BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.3146.p (522 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2727 [GEPR] COG0477 Permeases of the major facilitator superf... 680 0.0 PA3137 [GEPR] COG0477 Permeases of the major facilitator superfa... 348 3e-95 mll0994 [GEPR] COG0477 Permeases of the major facilitator superf... 338 2e-92 RC0200 [GEPR] COG0477 Permeases of the major facilitator superfa... 283 5e-76 RP157 [GEPR] COG0477 Permeases of the major facilitator superfam... 281 2e-75 >RSc2727 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 511 Score = 680 bits (1755), Expect = 0.0, Method: Compositional matrix adjust. Identities = 351/493 (71%), Positives = 415/493 (84%) Query: 30 GTLGALMATLDISIVNSSLPTIQGEIGASGTEGTWIATAYLVAEIVIIPMSAWLERLLGL 89 GTLGA+MATLDISIVNS+LPTIQGEIGA+ TEGTWIATAYLVAEI+IIP++ WLE+LLGL Sbjct: 19 GTLGAMMATLDISIVNSALPTIQGEIGATSTEGTWIATAYLVAEIIIIPLAGWLEKLLGL 78 Query: 90 RVLLLTAASLFTLFSVLCGLSTTLPMMIIGRVGQGFTGGALIPTAMTIIATRLPRSQQPV 149 R LLL A LFT FS+LCG++ TLPMM+IGR GQGFTGG LIPTAMTIIA RLPR+QQP+ Sbjct: 79 RNLLLAATGLFTGFSMLCGVAETLPMMVIGRAGQGFTGGVLIPTAMTIIAARLPRAQQPL 138 Query: 150 GNAMFGATAILGPVLGPVMGGWLTENVSWHYAFFINLPVGAALITLLLVAIPYERPKFEQ 209 G A+FG+T ILGPV GP++GGW+T ++WHYAFFINLP+ L LLL+ +P+ERP+ Sbjct: 139 GTALFGSTVILGPVFGPMLGGWMTTQLNWHYAFFINLPICGVLAALLLLGMPHERPRTAL 198 Query: 210 LAQADWFGIAGLALGLGGLTVVLEEGEREQWFSSPDIRWLAATSLLGFILLAIGQMRSRH 269 L +ADW GIAGLALGLGG+TVVLEEG+R QWF+SP IRWLAA S LGF LL GQ R+R Sbjct: 199 LREADWAGIAGLALGLGGMTVVLEEGQRLQWFTSPAIRWLAAVSALGFGLLGWGQARARA 258 Query: 270 PVIQLRLLRDRQFGSVVMMAMIVGVALYGTAYVIPQFLSGIAGYNSLQSGWIVLLSGVPM 329 PVI+L LLRDRQFG++ +MA+ +ALYGTAYVIPQFL GIAGY++LQSGWIVLLSG+PM Sbjct: 259 PVIRLGLLRDRQFGAIAVMAIAASMALYGTAYVIPQFLVGIAGYDALQSGWIVLLSGLPM 318 Query: 330 ILMMPFTPLLMRRVDIRIAVGTGFLLLATSAFLETDLSPLSYGGSFVASQLMRGLGTVLA 389 I++MP PL++R +D+R+AVG G L+LA SA++ET LSPLS G SFVASQLMRGLGTVL Sbjct: 319 IVLMPMLPLMLRWLDVRLAVGGGLLVLALSAYIETGLSPLSTGNSFVASQLMRGLGTVLT 378 Query: 390 MLFLNQAAIRSVPPAQAGDASGLYSAARNLGGSLALAAIAVIQDQRLWLHSRRLEESLSA 449 M+FLNQAAIRSVPP+QA DASGLY+ RNLGGS+ALA IA +Q+QRLWLHSRR+E++L A Sbjct: 379 MMFLNQAAIRSVPPSQASDASGLYNGLRNLGGSIALACIATLQEQRLWLHSRRIEDTLQA 438 Query: 450 NSDLVQSSIAAQAHLLGGQDVAIQLMGATIQAQALTMTYADLFWLLGVAIVCVTPLVLFL 509 N+ VQ IA QAH LG Q A+ M +IQ QALTM YADLFWLL VAI+ VTPLV+FL Sbjct: 439 NAAGVQDYIAGQAHALGSQAAALLSMEQSIQVQALTMAYADLFWLLTVAILLVTPLVVFL 498 Query: 510 RPLPTNAAPVASH 522 RPLP +A PVA H Sbjct: 499 RPLPRHAGPVAGH 511 >PA3137 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 499 Score = 348 bits (892), Expect = 3e-95, Method: Compositional matrix adjust. Identities = 193/482 (40%), Positives = 279/482 (57%) Query: 32 LGALMATLDISIVNSSLPTIQGEIGASGTEGTWIATAYLVAEIVIIPMSAWLERLLGLRV 91 LGA MA LDI I NSSL IQG + A+ EG+WI+T+YLVAEI++IPM+AWL +LL R Sbjct: 6 LGAFMAVLDIQITNSSLKDIQGALAATLEEGSWISTSYLVAEIIMIPMTAWLVQLLSARR 65 Query: 92 LLLTAASLFTLFSVLCGLSTTLPMMIIGRVGQGFTGGALIPTAMTIIATRLPRSQQPVGN 151 L + + F + S+LC + L MI+ R QGFTGGALIP A T+ +LP +P G Sbjct: 66 LAVMISVGFLVSSLLCSFAWNLESMIVFRAMQGFTGGALIPLAFTLALVKLPEHHRPKGM 125 Query: 152 AMFGATAILGPVLGPVMGGWLTENVSWHYAFFINLPVGAALITLLLVAIPYERPKFEQLA 211 A+F TA P +GP +GGWLTEN W Y F+IN+P G +I LL + + P +E L Sbjct: 126 ALFAITATFAPSIGPTLGGWLTENFGWEYIFYINVPPGLLMIAGLLYGLEKKAPHWELLK 185 Query: 212 QADWFGIAGLALGLGGLTVVLEEGEREQWFSSPDIRWLAATSLLGFILLAIGQMRSRHPV 271 D+ GI L +GLG L V LEEG R+ W S I L + +L +L I Q+ +P+ Sbjct: 186 STDYAGIVTLGIGLGCLQVFLEEGHRKDWLESQLIVSLGSVALFSLVLFVILQLSRPNPL 245 Query: 272 IQLRLLRDRQFGSVVMMAMIVGVALYGTAYVIPQFLSGIAGYNSLQSGWIVLLSGVPMIL 331 I L +LR+R FG + ++ +G+ LYG+ YV+P +L+ I GYN++Q G +++ G+P + Sbjct: 246 IDLGILRNRNFGLASISSIGLGMGLYGSIYVLPLYLAQIQGYNAMQIGEVIMWMGIPQLF 305 Query: 332 MMPFTPLLMRRVDIRIAVGTGFLLLATSAFLETDLSPLSYGGSFVASQLMRGLGTVLAML 391 ++P P LM+ V R+ GF L ++F L+P G F QL+R LG + M+ Sbjct: 306 LIPLVPKLMKLVSPRLLCAAGFGLFGLASFFSGVLNPDFAGPQFNQIQLLRALGQPMIMV 365 Query: 392 FLNQAAIRSVPPAQAGDASGLYSAARNLGGSLALAAIAVIQDQRLWLHSRRLEESLSANS 451 ++ A + P AG AS L++ RNLGG++ +A +A + D R ++ L E+L + Sbjct: 366 TISLIATAYLQPQDAGSASSLFNILRNLGGAIGIALLATLLDSRAKVYFDYLREALVPTN 425 Query: 452 DLVQSSIAAQAHLLGGQDVAIQLMGATIQAQALTMTYADLFWLLGVAIVCVTPLVLFLRP 511 V +A A LG Q A+ + QA+ M Y D F ++G+ + VL R Sbjct: 426 PQVDERLAQLAAQLGSQQAALGKLSEITHQQAMIMAYNDAFHVIGMVLAVSMLAVLLTRS 485 Query: 512 LP 513 LP Sbjct: 486 LP 487 >mll0994 [GEPR] COG0477 Permeases of the major facilitator superfamily Mlo Mesorhizobium loti Length = 537 Score = 338 bits (867), Expect = 2e-92, Method: Compositional matrix adjust. Identities = 198/520 (38%), Positives = 297/520 (57%), Gaps = 16/520 (3%) Query: 4 APAKPLAGP-GAQEEKADAAAWLAVAAGTLGALMATLDISIVNSSLPTIQGEIGASGTEG 62 APA+P G+ A W+AV +LGA MA L+I IVN+SL IQG IGA +G Sbjct: 10 APARPARNETGSAGTAASPRVWVAVVGSSLGAFMAVLNIQIVNASLADIQGAIGAGIDDG 69 Query: 63 TWIATAYLVAEIVIIPMSAWLERLLGLRVLLLTAASLFTLFSVLCGLSTTLPMMIIGRVG 122 WI+TAYL+AEIV+IP++ WL ++ LR L+ A LF FSV C + L MI+ R Sbjct: 70 GWISTAYLIAEIVVIPLTGWLSQVFSLRNYLIANAVLFLAFSVACAFAANLGQMIVLRAI 129 Query: 123 QGFTGGALIPTAMTIIATRLPRSQQPVGNAMFGATAILGPVLGPVMGGWLTENVSWHYAF 182 QGFTGG LIP A TI+ T LP+++QP+G A+F +A P +GP +GG+LTEN W Y F Sbjct: 130 QGFTGGVLIPMAFTIVITLLPKARQPIGLALFAMSATFAPAIGPTIGGYLTENWGWQYIF 189 Query: 183 FINLPVGAALITLLLVAIPYERPKFEQLAQADWFGIAGLALGLGGLTVVLEEGEREQWFS 242 ++N+ GA ++ +L ++ + + L + DW GIA +A+GL L VLEEG + WF Sbjct: 190 YVNIVPGALMVGMLWFSLDRQPMRLALLGEGDWPGIATMAIGLAALQTVLEEGNKNDWFG 249 Query: 243 SPDIRWLAATSLLGFILLAIGQMRSRHPVIQLRLLRDRQFGSVVMMAMIVGVALYGTAYV 302 S + LA + + L ++ S HP++ LRLL R FG ++ ++G ALYG+ ++ Sbjct: 250 SLFVLRLAIVAAVSLSLFVWIELTSSHPLLNLRLLLRRNFGFGILANFMLGTALYGSVFI 309 Query: 303 IPQFLSGIAGYNSLQSGWIVLLSGVPMILMMPFTPLLMRRVDIRIAVGTGFLLLATSAFL 362 +P +L+ I GYN+ Q G ++ +G+P +L++P P LM+R D+R+ + TGF L A S F+ Sbjct: 310 LPVYLARIQGYNAEQIGLVLAWTGLPQLLLIPLVPYLMQRFDVRLVIVTGFALFAASNFM 369 Query: 363 ETDLSPLSYGGSFVASQLMRGLGTVLAMLFLNQAAIRSVPPAQAGDASGLYSAARNLGGS 422 ++ ++R +G L L+ A+ + AG AS L++ RNLGG+ Sbjct: 370 NVHMTAGYASDQLFWPNIVRAIGQALVFAPLSAIAVSGIEQENAGSASSLFNMIRNLGGA 429 Query: 423 LALAAIAVIQDQRLWLHSRRLEESLSANSDLVQSSIAA----------QAHLLGGQD--V 470 + +A + +R HS L +S+S + +S IA H+L Q + Sbjct: 430 VGIALLQTFLTKRQQYHSNVLVQSISLFEEATRSRIAKLTAYFLSHGVSDHVLAAQKGVI 489 Query: 471 AIQLMGATIQAQALTMTYADLFWLLGVAIVCVTPLVLFLR 510 AI L ++ QA M ++D F+LLGVA+V L L+ Sbjct: 490 AIAL---RVRQQAFIMAFSDTFFLLGVALVIALAATLLLK 526 >RC0200 [GEPR] COG0477 Permeases of the major facilitator superfamily Rco Rickettsia conorii Length = 519 Score = 283 bits (725), Expect = 5e-76, Method: Compositional matrix adjust. Identities = 170/492 (34%), Positives = 276/492 (56%), Gaps = 14/492 (2%) Query: 32 LGALMATLDISIVNSSLPTIQGEIGASGTEGTWIATAYLVAEIVIIPMSAWLERLLGLRV 91 +G M+ LDI IV SSL I + AS E +W+ T+YL+AE++IIP++ +L RLL R+ Sbjct: 24 VGMFMSVLDIQIVASSLSVIAAGLAASSDELSWVQTSYLIAEVIIIPITGFLARLLTTRI 83 Query: 92 LLLTAASLFTLFSVLCGLSTTLPMMIIGRVGQGFTGGALIPTAMTIIATRLPRSQQPVGN 151 AA FT+ S+LC L+T + MII R QGF GGA+IPT + + P SQ+P+ Sbjct: 84 SYFIAALGFTVMSILCSLATNIESMIIFRALQGFFGGAMIPTVFSTVFILFPASQRPIVT 143 Query: 152 AMFGATAILGPVLGPVMGGWLTENVSWHYAFFINLPVGAALITLLLVAIPYERPKFEQLA 211 + G + P LGP +GG++TE +SWH+ F +N+ G + T++ + +++P ++ L Sbjct: 144 ILIGLVVTVAPTLGPTLGGYITEILSWHFMFLLNVIPGIFVCTVVFLYGDFDKPNYKLLK 203 Query: 212 QADWFGIAGLALGLGGLTVVLEEGEREQWFSSPDIRWLAATSLLGFILLAIGQMRSRHPV 271 D+ GI +AL LG L VLEEG ++ W I +L+ T +LGFILL I ++ +P+ Sbjct: 204 NFDFLGILLMALTLGLLQYVLEEGNKKGWLEDNLILFLSITVVLGFILLIIRELTCINPI 263 Query: 272 IQLR--LLRDRQFGSVVMMAMIVGVALYGTAYVIPQFLSGIAGYNSLQSGWIVLLSGVPM 329 + L+ L +D FG + + ++G+ LYGT Y++P FL IAGY++LQ G ++++G Sbjct: 264 LDLKTFLYKDFTFGC--LYSFVMGIGLYGTVYILPLFLFTIAGYDTLQIGATMMVTGGAQ 321 Query: 330 ILMMPFT-PLLMRRVDIRIAVGTGFLLLATSAFLETDLSPLSYGGSFVASQLMRGLGTVL 388 L P +L VD+R+ + G A L + L+P S +FV Q +RGL + Sbjct: 322 FLSAPLAGRMLGLGVDLRLMLIIGLGGFALGCHLNSFLTPDSKFAAFVLPQFVRGLSLMF 381 Query: 389 AMLFLNQAAIRSVPPAQAGDASGLYSAARNLGGSLALAAIAVIQDQRLWLHSRRLEESLS 448 + N A+ ++P + G+ASGLY+ RNLGG++ LA I+ I + L E++S Sbjct: 382 CFIPTNNIALGNMPKERVGNASGLYNLTRNLGGAVGLAIISTILTNDTKTFMQYLSENIS 441 Query: 449 ANSDLVQSSIAAQAHLLGG-----QDVAIQLMGATIQAQALTMTYADLFWLLGVAIVCVT 503 + S + + + LL G + + L+ + A + ++F ++G+ V Sbjct: 442 STSIMALEQLDSYTELLSGKVLNPEKASYLLLANKLNHDAFVIAINNIFNMIGLLFV--- 498 Query: 504 PLVLFLRPLPTN 515 ++ L P +N Sbjct: 499 -FIMLLIPFTSN 509 >RP157 [GEPR] COG0477 Permeases of the major facilitator superfamily Rpr Rickettsia prowazekii Length = 519 Score = 281 bits (720), Expect = 2e-75, Method: Compositional matrix adjust. Identities = 170/519 (32%), Positives = 281/519 (54%), Gaps = 19/519 (3%) Query: 5 PAKPLAGPGAQEEKADAAAWLAVAAGTLGALMATLDISIVNSSLPTIQGEIGASGTEGTW 64 P L P +++ LA +G M+ LDI IV SSL I + AS E +W Sbjct: 2 PNNDLKTPPLSKKQ-----LLAFFGMIVGMFMSVLDIQIVASSLSVIAAGLAASSDELSW 56 Query: 65 IATAYLVAEIVIIPMSAWLERLLGLRVLLLTAASLFTLFSVLCGLSTTLPMMIIGRVGQG 124 + T+YL+AE++IIP++ +L RLL R+ AA FT+ SVLC L+ + MII R QG Sbjct: 57 VQTSYLIAEVIIIPITGFLARLLSTRICYFIAALGFTIMSVLCSLANNIESMIIFRALQG 116 Query: 125 FTGGALIPTAMTIIATRLPRSQQPVGNAMFGATAILGPVLGPVMGGWLTENVSWHYAFFI 184 F GGA+IP + + P SQ+P + G + P LGP +GG++TE +SWH+ F + Sbjct: 117 FFGGAMIPLVFSTVYIIFPASQRPTVTILIGLVVTVAPTLGPTLGGYITEILSWHFMFLL 176 Query: 185 NLPVGAALITLLLVAIPYERPKFEQLAQADWFGIAGLALGLGGLTVVLEEGEREQWFSSP 244 N+ G + T++ + + +++P ++ L D+ GI ++L LG L VLEEG +E W Sbjct: 177 NVIPGIFVCTVVFLYVNFDKPNYQLLKNFDFLGILLMSLTLGLLQYVLEEGNKEGWLDDN 236 Query: 245 DIRWLAATSLLGFILLAIGQMRSRHPVIQLR--LLRDRQFGSVVMMAMIVGVALYGTAYV 302 I +L+ T LGFILL I ++ +P++ L+ L +D FG + + ++G+ LYG Y+ Sbjct: 237 LILFLSITVALGFILLIIRELTFINPILDLKTFLYKDFTFGCI--YSFVMGIGLYGAVYI 294 Query: 303 IPQFLSGIAGYNSLQSGWIVLLSGVPMILMMPFT-PLLMRRVDIRIAVGTGFLLLATSAF 361 +P FL IA Y++LQ G ++++GV L P +L +D+R+ + G A Sbjct: 295 LPLFLFTIAEYDTLQIGATMMVTGVAQFLSAPLAGRMLGLGIDLRMMLTIGLGGFALGCH 354 Query: 362 LETDLSPLSYGGSFVASQLMRGLGTVLAMLFLNQAAIRSVPPAQAGDASGLYSAARNLGG 421 L + L+P S +F+ Q +RG + + N A+ ++P + G+ASGLY+ RNLGG Sbjct: 355 LNSCLTPDSKFAAFILPQFVRGFSLMFCFIPTNNIALGNMPKEKVGNASGLYNLTRNLGG 414 Query: 422 SLALAAIAVIQDQRLWLHSRRLEESLSANSDLVQSSIAAQAHLLGGQDV-----AIQLMG 476 ++ LA I+ I + + L E++S S + + + + LL G+ + + L+ Sbjct: 415 AVGLAIISTILSNDTKIFMQYLSENISYTSIIALTRLDSYTELLSGKILNPEQGSYLLLA 474 Query: 477 ATIQAQALTMTYADLFWLLGVAIVCVTPLVLFLRPLPTN 515 + A + ++F ++G+ V ++ L P +N Sbjct: 475 NKLNNDAFVIAINNIFNMIGLLFV----FIMLLIPFTSN 509