BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.2861.p (789 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA3079 [R] COG1033 Predicted exporters of the RND superfamily Pa... 497 e-140 PH0287 [R] COG1033 Predicted exporters of the RND superfamily Ph... 68 1e-10 AF0459 [R] COG1033 Predicted exporters of the RND superfamily Af... 66 3e-10 PAB1101 [R] COG1033 Predicted exporters of the RND superfamily P... 63 3e-09 TP0790 [R] COG1033 Predicted exporters of the RND superfamily Tp... 63 3e-09 >PA3079 [R] COG1033 Predicted exporters of the RND superfamily Pae Pseudomonas aeruginosa Length = 793 Score = 497 bits (1279), Expect = e-140, Method: Compositional matrix adjust. Identities = 291/788 (36%), Positives = 450/788 (57%), Gaps = 20/788 (2%) Query: 13 LEACLFRLRIPILLALLACTAVLSFF-ALQLRMDAGFEKQMPTHHEYIDTFKQYRDDVLG 71 LE +F R P+++ L +V F+ A Q+R FEK +P H +I ++R+D+ Sbjct: 15 LERLIFNNR-PVVIFLCVLVSVFLFYQATQVRPSTSFEKMIPLEHPFIQKMLEHRNDLAN 73 Query: 72 -ANRLNIVLRARHGSIWTKEGLTRLSEMTQAVMFLPNISRLGVQSLWTPNTFVNEITEEG 130 N + I + A +G I+TKE + L ++ V ++P + R G++SLW+P+ E+TEEG Sbjct: 74 LGNTVRISVEAVNGDIFTKEYMETLRQIHDEVFYIPGVDRSGLKSLWSPSVRWTEVTEEG 133 Query: 131 FRADPVIPGTVIPSALTPENIEQIRNTAVNGGFVGTLISRNQDSAMIVAEINEF------ 184 F VIP T S P +E++RN + G +G L++ N S+++ + E Sbjct: 134 FAGGEVIPQTYDGS---PRALEELRNNVLKSGQIGRLVANNFKSSIVDVPLLEMYPNPKN 190 Query: 185 DAKGDKVDYLAYNKLLND-LRAKYE--NADFEVQIIGFAKQIGDVADGAEGVLKFCAMAL 241 ++ K+DY ++ L + +R KY+ N + +V I+GFAK++GD+ DG V+ F + L Sbjct: 191 QSELIKLDYRQFSHELEEKIRDKYQLQNPNVKVHIVGFAKKVGDLIDGLVMVVGFFGICL 250 Query: 242 LLTTVAVYWYCRSLPFTLLPVACSLVSLVWQFGTLRLLGYGLDPLAVLVPFLVFAIGVSH 301 L+T V +YW+ + + T+ + +LV+++WQ G L L+G+GLDP ++LVPFL+FAIG+SH Sbjct: 251 LITLVLLYWFTKCIRSTIAVLITTLVAVLWQLGLLNLVGFGLDPYSMLVPFLIFAIGISH 310 Query: 302 GVQQINTIVRGIASGQSCEAAARASFKGLLIPGVLALVTALVSFITLVMIPIPMVRELAI 361 GVQ+IN I + + AAR +F+ L +PG++A++ V FITL++I I ++RELAI Sbjct: 311 GVQKINGIALQSSGADNALMAARLTFRQLFLPGMIAILADAVGFITLLVIDIGVIRELAI 370 Query: 362 TASIGVGYKIITNLVMLPLAASLLKVGKTYAEAAMRAQQARGRWLAVLSRAAQPKVARSI 421 ASIGV + TNL++LP+A S + + K + + + +LS + PKVA Sbjct: 371 GASIGVAVIVFTNLILLPVAISYIGISKKAVQRSKDDAVREHPFWRLLSNFSSPKVAPVS 430 Query: 422 VVLTLLVLAGSAWYSHDRLVGTLQPGAPELHANARYNQDARWIADNYGNGLDWLTVILAT 481 + + LL+L G WY +G L GAPEL ++RYN D +I NY D L V++ T Sbjct: 431 IAIALLMLGGGLWYGKHLKIGDLDQGAPELRPDSRYNLDNDFIIRNYSTSSDVLVVMVKT 490 Query: 482 PANSCDKVAFGRYQDQFDTVMRHVPGVLSVSSFADQMKIYNEGYNEGNPTMFTVPLDPAN 541 C D+ + + GV S S K +G NEGN T+ N Sbjct: 491 SPEGCSTHQALAAMDELAWKLENTEGVQSAISMVTVSKQVIKGMNEGNLKWETLS---RN 547 Query: 542 YAALAVEIGRVRGFLAKDCNMLATHLFLADHKASTINGVIQAVKTYRDQHQLAGLEIRLA 601 L I R G DC++ +FL DHKA T++ + AV+ + ++ L+ +LA Sbjct: 548 QDVLNNSIARADGLYNTDCSLAPLLVFLNDHKAETLDRAVAAVQAFAAENDKDDLQFQLA 607 Query: 602 AGNAGVIAAVNDEVEKSELPMMLYVYGAIVLLVFVVYRDWRAIIACCLPLTVATFIGYAF 661 AGNAG+ AA N+ +++SEL +++ VY + + + +R + A + LPL + + +G A Sbjct: 608 AGNAGIEAATNEVIKQSELIILVLVYICVAAMCMITFRSFAATLCIVLPLILTSVLGNAL 667 Query: 662 MKQLQIGLTVATLPVMVLAVGIGVDYAFYIYNRLQLHLAAGIEIEQALHHAIQEVGIATI 721 M L IG+ VATLPV+ L VGIGVDY YIY RL+ L G+ +++A + ++ G A + Sbjct: 668 MAALGIGVKVATLPVIALGVGIGVDYGIYIYTRLESFLRMGLPLQEAYYETLRSTGKAVL 727 Query: 722 FTAITLAVGVATWSFSALKFQADMGKLLAFMFLVNLVMAMTALPAFAVVLEKMFPRKSPI 781 FT + LA+GVATW FSA+KFQADMG +L FM L N+ A+ LPA A L + P K Sbjct: 728 FTGLCLAIGVATWIFSAIKFQADMGLMLTFMLLWNMFGALWLLPALARFL--INPAKLQA 785 Query: 782 KLNSALAH 789 + S AH Sbjct: 786 RKASLFAH 793 >PH0287 [R] COG1033 Predicted exporters of the RND superfamily Pho Pyrococcus horikoshii Length = 787 Score = 67.8 bits (164), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 148/667 (22%), Positives = 282/667 (42%), Gaps = 84/667 (12%) Query: 148 PENIEQIR-------NTAVNGGFVGTLISRNQDSAMIVAEINEFDAKGDKVDYLAYNKLL 200 P NIE+++ A NG L+SR+ S +I+ +N K + YN++ Sbjct: 163 PNNIEEVKFVLNMLPEDARNG-----LVSRDYSSTIIIVSLNR--EKNQRALVRVYNEIK 215 Query: 201 NDLRAKYENADFEVQIIGFAKQIGDVADGAEGVL-KFCAMALLLTTVAVYWYCRSLPFTL 259 N++ EV + G + + + + + A+A ++ + + ++ +S L Sbjct: 216 NEIEKSNFPEGVEVVLTGDLGITYKILEMLQNDMNRTMAVAGIIVIILLLYFYKSPIRML 275 Query: 260 LPVACSLVSLVWQFGTLRLLGYGLDPLAVLVPFLVFAIGVSHGVQQINTIVRGIASGQS- 318 +P+ + + G + LLG LD V ++ +G+ +GV N G+S Sbjct: 276 VPLIPLIFGVTMTLGFMGLLGIPLDIATSTVGAMIIGMGIDYGVHVTNRYYEERNKGRSP 335 Query: 319 -CEAAARASFKGLLIPGVLALVTALVSFITLVMIPIPMVRELAITASIGVGYKIITNLVM 377 A S G + G A +T + F+ L + +P ++ L+I+ +G+G + +++ Sbjct: 336 EEAAEEAISETGKALLG--AALTTIAGFLALSLSILPSLKRLSISLVMGLGLAAVNAVIV 393 Query: 378 LPLAASLLK------VGKTYAEAAMRAQQARGRWLAVLSRAAQPKVARS--IVVLTLLVL 429 P A L + +GK ++ ++ G+ + SR + RS + +L +++ Sbjct: 394 TPALAILEEEFRTKILGKKGEIISIGGEE--GKLGFIFSRLGL-FIKRSPWLALLIAVMI 450 Query: 430 AGSAWY------SHDRLVGTLQPGAPELHANARYNQDARWIADNYGNGLDWLTVILATPA 483 +G + Y + RL + PE+ A I +G G D +T+++ A Sbjct: 451 SGVSLYGATKITTEVRLEKMIPMDMPEIQALTD-------IRSEFG-GQDEITILIK--A 500 Query: 484 NSCDKVAFGRYQDQFDTVMR---HVPGVLSVSSFADQMKIYNEGYNEGNPTMFTVPLD-- 538 + R +F+ ++ ++ V S AD + I GY + L+ Sbjct: 501 DDVRDPEIVRSILRFEREVKADSYINNVFESESIADVV-IEKYGYIPEDKEKIAKALEGS 559 Query: 539 ---PANYAALAVEI-GRVRGFLAKDCNMLATHLFLADHKASTINGVIQAVKTYRDQHQLA 594 ++Y+ V++ G G +D N + + +A+ GV + +LA Sbjct: 560 SLVSSDYSLTIVKLKGNFMGVTQEDFNKIMEYFEEELKRANFPPGV---------KAELA 610 Query: 595 GLEIRLAAGNAGVIAAVNDEVEK-SELPMMLYVYGAIVLLVFVVYRDWRAIIACCLPLTV 653 G E L N + VN+E+ K S + ++ +VL+VF ++R +A +P+ + Sbjct: 611 G-ESYL---NYVLDNLVNEELGKISTIGTII-----VVLIVFAIFRRPTVAVAMIMPMFL 661 Query: 654 ATF--IGYAFMKQLQIGLTVATLPVMVLAVGIGVDYAFYIYNRLQLHLAAGIEIEQALHH 711 IGY + + T+A + M+ VG+GVDY +I +R L G + + Sbjct: 662 GALWTIGYMGLAGIPFSQTLAGVVSMI--VGLGVDYGMHITHRFLEELKEG--NKTPIIT 717 Query: 712 AIQEVGIATIFTAITLAVGVATWSFSALKFQADMGKLLAFMFLVNLVMAMTALPAFAVVL 771 A++ VG + A+T A G L D GK+LA +++ A PA +L Sbjct: 718 AMESVGPGILIGALTTAGGFLALLTGRLTAIHDFGKVLAVGIFSSMLAAYLVTPA---IL 774 Query: 772 EKMFPRK 778 + F RK Sbjct: 775 QLEFGRK 781 >AF0459 [R] COG1033 Predicted exporters of the RND superfamily Afu Archaeoglobus fulgidus Length = 736 Score = 66.2 bits (160), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 106/538 (19%), Positives = 219/538 (40%), Gaps = 47/538 (8%) Query: 252 CRSLPFTLLPVACSLVSLVWQFGTLRLLGYGLDPL-AVLVPFLVFAIGVSHGVQQINTIV 310 RS L P+ SL+S+ G L LLG + + +P L+ + + + Q N Sbjct: 230 VRSKLTVLFPLIVSLMSVAVMAGLLPLLGLQMTEYNSATIPILI-GLAIDYAAQLQNRYE 288 Query: 311 RGIASGQSCEAAARASFKGLLIPGVLALVTALVSFITLVMIPIPMVRELAITASIGVGYK 370 G+ + A + P +A+ T ++ F ++ IP + + S+G+ Sbjct: 289 EERRGGREVDEALEEALNHTRFPLFMAMATTVIGFASMCAPGIPSLFWFSFLLSVGLITA 348 Query: 371 IITNLVMLPLAASLLKVGKTYAEAAMRAQQARGRWLAVLSRAAQPKVA--RSIVVLTL-L 427 + + LP SLLK+ + G +L+ A+ +A R I+ LTL L Sbjct: 349 FLLSNTFLP---SLLKLSD---RGGREESISPGILEKLLTTIAKVTIANSRKILALTLIL 402 Query: 428 VLAGSAWYSHDRLVGTLQPGAP-ELHANARYNQDARWIADNYGNGLDWLTVILATPANSC 486 ++ G+ +H L + AP +L A ++ + R ++ Y L +L+T Sbjct: 403 IVVGAYASTHVELETNRRKYAPPDLPALVKFEEIERKVSPQYVYAL-----VLSTERIDA 457 Query: 487 DKVAFGRYQDQFDTVMRHVPGVLSVSSFADQMKIYNEGYNEGNPTMFTVPLDPANYAALA 546 + V + + + +++ + + K E Y +P + + A A Sbjct: 458 ESVV------KAEELAKYISSREEIYDYDSLGKTLEEYYG-------AIPAESFSKAIDA 504 Query: 547 VEIGRVRGFLAKDCNMLATHLFLADHKASTINGVIQAVKT------YRDQHQLAGLEIRL 600 + F++ N LA + + + ++++++ + + + G + L Sbjct: 505 LPKSIYSRFIS--GNQLAVYFYTNTQTEEEVEKMMRSIENDLRFLEWDGDYYITGFPVIL 562 Query: 601 AAGNAGVIAAVNDEVEKSELPMMLYVYGAIVLLVFVVYRDWRAIIACCLPLTVATFIGYA 660 + + +++N M L Y IV + + YR I + ++VA Sbjct: 563 GHLSEVLFSSLN--------LMTLVAYLLIVTFLLLAYRSVVRAIIPLISISVAVASMNV 614 Query: 661 FMKQLQIGLTVATLPVMVLAVGIGVDYAFYIYNRLQLHLAAGIEIEQALHHAIQEVGIAT 720 M + I T ++ + + +G+G+DY+ +I R +E+++ ++ G A Sbjct: 615 CMLLMGIKQTTISIALNSIVLGMGIDYSIHITER-YFEERGKFGVEESVKRTVERTGKAV 673 Query: 721 IFTAITLAVGVATWSFSALKFQADMGKLLAFMFLVNLVMAMTALPAFAVVLEKMFPRK 778 + +A+T A G FS ++ G L + +L+ A +A+PA ++ EK + R+ Sbjct: 674 LTSALTTAGGFGALYFSTFPVLSNFGILAFIAIIFSLLAATSAVPALLILYEKNYFRE 731 >PAB1101 [R] COG1033 Predicted exporters of the RND superfamily Pab Pyrococcus abyssi Length = 746 Score = 62.8 bits (151), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 148/674 (21%), Positives = 283/674 (41%), Gaps = 99/674 (14%) Query: 148 PENIEQIR-------NTAVNGGFVGTLISRNQDSAMIVAEINEFDAKGDKVDYLAYNKLL 200 P+N+++++ A NG LIS + S +I+ +N K K A ++ Sbjct: 122 PKNMDEVKFVLNMLPPEARNG-----LISGDYSSTIIIVNLNR--EKNQK----ALVRVY 170 Query: 201 NDLRAKYENADF----EVQIIGFAKQIGDVADGAEGVL-KFCAMALLLTTVAVYWYCRSL 255 ND+ + E +F EV + G + + + + + A++ ++ + + ++ +S Sbjct: 171 NDIEREIERTNFPQGVEVVLTGDLGITYKILEMLQNDMNRTMAISGIIVVLILLYFYKSP 230 Query: 256 PFTLLPVACSLVSLVWQFGTLRLLGYGLDPLAVLVPFLVFAIGVSHGVQQINTIVRGIAS 315 L+P+ + +V G + LLG LD V ++ +G+ +GV N Sbjct: 231 IRMLVPLVPLIFGVVMTLGFMGLLGIPLDIATTTVGAMIIGMGIDYGVHVTNRYYEERGK 290 Query: 316 GQSC----EAAARASFKGLLIPGVLALVTALVSFITLVMIPIPMVRELAITASIGVGYKI 371 G+S E A + K LL A +T + F+ L + +P ++ L+++ +G+G Sbjct: 291 GKSLEEAAEEAIAETGKALL----GAALTTIAGFLALSISILPSLKRLSVSLVMGLGLAA 346 Query: 372 ITNLVMLPLAASLLKVGKTYAEAAMRAQQ------ARGRWLAVLSRAAQPKVARS--IVV 423 + +++ P A L + + E M+ ++ + + + S + + RS + Sbjct: 347 LNAVIVTPALAIL---EEEFREKVMKKKEIIAIGGGKSKISFIFSMLGKA-IKRSPWTAL 402 Query: 424 LTLLVLAGSAWY------SHDRLVGTLQPGAPELHANARYNQDARWIADNYGNGLDWLTV 477 L L+++G + Y + RL + PE+ A + I +G G D +T+ Sbjct: 403 LIALIISGVSLYGASKITTEVRLEKMIPTDLPEIQALSD-------IRSEFG-GQDEVTI 454 Query: 478 ILAT-----PANSCDKVAFGRYQDQFDTVMRHVPGVLSVSSFADQMKIYNEGYNEGNPTM 532 ++ P D + F R + + D+ ++ V S AD + I GY + Sbjct: 455 LIKADDVRDPTLVRDILRFER-EIKADS---YINNVFETQSIADVV-IQKYGYIPQDKEK 509 Query: 533 FTVPLD-----PANYAALAVEI-GRVRGFLAKDCNMLATHLFLADHKASTINGVIQAVKT 586 + ++ ++Y+ +++ G G + N + + A +A GV Sbjct: 510 ISEAIEGSSLVSSDYSMTIIKLKGNFMGVTQSEFNRIMEYFERAIQRADFPPGV------ 563 Query: 587 YRDQHQLAGLEIRLAAGNAGVIAAVNDEVEKSELPMMLYVYGAIVLLVFVVYRDWRAIIA 646 + +LAG E L N + VN+E+ K L V V++VF ++R IA Sbjct: 564 ---KVELAG-ESYL---NYVLNDLVNEELGKISTIGTLIV----VMVVFAIFRRPTVSIA 612 Query: 647 CCLPLTVATF--IGYAFMKQLQIGLTVATLPVMVLAVGIGVDYAFYIYNRLQLHLAAGIE 704 +P+ + IGY + + T+A + M+ VG+GVDY +I +R L G Sbjct: 613 MIMPMFLGALWTIGYMGLAGIPFSQTLAGVVSMI--VGLGVDYGMHITHRFLEELNEG-- 668 Query: 705 IEQALHHAIQEVGIATIFTAITLAVGVATWSFSALKFQADMGKLLAFMFLVNLVMAMTAL 764 + + A++ VG A+T A G + L D G++LA ++ A Sbjct: 669 NKTPIITALESVGPGIFVGALTTAGGFLALLSAQLTAIHDFGRVLAVGIFASMFAAYLVT 728 Query: 765 PAFAVVLEKMFPRK 778 PA +L+ F RK Sbjct: 729 PA---ILQLEFGRK 739 >TP0790 [R] COG1033 Predicted exporters of the RND superfamily Tpa Treponema pallidum Length = 888 Score = 62.8 bits (151), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 60/228 (26%), Positives = 96/228 (42%), Gaps = 20/228 (8%) Query: 557 AKDCNMLATHLFLADHKASTINGVIQAVKTY------RDQHQLAGLEIRLAAGNAGVIAA 610 A D L ++ L GVI+AVK + +D H G G+ V + Sbjct: 669 AVDPRALKMNIQLGTKGQQDSYGVIEAVKKFIRENFPQDVHAEFG-------GSVLVEQS 721 Query: 611 VNDEVEKSELPMMLYVYGAIVLLVFVVYRDWRAIIACCLPLTVATFIGYAFMKQLQIGLT 670 +ND V +S+L +++ + +++ V YR A I LPL V+ + + M I L Sbjct: 722 LNDLVVQSQLISLVFSLCVVFIIIAVHYRSLFAGIIGTLPLGVSVLVNFGVMGFFGIKLN 781 Query: 671 VATLPVMVLAVGIGVDYAFYI---YNRLQLHLAAGIEIEQALHHAIQEVGIATIFTAITL 727 + T V + GIGVDY + Y R + Q + + G A +F +++ Sbjct: 782 ICTTMVAGFSSGIGVDYTIHYLAAYRRAWKECGGKDFLTQTFYGS----GRAILFNVLSV 837 Query: 728 AVGVATWSFSALKFQADMGKLLAFMFLVNLVMAMTALPAFAVVLEKMF 775 G A S AD G L+ L + V ++T LP V++ F Sbjct: 838 GSGFAVLMLSKFNVLADFGLLMVLAMLTSSVASLTLLPTLLNVVKPRF 885 Score = 56.2 bits (134), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 77/371 (20%), Positives = 164/371 (44%), Gaps = 27/371 (7%) Query: 24 ILLALLACTAVLSFFALQLR---MDAGFEKQMPTHHEYIDTFKQYRDDVLGAN-RLNIVL 79 +L+A+L +A+ FFA+QLR +D + +P + + Q D G+ + I + Sbjct: 30 VLVAVL--SALTLFFAVQLRTLRLDNNNFRFIPKENS-VRIADQRIDSTFGSQVPVLIGI 86 Query: 80 RARHGSIWTKEGLTRLSEMTQAVMFLPNISRLGVQSLWTPNTFVNEITEEGFRADPVIPG 139 + + S+ L + + + + +P + SL + G RA +I Sbjct: 87 KREYTSVVDPVFLADVRSLIERISAVPLVRAESTLSLLSAEYL-------GLRAGNIISE 139 Query: 140 TVIPSALT--PENIEQIRNTAVNGGFVG-TLISRNQDSAMIVAEINEFDAKGDKVDYLAY 196 V+P + E ++ + + F +L+SR+ S IV ++ + + + +A Sbjct: 140 RVVPDEFSGSAEEVQGVYRKLRDWDFYECSLVSRDLRSMQIVVFLDTSNEESSSPEAMAA 199 Query: 197 NKLLNDLRAKYENADFEVQIIGFA--KQIGDVADGAEGVLKFCAMALLLTTVAVYWYCRS 254 + + + +++ D + + G ++G+ A + + +L+ VA++ R Sbjct: 200 CRAIIRILGAWKSRDAQTFVTGVTVFNEMGNEA-STHDLTLLVPLVVLIIIVALFVSFRR 258 Query: 255 LPFTLLPVACSLVSLVWQFGTLRLLGYGLDPLAVLVPFLVFAIGVSHGVQQINTIVRGIA 314 L LP+ ++S VW G + L L L+ ++P ++ A+G ++G+ ++ G A Sbjct: 259 LAGIFLPLLTVVISTVWALGAMALCAIPLSILSAILPVILIAVGSAYGIHIVSAYFYG-A 317 Query: 315 SGQSC----EAAAR--ASFKGLLIPGVLALVTALVSFITLVMIPIPMVRELAITASIGVG 368 S + C E AR + ++ P L+ +T V F++ + + E + AS+GV Sbjct: 318 SSRICSTRQEHRARIVEAVDKIIQPVFLSALTTFVGFVSFCFTSVVPIFEFGVFASVGVA 377 Query: 369 YKIITNLVMLP 379 L+++P Sbjct: 378 SAFAVALMLIP 388