BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.2656.p (441 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value dctA [C] COG1301 Na+/H+-dicarboxylate symporters Eco Escherichia... 603 e-172 ZdctA [C] COG1301 Na+/H+-dicarboxylate symporters EcZ Escherichi... 602 e-172 ECs4408 [C] COG1301 Na+/H+-dicarboxylate symporters Ecs Escheric... 602 e-172 PA1183 [C] COG1301 Na+/H+-dicarboxylate symporters Pae Pseudomon... 599 e-171 YPO3992 [C] COG1301 Na+/H+-dicarboxylate symporters Ype Yersinia... 586 e-167 >dctA [C] COG1301 Na+/H+-dicarboxylate symporters Eco Escherichia coli K12 Length = 428 Score = 603 bits (1556), Expect = e-172, Method: Compositional matrix adjust. Identities = 299/425 (70%), Positives = 352/425 (82%), Gaps = 1/425 (0%) Query: 5 KPPLYKSLYFQVLCAIVIGILLGHFYPSTGEAMKPLGEGFVKLIKMIIAPVIFCTVVIGI 64 K L+KSLYFQVL AI IGILLGHFYP GE MKPLG+GFVKLIKMIIAPVIFCTVV GI Sbjct: 2 KTSLFKSLYFQVLTAIAIGILLGHFYPEIGEQMKPLGDGFVKLIKMIIAPVIFCTVVTGI 61 Query: 65 AGMEDMKKVGKTGGLALLYFEVVSTVALIIGLLLVNFLQPGVGMNVDPSTLDTKSIASYT 124 AGME MK VG+TG +ALLYFE+VST+ALIIGL++VN +QPG GMNVDP+TLD K++A Y Sbjct: 62 AGMESMKAVGRTGAVALLYFEIVSTIALIIGLIIVNVVQPGAGMNVDPATLDAKAVAVYA 121 Query: 125 APGKMGSVTDFIMGIIPTSMFDAFAKGDVLQVLLVAVLFGFALHKFGGRGTLVFDFIEKI 184 K + FIM +IP S+ AFA G++LQVLL AVLFGFALH+ G +G L+F+ IE Sbjct: 122 DQAKDQGIVAFIMDVIPASVIGAFASGNILQVLLFAVLFGFALHRLGSKGQLIFNVIESF 181 Query: 185 SHVLFSVVGAIMKVAPIGAFGAMSFTIGKYGVGSLFSLAKLMGTFYLTCLLFIFVVLGII 244 S V+F ++ IM++APIGAFGAM+FTIGKYGVG+L L +L+ FY+TC+LF+ +VLG I Sbjct: 182 SQVIFGIINMIMRLAPIGAFGAMAFTIGKYGVGTLVQLGQLIICFYITCILFVVLVLGSI 241 Query: 245 TRLHGFSIWKFVKYIKEELLIVLGTSSSESVLPRMLAKMENAGAKKTVVGLVIPTGYSFN 304 + GFSI+KF++YI+EELLIVLGTSSSES LPRML KME G +K+VVGLVIPTGYSFN Sbjct: 242 AKATGFSIFKFIRYIREELLIVLGTSSSESALPRMLDKMEKLGCRKSVVGLVIPTGYSFN 301 Query: 305 LDGTAIYLTMAAVFIAQATNTPMTFVQELTLLGVLLLTSKGAAGITGSGFIVLAATLSAV 364 LDGT+IYLTMAAVFIAQATN+ M V ++TLL VLLL+SKGAAG+TGSGFIVLAATLSAV Sbjct: 302 LDGTSIYLTMAAVFIAQATNSQMDIVHQITLLIVLLLSSKGAAGVTGSGFIVLAATLSAV 361 Query: 365 GHVPVAGLALILGIDRFMSEARALTNTIGNGVATLVVAKWSGELDSERLTKVLNNETVED 424 GH+PVAGLALILGIDRFMSEARALTN +GNGVAT+VVAKW ELD ++L VLNN D Sbjct: 362 GHLPVAGLALILGIDRFMSEARALTNLVGNGVATIVVAKWVKELDHKKLDDVLNNRA-PD 420 Query: 425 AQAPE 429 + E Sbjct: 421 GKTHE 425 >ZdctA [C] COG1301 Na+/H+-dicarboxylate symporters EcZ Escherichia coli O157:H7 EDL933 Length = 428 Score = 602 bits (1552), Expect = e-172, Method: Compositional matrix adjust. Identities = 298/425 (70%), Positives = 351/425 (82%), Gaps = 1/425 (0%) Query: 5 KPPLYKSLYFQVLCAIVIGILLGHFYPSTGEAMKPLGEGFVKLIKMIIAPVIFCTVVIGI 64 K L+KSLYFQVL AI IGILLGHFYP GE MKPLG+GFVKLIKMIIAPVIFCTVV GI Sbjct: 2 KTSLFKSLYFQVLTAIAIGILLGHFYPEIGEQMKPLGDGFVKLIKMIIAPVIFCTVVTGI 61 Query: 65 AGMEDMKKVGKTGGLALLYFEVVSTVALIIGLLLVNFLQPGVGMNVDPSTLDTKSIASYT 124 AGME MK VG+TG +ALLYFE+VST+ALIIGL++VN +QPG GMNVDP+TLD K++A Y Sbjct: 62 AGMESMKAVGRTGAVALLYFEIVSTIALIIGLIIVNVVQPGAGMNVDPATLDAKAVAVYA 121 Query: 125 APGKMGSVTDFIMGIIPTSMFDAFAKGDVLQVLLVAVLFGFALHKFGGRGTLVFDFIEKI 184 K + FIM +IP S+ AFA G++LQVLL AVLFGFALH+ G +G L+F+ IE Sbjct: 122 DQAKDQGIVAFIMDVIPASVIGAFASGNILQVLLFAVLFGFALHRLGSKGQLIFNVIESF 181 Query: 185 SHVLFSVVGAIMKVAPIGAFGAMSFTIGKYGVGSLFSLAKLMGTFYLTCLLFIFVVLGII 244 S V+F ++ IM++APIGAFGAM+FTIGKYGVG+L L +L+ FY+TC+LF+ +VLG I Sbjct: 182 SQVIFGIINMIMRLAPIGAFGAMAFTIGKYGVGTLVQLGQLIICFYITCILFVVLVLGSI 241 Query: 245 TRLHGFSIWKFVKYIKEELLIVLGTSSSESVLPRMLAKMENAGAKKTVVGLVIPTGYSFN 304 + GFSI+KF++YI+EELLIVLGTSSSES LPRML KME G +K+VVGLVIPTGYSFN Sbjct: 242 AKATGFSIFKFIRYIREELLIVLGTSSSESALPRMLDKMEKLGCRKSVVGLVIPTGYSFN 301 Query: 305 LDGTAIYLTMAAVFIAQATNTPMTFVQELTLLGVLLLTSKGAAGITGSGFIVLAATLSAV 364 LDGT+IYLTMAAVFIAQATN+ M V ++TLL VLLL+SKGAAG+TGSGFIVLAATLSAV Sbjct: 302 LDGTSIYLTMAAVFIAQATNSQMDIVHQITLLIVLLLSSKGAAGVTGSGFIVLAATLSAV 361 Query: 365 GHVPVAGLALILGIDRFMSEARALTNTIGNGVATLVVAKWSGELDSERLTKVLNNETVED 424 GH+PVAGLALILGIDRFMSEARALTN +GNGVAT+VVAKW ELD ++L LNN D Sbjct: 362 GHLPVAGLALILGIDRFMSEARALTNLVGNGVATIVVAKWVKELDHKKLDDALNNRA-PD 420 Query: 425 AQAPE 429 + E Sbjct: 421 GKTHE 425 >ECs4408 [C] COG1301 Na+/H+-dicarboxylate symporters Ecs Escherichia coli O157:H7 Length = 428 Score = 602 bits (1552), Expect = e-172, Method: Compositional matrix adjust. Identities = 298/425 (70%), Positives = 351/425 (82%), Gaps = 1/425 (0%) Query: 5 KPPLYKSLYFQVLCAIVIGILLGHFYPSTGEAMKPLGEGFVKLIKMIIAPVIFCTVVIGI 64 K L+KSLYFQVL AI IGILLGHFYP GE MKPLG+GFVKLIKMIIAPVIFCTVV GI Sbjct: 2 KTSLFKSLYFQVLTAIAIGILLGHFYPEIGEQMKPLGDGFVKLIKMIIAPVIFCTVVTGI 61 Query: 65 AGMEDMKKVGKTGGLALLYFEVVSTVALIIGLLLVNFLQPGVGMNVDPSTLDTKSIASYT 124 AGME MK VG+TG +ALLYFE+VST+ALIIGL++VN +QPG GMNVDP+TLD K++A Y Sbjct: 62 AGMESMKAVGRTGAVALLYFEIVSTIALIIGLIIVNVVQPGAGMNVDPATLDAKAVAVYA 121 Query: 125 APGKMGSVTDFIMGIIPTSMFDAFAKGDVLQVLLVAVLFGFALHKFGGRGTLVFDFIEKI 184 K + FIM +IP S+ AFA G++LQVLL AVLFGFALH+ G +G L+F+ IE Sbjct: 122 DQAKDQGIVAFIMDVIPASVIGAFASGNILQVLLFAVLFGFALHRLGSKGQLIFNVIESF 181 Query: 185 SHVLFSVVGAIMKVAPIGAFGAMSFTIGKYGVGSLFSLAKLMGTFYLTCLLFIFVVLGII 244 S V+F ++ IM++APIGAFGAM+FTIGKYGVG+L L +L+ FY+TC+LF+ +VLG I Sbjct: 182 SQVIFGIINMIMRLAPIGAFGAMAFTIGKYGVGTLVQLGQLIICFYITCILFVVLVLGSI 241 Query: 245 TRLHGFSIWKFVKYIKEELLIVLGTSSSESVLPRMLAKMENAGAKKTVVGLVIPTGYSFN 304 + GFSI+KF++YI+EELLIVLGTSSSES LPRML KME G +K+VVGLVIPTGYSFN Sbjct: 242 AKATGFSIFKFIRYIREELLIVLGTSSSESALPRMLDKMEKLGCRKSVVGLVIPTGYSFN 301 Query: 305 LDGTAIYLTMAAVFIAQATNTPMTFVQELTLLGVLLLTSKGAAGITGSGFIVLAATLSAV 364 LDGT+IYLTMAAVFIAQATN+ M V ++TLL VLLL+SKGAAG+TGSGFIVLAATLSAV Sbjct: 302 LDGTSIYLTMAAVFIAQATNSQMDIVHQITLLIVLLLSSKGAAGVTGSGFIVLAATLSAV 361 Query: 365 GHVPVAGLALILGIDRFMSEARALTNTIGNGVATLVVAKWSGELDSERLTKVLNNETVED 424 GH+PVAGLALILGIDRFMSEARALTN +GNGVAT+VVAKW ELD ++L LNN D Sbjct: 362 GHLPVAGLALILGIDRFMSEARALTNLVGNGVATIVVAKWVKELDHKKLDDALNNRA-PD 420 Query: 425 AQAPE 429 + E Sbjct: 421 GKTHE 425 >PA1183 [C] COG1301 Na+/H+-dicarboxylate symporters Pae Pseudomonas aeruginosa Length = 436 Score = 599 bits (1545), Expect = e-171, Method: Compositional matrix adjust. Identities = 297/433 (68%), Positives = 351/433 (81%) Query: 5 KPPLYKSLYFQVLCAIVIGILLGHFYPSTGEAMKPLGEGFVKLIKMIIAPVIFCTVVIGI 64 K P YKSLY QVL AI IGI LGH+YP T AMKP G+GFVKLIKM IAP+IFCTVV GI Sbjct: 3 KQPFYKSLYVQVLVAIAIGIALGHWYPETAVAMKPFGDGFVKLIKMAIAPIIFCTVVTGI 62 Query: 65 AGMEDMKKVGKTGGLALLYFEVVSTVALIIGLLLVNFLQPGVGMNVDPSTLDTKSIASYT 124 AGM+ MK VGKTGG+ALLYFEVVSTVALIIGL++VN +QPG GM+VDP+TLDT IA+Y Sbjct: 63 AGMQSMKSVGKTGGMALLYFEVVSTVALIIGLVVVNVVQPGAGMHVDPNTLDTSKIAAYA 122 Query: 125 APGKMGSVTDFIMGIIPTSMFDAFAKGDVLQVLLVAVLFGFALHKFGGRGTLVFDFIEKI 184 A G+ S DF+M +IP ++ AFA GD+LQVL +VLFG+ALH+ G G VF+FIE++ Sbjct: 123 AAGEKQSTVDFLMNVIPGTVVGAFANGDILQVLFFSVLFGYALHRLGSYGKPVFEFIERV 182 Query: 185 SHVLFSVVGAIMKVAPIGAFGAMSFTIGKYGVGSLFSLAKLMGTFYLTCLLFIFVVLGII 244 SHV+F+++ IMKVAPIGAFGAM+FTIG YGVGSL L +LM FY+TC+LF+ +VLG I Sbjct: 183 SHVMFNIINVIMKVAPIGAFGAMAFTIGAYGVGSLVQLGQLMLCFYITCILFVLIVLGGI 242 Query: 245 TRLHGFSIWKFVKYIKEELLIVLGTSSSESVLPRMLAKMENAGAKKTVVGLVIPTGYSFN 304 R HGFSI +F++YI+EELLIVLGTSSSES LPRM+ KME G K+VVGLVIPTGYSFN Sbjct: 243 ARAHGFSILRFIRYIREELLIVLGTSSSESALPRMIDKMEKLGCNKSVVGLVIPTGYSFN 302 Query: 305 LDGTAIYLTMAAVFIAQATNTPMTFVQELTLLGVLLLTSKGAAGITGSGFIVLAATLSAV 364 LDGT+IYLTMAAVFIAQAT+TPM ++TLL VLL+ SKGAAG+TGSGFIVLAATLSAV Sbjct: 303 LDGTSIYLTMAAVFIAQATDTPMDITHQITLLLVLLIASKGAAGVTGSGFIVLAATLSAV 362 Query: 365 GHVPVAGLALILGIDRFMSEARALTNTIGNGVATLVVAKWSGELDSERLTKVLNNETVED 424 GH+PVAGLALILGIDRFMSEARALTN +GNGVAT+VV+KW +LD L + L E Sbjct: 363 GHLPVAGLALILGIDRFMSEARALTNLVGNGVATVVVSKWCKQLDEGTLQRELAGEGNAS 422 Query: 425 AQAPEAVLDRTEA 437 + A + + EA Sbjct: 423 SPASDIPVGGREA 435 >YPO3992 [C] COG1301 Na+/H+-dicarboxylate symporters Ype Yersinia pestis Length = 429 Score = 586 bits (1510), Expect = e-167, Method: Compositional matrix adjust. Identities = 293/427 (68%), Positives = 359/427 (84%) Query: 5 KPPLYKSLYFQVLCAIVIGILLGHFYPSTGEAMKPLGEGFVKLIKMIIAPVIFCTVVIGI 64 K ++K+LYFQVL AI IG+LLGHFYP G MKPLG+GFVKLIKMIIAPVIFCTVV GI Sbjct: 2 KVSIFKTLYFQVLTAITIGVLLGHFYPEIGAQMKPLGDGFVKLIKMIIAPVIFCTVVTGI 61 Query: 65 AGMEDMKKVGKTGGLALLYFEVVSTVALIIGLLLVNFLQPGVGMNVDPSTLDTKSIASYT 124 AGME MK VG+TG +ALLYFE+VST+AL+IGL++VN QPGVGMN+DP+TLD K++A Y Sbjct: 62 AGMESMKAVGRTGAIALLYFEIVSTLALLIGLVVVNVAQPGVGMNIDPATLDAKAVALYA 121 Query: 125 APGKMGSVTDFIMGIIPTSMFDAFAKGDVLQVLLVAVLFGFALHKFGGRGTLVFDFIEKI 184 + F++ IIP S+ AFA G++LQVLL AVLFGFALH+ G +G L+F+ IE Sbjct: 122 EQASQQGIIPFLLDIIPGSVVGAFASGNILQVLLFAVLFGFALHRLGEKGQLIFNVIESF 181 Query: 185 SHVLFSVVGAIMKVAPIGAFGAMSFTIGKYGVGSLFSLAKLMGTFYLTCLLFIFVVLGII 244 S V+F V+ IM++AP+GAFGAM+FTIGKYGVGSL L +L+ FYLTC+LF+ +VLG I Sbjct: 182 SRVIFGVINMIMRLAPLGAFGAMAFTIGKYGVGSLVQLGQLILCFYLTCILFVVLVLGTI 241 Query: 245 TRLHGFSIWKFVKYIKEELLIVLGTSSSESVLPRMLAKMENAGAKKTVVGLVIPTGYSFN 304 + +GF+I+KF++YIKEELLIVLGTSSSESVLPRML KMENAG KK+VVGLVIPTGYSFN Sbjct: 242 AKFNGFNIFKFIRYIKEELLIVLGTSSSESVLPRMLDKMENAGCKKSVVGLVIPTGYSFN 301 Query: 305 LDGTAIYLTMAAVFIAQATNTPMTFVQELTLLGVLLLTSKGAAGITGSGFIVLAATLSAV 364 LDGT+IYLTMAAVFIAQATNT M + ++TLL VLLL+SKGAAG+TGSGFIVLAAT+SAV Sbjct: 302 LDGTSIYLTMAAVFIAQATNTHMDIMHQVTLLVVLLLSSKGAAGVTGSGFIVLAATISAV 361 Query: 365 GHVPVAGLALILGIDRFMSEARALTNTIGNGVATLVVAKWSGELDSERLTKVLNNETVED 424 GH+P+AGLALILGIDRFMSEARALTN +GNGVAT+VVAKW +LD+++L VL+N+ + + Sbjct: 362 GHLPLAGLALILGIDRFMSEARALTNLVGNGVATIVVAKWCKQLDNDQLQAVLSNKVLPN 421 Query: 425 AQAPEAV 431 ++ +V Sbjct: 422 VKSSVSV 428