BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.3021.p (481 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA4886 [T] COG0642 Signal transduction histidine kinase Pae Pseu... 383 e-106 RSp0488 [T] COG0642 Signal transduction histidine kinase Rso Ral... 247 4e-65 STM1095 [T] COG0642 Signal transduction histidine kinase Sty Sal... 219 9e-57 RSp0654 [T] COG0642 Signal transduction histidine kinase Rso Ral... 219 2e-56 ZybcZ [T] COG0642 Signal transduction histidine kinase EcZ Esche... 213 7e-55 >PA4886 [T] COG0642 Signal transduction histidine kinase Pae Pseudomonas aeruginosa Length = 463 Score = 383 bits (984), Expect = e-106, Method: Compositional matrix adjust. Identities = 206/437 (47%), Positives = 295/437 (67%), Gaps = 2/437 (0%) Query: 33 GLYLDRAAGDALAQRADQALIGRVEHFRNLMHDLYNVEQMEQRPALFESMMGNEQDVRIF 92 G YL R+ +A+ +R+D + GRVEHFRNL+ D + +++ RP LFE+M+GNEQD+ + Sbjct: 27 GFYLYRSVEEAMLRRSDVMVAGRVEHFRNLLRDNLTLAELKARPRLFENMLGNEQDILLL 86 Query: 93 RRQGEAPFIQSNPDHLVPPAMQPAPVDQPVSAARLLTSERADGVRVRWVSALADVGKGRD 152 + GEAP + NP H P+++ Q ++ + + + DG+ +R ++A VG GR+ Sbjct: 87 GQPGEAPIVAVNPRHERLPSLRVVAAGQALNPSVVHAALTHDGIPMRVLAAEVLVG-GRE 145 Query: 153 TVEIIAAYVMVQEDRMMRSYRWRIAGAAAAAILLTSLLGFVLLRRGLQPLEAMSQRAAQI 212 ++I AA++++ E RM+ YR R+ A A L T+LLG+++LR GL+PL ++ +AA+I Sbjct: 146 PLQITAAHLLLGETRMLAQYRDRVIAAVLLAFLGTALLGWLVLRHGLRPLRTLAAKAAEI 205 Query: 213 TPDRLSTRLEQEGMPAELRRVALSFNAMLDRLEAGYDHLAQFSGDLAHEIRTPINVLMGQ 272 P L TRL+ PAEL++VA SFNAML+RL+ GY L QFS DLAHEIRTPI LMG Sbjct: 206 HPTSLDTRLDVAAAPAELQQVAQSFNAMLERLDDGYQRLQQFSADLAHEIRTPIGSLMGH 265 Query: 273 SQVALGQRRSPEDYEQLLESNVEELQRLARIVENILFLAQADHSTLAVECSALDLQEELA 332 QVAL Q RS E+Y+ L+ SN EEL+R+AR+VE+ILFLA+AD AVE S LDL EEL Sbjct: 266 GQVALRQPRSNEEYQALIASNQEELERIARMVESILFLARADDVRAAVERSRLDLGEELR 325 Query: 333 KITDYFEGIADERGMHFALQAQGICQANLDMWRRAVSNLIINAVRYGEPDSIIRIQAEGD 392 + +YFEG+A+ERG+ +Q G +A+ ++RRA+SNL+ NA+RY DS+I ++ Sbjct: 326 RQAEYFEGLAEERGLSLDVQVSGQLRADPQLFRRALSNLLANAIRYASADSLIEVRGLRR 385 Query: 393 ASGSRILVDNRSGNVTPQVMARMFDRFYRGDRSRSALTESNGLGLAIVKAIMALHRGTAT 452 + + V+N + + ++R+FDRFYRGD +RS +S+GLGLAIV+AIM LH G A Sbjct: 386 SGEFLLSVENACDRLPAEPLSRLFDRFYRGDAARSD-AQSSGLGLAIVQAIMRLHGGRAE 444 Query: 453 VECPQPGWIRFSLRFPS 469 P PG IRF L FP+ Sbjct: 445 ASAPAPGRIRFDLAFPA 461 >RSp0488 [T] COG0642 Signal transduction histidine kinase Rso Ralstonia solanacearum Length = 465 Score = 247 bits (631), Expect = 4e-65, Method: Compositional matrix adjust. Identities = 157/460 (34%), Positives = 249/460 (54%), Gaps = 3/460 (0%) Query: 12 TLTTRVTALFALMTCLVVTGLGLYLDRAAGDALAQRADQALIGRVEHFRNLMHDLYNVEQ 71 +L R+ F L+ +++TG G YL A L D L+G++ R+ D +++ Sbjct: 7 SLAARLVLAFVLVAGVMLTGAGTYLYYALNAQLRATDDAMLLGKIVQLRHCAKDTQSIDD 66 Query: 72 MEQRPALFESMMGNEQDV--RIFRRQGEAPFIQSNPDHLVPPAMQPAPVDQPVSAARLLT 129 + + + ++ + + R+ G +++NP+ A P D S + L T Sbjct: 67 IVRDARRYTEVVSGHEGLILRVIGPDGRT-LVEANPEGEPVAAPAAVPPDVLASESALHT 125 Query: 130 SERADGVRVRWVSALADVGKGRDTVEIIAAYVMVQEDRMMRSYRWRIAGAAAAAILLTSL 189 G+ R ++A A +G RDTV ++ A +M SYR I A A + +L Sbjct: 126 WWSRTGIASRAIAAQARLGNHRDTVTVLVAQDGDSRAALMASYRRHIFLAVIAGVAAVAL 185 Query: 190 LGFVLLRRGLQPLEAMSQRAAQITPDRLSTRLEQEGMPAELRRVALSFNAMLDRLEAGYD 249 L L+R L+ L + ++AA + P +L TRL EG P EL + + NAML RL+ G+ Sbjct: 186 LSLWLVRSTLKGLARIGRQAASVVPSQLDTRLTLEGAPRELSDLLAALNAMLTRLQDGFA 245 Query: 250 HLAQFSGDLAHEIRTPINVLMGQSQVALGQRRSPEDYEQLLESNVEELQRLARIVENILF 309 L+QFS DLAH+ RTP+ L+GQ++V L R +Y +LES++EE RL+R++E++LF Sbjct: 246 RLSQFSADLAHDFRTPLANLIGQTEVTLAHPRPAGEYRAVLESSLEEYARLSRMIEDMLF 305 Query: 310 LAQADHSTLAVECSALDLQEELAKITDYFEGIADERGMHFALQAQGICQANLDMWRRAVS 369 LA+ADH+ +A+ + LD + E+ + DYFE +A +R + + G +A+L + RRA++ Sbjct: 306 LARADHARVALSVAPLDARHEIQVLVDYFEAVAADRDITIQVCGNGRVRADLTLLRRAIN 365 Query: 370 NLIINAVRYGEPDSIIRIQAEGDASGSRILVDNRSGNVTPQVMARMFDRFYRGDRSRSAL 429 NL+ NA+R+ + I + + + I V N + + +FDRFYRGD +R+ Sbjct: 366 NLLDNALRHTPGGARIDVAVQVLPHSTAIAVRNPGPGIPAASLPLLFDRFYRGDPARANS 425 Query: 430 TESNGLGLAIVKAIMALHRGTATVECPQPGWIRFSLRFPS 469 S GLGLAIV+ IM LH GTA P G F L FP+ Sbjct: 426 ERSAGLGLAIVQTIMDLHGGTAQASSPPGGLTEFRLIFPA 465 >STM1095 [T] COG0642 Signal transduction histidine kinase Sty Salmonella typhimurium LT2 Length = 454 Score = 219 bits (559), Expect = 9e-57, Method: Compositional matrix adjust. Identities = 145/457 (31%), Positives = 237/457 (51%), Gaps = 12/457 (2%) Query: 12 TLTTRVTALFALMTCLVVTGLGLYLDRAAGDALAQRADQALIGRVEHFRNLMHDLYNVEQ 71 ++T R+T F + L TG+ L A L R D LI R + L+ D E Sbjct: 5 SMTLRLTISFIAILILACTGISWTLYNALSKELTYRDDMTLINRAAQMQQLLLDGARPEN 64 Query: 72 MEQRPALFESMMGNEQDVRIFRRQGEAPFIQSNPDHLVPPAMQPAPVDQPVSAARLLTSE 131 + P F M+ +QD+ + + N + P+ + ++ L + Sbjct: 65 L---PLYFNRMVDTKQDILLIH-SATGHNVAINHSGIPDQRFNEIPLTKNITRETLF-RQ 119 Query: 132 RADGVRVRWVSALADVGKGRDTVEIIAAYVMVQEDRMMRSYRWRIAGAAAAAILLTSLLG 191 G + V A G D + + A + + +M+ YR + AIL+ S L Sbjct: 120 AVQGTELTAVRVSAR--SGDDPLTLTIARLATERRQMLAQYRRNSLLMSLIAILVCSALS 177 Query: 192 FVLLRRGLQPLEAMSQRAAQITPDRLSTRLEQEGMPAELRRVALSFNAMLDRLEAGYDHL 251 +++R GL+ + ++S+ A L L ++ +P ELR + + N M +L ++ L Sbjct: 178 PLVIRNGLRAITSLSRLTAATDSGTLRQPLAEQALPVELRPLGQALNTMRQKLSDDFERL 237 Query: 252 AQFSGDLAHEIRTPINVLMGQSQVALGQRRSPEDYEQLLESNVEELQRLARIVENILFLA 311 QF+ DLAHE+RTP+N+L+G++QV L Q RS E+Y+Q L N+EEL+ L+R+ ENILFLA Sbjct: 238 NQFADDLAHELRTPVNILLGKNQVMLSQERSAEEYQQALVDNIEELEGLSRLTENILFLA 297 Query: 312 QADHSTLAVECSALDLQEELAKITDYFEGIADERGMHFALQAQGICQANLDMWRRAVSNL 371 +A+H +AV+ + L + + DY +A+E+ + F Q QG A+ + +R +SNL Sbjct: 298 RAEHQNIAVKKQPVSLNALVENMLDYLSPLAEEKRICFINQCQGTVWADEILLQRVLSNL 357 Query: 372 IINAVRYGEPDSIIRIQAEGDASGSRILVDNRSGNVTPQVMARMFDRFYRGDRSRSALTE 431 + NA+RY + +++IRI++ D + + I V N + P ++F RF+RGD +R T Sbjct: 358 LTNAIRYSDENAVIRIESAYDDNVAEIRVANPGSH--PADADKLFRRFWRGDNARH--TA 413 Query: 432 SNGLGLAIVKAIMALHRGTATVECPQPGWIRFSLRFP 468 GLGL++V AI LH G+A+ I FS+R P Sbjct: 414 GFGLGLSLVNAIALLHGGSASYRYADEHNI-FSVRLP 449 >RSp0654 [T] COG0642 Signal transduction histidine kinase Rso Ralstonia solanacearum Length = 466 Score = 219 bits (557), Expect = 2e-56, Method: Compositional matrix adjust. Identities = 156/484 (32%), Positives = 251/484 (51%), Gaps = 39/484 (8%) Query: 9 RGWTLTTRVTALFALMTCLVVTGLGLYL------DRAAGDALAQRADQALIGR-VEHFRN 61 R +LT R+TALF+L + V+ GLG+ + A D A ++IG+ VE Sbjct: 3 RRLSLTARLTALFSLCSAAVLLGLGVVIALAMEQHFAVEDFTALGEHVSVIGKIVESGPA 62 Query: 62 LMHDLYNVEQMEQRPALFESMMGNEQ------DVRIFRRQGEAPFIQSNPDHLVPPAMQP 115 + + ++ R ++G ++ D FR EA ++ P Sbjct: 63 PQAEARIRDALQHRTGFVARILGPDRRALYASDGFDFRAADEA-LARARP---------- 111 Query: 116 APVDQPVSAARLLTSERADGVRVRWVS-ALADVGKGRDTVEIIAAYVMVQEDRMMRSYRW 174 + RL+ ++ R + AL D GR ++++ A + ++R Sbjct: 112 -------GSDRLVWAQGGQQYRAMHTTVALRDGTAGR--LDMLVAMNTDIHAHFLHTFRG 162 Query: 175 RIAGAAAAAILLTSLLGFVLLRRGLQPLEAMSQRAAQITPDRLSTRLEQEGMPAELRRVA 234 +A A A L + + G+ RRGL PL ++ RA +T D+L R+ + +PAE+ +A Sbjct: 163 TLAFYIALAALASGVFGWWAARRGLAPLRTLASRARTVTADKLDERMPVDTVPAEVADLA 222 Query: 235 LSFNAMLDRLEAGYDHLAQFSGDLAHEIRTPINVLMGQSQVALGQRRSPEDYEQLLESNV 294 ++ NAML+RL+ + L+ FS D+AHEIRTPI L+ Q++V L Q R Y +L SN Sbjct: 223 VTLNAMLERLQHDFRRLSDFSTDIAHEIRTPITNLLTQTEVVLSQPREGAKYRDVLTSNA 282 Query: 295 EELQRLARIVENILFLAQADHSTLAVECSALDLQEELAKITDYFEGIADERGMHFALQAQ 354 EELQRLAR+V ++L+LA+ +HS + L +EL + ++++ +A+++ + L+ Sbjct: 283 EELQRLARMVSDMLYLAKMEHSLTLPSAEDIHLADELRALFEFYDALAEDKAVRLELRGD 342 Query: 355 GICQANLDMWRRAVSNLIINAVRYGEPDSIIRIQAEGDASGSRILVDNRSGNVTPQVMAR 414 G + M RRA+SNL+ NA+R+ P + + G + VDN + PQV++R Sbjct: 343 GRVSGDRLMLRRALSNLLSNAIRHAPPRGAVLVSIADTGHGVTVSVDNDGDEIPPQVLSR 402 Query: 415 MFDRFYRGDRSRS-ALTESNGLGLAIVKAIMALHRGTATVECPQPGWIRFSLRF---PSV 470 +F+RFYR D+SR+ ++S GLGLAI KAI+ H G+ V G RF+L F P Sbjct: 403 IFERFYRADKSRARPESDSTGLGLAITKAIVVAHGGSIAV-SRVGGRTRFALHFARRPEA 461 Query: 471 AAAP 474 AAP Sbjct: 462 GAAP 465 >ZybcZ [T] COG0642 Signal transduction histidine kinase EcZ Escherichia coli O157:H7 EDL933 Length = 482 Score = 213 bits (543), Expect = 7e-55, Method: Compositional matrix adjust. Identities = 122/334 (36%), Positives = 193/334 (57%), Gaps = 7/334 (2%) Query: 140 WVSALADVGKGRDTVEIIAAYVMVQEDRMMRSYRWRIAGAAAAAILLTSLLGFVLL---R 196 W VG D I Y+ + D + + A +++ L+ F++L Sbjct: 148 WRMISLPVGPLVDGKPIYTLYIALSIDFHLHYINDLMNKLIMTASVISILIVFIVLLAVH 207 Query: 197 RGLQPLEAMSQRAAQITPDRLSTRLEQEGMPAELRRVALSFNAMLDRLEAGYDHLAQFSG 256 +G P+ ++S++ IT L RL+ + +P EL ++ LSFN M++R+E + + FS Sbjct: 208 KGHAPIRSVSRQIQNITSKDLDVRLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSA 267 Query: 257 DLAHEIRTPINVLMGQSQVALGQRRSPEDYEQLLESNVEELQRLARIVENILFLAQADHS 316 D+AHEIRTPI L+ Q+++AL Q RS ++ E +L SN+EEL R+A++V ++LFLAQAD++ Sbjct: 268 DIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNN 327 Query: 317 TLAVECSALDLQEELAKITDYFEGIADERGMHFALQAQGICQANLD--MWRRAVSNLIIN 374 L E L+L +E+ K+ D+FE +A++RG+ CQ D M RRA+SNL+ N Sbjct: 328 QLIPEKKMLNLADEVGKVFDFFEALAEDRGVELQFVGDE-CQVAGDPLMLRRALSNLLSN 386 Query: 375 AVRYGEPDSIIRIQAEGDASGSRILVDNRSGNVTPQVMARMFDRFYRGDRSRSALTESNG 434 A+RY P I ++ + +++V+N + P+ + R+FDRFYR D SR E +G Sbjct: 387 ALRYTPPGEAIVVRCQTVDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSG 446 Query: 435 LGLAIVKAIMALHRGTATVECPQPGWIRFSLRFP 468 +GLAIVK+I+ H+GT V G RF + P Sbjct: 447 IGLAIVKSIVVAHKGTVAVTSNARG-TRFVIVLP 479