BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.3233.p (261 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc1147 [R] COG1235 Metal-dependent hydrolases of the beta-lacta... 270 2e-72 PA1012 [R] COG1235 Metal-dependent hydrolases of the beta-lactam... 236 4e-62 lin0319 [R] COG1235 Metal-dependent hydrolases of the beta-lacta... 162 8e-40 BH4023 [R] COG1235 Metal-dependent hydrolases of the beta-lactam... 153 4e-37 CPn0879 [R] COG1235 Metal-dependent hydrolases of the beta-lacta... 150 4e-36 >RSc1147 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I Rso Ralstonia solanacearum Length = 261 Score = 270 bits (690), Expect = 2e-72, Method: Compositional matrix adjust. Identities = 141/260 (54%), Positives = 177/260 (68%), Gaps = 6/260 (2%) Query: 1 MKFASLGSGSEGNALLISAAAGDSRPSSGTTVMLDCGFTLREAEKRMLRLGLDPSDVSAI 60 ++FASLGSGS+GNALL+ + G ++ T ++LDCGF +RE +R+ RLG P+ + AI Sbjct: 3 VRFASLGSGSDGNALLVESTDG----TTSTRILLDCGFGIRETVRRLERLGCAPASLDAI 58 Query: 61 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTFQAVAE--QASDVDVRFCADGQKIAIGDLE 118 +VTHEH DH+ + FA +Y +PVW S+GT++A A A VRFC +IGDL Sbjct: 59 LVTHEHGDHIGSAYAFAAKYSVPVWTSHGTYRATASLRGADRAAVRFCRADDAFSIGDLR 118 Query: 119 LSPYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDREMLE 178 + PYTVPHDAREP+Q++ DG RRLGVLTDAG T +L L A +LECNHDREML Sbjct: 119 ILPYTVPHDAREPLQFIFDDGARRLGVLTDAGMSTEYLCGHLTGLHAFVLECNHDREMLA 178 Query: 179 RSPYPAFLKRRIGGDYGHLANDASAEILRLLDRSRLKRVIGAHLSQQNNTPELARAAIES 238 S YP LK+RIGGD+GHLAND +A IL + L V+ AHLS+QNNTPELA AAI S Sbjct: 179 NSAYPWSLKQRIGGDFGHLANDIAAAILARVRHDGLHTVVAAHLSKQNNTPELAAAAIAS 238 Query: 239 VLGHTFGDIGIACQEEGFSW 258 LG GD+ IA QE G W Sbjct: 239 ALGVPAGDVPIADQEAGLGW 258 >PA1012 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I Pae Pseudomonas aeruginosa Length = 252 Score = 236 bits (601), Expect = 4e-62, Method: Compositional matrix adjust. Identities = 123/261 (47%), Positives = 165/261 (63%), Gaps = 10/261 (3%) Query: 1 MKFASLGSGSEGNALLISAAAGDSRPSSGTTVMLDCGFTLREAEKRMLRLGLDPSDVSAI 60 M+FA LGSGS GN+ L+S SS T +++DCGF LRE KR+ RLGL P+ + AI Sbjct: 1 MRFAVLGSGSRGNSALVS--------SSDTRILIDCGFPLREIIKRLARLGLSPAQLDAI 52 Query: 61 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTFQAVAEQASDVDVRFCADGQKIAIGDLELS 120 +VTHEH+DH+ GV AR Y+IPV+LS GT + V+ GQ++AI LE+ Sbjct: 53 LVTHEHADHIHGVELLARHYQIPVYLSAGTLSGMRRPVHPVE--LLRAGQRLAIRGLEVQ 110 Query: 121 PYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDREMLERS 180 V HDAREP Q+V DG RR G+LTD G TA +++ A DAL++E NHD ML Sbjct: 111 VVGVSHDAREPTQFVLSDGQRRFGMLTDLGVATAEVLECYRAVDALVVEANHDSTMLAGG 170 Query: 181 PYPAFLKRRIGGDYGHLANDASAEILRLLDRSRLKRVIGAHLSQQNNTPELARAAIESVL 240 PYP FLK R+GG GHL N SAE+++ LD R++ ++ AHLS++NN+P+LAR L Sbjct: 171 PYPYFLKARVGGSRGHLNNHQSAELVKQLDWGRMQHLVLAHLSEKNNSPQLARQTFVDTL 230 Query: 241 GHTFGDIGIACQEEGFSWLDV 261 G G + +A Q G W ++ Sbjct: 231 GCDPGWLQVADQHSGLDWREI 251 >lin0319 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I Lin Listeria innocua Length = 276 Score = 162 bits (409), Expect = 8e-40, Method: Compositional matrix adjust. Identities = 83/243 (34%), Positives = 143/243 (58%), Gaps = 11/243 (4%) Query: 1 MKFASLGSGSEGNALLISAAAGDSRPSSGTTVMLDCGFTLREAEKRMLRLGLDPSDVSAI 60 ++F+ L SGS GNA L+ GD + +++DCG + ++ E ++G D +D+ AI Sbjct: 15 IRFSILASGSSGNATLVET--GDQK------ILIDCGLSGKKMEGLFAQVGRDMNDLDAI 66 Query: 61 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTFQAVAEQASDV--DVRFCADGQKI-AIGDL 117 ++THEHSDH+ G+ AR+Y++P++ + T++A+ +V + +F D + + + G + Sbjct: 67 LITHEHSDHIKGLGVLARKYKLPIYANAKTWKAMDNMIGEVSSEQKFQFDMETVKSFGSM 126 Query: 118 ELSPYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDREML 177 ++ + V HDA EP+ Y+ G+++ ++TD G + + + DA L E NHD EML Sbjct: 127 QVESFGVSHDAIEPMFYIFHKGNKKFVMITDTGYVSDRMKGHIAGADAYLFESNHDVEML 186 Query: 178 ERSPYPAFLKRRIGGDYGHLANDASAEILRLLDRSRLKRVIGAHLSQQNNTPELARAAIE 237 YP +KRRI GD GH++N+ +A + + + KR+ HLS+ NN ELAR ++ Sbjct: 187 RMGRYPWNVKRRILGDEGHVSNEDAAIAMSEVITDQTKRIYLGHLSKDNNMKELARMSVT 246 Query: 238 SVL 240 L Sbjct: 247 QTL 249 >BH4023 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I Bha Bacillus halodurans Length = 264 Score = 153 bits (387), Expect = 4e-37, Method: Compositional matrix adjust. Identities = 86/243 (35%), Positives = 136/243 (55%), Gaps = 11/243 (4%) Query: 1 MKFASLGSGSEGNALLISAAAGDSRPSSGTTVMLDCGFTLREAEKRMLRLGLDPSDVSAI 60 ++F+ L SGS GNAL + + +++D G + ++ ++ ++ DPS ++ I Sbjct: 3 LRFSVLASGSTGNALYVE--------TDKQKLLVDAGLSGKKMDELFQKIDCDPSQLNGI 54 Query: 61 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTFQAVAEQASDV--DVRFCAD-GQKIAIGDL 117 +VTHEHSDH+ GV AR+Y +P++ + T+QA+ + + D RF + G+ DL Sbjct: 55 LVTHEHSDHIKGVGIVARKYNLPIYANAKTWQAMEKALGTLTTDQRFHFEIGEVKTFADL 114 Query: 118 ELSPYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDREML 177 E+ + V HDA EP+ YV ++L + TD G + + + + D L+ E NHD ML Sbjct: 115 EVESFGVSHDAAEPMFYVFHHDGKKLVLATDMGYVSERIKKTIENADTLIFEANHDLNML 174 Query: 178 ERSPYPAFLKRRIGGDYGHLANDASAEILRLLDRSRLKRVIGAHLSQQNNTPELARAAIE 237 YP +KRRI D GH++N+ +A L + R +R+ AHLS NN ELAR +E Sbjct: 175 RMGRYPWNVKRRILSDVGHVSNEDAAYALAEVIGDRTERIYLAHLSLDNNMKELARLTVE 234 Query: 238 SVL 240 VL Sbjct: 235 QVL 237 >CPn0879 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I Cpn Chlamydophila pneumoniae CWL029 Length = 265 Score = 150 bits (378), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 78/235 (33%), Positives = 128/235 (54%), Gaps = 9/235 (3%) Query: 3 FASLGSGSEGNALLISAAAGDSRPSSGTTVMLDCGFTLREAEKRMLRLGLDPSDVSAIVV 62 F L SGS+GN SA G + +++D G + + + +L + +DP D+ AI V Sbjct: 4 FFPLASGSKGN----SAYLG----TDSCKILIDLGVSKQVVTRELLSMNIDPEDIQAIFV 55 Query: 63 THEHSDHVSGVFKFARRYRIPVWLSYGTFQAVAEQA-SDVDVRFCADGQKIAIGDLELSP 121 THEHSDH+SG+ F + Y P+ + T +A+ S + + + G DLE+ Sbjct: 56 THEHSDHISGIKSFVKAYNTPIVCNLETARALCHLLDSHPEFKIFSTGSSFCFQDLEVQT 115 Query: 122 YTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDREMLERSP 181 + VPHDA +P+ ++ + +LG TD G T+ + L CD LL+E NH E++ +S Sbjct: 116 FNVPHDAVDPVAFIFHYREEKLGFCTDLGWVTSWITHELYDCDYLLIESNHSPELVRQSQ 175 Query: 182 YPAFLKRRIGGDYGHLANDASAEILRLLDRSRLKRVIGAHLSQQNNTPELARAAI 236 P K+R+ GH++N ++L+ + +LK++ AHLS + NT ELA + + Sbjct: 176 RPDVYKKRVLSKLGHISNQECGQLLQKIITPKLKKLYLAHLSTECNTAELALSTV 230