BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.3227.p (523 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value VC1411 [GEPR] COG0477 Permeases of the major facilitator superfa... 663 0.0 RSc1852 [GEPR] COG0477 Permeases of the major facilitator superf... 616 e-176 YPO3268 [GEPR] COG0477 Permeases of the major facilitator superf... 440 e-123 RSc1292 [GEPR] COG0477 Permeases of the major facilitator superf... 437 e-122 STM2815 [GEPR] COG0477 Permeases of the major facilitator superf... 421 e-117 >VC1411 [GEPR] COG0477 Permeases of the major facilitator superfamily Vch Vibrio cholerae Length = 511 Score = 663 bits (1711), Expect = 0.0, Method: Compositional matrix adjust. Identities = 320/501 (63%), Positives = 396/501 (79%) Query: 23 PLSGGQLVGAGILLAAANFIAVLDTTIANVSVSTISGALGASTSQGTYVITSYAVAEAIT 82 PLSG L + LA ANF+A+LDTTIANVSVS I+G+LG STSQGTYVITSYAVAEAI+ Sbjct: 11 PLSGWALFFGALCLAMANFLAILDTTIANVSVSNIAGSLGTSTSQGTYVITSYAVAEAIS 70 Query: 83 VPLTGWLANRFGTVRVFILSMIMFGLFSALCGLANSLGMLIAFRVMQGLAGGPLMPLSQT 142 VPLTGWLA+RFG++RVF+ ++FG+FS LCGLANS+ L+ FRV+ G GGPLMPLSQT Sbjct: 71 VPLTGWLASRFGSIRVFVTCFLLFGVFSLLCGLANSMSTLVMFRVLLGFVGGPLMPLSQT 130 Query: 143 LLLRIFPKEKAPAAVGLWAMTTLVAPIAGPILGGVLCDQYSWPYIFWINVPVALICGYLG 202 L++RIFPK K+ AA+G+W+MTTLVAPI GPILGGVLCDQ SWPYIF+I +P A+ L Sbjct: 131 LMIRIFPKNKSHAAIGIWSMTTLVAPIMGPILGGVLCDQLSWPYIFFIKMPFAIAAALLC 190 Query: 203 WRMLKRFETKTSKLPIDRIGLILMVVWVAALQLMLDEGKEKDWFASTEIVLLAITAVVFF 262 W++LK+FETKT+ ID++GL L+VVWVAALQLMLDEGK+ DWF S+ IV LA+ AV+ F Sbjct: 191 WKLLKKFETKTTHSKIDKVGLALLVVWVAALQLMLDEGKDHDWFESSRIVFLAVIAVIGF 250 Query: 263 IAFLIWELTEHNPIVDLRVFRHRGFTASVTTICLAFGAFFGSVVLTPLWLQGYMGYTATW 322 IAFLIWELTE NP+VDL+VFRHRG++ S+ T+ LAFGAFF V+TPLWLQ YMGYTAT Sbjct: 251 IAFLIWELTERNPVVDLKVFRHRGYSISMVTLSLAFGAFFSISVVTPLWLQIYMGYTATI 310 Query: 323 SGCISALTGILAVMTAPLVAKMSATIDARKLVCFGVTWLGLITFVRAFNTTDMSFFQIGW 382 SG +A GILAV AP+VA +S+ D R V GV WLGL TF+R FNT DM+F QI W Sbjct: 311 SGHATASMGILAVFLAPIVANLSSKFDPRPFVFAGVMWLGLWTFMRGFNTVDMTFSQISW 370 Query: 383 PLFLQGIGLPLFFVPLTSLALSSVNEEETASAAGLMSFCRTMSGAIATSIVNTSWENDAT 442 PLF QGIG+PLFFVPLT++AL SV E SAAGLM+F RT+SGA ATS++NTSWE++ Sbjct: 371 PLFFQGIGMPLFFVPLTAIALGSVKPHEMESAAGLMNFIRTLSGAFATSMINTSWEHETR 430 Query: 443 HFHAELAGLVDRSGAAIQSMMASGMSLEQATASLAQTVQNQAVMLSTNHIFMMAAVSFSL 502 + HAELAGL D++G A Q+M SGMS EQ +++ +QNQ+VM++TN +F++ A+ F Sbjct: 431 YVHAELAGLTDKAGVATQAMQNSGMSAEQTRSAMDWILQNQSVMVATNQLFIVIALIFVF 490 Query: 503 AALAVWLAPKPTRVADTTAAH 523 AA +W APKP + DT+A H Sbjct: 491 AACMIWFAPKPKQAVDTSAVH 511 >RSc1852 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 512 Score = 616 bits (1589), Expect = e-176, Method: Compositional matrix adjust. Identities = 311/504 (61%), Positives = 388/504 (76%), Gaps = 1/504 (0%) Query: 21 EAPLSGGQLVGAGILLAAANFIAVLDTTIANVSVSTISGALGASTSQGTYVITSYAVAEA 80 +APL+GG L A I+LAAANF+AVLD TIANVSV ISG LG STSQGT+VITSYAVAEA Sbjct: 9 QAPLTGGMLWLAAIVLAAANFVAVLDMTIANVSVPNISGNLGVSTSQGTWVITSYAVAEA 68 Query: 81 ITVPLTGWLANRFGTVRVFILSMIMFGLFSALCGLANSLGMLIAFRVMQGLAGGPLMPLS 140 I VPLTGWLA+RFGTVRVF ++M FGLFSALCGLA SLGML+A R+ QGLAGGPLMPLS Sbjct: 69 ILVPLTGWLASRFGTVRVFAVAMGCFGLFSALCGLALSLGMLVAARICQGLAGGPLMPLS 128 Query: 141 QTLLLRIFPKEKAPAAVGLWAMTTLVAPIAGPILGGVLCDQYSWPYIFWINVPVALICGY 200 QTLLLRIFPKEKA AA+GLW+MTT+VAP+ GPILGG LCD+YSWP+IF+IN+P+A+ C + Sbjct: 129 QTLLLRIFPKEKAGAAIGLWSMTTIVAPVLGPILGGYLCDEYSWPWIFYINLPIAVGCAW 188 Query: 201 LGWRMLKRFETKTSKLPIDRIGLILMVVWVAALQLMLDEGKEKDWFASTEIVLLAITAVV 260 W+ML R+E+ ++ PID++GL L+V+WV +LQ+MLDEGK+ DWFAS+ I LA+ A + Sbjct: 189 AAWKMLARYESPIARNPIDKVGLALLVLWVGSLQIMLDEGKQLDWFASSTIAGLAVVAAI 248 Query: 261 FFIAFLIWELTEHNPIVDLRVFRHRGFTASVTTICLAFGAFFGSVVLTPLWLQGYMGYTA 320 F AFLIWEL +P V+LRVFRHRGF+ASV TI LAFGAFFG+ VLTP WLQ +MGYTA Sbjct: 249 GFAAFLIWELHAEHPAVNLRVFRHRGFSASVLTISLAFGAFFGANVLTPQWLQSFMGYTA 308 Query: 321 TWSGCISALTGILAVMTAPLVAKMSATIDARKLVCFGVTWLGLITFVRAFNTTDMSFFQI 380 +G +A +G A+ AP+ A + +DARKLV GV WLG+IT R TTDM+++Q+ Sbjct: 309 LEAGKTTAWSGFFALFAAPIAAGLGGKVDARKLVFGGVIWLGIITLWRTVATTDMTYWQV 368 Query: 381 GWPLFLQGIGLPLFFVPLTSLALSSVNEEETASAAGLMSFCRTMSGAIATSIVNTSWEND 440 PL G+G+P FFVP T LA++SV+EEE ASAAGLM+F RT+SGA ATS++ T W++ Sbjct: 369 AVPLMAMGLGIPFFFVPTTGLAMASVDEEEMASAAGLMNFLRTLSGAFATSLITTLWDDR 428 Query: 441 ATHFHAELAGLVDRSGAAIQSMMASGMSLEQATASLAQTVQNQAVMLSTNHIFMMAAVSF 500 AT HAEL G+ D G+ + +G +L+ S+ Q + +Q+VML+TN I V+F Sbjct: 429 ATLHHAELVGVSDGDGSVRTMLEGAGSTLDAINQSIDQLLTSQSVMLATNDIMAWVGVAF 488 Query: 501 SLAALAVWLAPKPTR-VADTTAAH 523 LAA A+WLAPKP R VA T H Sbjct: 489 VLAASAIWLAPKPRRTVAPGTGGH 512 >YPO3268 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 511 Score = 440 bits (1131), Expect = e-123, Method: Compositional matrix adjust. Identities = 235/509 (46%), Positives = 325/509 (63%), Gaps = 6/509 (1%) Query: 21 EAPLSGGQLVGAGILLAAANFIAVLDTTIANVSVSTISGALGASTSQGTYVITSYAVAEA 80 + PL G L + L+ A F+ VLD+TIANV++ TI+G LG+S SQGT+VITS+ VA A Sbjct: 3 QKPLEGAPLAWMTVALSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANA 62 Query: 81 ITVPLTGWLANRFGTVRVFILSMIMFGLFSALCGLANSLGMLIAFRVMQGLAGGPLMPLS 140 I++P+TGWLA R G VR+F+ S +F L S LCG++NSLGMLI FRV+QGL GPL+PLS Sbjct: 63 ISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFFRVIQGLVAGPLIPLS 122 Query: 141 QTLLLRIFPKEKAPAAVGLWAMTTLVAPIAGPILGGVLCDQYSWPYIFWINVPVALICGY 200 Q+LLL +P K A+ LW+MT +VAPI GPILGG + D Y W +IF+IN+P+ L+ Sbjct: 123 QSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLVVVL 182 Query: 201 LGWRMLKRFETKTSKLPIDRIGLILMVVWVAALQLMLDEGKEKDWFASTEIVLLAITAVV 260 L LK ETKT PID IGL+L+VV + ALQ+MLD+GKE DWF STEI++L + AVV Sbjct: 183 LAGSTLKGRETKTEIRPIDTIGLVLLVVGIGALQIMLDQGKELDWFNSTEIIVLTVVAVV 242 Query: 261 FFIAFLIWELTEHNPIVDLRVFRHRGFTASVTTICLAFGAFFGSVVLTPLWLQGYMGYTA 320 ++WELT+ +P++DL +F+ R FT + LA+ +FG++VL P LQ GYTA Sbjct: 243 AITFLIVWELTDDHPVIDLSLFKSRNFTIGCLCLSLAYMLYFGAIVLLPQLLQEVYGYTA 302 Query: 321 TWSGCISALTGILAVMTAPLVAKMSATIDARKLVCFGVTWLGLITFVRAFN-TTDMSFFQ 379 TW+G SA GIL V+ +PL+ + + ID R+LV F + + RA+ M F Sbjct: 303 TWAGLASAPVGILPVLLSPLIGRFAHRIDMRQLVTFSFIMYAVCFYWRAYTFEPGMDFGA 362 Query: 380 IGWPLFLQGIGLPLFFVPLTSLALSSVNEEETASAAGLMSFCRTMSGAIATSIVNTSWEN 439 WP F QG + FF+PLT++ LS + E A+A+ L +F RT++G+I TSI T W Sbjct: 363 SAWPQFFQGFAIACFFMPLTTITLSGLPPERMAAASSLSNFMRTLAGSIGTSITTTLWTQ 422 Query: 440 DATHFHAELAGLVD----RSGAAIQSMMASGMSLEQATASLAQTVQNQAVMLSTNHIFMM 495 + HA+L V+ + A Q + GMS +QA+A LA+ + NQ +++S N IF + Sbjct: 423 RESLHHAQLTEFVNPYNPNATQAYQELEKLGMSQQQASAYLAREITNQGLIISANEIFWL 482 Query: 496 AAVSFSLAALAVWLAPKP-TRVADTTAAH 523 +A F + +W A P T AH Sbjct: 483 SAGVFLMLLALIWFARPPFTSGGGGGGAH 511 >RSc1292 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 518 Score = 437 bits (1124), Expect = e-122, Method: Compositional matrix adjust. Identities = 229/503 (45%), Positives = 324/503 (64%), Gaps = 6/503 (1%) Query: 17 PGPLEAPLSGGQLVGAGILLAAANFIAVLDTTIANVSVSTISGALGASTSQGTYVITSYA 76 P PL+ PL+G +L + L+ A F+ VLD++IANVS+ ISG LG + +QGT+VITS+A Sbjct: 6 PRPLQ-PLTGAKLAIGTVALSLATFMNVLDSSIANVSIPAISGDLGVAPNQGTWVITSFA 64 Query: 77 VAEAITVPLTGWLANRFGTVRVFILSMIMFGLFSALCGLANSLGMLIAFRVMQGLAGGPL 136 VA AI+VPLTGWL RFG VR+F+ S+++F L S CGLA ++G LIA R++QG GP+ Sbjct: 65 VANAISVPLTGWLTQRFGQVRLFVTSILLFVLSSWACGLAPNMGTLIAARILQGAVAGPM 124 Query: 137 MPLSQTLLLRIFPKEKAPAAVGLWAMTTLVAPIAGPILGGVLCDQYSWPYIFWINVPVAL 196 +PLSQ+LLL +P K+ A+ LW MTTLVAPI GPI GG + D +WP+IF+IN+PV + Sbjct: 125 IPLSQSLLLSTYPPAKSSMALALWGMTTLVAPIMGPIFGGWISDNMTWPWIFYINIPVGI 184 Query: 197 ICGYLGWRMLKRFETKTSKLPIDRIGLILMVVWVAALQLMLDEGKEKDWFASTEIVLLAI 256 + Y W + K E+ T LPIDRIGL L+V+WV +LQLMLD GKE DWF S EIV L + Sbjct: 185 LAAYATWVIYKDRESPTRALPIDRIGLALLVIWVGSLQLMLDRGKELDWFNSAEIVTLTV 244 Query: 257 TAVVFFIAFLIWELTEHNPIVDLRVFRHRGFTASVTTICLAFGAFFGSVVLTPLWLQGYM 316 AVV F FL+WELTE +P+VDL +F+ R F+A V I +A+G FFG++V+ PLWLQ + Sbjct: 245 VAVVGFAFFLVWELTEDHPVVDLTLFKGRNFSAGVVAISVAYGLFFGNLVILPLWLQTIV 304 Query: 317 GYTATWSGCISALTGILAVMTAPLVAKMSATIDARKLVCFGVTWLGLITFVRAFNTTDMS 376 GYTAT +G + A GI A++ +P++ K +DAR + L+ ++R+ T + Sbjct: 305 GYTATDAGLVMAPVGIFAILLSPVIGKNLPKMDARWVATTAFITFALVFWMRSRFTIQVD 364 Query: 377 FFQIGWPLFLQGIGLPLFFVPLTSLALSSVNEEETASAAGLMSFCRTMSGAIATSIVNTS 436 + + P +QG + +FF+PLTS+ LS + E +A+GL +F R M G I SI T Sbjct: 365 TWTLMVPTLIQGAAMAMFFIPLTSIILSGLRPERIPAASGLSNFVRIMFGGIGASISTTV 424 Query: 437 WENDATHFHAELAGLVDRSGAAIQSMMAS----GMSLEQATASLAQTVQNQAVMLSTNHI 492 W+N + HA+L + A S + GM QA ++ + + QA M+ N I Sbjct: 425 WDNRSALHHAQLVERANPYNPAYASSLGDYTQMGMPSLQANGAIERIISQQAAMMGANDI 484 Query: 493 FMMAAVSFSLAALAVWLAPKPTR 515 F ++AV F + +WL +P + Sbjct: 485 FWISAVLFIVLIALIWLT-RPAK 506 >STM2815 [GEPR] COG0477 Permeases of the major facilitator superfamily Sty Salmonella typhimurium LT2 Length = 512 Score = 421 bits (1082), Expect = e-117, Method: Compositional matrix adjust. Identities = 222/498 (44%), Positives = 317/498 (63%), Gaps = 5/498 (1%) Query: 21 EAPLSGGQLVGAGILLAAANFIAVLDTTIANVSVSTISGALGASTSQGTYVITSYAVAEA 80 + PL G QLV I L+ A F+ VLD+TIANV++ TI+G LG+S SQGT+VITS+ VA A Sbjct: 4 QKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANA 63 Query: 81 ITVPLTGWLANRFGTVRVFILSMIMFGLFSALCGLANSLGMLIAFRVMQGLAGGPLMPLS 140 I++PLTGWLA RFG V++F+ S + F S CG+++SL MLI FRV+QG+ GPL+PLS Sbjct: 64 ISIPLTGWLAKRFGEVKLFMWSTVAFAAASWACGVSSSLNMLIFFRVVQGVVAGPLIPLS 123 Query: 141 QTLLLRIFPKEKAPAAVGLWAMTTLVAPIAGPILGGVLCDQYSWPYIFWINVPVALICGY 200 Q+LLL +P K A+ LW+MT +VAPI GPILGG + D Y W +IF+INVP+ + Sbjct: 124 QSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGIAVVL 183 Query: 201 LGWRMLKRFETKTSKLPIDRIGLILMVVWVAALQLMLDEGKEKDWFASTEIVLLAITAVV 260 + L+ ET T + ID +GL L+V+ + +LQ+MLD GKE DWF+S EI++L + AV+ Sbjct: 184 MTLHTLRGRETHTERRRIDAVGLALLVIGIGSLQIMLDRGKELDWFSSQEIIILTVVAVI 243 Query: 261 FFIAFLIWELTEHNPIVDLRVFRHRGFTASVTTICLAFGAFFGSVVLTPLWLQGYMGYTA 320 ++WELT+ +PIVDL +F+ R FT I LA+ +FG++VL P LQ GYTA Sbjct: 244 AISFLIVWELTDDHPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTA 303 Query: 321 TWSGCISALTGILAVMTAPLVAKMSATIDARKLVCFGVTWLGLITFVRAFN-TTDMSFFQ 379 TW+G SA GI+ V+ +P++ + + +D R+LV F + + RA+ M F Sbjct: 304 TWAGLASAPVGIIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAWTFEPGMDFGA 363 Query: 380 IGWPLFLQGIGLPLFFVPLTSLALSSVNEEETASAAGLMSFCRTMSGAIATSIVNTSWEN 439 WP F+QG + FF+PLT++ LS + E A+A+ L +F RT++G+I TSI T W + Sbjct: 364 SAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTTMWTD 423 Query: 440 DATHFHAELAGLVDRSGAAIQSMMAS----GMSLEQATASLAQTVQNQAVMLSTNHIFMM 495 + HA+L V Q+M GM+ +QA+ +AQ + NQ +++S N IF M Sbjct: 424 RESLHHAQLTESVTAYNPNAQTMYDKLEGLGMTHQQASGWIAQQITNQGLIISANEIFWM 483 Query: 496 AAVSFSLAALAVWLAPKP 513 +A F + VW A P Sbjct: 484 SAGIFLVLLGLVWFAKPP 501