BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.2665.p (505 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value yaaU [GEPR] COG0477 Permeases of the major facilitator superfami... 97 7e-20 ZyaaU [GEPR] COG0477 Permeases of the major facilitator superfam... 97 8e-20 ECs0048 [GEPR] COG0477 Permeases of the major facilitator superf... 97 8e-20 Ta1391 [GEPR] COG0477 Permeases of the major facilitator superfa... 94 7e-19 Ta0452 [GEPR] COG0477 Permeases of the major facilitator superfa... 92 2e-18 >yaaU [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 443 Score = 97.4 bits (241), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 123/474 (25%), Positives = 210/474 (44%), Gaps = 50/474 (10%) Query: 26 PLRDIDDV-VAFINSRPSLHGHAGLVWWLLLGGLFLEALSHSALSVGLPAMIGQLGLGPP 84 P R+ DD+ + I+ R L G GG FL+ + V L + L L Sbjct: 3 PSRNFDDLKFSSIHRRILLWGS---------GGPFLDGYVLVMIGVALEQLTPALKLDAD 53 Query: 85 EVAWLASSAAASALLANPLGGWLADRWGRRRPLLLAKLLALGGAVLVACAPDFAS----I 140 + L + A + L G+++D+ GRR+ + L ++A+G +++ A F S + Sbjct: 54 WIGLLGAGTLAGLFVGTSLFGYISDKVGRRK-MFLIDIIAIG---VISVATMFVSSPVEL 109 Query: 141 LMGRLLAGIAFGLDFAVAMAMLAEITPQHLRS-RLSLWQALWYL-AVCGNLLLVLLVEPW 198 L+ R+L GI G D+ +A +M+ E + R+ +S A+WY+ A C +L+ L + Sbjct: 110 LVMRVLIGIVIGADYPIATSMITEFSSTRQRAFSISFIAAMWYVGATCADLVGYWL---Y 166 Query: 199 DVGQSLWRYPLAATALAAFLMLNLQLLFLVESPCWLARRRRWQECAEALSRLYDAPYFQL 258 DV + WR+ L + A+ L+L + L ESP WL R+ R +EC E + +L+ P Sbjct: 167 DV-EGGWRWMLGSAAIPCLLIL-IGRFELPESPRWLLRKGRVKECEEMMIKLFGEPV-AF 223 Query: 259 LERHPAQHNGGLTKAPHASLRQLLHQPYLLRLILAATVQVVQAVQYFAIGWYLP-ILGLE 317 E P Q R L ++ + ++ A + Q + FAI + P I+GL Sbjct: 224 DEEQPQQTR----------FRDLFNRRHFPFVLFVAAIWTCQVIPMFAIYTFGPQIVGLL 273 Query: 318 LFGEDARQAAWGALVFNLCGIAGGLLAPWLARRLGLRNAAACGFGATGLVLLMLAASWPQ 377 G + AA G +V +L + G + P L R G A + L + P Sbjct: 274 GLGV-GKNAALGNVVISLFFML-GCIPPMLWLNTAGRRPLLIGSFAMMTLALAVLGLIPD 331 Query: 378 LRSWQAWLLPSLFLLCHAAGPGANGKSLSSLSFPSELRARANGITGALGAGGATLGLLLF 437 + W + +++ + GPG + FP+++RA A G+ +L G + Sbjct: 332 MGIWLVVMAFAVYAF-FSGGPGNLQWLYPNELFPTDIRASAVGVIMSLSRIGTIVSTWAL 390 Query: 438 PLLQASLGSSLCLLLVAMLPLAASALCRLIPWDPERVDFHPDLERPCAVADTSD 491 P+ + G S +L+ A + L + V F P+ R ++A TS+ Sbjct: 391 PIFINNYGISNTMLMGAGISLFGLLIS---------VAFAPE-TRGMSLAQTSN 434 >ZyaaU [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 443 Score = 97.1 bits (240), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 123/474 (25%), Positives = 210/474 (44%), Gaps = 50/474 (10%) Query: 26 PLRDIDDV-VAFINSRPSLHGHAGLVWWLLLGGLFLEALSHSALSVGLPAMIGQLGLGPP 84 P R+ DD+ + I+ R L G GG FL+ + V L + L L Sbjct: 3 PSRNFDDLKFSSIHRRILLWGS---------GGPFLDGYILVMIGVALEQLTPALKLDAD 53 Query: 85 EVAWLASSAAASALLANPLGGWLADRWGRRRPLLLAKLLALGGAVLVACAPDFAS----I 140 + L + A + L G+++D+ GRR+ + L ++A+G +++ A F S + Sbjct: 54 WIGLLGAGTLAGLFVGTSLFGYISDKVGRRK-MFLIDIIAIG---VISVATMFVSSPVEL 109 Query: 141 LMGRLLAGIAFGLDFAVAMAMLAEITPQHLRS-RLSLWQALWYL-AVCGNLLLVLLVEPW 198 L+ R+L GI G D+ +A +M+ E + R+ +S A+WY+ A C +L+ L + Sbjct: 110 LVMRVLIGIVIGADYPIATSMITEFSSTRQRAFSISFIAAMWYVGATCADLVGYWL---Y 166 Query: 199 DVGQSLWRYPLAATALAAFLMLNLQLLFLVESPCWLARRRRWQECAEALSRLYDAPYFQL 258 DV + WR+ L + A+ L+L + L ESP WL R+ R +EC E + +L+ P Sbjct: 167 DV-EGGWRWMLGSAAIPCLLIL-IGRFELPESPRWLLRKGRVKECEEMMIKLFGEPV-AF 223 Query: 259 LERHPAQHNGGLTKAPHASLRQLLHQPYLLRLILAATVQVVQAVQYFAIGWYLP-ILGLE 317 E P Q R L ++ + ++ A + Q + FAI + P I+GL Sbjct: 224 DEEQPQQTR----------FRDLFNRRHFPFVLFVAAIWTCQVIPMFAIYTFGPQIVGLL 273 Query: 318 LFGEDARQAAWGALVFNLCGIAGGLLAPWLARRLGLRNAAACGFGATGLVLLMLAASWPQ 377 G + AA G +V +L + G + P L R G A + L + P Sbjct: 274 GLGV-GKNAALGNVVISLFFML-GCIPPMLWLNTAGRRPLLIGSFAMMTLALAVLGLIPD 331 Query: 378 LRSWQAWLLPSLFLLCHAAGPGANGKSLSSLSFPSELRARANGITGALGAGGATLGLLLF 437 + W + +++ + GPG + FP+++RA A G+ +L G + Sbjct: 332 MGIWLVVMAFAVYAF-FSGGPGNLQWLYPNELFPTDIRASAVGVIMSLSRIGTIVSTWAL 390 Query: 438 PLLQASLGSSLCLLLVAMLPLAASALCRLIPWDPERVDFHPDLERPCAVADTSD 491 P+ + G S +L+ A + L + V F P+ R ++A TS+ Sbjct: 391 PIFINNYGISNTMLMGAGISLFGLLIS---------VAFAPE-TRGMSLAQTSN 434 >ECs0048 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 443 Score = 97.1 bits (240), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 123/474 (25%), Positives = 210/474 (44%), Gaps = 50/474 (10%) Query: 26 PLRDIDDV-VAFINSRPSLHGHAGLVWWLLLGGLFLEALSHSALSVGLPAMIGQLGLGPP 84 P R+ DD+ + I+ R L G GG FL+ + V L + L L Sbjct: 3 PSRNFDDLKFSSIHRRILLWGS---------GGPFLDGYILVMIGVALEQLTPALKLDAD 53 Query: 85 EVAWLASSAAASALLANPLGGWLADRWGRRRPLLLAKLLALGGAVLVACAPDFAS----I 140 + L + A + L G+++D+ GRR+ + L ++A+G +++ A F S + Sbjct: 54 WIGLLGAGTLAGLFVGTSLFGYISDKVGRRK-MFLIDIIAIG---VISVATMFVSSPVEL 109 Query: 141 LMGRLLAGIAFGLDFAVAMAMLAEITPQHLRS-RLSLWQALWYL-AVCGNLLLVLLVEPW 198 L+ R+L GI G D+ +A +M+ E + R+ +S A+WY+ A C +L+ L + Sbjct: 110 LVMRVLIGIVIGADYPIATSMITEFSSTRQRAFSISFIAAMWYVGATCADLVGYWL---Y 166 Query: 199 DVGQSLWRYPLAATALAAFLMLNLQLLFLVESPCWLARRRRWQECAEALSRLYDAPYFQL 258 DV + WR+ L + A+ L+L + L ESP WL R+ R +EC E + +L+ P Sbjct: 167 DV-EGGWRWMLGSAAIPCLLIL-IGRFELPESPRWLLRKGRVKECEEMMIKLFGEPV-AF 223 Query: 259 LERHPAQHNGGLTKAPHASLRQLLHQPYLLRLILAATVQVVQAVQYFAIGWYLP-ILGLE 317 E P Q R L ++ + ++ A + Q + FAI + P I+GL Sbjct: 224 DEEQPQQTR----------FRDLFNRRHFPFVLFVAAIWTCQVIPMFAIYTFGPQIVGLL 273 Query: 318 LFGEDARQAAWGALVFNLCGIAGGLLAPWLARRLGLRNAAACGFGATGLVLLMLAASWPQ 377 G + AA G +V +L + G + P L R G A + L + P Sbjct: 274 GLGV-GKNAALGNVVISLFFML-GCIPPMLWLNTAGRRPLLIGSFAMMTLALAVLGLIPD 331 Query: 378 LRSWQAWLLPSLFLLCHAAGPGANGKSLSSLSFPSELRARANGITGALGAGGATLGLLLF 437 + W + +++ + GPG + FP+++RA A G+ +L G + Sbjct: 332 MGIWLVVMAFAVYAF-FSGGPGNLQWLYPNELFPTDIRASAVGVIMSLSRIGTIVSTWAL 390 Query: 438 PLLQASLGSSLCLLLVAMLPLAASALCRLIPWDPERVDFHPDLERPCAVADTSD 491 P+ + G S +L+ A + L + V F P+ R ++A TS+ Sbjct: 391 PIFINNYGISNTMLMGAGISLFGLLIS---------VAFAPE-TRGMSLAQTSN 434 >Ta1391 [GEPR] COG0477 Permeases of the major facilitator superfamily Tac Thermoplasma acidophilum Length = 459 Score = 94.0 bits (232), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 99/406 (24%), Positives = 181/406 (44%), Gaps = 23/406 (5%) Query: 56 GGLFLEALSHSALSVGLPAMIGQLGLGPPEVAWLASSAAASALLANPLG----GWLADRW 111 GG+F++ + +S GL + GL A+L S ++ N +G G+ D+ Sbjct: 38 GGIFVDGYNIVIISFGLAGIETLFGL--QHNAFLVGLIGISVIIGNLVGALLSGYFVDKV 95 Query: 112 GRRRPLLLAKLLALGGAVLVACAPDFASILMGRLLAGIAFGLDFAVAMAMLAEITPQHLR 171 GRR ++ +L + A++ + +++ RLL G+ GLD+ +A + L+E TP + R Sbjct: 96 GRRTIFIIDLILFVFFAIISGLVTNAYELVVARLLVGLGIGLDYPIATSYLSEYTPINPR 155 Query: 172 SRLSLWQALWYLAVCGNLLLVLLVEPWDVGQSL-WRYPLAATALAAFLMLNLQLLFLVES 230 + L + + + G + ++ +G ++ WRY L + A+ A + + ++ ES Sbjct: 156 GKF-LVMNITFFNIAGVVAAIVGYSLLPLGATIAWRYMLMSAAVPAAITIAGRIR-TPES 213 Query: 231 PCWLARRRRWQECAEALSRLYDAPYFQLLERHPAQHNGGLTKAPHASLRQLLHQPYLLRL 290 P WL R +E +A+ R+ ++ ++ N K P + + L Y Sbjct: 214 PRWLLEHGRKKEAIQAIERVTESTLPDDTQKFIMDSN---VKPPVSGYYKELLTKYTKSA 270 Query: 291 ILAATVQVVQAVQYFAIGWYLPILGLELFGEDARQAAWGALVFNLCGIAGGLLAPWLARR 350 I A+ + Y P + L FGE G+ ++ L + G ++ + Sbjct: 271 IFIGLFYFFFAIAFVNASLYGPSI-LASFGE---AGLIGSSLYWLLFVVGDIICILVIDS 326 Query: 351 LGLRNAAACGFGA--TGLVLLMLAASWPQLRSWQAWLLPSLFLLCHAAGPGANGKSLSSL 408 G RN+ G+ +++L A S +L S A++L ++F GPG+ S Sbjct: 327 FGRRNSTLTGWAGMLITMIILAFAPSNLKLLSLGAFILFAMF---QGIGPGSLHMVYSPE 383 Query: 409 SFPSELRARANGITGALGAGGATLGLLLFPLLQASLGSSLCLLLVA 454 FP+ +RA A G +G G L L FP L +G L +L++ Sbjct: 384 LFPTRIRATAEGWKQGIGRLGGVLTGLFFPSL--VIGDKLLILILT 427 >Ta0452 [GEPR] COG0477 Permeases of the major facilitator superfamily Tac Thermoplasma acidophilum Length = 486 Score = 92.4 bits (228), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 105/413 (25%), Positives = 176/413 (42%), Gaps = 27/413 (6%) Query: 57 GLFLEALSHSALSVGLPAMIGQLGLGPPEVAWLASSAAASALLANPLGGWLADRWGRRRP 116 G+F++ S S S L + + + V+ AS+ L + G L+DR GR+R Sbjct: 73 GVFMDGFSLSIFSAALTYLKSYILVRAIFVSLAASAIYIGMFLGSFTMGHLSDRIGRKRM 132 Query: 117 LLLAKLLALGGAVLVACAPDFASILMGRLLAGIAFGLDFAVAMAMLAEITPQHLRSRLSL 176 + VL A + F + LLAGI G D+ ++ ++ AE +P+ R R + Sbjct: 133 YTYDLAITSVFLVLTALSTSFYEFFIFELLAGIGIGADYPLSSSIEAEFSPRRSRGRFLV 192 Query: 177 WQALWYLAVCGNLLLVLLVEP--WDVGQSLWRYPLAATALAAFLMLNLQLLFLVESPCWL 234 + ++ G+++ ++ P + G WR+ A+ +++ L L ESP WL Sbjct: 193 FNI--FMWTIGSIVFYVISIPLIFRFGSESWRWMYGVGAIVPVVVI-LARRALPESPYWL 249 Query: 235 ARRRRWQE---CAEALSRLYDAPYFQLLERHPAQHNGGLTKAPHASLRQLLHQPYLLRLI 291 + + E A+++ R +A Y + P G +S R + YL +I Sbjct: 250 VKAGKDSEAKTVADSMGR--EAGYTDV--DLPNVEKGS------SSFRSVFSGSYLPLII 299 Query: 292 LAATVQVVQAVQYFAIGWYLPILGLELFGEDARQAAWGALVFNLCGIAGGLLAPWLARRL 351 A+ V + + Y P + G A + L+ +L I G ++ L R+ Sbjct: 300 FASLAWFSYDVSSYGVWNYTPSI-FVSVGVSAVSSILSTLLEDLPVIVGFIICLLLIERV 358 Query: 352 GLRNAAACGFGATGLVLLMLA-----ASWPQLRSWQAWLLPSLFLLCHAAGPGANGKSLS 406 G + + GFG G+ LL A + P + + A+ + LF H GP Sbjct: 359 GRKILQSVGFGLAGVSLLSFALYADHRTLPFIMLFTAFAMMHLF---HNIGPTNLTYVYP 415 Query: 407 SLSFPSELRARANGITGALGAGGATLGLLLFPLLQASLGSSLCLLLVAMLPLA 459 FP+ +R A GI A GA LG+ FPL+ AS+G S L+ A+ Sbjct: 416 VEIFPTRIRGTAMGIATAASRIGAILGVFAFPLITASMGMSASLMFFAIFEFV 468