BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.3085.p (549 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value STM0367 [KT] COG1221 Transcriptional regulators containing an AA... 649 0.0 ZprpR [KT] COG1221 Transcriptional regulators containing an AAA-... 641 0.0 ECs0384 [KT] COG1221 Transcriptional regulators containing an AA... 641 0.0 prpR [KT] COG1221 Transcriptional regulators containing an AAA-t... 640 0.0 CAC0459 [KT] COG3829 Transcriptional regulator containing PAS, A... 276 1e-73 >STM0367 [KT] COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain Sty Salmonella typhimurium LT2 Length = 541 Score = 649 bits (1673), Expect = 0.0, Method: Compositional matrix adjust. Identities = 329/539 (61%), Positives = 411/539 (76%), Gaps = 24/539 (4%) Query: 10 DTDKPVIWTVSVSRLSELFRDITLEFDAVADIEPIQLGFDEAVRQIRERLASERCDVVIS 69 ++DKPVIWTVSV+RL ELFRDI+LEFD +A I PIQLGF++AV IR++LA+ERCD +I+ Sbjct: 11 NSDKPVIWTVSVTRLFELFRDISLEFDHLATITPIQLGFEKAVTYIRKKLATERCDAIIA 70 Query: 70 AGSNGAYLKSRLPVPVVVARASGFDVMQALARARQISARIALVTYQEAMPALSEFQQMFG 129 AGSNGAYLKSRL +PV++ + SGFDV+QALA+A ++++ I +VTYQE +PAL FQ+ F Sbjct: 71 AGSNGAYLKSRLSIPVILIKPSGFDVLQALAKAGKLTSSIGIVTYQETIPALLAFQKTFH 130 Query: 130 LDIVQRTYATEEDARAVVHELKAAGIKAVVGAGLITDLAEEAGMQGIFLYSAATVRQAFE 189 L + QR+Y TEEDAR ++ELKA GI+AVVGAGLITDLAEEAGM IF+YSAATVRQAF Sbjct: 131 LRLEQRSYVTEEDARGQINELKANGIEAVVGAGLITDLAEEAGMTAIFIYSAATVRQAFH 190 Query: 190 DALELARLTQLESTRGPSLPVAENLRARHHLKDLRGDSAVMETVRQSITLFARSPANVLI 249 DAL++ RLT+ + PS + L+ R+ L D+RG S ME +RQ+ITL+ARS A VLI Sbjct: 191 DALDMTRLTRRQRVDYPS---GKGLQTRYELGDIRGQSPQMEQLRQTITLYARSRAAVLI 247 Query: 250 QGETGTGKELAAQAIHRA----HPLMQGKTHAAHPFVAINCGALAESLLESELFGYEEGA 305 QGETGTGKELAAQAIH+ P Q K + PFVA+NCGA+ ESLLE+ELFGYEEGA Sbjct: 248 QGETGTGKELAAQAIHQTFFHRQPHRQNK--PSPPFVAVNCGAITESLLEAELFGYEEGA 305 Query: 306 FTGSRRGGRPGVFEAAHRGSLLLDEIGEMPLPLQTRLLRVLEEREVVRVGGTRPIPVQVR 365 FTGSRRGGR G+FE AH G+L LDEIGEMPLPLQTRLLRVLEE+ V RVGG +PIPV VR Sbjct: 306 FTGSRRGGRAGLFEIAHGGTLFLDEIGEMPLPLQTRLLRVLEEKAVTRVGGHQPIPVDVR 365 Query: 366 IISATHCDLEARVREGRFRADLYYRLSVLRLQLPPLRARREDIPALAEWHLKHALAALDA 425 +ISATHCDL+ + +GRFR DL+YRLS+LRL LPPLR R+ DI LAE LK +LAA++ Sbjct: 366 VISATHCDLDREIMQGRFRPDLFYRLSILRLTLPPLRERQADILPLAESFLKQSLAAMEI 425 Query: 426 RAHANLSAEILRCAPLLCAYEWPGNVRELRNLMERLALFLAAEPLQALTAALIQRVAPEL 485 ++ + +C PLL A+ WPGN+RELRN+MERLALFL+ +P L ++++ PEL Sbjct: 426 PFTESIRHGLTQCQPLLLAWRWPGNIRELRNMMERLALFLSVDPAPTLDRQFMRQLLPEL 485 Query: 486 VARSVDANTELPAVNDMETAPDLEDIHA---ALRRFRGNRAAAARHLGMSRTTLWRKLK 541 + VN E P D +A L RF+G++ AAAR+LG+SRTTLWR+LK Sbjct: 486 M------------VNTAELTPSTVDANALQDVLARFKGDKTAAARYLGISRTTLWRRLK 532 >ZprpR [KT] COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain EcZ Escherichia coli O157:H7 EDL933 Length = 528 Score = 641 bits (1654), Expect = 0.0, Method: Compositional matrix adjust. Identities = 334/542 (61%), Positives = 409/542 (75%), Gaps = 21/542 (3%) Query: 5 AHYDR-DTDKPVIWTVSVSRLSELFRDITLEFDAVADIEPIQLGFDEAVRQIRERLASER 63 AH R + DKPVIWTVSV+RL ELFRDI+LEFD +A+I PIQLGF++AV IR++LA+ER Sbjct: 2 AHPPRLNDDKPVIWTVSVTRLFELFRDISLEFDHLANITPIQLGFEKAVTYIRKKLANER 61 Query: 64 CDVVISAGSNGAYLKSRLPVPVVVARASGFDVMQALARARQISARIALVTYQEAMPALSE 123 CD +I+AGSNGAYLKSRL VPV++ + SG+DV+QALA+A ++++ I +VTYQE +PAL Sbjct: 62 CDAIIAAGSNGAYLKSRLSVPVILIKPSGYDVLQALAKAGKLTSSIGVVTYQETIPALVA 121 Query: 124 FQQMFGLDIVQRTYATEEDARAVVHELKAAGIKAVVGAGLITDLAEEAGMQGIFLYSAAT 183 FQ+ F L + QR+Y TEEDAR ++ELKA G +AVVGAGLITDLAEEAGM GIF+YSAAT Sbjct: 122 FQKTFNLRLDQRSYITEEDARGQINELKANGTEAVVGAGLITDLAEEAGMTGIFIYSAAT 181 Query: 184 VRQAFEDALELARLTQLESTRGPSLPVAENLRARHHLKDLRGDSAVMETVRQSITLFARS 243 VRQAF DAL++ R++ +T + LR R+ L D+ G S ME VRQ+I L+ARS Sbjct: 182 VRQAFSDALDMTRMSLRHNTHDAT---RNALRTRYVLGDMLGQSPQMEQVRQTILLYARS 238 Query: 244 PANVLIQGETGTGKELAAQAIHRA----HPLMQGKTHAAHPFVAINCGALAESLLESELF 299 A VLI+GETGTGKELAAQAIHR H QGK +HPFVA+NCGA+AESLLE+ELF Sbjct: 239 SAAVLIEGETGTGKELAAQAIHREYFARHDARQGKK--SHPFVAVNCGAIAESLLEAELF 296 Query: 300 GYEEGAFTGSRRGGRPGVFEAAHRGSLLLDEIGEMPLPLQTRLLRVLEEREVVRVGGTRP 359 GYEEGAFTGSRRGGR G+FE AH G+L LDEIGEMPLPLQTRLLRVLEE+EV RVGG +P Sbjct: 297 GYEEGAFTGSRRGGRAGLFEIAHGGTLFLDEIGEMPLPLQTRLLRVLEEKEVTRVGGHQP 356 Query: 360 IPVQVRIISATHCDLEARVREGRFRADLYYRLSVLRLQLPPLRARREDIPALAEWHLKHA 419 +PV VR+ISATHC+LE +R+G+FR DL+YRLS+LRLQLPPLR R DI LAE LK + Sbjct: 357 VPVDVRVISATHCNLEEDMRQGQFRRDLFYRLSILRLQLPPLRERVADILPLAESFLKVS 416 Query: 420 LAALDARAHANLSAEILRCAPLLCAYEWPGNVRELRNLMERLALFLAAEPLQALTAALIQ 479 LAAL A A L + +L Y+WPGN+RELRN+MERLALFL+ EP LT +Q Sbjct: 417 LAALSAPFSAALRQGLQASETVLVHYDWPGNIRELRNMMERLALFLSVEPTPDLTPQFLQ 476 Query: 480 RVAPELVARSVDANTELPAVNDMETAPDLEDIHAALRRFRGNRAAAARHLGMSRTTLWRK 539 + PEL S ++P AP L AL +F G++ AAA +LG+SRTT WR+ Sbjct: 477 LLLPELARESA----KIP-------APRLLTPQQALEKFNGDKTAAANYLGISRTTFWRR 525 Query: 540 LK 541 LK Sbjct: 526 LK 527 >ECs0384 [KT] COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain Ecs Escherichia coli O157:H7 Length = 528 Score = 641 bits (1654), Expect = 0.0, Method: Compositional matrix adjust. Identities = 334/542 (61%), Positives = 409/542 (75%), Gaps = 21/542 (3%) Query: 5 AHYDR-DTDKPVIWTVSVSRLSELFRDITLEFDAVADIEPIQLGFDEAVRQIRERLASER 63 AH R + DKPVIWTVSV+RL ELFRDI+LEFD +A+I PIQLGF++AV IR++LA+ER Sbjct: 2 AHPPRLNDDKPVIWTVSVTRLFELFRDISLEFDHLANITPIQLGFEKAVTYIRKKLANER 61 Query: 64 CDVVISAGSNGAYLKSRLPVPVVVARASGFDVMQALARARQISARIALVTYQEAMPALSE 123 CD +I+AGSNGAYLKSRL VPV++ + SG+DV+QALA+A ++++ I +VTYQE +PAL Sbjct: 62 CDAIIAAGSNGAYLKSRLSVPVILIKPSGYDVLQALAKAGKLTSSIGVVTYQETIPALVA 121 Query: 124 FQQMFGLDIVQRTYATEEDARAVVHELKAAGIKAVVGAGLITDLAEEAGMQGIFLYSAAT 183 FQ+ F L + QR+Y TEEDAR ++ELKA G +AVVGAGLITDLAEEAGM GIF+YSAAT Sbjct: 122 FQKTFNLRLDQRSYITEEDARGQINELKANGTEAVVGAGLITDLAEEAGMTGIFIYSAAT 181 Query: 184 VRQAFEDALELARLTQLESTRGPSLPVAENLRARHHLKDLRGDSAVMETVRQSITLFARS 243 VRQAF DAL++ R++ +T + LR R+ L D+ G S ME VRQ+I L+ARS Sbjct: 182 VRQAFSDALDMTRMSLRHNTHDAT---RNALRTRYVLGDMLGQSPQMEQVRQTILLYARS 238 Query: 244 PANVLIQGETGTGKELAAQAIHRA----HPLMQGKTHAAHPFVAINCGALAESLLESELF 299 A VLI+GETGTGKELAAQAIHR H QGK +HPFVA+NCGA+AESLLE+ELF Sbjct: 239 SAAVLIEGETGTGKELAAQAIHREYFARHDARQGKK--SHPFVAVNCGAIAESLLEAELF 296 Query: 300 GYEEGAFTGSRRGGRPGVFEAAHRGSLLLDEIGEMPLPLQTRLLRVLEEREVVRVGGTRP 359 GYEEGAFTGSRRGGR G+FE AH G+L LDEIGEMPLPLQTRLLRVLEE+EV RVGG +P Sbjct: 297 GYEEGAFTGSRRGGRAGLFEIAHGGTLFLDEIGEMPLPLQTRLLRVLEEKEVTRVGGHQP 356 Query: 360 IPVQVRIISATHCDLEARVREGRFRADLYYRLSVLRLQLPPLRARREDIPALAEWHLKHA 419 +PV VR+ISATHC+LE +R+G+FR DL+YRLS+LRLQLPPLR R DI LAE LK + Sbjct: 357 VPVDVRVISATHCNLEEDMRQGQFRRDLFYRLSILRLQLPPLRERVADILPLAESFLKVS 416 Query: 420 LAALDARAHANLSAEILRCAPLLCAYEWPGNVRELRNLMERLALFLAAEPLQALTAALIQ 479 LAAL A A L + +L Y+WPGN+RELRN+MERLALFL+ EP LT +Q Sbjct: 417 LAALSAPFSAALRQGLQASETVLVHYDWPGNIRELRNMMERLALFLSVEPTPDLTPQFLQ 476 Query: 480 RVAPELVARSVDANTELPAVNDMETAPDLEDIHAALRRFRGNRAAAARHLGMSRTTLWRK 539 + PEL S ++P AP L AL +F G++ AAA +LG+SRTT WR+ Sbjct: 477 LLLPELARESA----KIP-------APRLLTPQQALEKFNGDKTAAANYLGISRTTFWRR 525 Query: 540 LK 541 LK Sbjct: 526 LK 527 >prpR [KT] COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain Eco Escherichia coli K12 Length = 528 Score = 640 bits (1652), Expect = 0.0, Method: Compositional matrix adjust. Identities = 333/542 (61%), Positives = 406/542 (74%), Gaps = 21/542 (3%) Query: 5 AHYDR-DTDKPVIWTVSVSRLSELFRDITLEFDAVADIEPIQLGFDEAVRQIRERLASER 63 AH R + DKPVIWTVSV+RL ELFRDI+LEFD +A+I PIQLGF++AV IR++LA+ER Sbjct: 2 AHPPRLNDDKPVIWTVSVTRLFELFRDISLEFDHLANITPIQLGFEKAVTYIRKKLANER 61 Query: 64 CDVVISAGSNGAYLKSRLPVPVVVARASGFDVMQALARARQISARIALVTYQEAMPALSE 123 CD +I+AGSNGAYLKSRL VPV++ + SG+DV+QALA+A ++++ I +VTYQE +PAL Sbjct: 62 CDAIIAAGSNGAYLKSRLSVPVILIKPSGYDVLQALAKAGKLTSSIGVVTYQETIPALVA 121 Query: 124 FQQMFGLDIVQRTYATEEDARAVVHELKAAGIKAVVGAGLITDLAEEAGMQGIFLYSAAT 183 FQ+ F L + QR+Y TEEDAR ++ELKA G +AVVGAGLITDLAEEAGM GIF+YSAAT Sbjct: 122 FQKTFNLRLDQRSYITEEDARGQINELKANGTEAVVGAGLITDLAEEAGMTGIFIYSAAT 181 Query: 184 VRQAFEDALELARLTQLESTRGPSLPVAENLRARHHLKDLRGDSAVMETVRQSITLFARS 243 VRQAF DAL++ R++ +T + LR R+ L D+ G S ME VRQ+I L+ARS Sbjct: 182 VRQAFSDALDMTRMSLRHNTHDAT---RNALRTRYVLGDMLGQSPQMEQVRQTILLYARS 238 Query: 244 PANVLIQGETGTGKELAAQAIHRA----HPLMQGKTHAAHPFVAINCGALAESLLESELF 299 A VLI+GETGTGKELAAQAIHR H QGK +HPFVA+NCGA+AESLLE+ELF Sbjct: 239 SAAVLIEGETGTGKELAAQAIHREYFARHDARQGKK--SHPFVAVNCGAIAESLLEAELF 296 Query: 300 GYEEGAFTGSRRGGRPGVFEAAHRGSLLLDEIGEMPLPLQTRLLRVLEEREVVRVGGTRP 359 GYEEGAFTGSRRGGR G+FE AH G+L LDEIGEMPLPLQTRLLRVLEE+EV RVGG +P Sbjct: 297 GYEEGAFTGSRRGGRAGLFEIAHGGTLFLDEIGEMPLPLQTRLLRVLEEKEVTRVGGHQP 356 Query: 360 IPVQVRIISATHCDLEARVREGRFRADLYYRLSVLRLQLPPLRARREDIPALAEWHLKHA 419 +PV VR+ISATHC+LE +++GRFR DL+YRLS+LRLQLPPLR R DI LAE LK + Sbjct: 357 VPVDVRVISATHCNLEEDMQQGRFRRDLFYRLSILRLQLPPLRERVADILPLAESFLKVS 416 Query: 420 LAALDARAHANLSAEILRCAPLLCAYEWPGNVRELRNLMERLALFLAAEPLQALTAALIQ 479 LAAL A A L + +L Y+WPGN+RELRN+MERLALFL+ EP LT +Q Sbjct: 417 LAALSAPFSAALRQGLQASETVLLHYDWPGNIRELRNMMERLALFLSVEPTPDLTPQFMQ 476 Query: 480 RVAPELVARSVDANTELPAVNDMETAPDLEDIHAALRRFRGNRAAAARHLGMSRTTLWRK 539 + PEL S AP L AL +F G++ AAA +LG+SRTT WR+ Sbjct: 477 LLLPELARESAKT-----------PAPRLLTPQQALEKFNGDKTAAANYLGISRTTFWRR 525 Query: 540 LK 541 LK Sbjct: 526 LK 527 >CAC0459 [KT] COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Cac Clostridium acetobutylicum Length = 627 Score = 276 bits (705), Expect = 1e-73, Method: Compositional matrix adjust. Identities = 140/327 (42%), Positives = 203/327 (62%), Gaps = 16/327 (4%) Query: 216 ARHHLKDLRGDSAVMETVRQSITLFARSPANVLIQGETGTGKELAAQAIHRAHPLMQGKT 275 A+++ D+ M +++ L++++ +++LIQGE+G+GKEL AQ+IH + P G Sbjct: 313 AKYNFDDILTQDKNMIELKKLALLYSKTDSSILIQGESGSGKELFAQSIHNSSPRKNG-- 370 Query: 276 HAAHPFVAINCGALAESLLESELFGYEEGAFTGSRRGGRPGVFEAAHRGSLLLDEIGEMP 335 PFVAINC AL E LLESELFGYE G+FTG+++ G+ G+FE AH G++ LDEIGE+ Sbjct: 371 ----PFVAINCAALPEHLLESELFGYEGGSFTGAKKEGKQGLFELAHNGTIFLDEIGELS 426 Query: 336 LPLQTRLLRVLEEREVVRVGGTRPIPVQVRIISATHCDLEARVREGRFRADLYYRLSVLR 395 PLQ +LLRVLEE+E++ +GG + IPV +RIIS+T+ +L + G FR DLYYRL+V Sbjct: 427 KPLQAQLLRVLEEKEIMHIGGDKIIPVDIRIISSTNRNLLNSIENGTFREDLYYRLNVFN 486 Query: 396 LQLPPLRARREDIPALAEWHLKHALAALDARAHANLSAEILRCAPLLCAYEWPGNVRELR 455 L LPPLR R +DI LAE L++ +N S + + P L AY WPGN REL Sbjct: 487 LTLPPLRERGKDIEILAEHFLENT-----HNFSSNRSKILNQITPFLMAYNWPGNTRELS 541 Query: 456 NLMERLALFLAAEPLQALTAALIQRVAPELVARSVDANTELPAVNDMETAPDLED---IH 512 N+MER++LF+ + L + V E + ++ ++P M+ +L + IH Sbjct: 542 NVMERISLFIENSMTINWSQVLYKVVHKEKIEDTL--TLKVPYNLTMKEIIELTEKRVIH 599 Query: 513 AALRRFRGNRAAAARHLGMSRTTLWRK 539 + L R+ + A L + RTTLWRK Sbjct: 600 SLLERYDNDHNRVAEILNIGRTTLWRK 626 Score = 79.0 bits (193), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 49/209 (23%), Positives = 99/209 (47%), Gaps = 14/209 (6%) Query: 62 ERCDVVISAGSNGAYLKSRLPVPVVVARASGFDVMQALARARQISARIALVTYQEAMPAL 121 + D +IS G+ Y+K + +P + + + FD M+A+ A++ +AL+ Y+ ++ Sbjct: 48 DEVDAIISRGATSDYIKKSVSIPSISIKVTRFDTMRAVYNAKRFGNELALIAYKHSIVDK 107 Query: 122 SEFQQMFGLDIVQRTYATEEDARAVVHELKAAGIKAVVGAGLITDLAEEAGMQGIFLYSA 181 E + M G+ I + +++E++ ++ ++K IK VV +TD A + G+ G + S Sbjct: 108 HEIEAMLGVKIKEFLFSSEDEITTLISKVKTENIKIVVSGKTVTDEAIKQGLYGETINSG 167 Query: 182 -ATVRQAFEDALELARLTQLESTRGPSLPVAENLRARHHLKDLRGDSAVMETVRQSITLF 240 ++R+A E+AL L + +E R + D G+ ++ + I + Sbjct: 168 EESLRRAIEEALNLIEVRNIELRRSARFKA---------ILDAIGEGIIVTDQFKKIITY 218 Query: 241 ARSPANVLIQGETGTGKELAAQAIHRAHP 269 S + T TG +L ++I P Sbjct: 219 NNSINKIF----TKTGSKLLGKSIQSVIP 243