BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.2512.p (255 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value YPO1287 [IQR] COG1028 Dehydrogenases with different specificitie... 322 4e-88 SMc02034 [IQR] COG1028 Dehydrogenases with different specificiti... 290 2e-78 SMc02339 [IQR] COG1028 Dehydrogenases with different specificiti... 253 2e-67 SMc02037 [IQR] COG1028 Dehydrogenases with different specificiti... 201 2e-51 AGc3482 [IQR] COG1028 Dehydrogenases with different specificitie... 199 7e-51 >YPO1287 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Ype Yersinia pestis Length = 271 Score = 322 bits (826), Expect = 4e-88, Method: Compositional matrix adjust. Identities = 167/246 (67%), Positives = 200/246 (81%), Gaps = 3/246 (1%) Query: 13 SLSARLALVTGAGQGIGAACADALARQGATVICTDLDGERARATASRL---GSSAQAFAL 69 SLS + ALVTGAGQGIGAA A+ LA GA VICTD+ ERA ATA L G + +A L Sbjct: 26 SLSGKRALVTGAGQGIGAAIAEGLAATGAEVICTDISRERAAATAQALNAKGYNVRAEGL 85 Query: 70 DVTDSSALNNLAARLPALDVLVCNAGVVSNTPAEEMSDEEWERVLSVNLGGVFKTCRAFA 129 DVTDS+A++ LAA LP LDVLVCNAG+V++TPAEEM+D +W++V++VNL GVF+TCR F Sbjct: 86 DVTDSAAIDALAAALPPLDVLVCNAGIVTHTPAEEMTDADWDKVIAVNLTGVFRTCRGFG 145 Query: 130 RAMLARGRGAIVNIGSMSGMIVNVPQPQCHYNASKAAVHHLTRSLAVEWATRGVRVNAVA 189 R ML GRG+I+NIGS+SG IVNVPQPQCHYNASKA VHHLT+SLAVEWATRGVRVNAVA Sbjct: 146 RRMLEAGRGSIINIGSISGQIVNVPQPQCHYNASKAGVHHLTKSLAVEWATRGVRVNAVA 205 Query: 190 PTYIATPLLQELEKEQALISRWLDLTPQQRMGRPEEIAAVVAFLASDAASLITGAVINAD 249 PTYI TPL+Q L + +SRWLD+TP R+G P EIA+VV FLAS+A+SL+TG++I AD Sbjct: 206 PTYIETPLIQGLTSQPGRVSRWLDMTPMGRLGSPHEIASVVQFLASEASSLLTGSIITAD 265 Query: 250 GGYTCI 255 GYT I Sbjct: 266 AGYTSI 271 >SMc02034 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Sme Sinorhizobium meliloti Length = 257 Score = 290 bits (742), Expect = 2e-78, Method: Compositional matrix adjust. Identities = 143/249 (57%), Positives = 186/249 (74%), Gaps = 8/249 (3%) Query: 14 LSARLALVTGAGQGIGAACADALARQGATVICTDLDGER---ARATASRLGSSAQAFALD 70 LS R+A+VTGAGQGIG ACA+AL GA V+ TD+ ER RA + G + +D Sbjct: 8 LSGRVAVVTGAGQGIGLACAEALCEAGAAVVLTDISAERCEAGRAALAAKGYVVETDLID 67 Query: 71 VTDSSALNNLAARLP----ALDVLVCNAGVV-SNTPAEEMSDEEWERVLSVNLGGVFKTC 125 + DS+++N +A RL A D+LV NAG+ + PAEE+SD +WER++ +NL G F++C Sbjct: 68 IGDSASVNAVADRLAVSGRAADILVANAGIAHAGVPAEELSDADWERMIGINLSGAFRSC 127 Query: 126 RAFARAMLARGRGAIVNIGSMSGMIVNVPQPQCHYNASKAAVHHLTRSLAVEWATRGVRV 185 RAF R MLA+GRG+IV IGSMSG IVN PQ Q HYNA+KA VHHLTRSLA EWA RGVRV Sbjct: 128 RAFGRHMLAKGRGSIVTIGSMSGTIVNRPQQQVHYNAAKAGVHHLTRSLAAEWAARGVRV 187 Query: 186 NAVAPTYIATPLLQELEKEQALISRWLDLTPQQRMGRPEEIAAVVAFLASDAASLITGAV 245 N+VAPTYI TPLL ++++ + +WLD+TP R+G+P+EIA+VV FLASDA+SL+TG++ Sbjct: 188 NSVAPTYIDTPLLTFAKEDKPMYEQWLDMTPMHRLGQPDEIASVVLFLASDASSLMTGSI 247 Query: 246 INADGGYTC 254 + AD GYTC Sbjct: 248 VAADAGYTC 256 >SMc02339 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Sme Sinorhizobium meliloti Length = 256 Score = 253 bits (647), Expect = 2e-67, Method: Compositional matrix adjust. Identities = 134/248 (54%), Positives = 167/248 (67%), Gaps = 7/248 (2%) Query: 14 LSARLALVTGAGQGIGAACADALARQGATVICTDLDG---ERARATASRLGSSAQAFALD 70 L LA+VTG G+GIG A ADAL GA + + D E A A G D Sbjct: 8 LDGELAVVTGGGRGIGLASADALGEAGARLAIIERDPALLEEAHAILQAKGYDVSVHEGD 67 Query: 71 VTDSSALNNLAARLP---ALDVLVCNAGV-VSNTPAEEMSDEEWERVLSVNLGGVFKTCR 126 VTD + + +A L +LV NAG+ +S+ PAE+M DE W +V+ VNL GV+ R Sbjct: 68 VTDPARMQAIADELTVKGGASILVNNAGIALSDIPAEDMEDERWLKVIDVNLNGVYWCSR 127 Query: 127 AFARAMLARGRGAIVNIGSMSGMIVNVPQPQCHYNASKAAVHHLTRSLAVEWATRGVRVN 186 AF R ML+ GRG+IVN+GSMSG IVN PQPQ HYNASKAAVHHLT+SLA EWA RGVRVN Sbjct: 128 AFGRHMLSAGRGSIVNVGSMSGFIVNRPQPQAHYNASKAAVHHLTKSLAAEWAPRGVRVN 187 Query: 187 AVAPTYIATPLLQELEKEQALISRWLDLTPQQRMGRPEEIAAVVAFLASDAASLITGAVI 246 AVAPTYI TPL +E ++ ++ RWLD TP RMG+ E+A+V+ FL+S AASL+TG+++ Sbjct: 188 AVAPTYIETPLNALVENDRPMLDRWLDSTPMARMGKDHEVASVILFLSSRAASLMTGSIV 247 Query: 247 NADGGYTC 254 ADGGYT Sbjct: 248 LADGGYTL 255 >SMc02037 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Sme Sinorhizobium meliloti Length = 256 Score = 201 bits (510), Expect = 2e-51, Method: Compositional matrix adjust. Identities = 116/251 (46%), Positives = 152/251 (60%), Gaps = 7/251 (2%) Query: 10 DLSSLSARLALVTGAGQGIGAACADALARQGATVICTDL---DGERARATASRLGSSAQA 66 +L L+ R A VTG +GIG ACA+AL GA V + +GE+A + G A Sbjct: 4 ELFRLNGRAAFVTGGSRGIGFACAEALGEAGARVAISARSRDEGEKAVRQLRQKGIEAIY 63 Query: 67 FALDVTDSSALNNL----AARLPALDVLVCNAGVVSNTPAEEMSDEEWERVLSVNLGGVF 122 D+++ SA + AA L LD+LV NAG+ + + ++ E W+ V++ NL G+F Sbjct: 64 LPADISNESAAQQVVRQAAAELGGLDILVNNAGIARHCDSLKLEPETWDEVINTNLTGLF 123 Query: 123 KTCRAFARAMLARGRGAIVNIGSMSGMIVNVPQPQCHYNASKAAVHHLTRSLAVEWATRG 182 CRA M A GRG+IVNIGS+SG I N+PQ Q YNASKA VH LT+SLA E+A Sbjct: 124 WCCRAAIETMSAAGRGSIVNIGSISGYISNLPQNQVAYNASKAGVHMLTKSLAGEFAKSN 183 Query: 183 VRVNAVAPTYIATPLLQELEKEQALISRWLDLTPQQRMGRPEEIAAVVAFLASDAASLIT 242 +R+NAVAP YI T + Q + WL +TP R G+ E+AA V FLASDAAS IT Sbjct: 184 IRINAVAPGYIETAMTQGGLDDPEWSKIWLGMTPLGRAGKASEVAAAVLFLASDAASYIT 243 Query: 243 GAVINADGGYT 253 G+V+ DGGYT Sbjct: 244 GSVLTIDGGYT 254 >AGc3482 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 262 Score = 199 bits (505), Expect = 7e-51, Method: Compositional matrix adjust. Identities = 117/264 (44%), Positives = 156/264 (59%), Gaps = 13/264 (4%) Query: 1 MPTTSPHAHDLSSLSARLALVTGAGQGIGAACADALARQGATVICTDLDGERARATAS-- 58 M T + +A L LS ++ALVTGAG GIG A LA+ GA V D + A + Sbjct: 1 MSTITLNAPKLFDLSGQVALVTGAGSGIGQRIAMGLAQSGANVALLDRRTDDGLAQTADF 60 Query: 59 --RLGSSAQAFALDVTDSSALNNLAAR----LPALDVLVCNAGVVSNTPAEEMSDEEWER 112 R G + A DVT AL + AR L AL + V AG+ + PAEEM + +++ Sbjct: 61 IARAGRKSIQIAADVTSKQALTDAVARTQAELGALSLAVNAAGIANANPAEEMEESQFQT 120 Query: 113 VLSVNLGGVFKTCRAFARAMLARGRGAIVNIGSMSGMIVNVPQPQCHYNASKAAVHHLTR 172 ++ +NL GVF +C+A A AML GRGAIVNI SMSG+IVN QCHYNASKA V H+++ Sbjct: 121 MMDINLKGVFLSCQAEANAMLKNGRGAIVNIASMSGVIVNRGLMQCHYNASKAGVIHMSK 180 Query: 173 SLAVEWATRGVRVNAVAPTYIATPL--LQELEKEQALISRWLDLTPQQRMGRPEEIAAVV 230 S+A+EW RG+RVN ++P Y ATP+ E+ + L + TP QRM +E+ Sbjct: 181 SMAMEWVGRGIRVNTISPGYTATPMNTRPEMVHQTKLFE---EQTPMQRMAGVDEMVGPA 237 Query: 231 AFLASDAASLITGAVINADGGYTC 254 FL SDAAS +TG + DGG+ C Sbjct: 238 IFLLSDAASFVTGVDLLVDGGFCC 261