BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.2702.p (1396 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value alr1689 [H] COG1429 Cobalamin biosynthesis protein CobN and rela... 972 0.0 slr1211 [H] COG1429 Cobalamin biosynthesis protein CobN and rela... 880 0.0 RSp0626 [H] COG1429 Cobalamin biosynthesis protein CobN and rela... 833 0.0 VNG1566G [H] COG1429 Cobalamin biosynthesis protein CobN and rel... 789 0.0 MA0872 [H] COG1429 Cobalamin biosynthesis protein CobN and relat... 662 0.0 >alr1689 [H] COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases Nos Nostoc sp. PCC 7120 Length = 1302 Score = 972 bits (2513), Expect = 0.0, Method: Compositional matrix adjust. Identities = 562/1397 (40%), Positives = 768/1397 (54%), Gaps = 150/1397 (10%) Query: 17 ARIVLLTHAPTDLAMLAAARGQLPVDFPPVAGYDLQGLQAHTDEDGQPLHTLAALLRTEL 76 A VL+T A TD+ LAAA +LP FP + +L LQ D L EL Sbjct: 25 APFVLITAADTDIQTLAAAVPKLPATFPAIRVANLLLLQQQISIDTYAEQVL------EL 78 Query: 77 AGAQVIVLRILG-RLGAVSGFPELLRLARAQGRQLIVLSGTGEPDAELAAASTAPADVQQ 135 A QVI+LR+LG R G + + G LIV+ G D EL + STAP Sbjct: 79 A--QVIILRLLGGRSYWAYGLEVVQEIVERTGITLIVMPGDDALDPELISQSTAPVGTVN 136 Query: 136 QALAYFNGGGSVNLAQLLRCLSDRLLLSGYGYEPAQALPEHGLYHPDL---EQGAGVADW 192 Q YF GG N+ L+ +SD L + Y Q +P GLY + QG + Sbjct: 137 QIWQYFYEGGVENIVNALQLISDVSLKTTYKPPAPQRVPRVGLYEWGMGTNRQGDKGNEV 196 Query: 193 LALRAQAPSGKPAVGIIFYRAHWLSGNTGFIDALVAALEARGMDVLPVFTSSLRVSAAGA 252 + S P VGI+FYRAH+L+GN IDAL AAL R + +PVF SSLR A Sbjct: 197 EFSPTSSQSLIPKVGILFYRAHYLAGNIQVIDALCAALWQRNLQPVPVFISSLRDPDVQA 256 Query: 253 QALPPALAYFA---TGQVDLILNTTSFAMGEITSGGVTPAGWSVSVLEQLDIPVLQAITS 309 + + +F + Q+ L+LNTTSF++ + + W E+LD+PVLQ I S Sbjct: 257 ELI----DFFQPKDSQQISLLLNTTSFSLARLETEAPQTELW-----EKLDVPVLQVILS 307 Query: 310 GMSQAQWQHSTRGMNPLDAAMNVVLPEFDGRIIGVPLSFKQ------STPTGAVHYQPLA 363 G QW+ G++P D AMNV LPE DGRII +SFK T V Y+P++ Sbjct: 308 GGFVEQWEAQLNGLSPRDIAMNVALPEVDGRIISRAVSFKAIQTRNPDLETDVVVYEPIS 367 Query: 364 DRVRRIAGLTQRLVRLRRTPNAQKRIAFIFTNSNSKAAQIGNAVGLDAPESLMAVLRALA 423 DR+ +A L V LR P Q+RIA I N ++ ++ N VGLD PES + +L+AL Sbjct: 368 DRIDFVAQLAANWVHLRSQPPQQRRIALILANYPNRDGRLANGVGLDTPESCVEILKALQ 427 Query: 424 AEGYAIDELPASGTALIHELVDRCSYDDILLTEDQLRRAAARIPAQRYAQWFAALPPALQ 483 GY + LPA+G LI L + D ++R + ++ Y ++FA LP +Q Sbjct: 428 QSGYVVSNLPANGDELIQLLTAGVTNDP---EGREIRPVQQSLSSEEYQEYFAGLPATVQ 484 Query: 484 ----ARMQRQWGAAPGQAYVHDQHLVIAGLDLGNAFVVLQPPRGYGMDPDAIYHQPDLPP 539 R R WG + I G+ GN FV +QP RGY +DP+ YH PDL P Sbjct: 485 QGINERWGRDWGLGEQASNFPSSSCPIPGIQFGNVFVGIQPSRGYDIDPNLNYHAPDLEP 544 Query: 540 THHYYALYRWLDEEWGADAIVHVGKHGTLEWLPGKGVGLSEECFPDALLGDVPLFYPFII 599 TH Y A Y W+ E +GADA+VHVGKHG LEWLPGK + LS C+P+A+ G +P YPFI+ Sbjct: 545 THAYLAFYYWVRESFGADAVVHVGKHGNLEWLPGKSLALSSNCYPEAVFGPMPHLYPFIV 604 Query: 600 NDPGEGSQAKRRAHAVVVDHLTPPMTTADSYGALAQLTQLVDEYYQVEVLDPSKLPLLQQ 659 NDPGEGSQAKRRA AV++DHLTPPMT A+ YGAL +L LVDEYY+ E LDPS+L +++ Sbjct: 605 NDPGEGSQAKRRAQAVIIDHLTPPMTRAELYGALQKLENLVDEYYEAESLDPSRLGVIRD 664 Query: 660 QIWELVRQTNLDTDLQFKLLHHDHDHDHDHGHHHHGHHHHHDHGAHDHAHHDHAHDADQL 719 +I +LV Q NL DL + Sbjct: 665 RIRDLVIQENLYKDLGIE------------------------------------------ 682 Query: 720 PHALTELDGAGVAHLI-EDLDGYLCELGAAQIRDGLHILGRTPDSQQMPDMLVALTRLPN 778 E D LI LDGYLCEL AQIRDGLHI G+ P +Q+ D++VA+ R+PN Sbjct: 683 ----KEEDIVNFESLILNSLDGYLCELKEAQIRDGLHIFGQCPQGRQLRDLIVAIARIPN 738 Query: 779 QDLPGLQEELAKLFGLSLDMLLEHKGRRLNIDDT--LARVAGRAIVTRADALEAIDALCL 836 + G+ LA ++GL D L ++ L+ D LA T DA Sbjct: 739 RYSTGITRALANVWGLDFDPLTDNFSTPLSTQDQKLLAAKTPNPCRTVGDA--------- 789 Query: 837 ALMQALQQHGFAVTAIDDVLQSVLGSLQNTPAEQQPRLQPALAKGPGSVLGAMRSLSRPA 896 + AL++H + + L P Sbjct: 790 --VTALEEHAALL---------------------------------------VEQLINPP 808 Query: 897 AAPAAAPAAAPAAAPVKRTAAQIQTKTSDTGALRRVLVFTCEQLVPRLLRTEEEISNLLH 956 AP P P P ++ + + +S L VL + +L+P L +T EI+NLLH Sbjct: 809 TAPEVRPEGNP---PCDFSSCPLPSSSSPPAPLNTVLNWIKSKLLPSLQQTHAEITNLLH 865 Query: 957 GLRGGYIPAGPSGSPTRGMAHILPTGRNFYSVDPRSVPSQSAWRVGQQLALEVLQRHHRE 1016 GL GGYIP+ SG+PTRG +LPTGRNFY+VD R++P+++AW +G++ A +++ + +E Sbjct: 866 GLDGGYIPSAASGAPTRGRPEVLPTGRNFYAVDIRAIPTETAWDIGRKAAENLVECYTQE 925 Query: 1017 SGDYPESVAISIWGTSAMRTHGDDVAQILALMGARPIWREGNRQVAGVELVPLAQLQRPR 1076 G+YP+++ +S+WGT+ MRT GDD+A+ LAL+G +P+W R+V ++++PL+ L RPR Sbjct: 926 HGEYPKTLGLSVWGTATMRTGGDDIAEALALLGVQPVWDGAARRVVDLDILPLSILGRPR 985 Query: 1077 IDVTTRISGFFRDAFPQLIELIDDAVQLAIAADEPEHMNFVRKHYLRDLQAAVTSGMGQA 1136 +DVT RISGFFRDAFP L++L + AV A DEP N + +D + G+ Sbjct: 986 VDVTLRISGFFRDAFPNLMDLFEQAVNAVAALDEPPEQNPLAAQIRQDTDFWIQQGLTPE 1045 Query: 1137 EAAAQAAYRVFGAKPGSYGAGILPLIQEKNWQDQADFAEAYINWGGYAY--GRKVQGADQ 1194 A ++ YR+FG+KPG+YGAG+ LI+ +NWQ+ D A AYINW YAY G+ + + Sbjct: 1046 TAFERSRYRLFGSKPGAYGAGLQGLIESQNWQNDQDLANAYINWSCYAYSSGKSQEAGTE 1105 Query: 1195 ---------REAFRQRLSGVQVALHNQDNREHDIFDSDDYLQYHGGMIATIRALSGQQPR 1245 EAF QRL +Q+ L NQDNREHD+ DSDDY Q+ GG+ A IR+L G+ P Sbjct: 1106 INPPSPIPSPEAFTQRLGQMQIVLQNQDNREHDLLDSDDYYQFQGGLTAAIRSLQGKNPE 1165 Query: 1246 HYFGDSHDPQRAAVRDLKEETLRVFRARVVNPKWLASIRRHGYKGGLELTATVDYLFGYD 1305 YFGD+ P + VR L+EE RV+R+RVVNPKW+ + RHGYKG E+ ATVD+LF YD Sbjct: 1166 TYFGDNSIPSQPRVRQLREEIARVYRSRVVNPKWIEGMMRHGYKGAFEMAATVDFLFAYD 1225 Query: 1306 ATAQVLEDWMYQQLAETYGFDPEMRAFLEQANPWAQNAIAERLLEAASRGMWQTPPAQTI 1365 AT + +ED+MYQ + + Y DP + ++E NP A IAERLLEA RG+W+ +T+ Sbjct: 1226 ATTRCVEDYMYQGVMQAYLLDPVVCTYIENKNPHALRDIAERLLEANQRGLWENVNIETL 1285 Query: 1366 QQLRTLYLHSEALLEAR 1382 + LR L +EA +EA+ Sbjct: 1286 ENLRNLVHQAEATIEAK 1302 >slr1211 [H] COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases Syn Synechocystis Length = 1092 Score = 880 bits (2275), Expect = 0.0, Method: Compositional matrix adjust. Identities = 470/1185 (39%), Positives = 686/1185 (57%), Gaps = 122/1185 (10%) Query: 205 AVGIIFYRAHWLSGNTGFIDALVAALEARGMDVLPVFTSSLRVSAAGAQALPPALAYFAT 264 + IIFYR+H+LSGNT IDAL ALE ++ L ++ SSLR A+ L A+ Sbjct: 9 TIAIIFYRSHYLSGNTTPIDALCQALEKHNLNPLAIYVSSLREPDVQAEIL--AILENLD 66 Query: 265 GQVDLILNTTSFAMGEITS--GGVTPAGWSVSVLEQLDIPVLQAITSGMSQAQWQHSTRG 322 + ILNTTSF++ ++ G + + + ++L++PVLQ I SG + QWQ RG Sbjct: 67 QPLGAILNTTSFSLAKLQRQIGNLE----MIPLWQKLNVPVLQVILSGGDRQQWQEGLRG 122 Query: 323 MNPLDAAMNVVLPEFDGRIIGVPLSFKQ------STPTGAVHYQPLADRVRRIAGLTQRL 376 +NP D AMNV LPE DGRII +SFK T Y+P+ DRV IA LT+ + Sbjct: 123 LNPRDLAMNVALPEVDGRIITRAISFKAMAARHPQLETEVAIYEPVLDRVEWIAELTKNI 182 Query: 377 VRLRRTPNAQKRIAFIFTNSNSKAAQIGNAVGLDAPESLMAVLRALAAEGYAIDELPASG 436 + +T Q++IA I N +K ++ N VGLD P S + +L AL GY + +P Sbjct: 183 INCAQTEIFQRKIALILANYPNKDGRLANGVGLDTPASCLQILEALKIAGYHLSAIPKDT 242 Query: 437 TALIHELVDRCSYDDILLTEDQLRRAAARIPAQRYAQWFAALPPALQARMQRQWGAAPGQ 496 LI +L + D L Q R I ++ Q+F +LP ++Q M +W Sbjct: 243 ETLIKQLTQGVTNDQELA---QYRTVNQTIVTEKVWQFFYSLPQSVQQAMTERWQVRENW 299 Query: 497 AYVHDQHLVIAGLDLGNAFVVLQPPRGYGMDPDAIYHQPDLPPTHHYYALYRWLDEEWGA 556 + DQ I+G+ GN FV +QP RGY DP YH PDL PT HY A Y WL +E+ A Sbjct: 300 DNLPDQ-FAISGIQFGNIFVGIQPARGYDFDPSLNYHAPDLEPTLHYLAFYLWLRQEFSA 358 Query: 557 DAIVHVGKHGTLEWLPGKGVGLSEECFPDALLGDVPLFYPFIINDPGEGSQAKRRAHAVV 616 AI+H+GKHG LEWLPGK V LS+ C P+ LG +P FYPFI+NDPGEG+QAKRR+ A + Sbjct: 359 QAIIHLGKHGNLEWLPGKSVVLSDHCHPEIALGPLPNFYPFIVNDPGEGTQAKRRSQACI 418 Query: 617 VDHLTPPMTTADSYGALAQLTQLVDEYYQVEVLDPSKLPLLQQQIWELVRQTNLDTDLQF 676 +DHLTPP+T A+ YG L +L L+DEYY+ + LDP+++ + ++ +L+ +NL TDL Sbjct: 419 IDHLTPPLTRAELYGDLEKLEALIDEYYEAQALDPTRVKTIGDRLRKLLATSNLQTDLGL 478 Query: 677 KLLHHDHDHDHDHGHHHHGHHHHHDHGAHDHAHHDHAHDADQLPHALTELDGAGVAHLIE 736 P AL +L L+ Sbjct: 479 T------------------------------------------PPALKDLQP-----LLT 491 Query: 737 DLDGYLCELGAAQIRDGLHILGRTPDSQQMPDMLVALTRLPNQDLPGLQEELAKLFGLSL 796 D YLCEL AQIRDGLHILG+TP +Q+ D+ +++ R P+ GL + +A L Sbjct: 492 SADSYLCELKEAQIRDGLHILGQTPTGEQLRDLAISIARSPSYQRLGLTQAIAFDLELEF 551 Query: 797 DMLLEHKGRRLNIDDTLARVAGRAIVTRADALEAIDALCLALMQALQQHGFAVTAIDDVL 856 D +L+ + T+ + +T+ + L + + G + ++++ Sbjct: 552 DPVLDDPNEPWQLSSTMQMKLQQWELTQ----------FIELFNSCRIGGQVIEILEEIA 601 Query: 857 QSVLGSL-QNTPAEQQPRLQPALAKGPGSVLGAMRSLSRPAAAPAAAPAAAPAAAPVKRT 915 + ++GSL + +Q+ L + P S Sbjct: 602 KQLVGSLLEIVIVDQKVNL---FFQKPDS------------------------------- 627 Query: 916 AAQIQTKTSDTGALRRVLVFTCEQLVPRLLRTEEEISNLLHGLRGGYIPAGPSGSPTRGM 975 +TK++ L + + L+P L +T +EI+NLL GL G YI +GP+G+P+RG Sbjct: 628 ----KTKSN--------LDYIEQTLLPMLQQTPQEITNLLRGLNGEYIASGPAGAPSRGR 675 Query: 976 AHILPTGRNFYSVDPRSVPSQSAWRVGQQLALEVLQRHHRESGDYPESVAISIWGTSAMR 1035 +LPTGRNFY+VD R++P+++AW +G++ A +++R+ ++ G+YP+++AISIWGTS MR Sbjct: 676 PDVLPTGRNFYAVDIRAIPTETAWDIGRRAAETLIERYTQDHGEYPQTLAISIWGTSTMR 735 Query: 1036 THGDDVAQILALMGARPIWREGNRQVAGVELVPLAQLQRPRIDVTTRISGFFRDAFPQLI 1095 T GDD+AQ+LAL+G +P+W +R++ E++P L+RPR+DVT RISGFFRD+FP L+ Sbjct: 736 TGGDDIAQVLALLGVQPVWDSPSRRIVDFEILPTTVLKRPRVDVTIRISGFFRDSFPNLV 795 Query: 1096 ELIDDAVQLAIAADEPEHMNFVRKHYLRDLQAAVTSGMGQAEAAAQAAYRVFGAKPGSYG 1155 E + A+ DEP ++N + + ++ + G+ EA +A YR+FG+KPG+YG Sbjct: 796 EFLHQAIAAVSQLDEPANLNPLAEKVKQETEQWQQLGLATEEAVTKATYRIFGSKPGAYG 855 Query: 1156 AGILPLIQEKNWQDQADFAEAYINWGGYAYGRKVQGADQREAFRQRLSGVQVALHNQDNR 1215 AG+ LI+ +NWQD +D A AY+NW YAY R+ G +Q E F QRL +Q+ LHNQDNR Sbjct: 856 AGLQGLIEAQNWQDDSDLARAYLNWSCYAYDRQGVGHNQPEVFAQRLQNLQIVLHNQDNR 915 Query: 1216 EHDIFDSDDYLQYHGGMIATIRALSGQQPRHYFGDSHDPQRAAVRDLKEETLRVFRARVV 1275 EHD+ DSDDY Q+ GG+ A +R+L+G+ P YFGD+ +P + V+ L +E +V+R+RVV Sbjct: 916 EHDLLDSDDYYQFQGGLTAAVRSLTGKNPTVYFGDNSNPAQPKVKLLTQEIAKVYRSRVV 975 Query: 1276 NPKWLASIRRHGYKGGLELTATVDYLFGYDATAQVLEDWMYQQLAETYGFDPEMRAFLEQ 1335 NPKW+A + RHGYKG E+ AT+DYLF YDATA +ED+MY +A+ Y D E++ F++Q Sbjct: 976 NPKWIAGVMRHGYKGAFEMAATLDYLFAYDATAHCVEDFMYTGIAQAYLLDEEVQKFVQQ 1035 Query: 1336 ANPWAQNAIAERLLEAASRGMWQTPPAQTIQQLRTLYLHSEALLE 1380 NPWA +AERLLEA R +W Q + QLR + +E +LE Sbjct: 1036 HNPWALRDMAERLLEAEQRQLWSNVDPQLLDQLRAIAHGAEEILE 1080 >RSp0626 [H] COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases Rso Ralstonia solanacearum Length = 1379 Score = 833 bits (2151), Expect = 0.0, Method: Compositional matrix adjust. Identities = 418/659 (63%), Positives = 503/659 (76%), Gaps = 18/659 (2%) Query: 19 IVLLTHAPTDLAMLAAARGQLPVDFPPVAGYDLQGLQAHTDEDGQPLHTLAALLRTELAG 78 IVLLTHA TDL+ L A QLP F V G LQ + +D + +A LL +AG Sbjct: 9 IVLLTHAGTDLSTLQRATAQLPDGFAGVTGLHLQAI----GDDAR----MADLLAGPIAG 60 Query: 79 AQVIVLRILGRLGAVSGFPELLRLARAQGRQLIVLSGTGEPDAELAAASTAPADVQQQAL 138 A+++++R+LGRL A+ G LL RAQGR L+++SGTGEPD ELAA ST P +QQ+ Sbjct: 61 ARIVIVRVLGRLQAIPGIDALLHDTRAQGRALVIVSGTGEPDPELAARSTVPPALQQEVA 120 Query: 139 AYFNGGGSVNLAQLLRCLSDRLLLSGYGYEPAQALPEHGLYHPDLEQGAGVADWLALRAQ 198 AY GG+ NLAQLLRCLSDRLL++G+GY+P ALPEHG+YHP+L A + DW A+R Sbjct: 121 AYLQAGGTGNLAQLLRCLSDRLLMTGFGYQPPMALPEHGIYHPELAAPATLDDWAAIRNP 180 Query: 199 APSGKPAVGIIFYRAHWLSGNTGFIDALVAALEARGMDVLPVFTSSLRVSAAGAQALPPA 258 A P VGI FYRAHWL GNT FID LV AL + ++ LPV+T+SLR A +P A Sbjct: 181 A---WPTVGIAFYRAHWLCGNTRFIDQLVDALAEQRLNALPVYTASLRT--LDATGMPAA 235 Query: 259 LAYFA---TGQVDLILNTTSFAMGEITSGGVTPAGWSVSVLEQLDIPVLQAITSGMSQAQ 315 L FA G++D ++NTTSFAMG++ + G T AGWSV+ +LD+PV+QAI S M+QAQ Sbjct: 236 LDVFADDGVGRIDALVNTTSFAMGDVNADGPTAAGWSVAAFTRLDVPVVQAIASSMTQAQ 295 Query: 316 WQHSTRGMNPLDAAMNVVLPEFDGRIIGVPLSFKQSTPTGAVHYQPLADRVRRIAGLTQR 375 W S RG+NPLD AMNV LPEFDGRI+ VP+SFK A Y PL DRVRR+AG+ R Sbjct: 296 WAASERGLNPLDTAMNVALPEFDGRIVSVPMSFKDERDETA--YAPLPDRVRRVAGIVAR 353 Query: 376 LVRLRRTPNAQKRIAFIFTNSNSKAAQIGNAVGLDAPESLMAVLRALAAEGYAIDELPAS 435 V LRRT A KRIAF+FTNS+SKA+QIGNAVGLD+P SL+ +LRA+ A+GY ID LP S Sbjct: 354 QVALRRTAPADKRIAFLFTNSSSKASQIGNAVGLDSPASLLTLLRAMQAQGYRIDGLPES 413 Query: 436 GTALIHELVDRCSYDDILLTEDQLRRAAARIPAQRYAQWFAALPPALQARMQRQWGAAPG 495 G ALIH L+DR +YD+ L+ QL +A A +PA RYA WF+ LP LQ +M+++WG APG Sbjct: 414 GDALIHALIDRGAYDEDYLSAAQLEQAIATVPAARYAAWFSDLPAPLQDKMRQRWGDAPG 473 Query: 496 QAYVHDQHLVIAGLDLGNAFVVLQPPRGYGMDPDAIYHQPDLPPTHHYYALYRWLDEEWG 555 AYVHD LV AG++ GNAFV LQPPRGYGMDPDAIYH PDLPPTHHYYALYRWL +EW Sbjct: 474 NAYVHDGKLVFAGMEYGNAFVALQPPRGYGMDPDAIYHTPDLPPTHHYYALYRWLRDEWR 533 Query: 556 ADAIVHVGKHGTLEWLPGKGVGLSEECFPDALLGDVPLFYPFIINDPGEGSQAKRRAHAV 615 ADAIVHVGKHGTLEWLPGKGVG+S+ CFPDALLGD+PLFYPFI+NDPGEGSQAKRRAHAV Sbjct: 534 ADAIVHVGKHGTLEWLPGKGVGVSQTCFPDALLGDLPLFYPFILNDPGEGSQAKRRAHAV 593 Query: 616 VVDHLTPPMTTADSYGALAQLTQLVDEYYQVEVLDPSKLPLLQQQIWELVRQTNLDTDL 674 ++DHLTPPMTTAD+YG LAQLTQLVDEYYQVE+LDP+KLPLLQQQIW+L+++ LD DL Sbjct: 594 IIDHLTPPMTTADTYGPLAQLTQLVDEYYQVEMLDPAKLPLLQQQIWDLIKEARLDADL 652 Score = 691 bits (1782), Expect = 0.0, Method: Compositional matrix adjust. Identities = 322/471 (68%), Positives = 381/471 (80%) Query: 917 AQIQTKTSDTGALRRVLVFTCEQLVPRLLRTEEEISNLLHGLRGGYIPAGPSGSPTRGMA 976 A + + TGA+R+ L F C +LVP L RT EEI NLLHGL GGY+PAGPSG+PTRGMA Sbjct: 908 ASVLPGIAHTGAIRQTLAFVCRELVPNLARTTEEIGNLLHGLAGGYVPAGPSGAPTRGMA 967 Query: 977 HILPTGRNFYSVDPRSVPSQSAWRVGQQLALEVLQRHHRESGDYPESVAISIWGTSAMRT 1036 H+LPTGRNFYSVDPRS+PSQ+AWR+G LA E L RH E+G PESV+IS+WGTSAMRT Sbjct: 968 HVLPTGRNFYSVDPRSLPSQAAWRIGTALANEALARHRTETGHDPESVSISVWGTSAMRT 1027 Query: 1037 HGDDVAQILALMGARPIWREGNRQVAGVELVPLAQLQRPRIDVTTRISGFFRDAFPQLIE 1096 HGDD+AQILAL+G RP W+ +R+VAG+E++PLA+L RPRIDVT RISGFFRDAFP LI Sbjct: 1028 HGDDIAQILALLGVRPRWQAESRRVAGIEVIPLAELGRPRIDVTVRISGFFRDAFPHLIH 1087 Query: 1097 LIDDAVQLAIAADEPEHMNFVRKHYLRDLQAAVTSGMGQAEAAAQAAYRVFGAKPGSYGA 1156 L+D+AV DEP NFVRKHYL DL + +G+ A + YRVFG++PG+YGA Sbjct: 1088 LVDEAVHTVARLDEPVERNFVRKHYLADLAHQLFAGLPPEAAEQRTLYRVFGSRPGTYGA 1147 Query: 1157 GILPLIQEKNWQDQADFAEAYINWGGYAYGRKVQGADQREAFRQRLSGVQVALHNQDNRE 1216 GILPLIQE++WQD ADFA+AYINWGGYAYGR+ G D R FR RLSGV++ALHNQDNRE Sbjct: 1148 GILPLIQEQHWQDDADFAQAYINWGGYAYGRRDNGTDARADFRHRLSGVEIALHNQDNRE 1207 Query: 1217 HDIFDSDDYLQYHGGMIATIRALSGQQPRHYFGDSHDPQRAAVRDLKEETLRVFRARVVN 1276 HDIFDSDDYLQYHGGMIATIR+L+G+QPR YFGDSH+P AVR LKEETLRVFR+RV N Sbjct: 1208 HDIFDSDDYLQYHGGMIATIRSLTGRQPRQYFGDSHNPDHPAVRSLKEETLRVFRSRVAN 1267 Query: 1277 PKWLASIRRHGYKGGLELTATVDYLFGYDATAQVLEDWMYQQLAETYGFDPEMRAFLEQA 1336 PKW+A I++HGYKGGLELTATVDYLFGYDATA V++DW+Y+QLA+ Y FDP M+ FL ++ Sbjct: 1268 PKWIAGIQKHGYKGGLELTATVDYLFGYDATAHVVDDWVYEQLAQAYAFDPAMQQFLAES 1327 Query: 1337 NPWAQNAIAERLLEAASRGMWQTPPAQTIQQLRTLYLHSEALLEARGETVR 1387 NPWA NAI ERLLEA R MW P T+ L+ L+L SEA+LEARGET + Sbjct: 1328 NPWALNAITERLLEAIQRQMWAEPKPDTVAALQALHLRSEAMLEARGETTQ 1378 Score = 152 bits (383), Expect = 8e-36, Method: Compositional matrix adjust. Identities = 83/162 (51%), Positives = 108/162 (66%), Gaps = 1/162 (0%) Query: 711 DHAHDADQLPHALTELDGAGVAHLIEDLDGYLCELGAAQIRDGLHILGRTPDSQQMPDML 770 D +AD +P +L ++DG VAHLIED+DGYLCELGAAQIRDGLH+LGR P + DM+ Sbjct: 761 DATLNADGVPLSLAKMDGVDVAHLIEDIDGYLCELGAAQIRDGLHVLGRVPADDALVDMV 820 Query: 771 VALTRLPNQDLPGLQEELAKLFGLSLDMLLEHKGRRLN-IDDTLARVAGRAIVTRADALE 829 A+ RLPN +P L +A+ GL+ D L KG+RL + L R+A R +VTRADAL+ Sbjct: 821 CAMVRLPNLGVPSLPAGVAEALGLAWDALQHDKGKRLEAVSPPLQRLADRPLVTRADALD 880 Query: 830 AIDALCLALMQALQQHGFAVTAIDDVLQSVLGSLQNTPAEQQ 871 A+ AL AL+ AL +HGF T D L SVL + +T A +Q Sbjct: 881 AVSALTRALIAALAEHGFDATRSDAALASVLPGIAHTGAIRQ 922 >VNG1566G [H] COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases Hbs Halobacterium sp. NRC-1 Length = 1234 Score = 789 bits (2038), Expect = 0.0, Method: Compositional matrix adjust. Identities = 480/1296 (37%), Positives = 685/1296 (52%), Gaps = 106/1296 (8%) Query: 101 RLARAQGRQLIVLSGTGEPDAELAAASTAPADVQQQALAYFNGGGSVNLAQLLRCLSDRL 160 RLA A G L+V S TG DA +T A+ + Y + GGS N+A LR L DR Sbjct: 10 RLADA-GVPLVVKS-TG--DAYAVEDTTVAAEDRDTVYEYLDRGGSANVANCLRFLGDRY 65 Query: 161 LLSGYGYEPAQALPEHGLYHPDLEQGAGVADWLALRAQAPSGKPAVGIIFYRAHWLSGNT 220 + + Y+ ALP G+YHPD G+ D+ LRA P V + FY +HW NT Sbjct: 66 SGTEFAYDDPVALPTEGVYHPDH---PGI-DYDGLRATFDPDAPTVAVWFYESHWTHENT 121 Query: 221 GFIDALVAALEARGMDVLPVFTSSLRVSAAGAQALPPALAYF-ATGQ--VDLILNTTSFA 277 ++D +V ALE++G + LPVF + + A + A G+ VD ++++ F+ Sbjct: 122 RYVDGVVHALESQGANALPVFCNPATDTDEQEDAEWVTDQWLLADGEPVVDAVVSSFMFS 181 Query: 278 MGEITSG-GVTPAGWSVS--VLEQLDIPVLQAITSGMSQAQWQHSTRGMNPLDAAMNVVL 334 + G + G + L++L +PVLQ +T+ S+++++ + G+ + A++V L Sbjct: 182 LSMDERGRSASDEGDAAEDVFLDRLGVPVLQTVTTMRSRSRYESADTGVMGFELALSVAL 241 Query: 335 PEFDGRIIGVPLSFKQSTP------TGAVHYQPLADRVRRIAGLTQRLVRLRRTPNAQKR 388 PEFDG +I P+S K+ T T + P+ADRV A L RLR N +KR Sbjct: 242 PEFDGNVITHPISGKERTDDDAGIGTAPKQHFPIADRVEHAASLAVNWARLRHLDNDEKR 301 Query: 389 IAFIFTNSNSKAAQIGNAVGLDAPESLMAVLRALAAEGYAID-ELPASGTALIHELVDRC 447 +A + N IG A GLD PES + +L L A GY++ + P G ALI +L + Sbjct: 302 VAVVLHNYPPSDDGIGTAFGLDTPESTVNLLDELDARGYSLGGKTPPEGQALIEQLTSQL 361 Query: 448 SYDDILLT-EDQLRRAAARIPAQRYAQWFAALPPALQARMQRQWGAAPGQAYVHDQHLVI 506 + DD + ED R+ + YA W+A P +A + +WG P + + I Sbjct: 362 TLDDRWVAPEDVRERSVDVVSTDEYAAWWADTDPEFRANVVAEWGEPPERPFA------I 415 Query: 507 AGLDLGNAFVVLQPPRGYGMDPDAIYHQPDLPPTHHYYALYRWLDEEWGADAIVHVGKHG 566 G++ GN V +QPPRG+GMDP+ +YH DL P H YYA Y WL EE+GADA+VH+G HG Sbjct: 416 PGVEYGNVLVTVQPPRGFGMDPEKVYHDSDLQPPHDYYAFYAWLREEFGADAVVHLGTHG 475 Query: 567 TLEWLPGKGVGLSEECFPDALLGDVPLFYPFIINDPGEGSQAKRRAHAVVVDHLTPPMTT 626 +LEWLPGK VGL E PDALLGD+P YP+I+N+PGEG+QAKRR++A VVD+LTP M+ Sbjct: 476 SLEWLPGKTVGLDAESAPDALLGDLPNVYPYIVNNPGEGTQAKRRSYAAVVDYLTPVMSN 535 Query: 627 ADSYGALAQLTQLVDEYYQVEVLDPSKLPLLQQQIWELVRQTNLDTDLQFKLLHHDHDHD 686 A +Y LA+L +L Y + + I + +R+ D DL +L Sbjct: 536 AGTYDELAELEELASRYREAGA---GAGADAESHIADRIREQVADLDLAVEL-------- 584 Query: 687 HDHGHHHHGHHHHHDHGAHDHAHHDHAHDADQLPHALTELDGAGVAHLIEDLDGYLCELG 746 G A D D A L + D G+ L+E + Y+ ++ Sbjct: 585 --------GIEGEISEKA-DVRGPDAA--GSSLAEGAVDGDTVGIEALVERVHEYVTDVK 633 Query: 747 AAQIRDGLHILGRTPDSQQMPDMLVALTRLPNQDLPGLQEELAKLFGLSLDMLLEHKGRR 806 QIR GLH +G P ++ + LVALTRL N P L+E +A + G+ +L+ G Sbjct: 634 TTQIRLGLHTMGEPPADDRLVEYLVALTRLENPGAPSLRESVAGVLGVDYGTMLDSPGE- 692 Query: 807 LNIDDTLARVAGRAIVTRADALEAIDALCLALMQALQQHGFAVTAIDDVLQSVLGSLQNT 866 + G +T A+A + + + L++ L GF V A + Sbjct: 693 ------YSEALG---MTYAEAADEVYETSVDLVETLAAEGFDVPASN------------- 730 Query: 867 PAEQQPRLQPALAKGPGSVLGAMRSLSRPAAAPAAAPAAAPAAAPVKRTAAQIQTKTSDT 926 +A GP + M L T + K+ Sbjct: 731 -----------VAAGPDDEVN-MNLLVVDI-----------------DTIGDARAKSGAH 761 Query: 927 GALRRVLVFTCEQLVPRLLRTEEEISNLLHGLRGGYIPAGPSGSPTRGMAHILPTGRNFY 986 LR VL F CE+ PR+ E EI L G Y+ G SG+PTRG +LPTGRNFY Sbjct: 762 DDLRAVLAFICEEAAPRVFGAESEIPQTADALDGEYVEPGGSGAPTRGGVDLLPTGRNFY 821 Query: 987 SVDPRSVPSQSAWRVGQQLALEVLQRHHRESGDYPESVAISIWGTSAMRTHGDDVAQILA 1046 ++DPR VP+++AW VG+++A V QRH + G+YPE V + WGT +RT G+ +AQ+L Sbjct: 822 TLDPRKVPARTAWDVGKEVADGVAQRHQEDEGEYPEEVGVVAWGTPTVRTRGETIAQVLG 881 Query: 1047 LMGARPIWREGNRQVAGVELVPLAQLQRPRIDVTTRISGFFRDAFPQLIELIDDAVQLAI 1106 LMG RP+W + R V VE +PL L RPRIDVTTR+SG FRDAFPQ ++ DAV + Sbjct: 882 LMGVRPVWTDAGR-VDDVEPIPLGDLGRPRIDVTTRVSGLFRDAFPQAAGVVHDAVDAVV 940 Query: 1107 AADEPEHMNFVRKHYLRDLQAAVTSGMGQAEAAAQAAYRVFGAKPGSYGAGILPLIQEKN 1166 DEP MN+V+KH + G+ E AA+ RVF +PG YGAG + E Sbjct: 941 DLDEPHDMNYVKKHVEAEAAELEAEGVENPEQAAK--RRVFTTRPGGYGAGTNKAVDEGE 998 Query: 1167 WQDQADFAEAYINWGGYAYGRKVQGADQREAFRQRLSGVQVALHNQDNREHDIFDSDDYL 1226 W D++D A+ Y+ WGGYA G + + ++ +AF +RL V + +D E D FDS D+ Sbjct: 999 WDDRSDLADVYVQWGGYAMGSRGRVSEAHDAFERRLGNVDATVKIEDTMEQDEFDSSDWY 1058 Query: 1227 QYHGGMIATIRALSGQQPRHYFGDSHDPQRAAVRDLKEETLRVFRARVVNPKWLASIRRH 1286 +HGG I + SG +P Y GDS DP V +E+ + RARV+NP+WL S+ H Sbjct: 1059 AFHGGFITAVAEESGAEPASYVGDSSDPDNVDVYTNEEKVRKAMRARVLNPEWLDSMEDH 1118 Query: 1287 GYKGGLELTATVDYLFGYDATAQVLEDWMYQQLAETYGFDPEMRAFLEQANPWAQNAIAE 1346 GYKG +L++TVD G+DAT V+ D ++ +AE Y FD + + +L NPWA ++I + Sbjct: 1119 GYKGAGDLSSTVDVTLGWDATTGVVSDTLWADVAEKYAFDEDRQEWLRDVNPWALSSITD 1178 Query: 1347 RLLEAASRGMWQTPPAQTIQQLRTLYLHSEALLEAR 1382 LLEA R +W +T ++LR L+L LEAR Sbjct: 1179 TLLEAIERDLWGADD-ETAERLRDLHLQVSGDLEAR 1213 >MA0872 [H] COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases Mac Methanosarcina acetivorans str.C2A Length = 1302 Score = 662 bits (1707), Expect = 0.0, Method: Compositional matrix adjust. Identities = 413/1318 (31%), Positives = 669/1318 (50%), Gaps = 159/1318 (12%) Query: 101 RLARAQGRQLIVLSGTGEPDAELAAASTAPADVQQQALAYFNGGGSVNLAQLLRCLSDRL 160 RL + R ++ G+ EP + S+ ++ +Y GG N A +LR + + Sbjct: 70 RLESLKTRIPVICVGS-EPSS--LTLSSVKLEIAATCFSYLIYGGKENFANMLRYILKEV 126 Query: 161 LLSGYGYEPAQALPEHGLYHPDLEQ-GAGVADWLALRAQAPSGKPAVGIIFYRAHWLSGN 219 + +P + +P GLYHPD E+ + + D+L P VG++ R +W++ + Sbjct: 127 FGTEIEVKPPEKIPWDGLYHPDSEEIFSSLRDYLDW--YGPLKDKTVGLLISRTYWVNND 184 Query: 220 TGFIDALVAALEARGMDVLPVFTSSLRVSAAGAQALPPALA-YF---ATGQVDLILNTTS 275 L+ E G+ V+PVF SL+ G++ + + YF +D+++ + Sbjct: 185 LEIEKTLIKDFEKLGISVVPVFAYSLKDEELGSRGMNEVIEDYFMKDGKTVIDVLVKLSP 244 Query: 276 FAMGEITSGG--VTPAGWSVSVLEQLDIPVLQAITSG-MSQAQWQHSTRGMNPLDAAMN- 331 F + G + A V +L+ LD+PV Q + S ++ QWQ S N LD+ + Sbjct: 245 FFIMSNKKKGDENSCAAKGVELLQNLDVPVFQPVVSHHVTLEQWQES----NGLDSEIGW 300 Query: 332 -VVLPEFDGRI--IGVPLSFKQSTPTGAVHYQPLADRVRRIAGLTQRLVRLRRTPNAQKR 388 V +PEF+G I I + K+ G P+ +R ++ + + LR+ P +++ Sbjct: 301 GVAMPEFEGVIEPILIGAGKKKENYMGRT---PIQERCSKLTSRVLKWIELRKKPADRRK 357 Query: 389 IAFIFTNSNSKAAQ--IGNAVGLDAPESLMAVLRALAAEGYAIDELPASGTALIHELVDR 446 IAFI N + +G+A LD+ ES+ +L + GYAI+ P G LI ++ + Sbjct: 358 IAFILHNRPCTGVEGSVGDAANLDSLESVAGILNRMQEAGYAINP-PRDGKELIETILRK 416 Query: 447 CSYDDILLTE-DQLRRAA---ARIPAQRYAQWFAALPPALQARMQRQWGAAPGQ------ 496 + + T +++ + A + Y ++F L P ++ R+ WG PG+ Sbjct: 417 KAISEFRWTPINEIVKNGGVLALVEKAEYEEFFNTLSPNVRQRVIEGWGNPPGEEVNGIP 476 Query: 497 -AYVHDQHLVIAGLDLGNAFVVLQPPRGY-GMDPDA----IYHQPDLPPTHHYYALYRWL 550 A V++ +V+ G+ GNA V +QP RG G D I H PD+PPTH Y A YR+L Sbjct: 477 AAMVYENKIVVTGVRYGNAVVCVQPKRGCAGARCDGKVCKILHDPDIPPTHQYLATYRYL 536 Query: 551 DEEWGADAIVHVGKHGTLEWLPGKGVGLSEECFPDALLGDVPLFYPFIINDPGEGSQAKR 610 + +GAD +VHVG HG LE+LPGKGVGLS++C+PD +G +P Y + ++P EG+ AKR Sbjct: 537 ENTFGADVLVHVGTHGNLEFLPGKGVGLSKDCYPDIAIGTIPHLYIYNSDNPPEGTIAKR 596 Query: 611 RAHAVVVDHLTPPMTTADSYGALAQLTQLVDEYYQVEVLDPSKLPLLQQQIWELVRQTNL 670 R+ A ++DH+ MT+ YG+L +L +L+ EY QV+ D + L+ I + ++++NL Sbjct: 597 RSLACLIDHMQTVMTSGGLYGSLEELDRLLGEYEQVK-YDKGRTHALKHLILDEIKKSNL 655 Query: 671 DTDLQFKLLHHDHDHDHDHGHHHHGHHHHHDHGAHDHAHHDHAHDADQLPHALTELDGAG 730 D++++ DH +++ E+ G Sbjct: 656 DSEIK----------------------------------ADHQTPFEEIIRKAHEVLG-- 679 Query: 731 VAHLIEDLDGYLCELGAAQIRDGLHILGRTPDSQQMPDMLVALTRLPNQDLPGLQEELAK 790 ++ +QI +G+HI G+ P+ ++ + + ++ R Q+ G + + Sbjct: 680 -------------KIRNSQIHNGMHIFGQLPEGEKKVEFINSILRYDEQENEGKGVSIRR 726 Query: 791 L----FGLSLDMLLEHKGRRLNIDDTLARVAGRAIVTRADALEAIDALCLALMQAL--QQ 844 L GL LD L+ D +L G++ R LE ID+L A ++ Sbjct: 727 LIAGPLGLDLDELIS--------DQSLISANGKSNGQR---LEEIDSLSKAFIRTFIANP 775 Query: 845 HGFAVTAIDDVLQSVLGSLQNTPAEQQPRLQPALAKGPGSVLGAMRSLSRPAAAPAAAPA 904 V+ I++VL S QN + ++ + + P + Sbjct: 776 EKEPVSIINEVL-----SGQNFTDQSITE----------------QNFTGNSINPEISQN 814 Query: 905 AAPAAAPVKRTAAQIQTKTSDTGALRRVLVFTCEQLVPRLLRTE--EEISNLLHGLRGGY 962 + PV A AL C++++ R E +EI LLHG GGY Sbjct: 815 TVISQNPVISQGA---------AAL-------CDRILDLESRIEASQEIEALLHGFDGGY 858 Query: 963 IPAGPSGSPTRGMAHILPTGRNFYSVDPRSVPSQSAWRVGQQLALEVLQRHHRESGDYPE 1022 IPAGPSG RG +LPTGRNFYS+DP+ VP+++AWRVGQQL+ ++ +H R+ G YPE Sbjct: 859 IPAGPSGLIMRGRDDVLPTGRNFYSLDPKRVPTKAAWRVGQQLSGVLIDKHLRDEGRYPE 918 Query: 1023 SVAISIWGTSAMRTHGDDVAQILALMGARPIWREGNRQVAGVELVPLAQLQRPRIDVTTR 1082 +VA M G+ +AQI++L+G P+W GN ++ G ++PL +L RPRIDVT R Sbjct: 919 NVAFYWMANDIMWADGEGMAQIMSLLGVEPLWL-GNGRLKGFSVIPLKELGRPRIDVTIR 977 Query: 1083 ISGFFRDAFPQLIELIDDAVQLAIAADEPEHMNFVRKHYLRDLQAAVTSGMGQAEAAAQA 1142 ISG RD FP +E+ID+A+Q + DEPE MN+ RKH L L+ S +A Sbjct: 978 ISGILRDNFPNCLEVIDEAIQAVASLDEPEDMNYPRKHSLGMLEEGADS--------REA 1029 Query: 1143 AYRVFGAKPGSYGAGILPLIQEKNWQDQADFAEAYINWGGYAYGRKVQGADQREAFRQRL 1202 R+F +KPG+Y AG+ + W+D+ D A+ ++ W GYAYG+ V G + L Sbjct: 1030 TLRIFSSKPGTYSAGVQLAVYASAWKDEKDLADIFLYWNGYAYGKDVNGREAHTRLASNL 1089 Query: 1203 SGVQVALHNQDNREHDIFDSDDYLQYHGGMIATIRALSGQQPRHYFGDSHDPQRAAVRDL 1262 V + + E+D+ Y HGG+ A R SG+ + YFGD+ +PQ VRD+ Sbjct: 1090 KTVDATFNKVVSDEYDLLGCCCYFGVHGGLTAAARQASGRDVKVYFGDTREPQHVEVRDM 1149 Query: 1263 KEETLRVFRARVVNPKWLASIRRHGYKGGLELTATVDYLFGYDATAQVLEDWMYQQLAET 1322 +E RV R R++NPKW+ +++HGYKG +++ V ++G++A+ Q ++DW++ + + Sbjct: 1150 ADELRRVVRTRLLNPKWIEGMKQHGYKGAQDISKRVGRVYGWEASTQEVDDWIFDDITKA 1209 Query: 1323 YGFDPEMRAFLEQANPWAQNAIAERLLEAASRGMWQTPPAQTIQQLRTLYLHSEALLE 1380 + D EMR F E+ NP+A ++ RLLEA SRG+W P Q ++ L+ YL E+ +E Sbjct: 1210 FVLDEEMRRFFEENNPYALEEMSRRLLEAQSRGLW-NPDPQVLEALKNSYLEIESWME 1266