63 Query: 62 LFILPFFLFSATSGQLADKLEKGRMARAVKLLEIVIMAIAAYGWMTHHLVLLIAAVIGMG 121 LFILP+FLFS+ SGQL +K +K +AR VK+LE++IMA+AAYG+ LL+A + MG Sbjct: 64 LFILPYFLFSSLSGQLGNKFDKAVLARWVKVLEMIIMAVAAYGFYIRSAPLLLACLFCMG 123 Query: 122 IHSTLFGPVKYAYLPQQLRQDELVGGNGLIEMGTFVGILLGEILGAVLVVHKPWGLHLVA 181 STLFGP+KYA LP L EL+ GN LIE GTFV IL G+ILG + P ++V Sbjct: 124 AQSTLFGPLKYAILPDYLDDKELMMGNSLIESGTFVAILFGQILGTAVAGVPP---YIVG 180 Query: 182 GVTIGIAVLGWLASLRIPLSPAPVPELKVNWNPFTETVRNIGFSRRNRPVFLSLLGNSWF 241 + + +AV G + SL +P PA + ++ WN T + + R++PVF +++G SWF Sbjct: 181 ILVLLVAVGGTVGSLFMPSVPAKAADTQIEWNIVRGTKSLLRETVRHKPVFTAIIGISWF 240 Query: 242 WFYGAIMLAQFPVYAKNYLHGDHGVFVLLLAVFSVGIGAGSLLCERLSGHKVEIGLVPFG 301 WF GA+ Q P + + +L G+ VF L+LA+FS+GI AGS+LC + S ++ + V G Sbjct: 241 WFVGAVYTTQLPTFTQIHLGGNDNVFNLMLALFSIGIAAGSVLCAKFSRERLMLAWVTVG 300 Query: 302 SIGLSVFGLELYFASQAYVTPAAMLDVAGFLAQGGSWRILGDCLGIGLFGGLYIVPLFAL 361 ++GL+V GL L + + + + + FL+QG ++ ++ IG FGG + VPL+ Sbjct: 301 ALGLTVCGLVLVWLTHGH-RFEGLNGIFWFLSQGWAYPVMAVMTLIGFFGGFFSVPLYTW 359 Query: 362 IQTRCDPAHVSRTIAGMNIMNALFMVVSALVAMVLLKAGLTIPQIFLATAIMNGVVAVYI 421 +QT +R +A NI+N +FMV +A+++ VLL +I ++L A+ N ++V++ Sbjct: 360 LQTASSETFRARAVAANNIVNGIFMVSAAVLSAVLLFLFDSISLLYLIVALGNIPLSVFL 419 Query: 422 FSLVPEFL 429 FL Sbjct: 420 IKRERRFL 427