BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.3061.p (630 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value Cj0284c_1 [NT] COG0643 Chemotaxis protein histidine kinase and r... 343 5e-94 HP0392_1 [NT] COG0643 Chemotaxis protein histidine kinase and re... 328 2e-89 jhp0989_1 [NT] COG0643 Chemotaxis protein histidine kinase and r... 328 2e-89 CC0594 [NT] COG0643 Chemotaxis protein histidine kinase and rela... 293 1e-78 AF1040 [NT] COG0643 Chemotaxis protein histidine kinase and rela... 280 9e-75 >Cj0284c_1 [NT] COG0643 Chemotaxis protein histidine kinase and related kinases Cje Campylobacter jejuni Length = 622 Score = 343 bits (881), Expect = 5e-94, Method: Compositional matrix adjust. Identities = 209/634 (32%), Positives = 350/634 (55%), Gaps = 29/634 (4%) Query: 1 MDD--EMLKDFVVEALELATNVEEHLLTLERHPDDLEILNAVFRAFHTIKGGAGFVNLPA 58 M+D E+L+DF+VEA EL ++ L+ LE +P+DLE+LN +FR HT+KG + F+N Sbjct: 1 MEDMQEILEDFLVEAFELVEQIDHDLVELESNPEDLELLNRIFRVAHTVKGSSSFLNFDV 60 Query: 59 MVSACHLTENLFDALRTGKAPVTPLAIEAALQASGFVADQLNELSNGAAPDSLASMPAE- 117 + H E++ + R G+ +TP ++ L++ + LN + + D+ M E Sbjct: 61 LTKLTHHMEDVLNKARHGELKITPDIMDVVLESIDRMKTLLNSIRDNGN-DTAIGMDIEP 119 Query: 118 LKDILTQAIEGKSEAAPAAAAPATAPAAPVAPQVQATSAAPASVDGSASVMKDGELDWPA 177 + LT EG+S + + P A + Q + VD + + D E++ Sbjct: 120 ICARLTAISEGESPVVATDSNEKSIPQAELEAPKQEIATPEPEVD--VNQLSDSEVEAEI 177 Query: 178 MYQALVPGAAVAAPAAADSTASAAAATPAPAAAPAAAAEGEPKAAAPVQQNRRATDSPGG 237 V A A A + AA P A GE K A + S Sbjct: 178 ERLLKVRKAEDQARRAQKKQTTNAAPKPTNNTANKPTESGEKKVPA--------SGSNAS 229 Query: 238 AKEESIRIDAVKLDALLEVAGESVQAANQASVLLEKLQQFKFEGTAAALMSTLAETLGRA 297 + +++IR++ +LD L+ + GE V N+ + + +++ ++EG + L + + + Sbjct: 230 SMDQTIRVEVKRLDHLMNLIGELVLGKNRLLKIYDDVEE-RYEG--EKFLEELNQVVSQL 286 Query: 298 SRYSSELQRATLSTRMQPVGRLFQKFPRLVRELAKDLGKDVDLVITGADTEVDRVVVDSL 357 S +++Q A + TRMQP+ ++F KFPR+VR+L+++LGK ++L ITG +TE+D+ +V+ + Sbjct: 287 SIIITDVQLAVMKTRMQPIAKVFNKFPRVVRDLSRELGKQIELEITGEETELDKSIVEEI 346 Query: 358 YDPLVHMLRNSLDHGIE--VDRAAAGKPNKATISLNAWQAGSSVMIEVFDDGKGMDPDML 415 DP++HM+RNS DHG+E RAA GKP K + L A+ G+ +++E+ DDGKG+DP+ L Sbjct: 347 GDPIMHMIRNSCDHGVEDPATRAANGKPEKGIVQLKAYNEGNHIVVEITDDGKGLDPNGL 406 Query: 416 RSKALAKGLINEHQA--LTADEALQLVFLPGFSTKEVASSVSGRGVGMDVVKTAVEKHRG 473 ++KA+ K LI E +A +T EA L+F PGFST ++VSGRGVGMDVVKT +EK G Sbjct: 407 KAKAIEKNLITEREADQMTDKEAFALIFKPGFSTAAKVTNVSGRGVGMDVVKTNIEKLNG 466 Query: 474 TIRIESTIGKGTKFSIRLPIELSIIPTMLVRCAGAPLALPMAVVERVVELP-ETFDEVGG 532 I I+S +GKG+ F +++P+ L+II ++LV A+P+A V V +P + + G Sbjct: 467 VIEIDSELGKGSSFKLKIPLTLAIIQSLLVGTQEEFYAIPLASVLETVRVPIDDIYTIEG 526 Query: 533 APVLRDQGRPLPVNSLAGVLG----YEPGNERVGIVMAVPHPYI-LGVESVEGTADLVIK 587 VLR + L + L+ V G E G++ +V+ V + + V+++ G ++VIK Sbjct: 527 KNVLRLRDEVLSLVRLSDVFGVKQVLESGDQTYVVVIGVAESKLGIIVDTLVGQEEIVIK 586 Query: 588 PLTAI--HTAGITGTARSAEGELVLVVGLSFLLD 619 + + GI G +G + L++ + ++D Sbjct: 587 SMGDYLQNIQGIAGATIRGDGRVTLIIDVGAMMD 620 >HP0392_1 [NT] COG0643 Chemotaxis protein histidine kinase and related kinases Hpy Helicobacter pylori 26695 Length = 651 Score = 328 bits (842), Expect = 2e-89, Method: Compositional matrix adjust. Identities = 208/658 (31%), Positives = 353/658 (53%), Gaps = 48/658 (7%) Query: 1 MDD--EMLKDFVVEALELATNVEEHLLTLERHPDDLEILNAVFRAFHTIKGGAGFVNLPA 58 MDD E+++DF++EA E+ +++ L+ LE +P+DL++LN +FR HTIKG + F+NL Sbjct: 1 MDDLQEIMEDFLIEAFEMNEQLDQDLVELEHNPEDLDLLNRIFRVAHTIKGSSSFLNLNI 60 Query: 59 MVSACHLTENLFDALRTGKAPVTPLAIEAALQASGFVADQLNEL------SNGAAPDSLA 112 + H E++ + R G+ +TP ++ L++ + L + +N + + Sbjct: 61 LTHLTHNMEDVLNRARKGEIKITPDIMDVVLRSIDLMKTLLVTIRDTGSDTNNGKENEIE 120 Query: 113 SMPAELKDILTQAIEGKSE---AAPAAAAPATAPAAPVAPQVQATSAAPASVDGSAS--V 167 +L+ I +Q +E E AP + + AP + + S+ + Sbjct: 121 EAVKQLQAITSQNLESAKERTTEAPQKENKEETKEEAKEENKENKAKAPTAENTSSDNPL 180 Query: 168 MKDGELDWPAMYQALVPGAA---VAAPAAADSTASAAA---------ATPAPAAAPAAAA 215 + +LD+ M V + AD A TP A Sbjct: 181 ADEPDLDYANMSAEEVEAEIERLLNKRQEADKERRAQKKQEAKPKQEVTPTKETPKAPKT 240 Query: 216 EGEPKAAAPVQQNRRATDSPGGAKEESIRIDAVKLDALLEVAGESVQAANQASVLLEKLQ 275 E + KA A ++N+ +P E+++R+D +LD L+ + GE V N+ + ++ Sbjct: 241 ETKAKAKADTEENK----APSIGVEQTVRVDVRRLDHLMNLIGELVLGKNRLIRIYSDVE 296 Query: 276 QFKFEGTAAALMSTLAETLGRASRYSSELQRATLSTRMQPVGRLFQKFPRLVRELAKDLG 335 + +++G + L + + S +++LQ A + TRMQPVG++F KFPR+VR+L+++LG Sbjct: 297 E-RYDG--EKFLEELNQVVSSISAVTTDLQLAVMKTRMQPVGKVFNKFPRMVRDLSRELG 353 Query: 336 KDVDLVITGADTEVDRVVVDSLYDPLVHMLRNSLDHGIE--VDRAAAGKPNKATISLNAW 393 K ++L+I G +TE+D+ +V+ + DPL+H++RNS DHGIE +R KP + L+A+ Sbjct: 354 KSIELIIEGEETELDKSIVEEIGDPLIHIIRNSCDHGIEPLEERRKLNKPETGKVQLSAY 413 Query: 394 QAGSSVMIEVFDDGKGMDPDMLRSKALAKGLINEHQA--LTADEALQLVFLPGFSTKEVA 451 G+ ++I++ DDGKG+DP ML+ KA+ KG+I+E A ++ EA L+F PGFST +V Sbjct: 414 NEGNHIVIKISDDGKGLDPVMLKEKAIEKGVISERDAEGMSDREAFNLIFKPGFSTAKVV 473 Query: 452 SSVSGRGVGMDVVKTAVEKHRGTIRIESTIGKGTKFSIRLPIELSIIPTMLVRCAGAPLA 511 S+VSGRGVGMDVVKT +EK G I I+S +G GT +++P+ L+II +LV A Sbjct: 474 SNVSGRGVGMDVVKTNIEKLNGIIEIDSEVGVGTTQKLKIPLTLAIIQALLVGVQEEYYA 533 Query: 512 LPMAVVERVVELPETFDE---VGGAPVLRDQGRPLPVNSLAGVLGYE---PGNERVGIVM 565 +P++ V V + + DE V G VLR + L + L+ + + N V +V+ Sbjct: 534 IPLSSVLETVRISQ--DEIYTVDGKSVLRLRDEVLSLVRLSDIFKVDAILESNSDVYVVI 591 Query: 566 AVPHPYILG--VESVEGTADLVIKPLTAI--HTAGITGTARSAEGELVLVVGLSFLLD 619 +G V+ + G ++VIK L +T GI G +G++ L+V + ++D Sbjct: 592 IGLADQKIGVIVDYLIGQEEVVIKSLGYYLKNTRGIAGATVRGDGKITLIVDVGAMMD 649 >jhp0989_1 [NT] COG0643 Chemotaxis protein histidine kinase and related kinases jHp Helicobacter pylori J99 Length = 663 Score = 328 bits (841), Expect = 2e-89, Method: Compositional matrix adjust. Identities = 205/669 (30%), Positives = 355/669 (53%), Gaps = 58/669 (8%) Query: 1 MDD--EMLKDFVVEALELATNVEEHLLTLERHPDDLEILNAVFRAFHTIKGGAGFVNLPA 58 MDD E+++DF++EA E+ +++ L+ LE +P+DL++LN +FR HTIKG + F+NL Sbjct: 1 MDDLQEIMEDFLIEAFEMNEQLDQDLVELEHNPEDLDLLNRIFRVAHTIKGSSSFLNLNI 60 Query: 59 MVSACHLTENLFDALRTGKAPVTPLAIEAALQASGFVADQLNEL------SNGAAPDSLA 112 + H E++ + R G+ +TP ++ L++ + L + +N + + Sbjct: 61 LTHLTHNMEDVLNRARKGEIKITPDIMDVVLRSIDLMKTLLVTIRDTGSDTNNGKENEIE 120 Query: 113 SMPAELKDILTQAIEGKSEAAPAAAAPATAPAAPVAPQVQAT---SAAPASVDGSAS--V 167 + +L+ I +Q +EG E + AP + + + P + + ++ + Sbjct: 121 EVVKKLQAITSQNLEGAKETSGTKEAPEKEVKKENKEKAKEEVKANKTPTTENLTSDNPL 180 Query: 168 MKDGELDWPAM--------YQALVPGAAVAAPAAADSTASAAAATPAPAAAPAAAAEGEP 219 + +LD+ M + L+ A A P APA P Sbjct: 181 ADEPDLDYANMSAEEVEAEIERLLNKRQEADKERRAQKKQEDQAKPKQEVAPAKET---P 237 Query: 220 KAAAPVQQNRRA---------------TDSPGGAKEESIRIDAVKLDALLEVAGESVQAA 264 K P + R+ +P E+++R+D +LD L+ + GE V Sbjct: 238 KTETPKTETRKVPKAETKAKAKADTEENKAPSIGVEQTVRVDVRRLDHLMNLIGELVLGK 297 Query: 265 NQASVLLEKLQQFKFEGTAAALMSTLAETLGRASRYSSELQRATLSTRMQPVGRLFQKFP 324 N+ + +++ +++G + L + + S +++LQ A + TRMQPVG++F KFP Sbjct: 298 NRLIRIYSDVEE-RYDG--EKFLEELNQVVSSISAVTTDLQLAVMKTRMQPVGKVFNKFP 354 Query: 325 RLVRELAKDLGKDVDLVITGADTEVDRVVVDSLYDPLVHMLRNSLDHGIE--VDRAAAGK 382 R+VR+L+++LGK ++L+I G +TE+D+ +V+ + DPL+H++RNS DHGIE +R K Sbjct: 355 RMVRDLSRELGKSIELIIEGEETELDKSIVEEIGDPLIHIIRNSCDHGIEPLEERRRLNK 414 Query: 383 PNKATISLNAWQAGSSVMIEVFDDGKGMDPDMLRSKALAKGLINEHQA--LTADEALQLV 440 P + L+A+ G+ ++I++ DDGKG+DP ML+ KA+ KG+I+E A ++ EA L+ Sbjct: 415 PETGKVQLSAYNEGNHIVIKISDDGKGLDPVMLKEKAIEKGVISERDAESMSDREAFNLI 474 Query: 441 FLPGFSTKEVASSVSGRGVGMDVVKTAVEKHRGTIRIESTIGKGTKFSIRLPIELSIIPT 500 F PGFST++V S+VSGRGVGMDVVKT +EK G I I+S +G GT +++P+ L+II Sbjct: 475 FKPGFSTRKVVSNVSGRGVGMDVVKTNIEKLNGIIEIDSEVGVGTTQKLKIPLTLAIIQA 534 Query: 501 MLVRCAGAPLALPMAVVERVVELPETFDE---VGGAPVLRDQGRPLPVNSLAGVLGYE-- 555 +LV A+P++ V V + + DE V G VLR + L + L+ + + Sbjct: 535 LLVGVQEEYYAIPLSSVLETVRISQ--DEIYTVDGKSVLRLRDEVLSLVRLSDIFKVDAI 592 Query: 556 -PGNERVGIVMAVPHPYILG--VESVEGTADLVIKPLTAI--HTAGITGTARSAEGELVL 610 N V +V+ +G V+ + G ++VIK L +T GI G +G++ L Sbjct: 593 LESNSDVYVVIIGLADQKIGVIVDYLIGQEEVVIKSLGYYLKNTRGIAGATVRGDGKITL 652 Query: 611 VVGLSFLLD 619 +V + +++ Sbjct: 653 IVDVGAMME 661 >CC0594 [NT] COG0643 Chemotaxis protein histidine kinase and related kinases Ccr Caulobacter vibrioides Length = 764 Score = 293 bits (749), Expect = 1e-78, Method: Compositional matrix adjust. Identities = 213/637 (33%), Positives = 342/637 (53%), Gaps = 56/637 (8%) Query: 3 DEMLKDFVVEALELATNVEEHLLTLERHPDDLEILNAVFRAFHTIKGGAGFVNLPAMVSA 62 D+++ DF+VEA E ++ L+ E P+D L+ +FR HT+KG GF+ L + + Sbjct: 2 DDLIADFLVEAHEGLEVIDVELVRFEARPEDRAALDKIFRLVHTLKGACGFLGLGRLEAI 61 Query: 63 CHLTENLFDALRTGKAPVTPLAIEAALQASGFVADQLNELSNGAAPDSLASMPAELKDIL 122 H E L R G+ V+ A+ A L A D++ + +G L P L Sbjct: 62 AHAGETLLGRFRDGRLEVSSQAVTAVLSA----IDRIKMILDGLG--DLGREPEGDDTAL 115 Query: 123 TQAIEGKSE-AAPAAAAPATAPAAPVAPQVQATSAAPASVDGSASVMKDGELDWPAMYQA 181 QA+E S+ AAP+ +P A P+A V AAP ++ GE+ + A Sbjct: 116 IQALEAFSDGAAPSEQSPVAAEPEPLAADV----AAPERT------LRPGEVSLEELEAA 165 Query: 182 LV--PGAAVAAPAAADSTASAAAATPAPAAAPAAAAEGEPKAAAPVQQNRRATDSPGGAK 239 + G APA T SAA+ PAA E + +AP ++S G Sbjct: 166 FLAAEGPVFDAPAPPVETPSAAS--------PAATFEPDQTDSAP---EALVSESLG--- 211 Query: 240 EESIRIDAVKLDALLEVAGESVQAANQASVLLEKLQQFKFEGTAAALMSTLAETLGRASR 299 ++IR+ L+ ++ + E V NQ LQ + G T L R S Sbjct: 212 PQTIRVGVDVLEDMMTLVSELVLTRNQL------LQLNRGRGD-----ETFTPPLQRLSS 260 Query: 300 YSSELQRATLSTRMQPVGRLFQKFPRLVRELAKDLGKDVDLVITGADTEVDRVVVDSLYD 359 + ELQ + + TRMQP+G+ ++K PRLVR+L+ +LGK ++LV+ G TE+DR V++ + D Sbjct: 261 ITGELQDSVMKTRMQPIGQAWKKLPRLVRDLSGELGKPIELVMEGEATELDRQVLEQIRD 320 Query: 360 PLVHMLRNSLDHGIE--VDRAAAGKPNKATISLNAWQAGSSVMIEVFDDGKGMDPDMLRS 417 PL HM+RNS DHG+E R AAGKP I L+A+ G +++I + DDG+G+D +R Sbjct: 321 PLTHMVRNSADHGLEGPEARRAAGKPEAGLIHLSAYHEGGAIVIRLRDDGRGLDTARIRE 380 Query: 418 KALAKGLINEHQALTADEAL--QLVFLPGFSTKEVASSVSGRGVGMDVVKTAVEKHRGTI 475 KA+ KG++ +A T EA +L+F PGFST V ++VSGRGVGMDVV++ +E+ G I Sbjct: 381 KAIEKGIVGRAEAETMTEAQVHRLIFAPGFSTAAVVTNVSGRGVGMDVVRSNIEQIGGQI 440 Query: 476 RIESTIGKGTKFSIRLPIELSIIPTMLVRCAGAPLALPMAVVERVVELP----ETFDEVG 531 ++ST+G+G ++++P+ L+I+ +++R AG A+P A V+ +V++ F+E+ Sbjct: 441 ELQSTLGQGCVVTVKIPLTLAIVSALIIRAAGERFAVPQASVQELVKVSADSDHRFEEIE 500 Query: 532 GAPVLRDQGRPLPVNSLAGVLGYEPGNE-RVGIVMAV-PHPYILGVESVEGTADLVIKPL 589 +LR + + +P+ L+ LG E +E + ++M V H + + VE V T ++V+KPL Sbjct: 501 HVRMLRLREQLIPLIDLSEELGRERRHEAKFVLIMRVGAHRFGVLVEEVIDTEEIVVKPL 560 Query: 590 TAIHTA--GITGTARSAEGELVLVVGLSFLLDGCRDL 624 ++ +G +G +VL++ + L D D+ Sbjct: 561 ASVLRTIPVFSGATLLGDGSVVLIIDPNGLSDRAGDM 597 >AF1040 [NT] COG0643 Chemotaxis protein histidine kinase and related kinases Afu Archaeoglobus fulgidus Length = 656 Score = 280 bits (715), Expect = 9e-75, Method: Compositional matrix adjust. Identities = 210/671 (31%), Positives = 338/671 (50%), Gaps = 66/671 (9%) Query: 1 MDDEM---LKDFVVEALELATNVEEHLLTLERHPDDLEILNAVFRAFHTIKGGAGFVNLP 57 M DEM ++F+ EA E + ++ + +E+ D++ +N +FR HTIKG AGF+ Sbjct: 1 MSDEMEEYKQEFIQEAREYLDVMNQNFIKVEKG--DVDAINEIFRVAHTIKGMAGFMGYK 58 Query: 58 AMVSACHLTENLFDALRTGKAPVTPLAIEAALQASGFVADQLNELSNGAAPDSLASMPAE 117 + CH E+ +R G+ VT I+ L+A + + ++ + + DS + + Sbjct: 59 NLEELCHKLESAMGKVRDGEIEVTEELIDVMLKAVDAIGEMIDRIED---EDSDSVDVRD 115 Query: 118 LKDILTQAIEGKSEAAPA---AAAPATA--------------PAAPVAPQVQATS--AAP 158 + + LT +E + E A PATA + A V+A S A Sbjct: 116 IIEALTMFMESREEEEVADRHELKPATANLRVDVYISEDCVMKSVRAALVVEALSEVAEV 175 Query: 159 ASVDGSASVMKDGELDWPAMYQALVPGAAVAAPAAAD--------------STASAAAAT 204 V S M+ D + P A+V + T A Sbjct: 176 VGVIPDESDMEKETFDGHFVVYLNAPDASVVEDTISKIAEIDRFEVSPVDGETVEMGQAV 235 Query: 205 PAPAAAPAAAAEGEPKAAAPVQQNRRATDSPG---GAKEESIRIDAVKLDALLEVAGESV 261 A A + A V++ + D PG K ESIR++ +LD ++ + GE V Sbjct: 236 SEEEAEEKAEGAARAETEAKVEKTEKRVD-PGRKDKKKLESIRVNISQLDTIMNLVGELV 294 Query: 262 QAANQASVLLEKLQQFKFEGTAAALMSTLAETLGRASRYSSELQRATLSTRMQPVGRLFQ 321 + + LL+ ++ + L E + + + LQ + RM V R+F Sbjct: 295 ISKGR---LLQIASEYD--------IPELKEAVAIMDKSITSLQDEIMQIRMVRVERVFS 343 Query: 322 KFPRLVRELAKDLGKDVDLVITGADTEVDRVVVDSLYDPLVHMLRNSLDHGIEV--DRAA 379 KFPR+VR+LA+ LGK +D + G +TE+DR V+D + DPLVH++RN++DHGIE +R A Sbjct: 344 KFPRMVRDLARKLGKKIDFTMEGLETELDRTVLDEISDPLVHLVRNAVDHGIETPEERVA 403 Query: 380 AGKPNKATISLNAWQAGSSVMIEVFDDGKGMDPDMLRSKALAKGLIN--EHQALTADEAL 437 AGK I L AW+ ++++IE+ DDG+G+D + ++ KA+ KG+++ E +++ DE Sbjct: 404 AGKDEVGRIKLAAWREKNNIIIELEDDGRGLDVEKIKQKAIEKGIVSPAEADSMSEDEIK 463 Query: 438 QLVFLPGFSTKEVASSVSGRGVGMDVVKTAVEKHRGTIRIESTIGKGTKFSIRLPIELSI 497 L+F PGFSTK+ A+ VSGRGVGMDVVKT VE+ G++RI S G GT+ I LP ++I Sbjct: 464 MLIFSPGFSTKDEATEVSGRGVGMDVVKTTVERLGGSVRISSEKGNGTRIRIHLPPTVAI 523 Query: 498 IPTMLVRCAGAPLALPM-AVVERVVELPETFDEVGGAPVLRDQGRPLPVNSLAGVLGYEP 556 + ++LV+ A A+P+ +VVE + + + + G P L +G+ +P L + Sbjct: 524 VKSLLVKVANETYAIPISSVVEALYVGEDNWKVIHGNPFLIVRGKLVPAFKLRELFNVRN 583 Query: 557 GN-ER-VGIVMAVP-HPYILGVESVEGTADLVIKPLTAI--HTAGITGTARSAEGELVLV 611 G ER VGI++ Y L +++ ++VIKPLT G +G +G +V + Sbjct: 584 GRPEREVGIIVEKEGEKYALIADTIAEQQEIVIKPLTGYLAKIKGFSGVTILGDGRVVPI 643 Query: 612 VGLSFLLDGCR 622 + +S LL G R Sbjct: 644 LDVSSLLGGDR 654