BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.2272.p (401 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value YPO3263 [GEPR] COG0477 Permeases of the major facilitator superf... 134 4e-31 CAC3482 [GEPR] COG0477 Permeases of the major facilitator superf... 128 2e-29 ECs3543 [GEPR] COG0477 Permeases of the major facilitator superf... 120 7e-27 CAC0560 [GEPR] COG0477 Permeases of the major facilitator superf... 119 9e-27 Z3982 [GEPR] COG0477 Permeases of the major facilitator superfam... 119 2e-26 >YPO3263 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 399 Score = 134 bits (336), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 113/365 (30%), Positives = 168/365 (46%) Query: 4 QTDQHVRLSGRALAVLSVAAGSAIANNYAMQPALSLIAADFGVPVAPMTALASAAIIGYL 63 Q LS + ++SVA G A+A+NY QP L IA +F + V + +AA +GY Sbjct: 2 QKTDTPGLSPALIVLMSVATGLAVASNYYAQPLLETIATNFNLSVNQAGFIVTAAQLGYA 61 Query: 64 LGLVLLVPLTDKLSPRVLIPGQLFALACALLLAAWAASPEVLIGCFVLIGATTTVAAQSS 123 +GL+ LVPL D R LI G A +L+ A + + ++I L G + VA Sbjct: 62 VGLMFLVPLGDMFERRGLIVGMTLLAAGGMLITAMSQNLTMMIIGTALTGLFSVVAQLLV 121 Query: 124 AVVGKYAHAQHRALSMATISAGISAGILLSRFVGGVLAQWWGWRGALLAFAAFAAVSALC 183 + A + R + I +G+ GILL+R V G LA GWR +A + AL Sbjct: 122 PLAATLAAPEKRGKVVGIIMSGLLLGILLARTVAGALATLGGWRTIYWVASALMFIMALV 181 Query: 184 VLPLLPTQGPDAQSGYFSNLRSMPILMKTSRELRLRIYAGMLWFFAFNLIWVGLVVRLAA 243 + LP Y L S+ L + LR R G L F F+++W + LAA Sbjct: 182 LWRCLPRYKQHTGLNYGQLLGSIFALFIHTPVLRTRALLGALSFANFSVLWTSMAFLLAA 241 Query: 244 PPFNLDAAHIGLYSLAGLMGLLMTRVAGRLADRFGHRRVVVSGLTSAFFAAIGLALVLGH 303 PPF A IGL+ L G G LM AG+LAD+ R +GL + + +A Sbjct: 242 PPFGYSEATIGLFGLVGAAGALMATKAGQLADKGKARVTTSAGLVLLLLSWLPIAFGQHS 301 Query: 304 PAAIAVALAVFDAGCFTAQVANQAGVVAIEPSRAGVLNSAYLFFYYVAGTIGAALAGVIV 363 A+ + + V D V NQ+ + + P L + Y+ Y++ G +G+ ++ Sbjct: 302 IIALIIGIIVLDLAVQAVHVTNQSVMYRMMPEARNRLTAGYMTSYFIGGALGSLISAAAY 361 Query: 364 GSAGW 368 AGW Sbjct: 362 QHAGW 366 >CAC3482 [GEPR] COG0477 Permeases of the major facilitator superfamily Cac Clostridium acetobutylicum Length = 394 Score = 128 bits (321), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 96/359 (26%), Positives = 171/359 (47%), Gaps = 2/359 (0%) Query: 11 LSGRALAVLSVAAGSAIANNYAMQPALSLIAADFGVPVAPMTALASAAIIGYLLGLVLLV 70 L+ + V+S+A G +AN Y +QP L+ I+ F V + + A IGY +G+VL++ Sbjct: 15 LNKLLIMVMSIACGLTVANLYYIQPLLADISKTFNVSEISVGSAAMLTQIGYAVGMVLIL 74 Query: 71 PLTDKLSPRVLIPGQLFALACALLLAAWAASPEVLIGCFVLIGATTTVAAQSSAVVGKYA 130 PL D R LI L +L ++++ +L +G T+ + + + + Sbjct: 75 PLGDIKERRNLITTILLFSVISLASMFFSSNIYILTISSFAVGFTSIIPQLIIPLAAQLS 134 Query: 131 HAQHRALSMATISAGISAGILLSRFVGGVLAQWWGWRGALLAFAAFAAVSALCVLPLLPT 190 + + R + T+ +G+ GIL+SR G+L +WGWR + A + + LLP Sbjct: 135 NQKDRGRIIGTVMSGLLIGILVSRTFSGILGAYWGWRVVYIIAAIMMIFLMIALRKLLPV 194 Query: 191 QGPDAQSGYFSNLRSMPILMKTSRELRLRIYAGMLWFFAFNLIWVGLVVRLAAPPFNLDA 250 P + Y L+SM L+K+ LR G + F AF+ W L L +P +N+ + Sbjct: 195 SKPSSNVKYIELLKSMFQLIKSEPVLREASINGAMMFAAFSAFWTSLTFLLQSPHYNMGS 254 Query: 251 AHIGLYSLAGLMGLLMTRVAGRLADRFGHRRVVVSGLTSAFFAAIGLALVLGHPA-AIAV 309 GL+ L G+ G L + GR+AD+ G R ++ + + + L L+LG + + Sbjct: 255 QAAGLFGLVGVSGALAAPLVGRIADKKGPRFIIGICIPIITISYL-LFLLLGFKIFGLIL 313 Query: 310 ALAVFDAGCFTAQVANQAGVVAIEPSRAGVLNSAYLFFYYVAGTIGAALAGVIVGSAGW 368 + + D G + V+NQ V ++ +N+ Y+ +++ G G+ + GW Sbjct: 314 GVMLLDLGVQSGNVSNQTRVHSLNEKMRNRINTVYMVSFFLGGAFGSFMGSFTYVHFGW 372 >ECs3543 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 394 Score = 120 bits (300), Expect = 7e-27, Method: Compositional matrix adjust. Identities = 118/386 (30%), Positives = 179/386 (46%), Gaps = 8/386 (2%) Query: 5 TDQHVRLSGRALAVLSVAAGSAIANNYAMQPALSLIAADFGVPVAPMTALASAAIIGYLL 64 T + LS + ++S+A G A+A+NY QP L IA +F + + + +AA +GY Sbjct: 2 TKPNHELSPALIVLMSIATGLAVASNYYAQPLLDTIARNFSLSASSAGFIVTAAQLGYAA 61 Query: 65 GLVLLVPLTDKLSPRVLIPGQLFALACALLLAAWAASPEVLIGCFVLIGATTTVAAQSSA 124 GL+ LVPL D R LI A +L+ A + S ++I L G + VA Sbjct: 62 GLLFLVPLGDMFERRRLIVSMTLLAAGGMLITASSQSLAMMILGTALTGLFSVVAQILVP 121 Query: 125 VVGKYAHAQHRALSMATISAGISAGILLSRFVGGVLAQWWGWRGALLAFAAFAAVSALCV 184 + A R + TI +G+ GILL+R V G+LA GWR + A+ AL + Sbjct: 122 LAATLASPDKRGKVVGTIMSGLLLGILLARTVAGLLANLGGWRTVFWVASVLMALMALAL 181 Query: 185 LPLLPTQGPDAQSGYFSNLRSMPILMKTSRELRLRIYAGMLWFFAFNLIWVGLVVRLAAP 244 LP + Y L S+ + +++ LR R G L F F+++W + LAAP Sbjct: 182 WRGLPQMKSETHLNYPQLLGSVFSMFISNKILRTRALLGCLTFANFSILWTSMAFLLAAP 241 Query: 245 PFNLDAAHIGLYSLAGLMGLLMTRVAGRLADRFGHRRVVVSGLTSAFFAAIGLALVLGHP 304 PFN IGL+ LAG G L R AG AD+ GL + LA+ GH Sbjct: 242 PFNYSDGVIGLFGLAGAAGALGARPAGGFADKGKSHHTTTFGLLLLLLS--WLAIWFGHT 299 Query: 305 AAIA--VALAVFDAGCFTAQVANQAGVVAIEPSRAGVLNSAYLFFYYVAGTIGAALAGVI 362 + +A + + V D + NQ + I P L + Y+ Y++ G G+ ++ Sbjct: 300 SVLALIIGILVLDLTVQGVHITNQTVIYRIHPDARNRLTAGYMTSYFIGGAAGSLISASA 359 Query: 363 VGSAGWEALTLLAAVATASAAIISLL 388 GW + L A A+ A+++LL Sbjct: 360 WQHGGWAGVCL----AGATIALVNLL 381 >CAC0560 [GEPR] COG0477 Permeases of the major facilitator superfamily Cac Clostridium acetobutylicum Length = 441 Score = 119 bits (299), Expect = 9e-27, Method: Compositional matrix adjust. Identities = 104/373 (27%), Positives = 171/373 (45%), Gaps = 12/373 (3%) Query: 2 KSQTDQHVRLSGRALAVLSVAAGSAIANNYAMQPALSLIAADFGVPVAPMTALASAAIIG 61 K + L+ + ++++ +AN Y QP L IA F V A + + +G Sbjct: 39 KMTIKESFELNKFIIFIMALTCTVTVANLYYCQPLLGQIAKSFNVTEANAGFVVTLTQVG 98 Query: 62 YLLGLVLLVPLTDKLSPRVLIPGQLFALACALLLAAWAASPEVLIGCFVLIGATTTVAAQ 121 Y LG++ LVPL D + LI L ++ L A + + VL+ LIG TT V Sbjct: 99 YALGMLFLVPLGDIKERKKLIIEMLLLVSVFLFAAFISRNYYVLLVTSFLIGFTTIVPQL 158 Query: 122 SSAVVGKYAHAQHRALSMATISAGISAGILLSRFVGGVLAQWWGWRGALLAFAAFAAVSA 181 + + R + + +G+ GILLSR G++ GWR L A+ VS Sbjct: 159 IVPFAAHLSKPEERGQVIGNVLSGLLIGILLSRVFSGIIGDILGWRNVYLI-ASLLMVSF 217 Query: 182 LCVLP-LLPTQGPDAQSGYFSNLRSMPILMKTSRELRLRIYAGMLWFFAFNLIWVGLVVR 240 L ++ L P P ++ Y + SM L+K + LR G L F +F++ W LV Sbjct: 218 LFIIVFLFPKSKPTSKISYKKLIFSMWGLIKREKVLREASINGALMFGSFSIFWTALVFL 277 Query: 241 LAAPPFNLDAAHIGLYSLAGLMGLLMTRVAGRLADRFGHRR-----VVVSGLTSAFFAAI 295 L + +N+ + G + L G++G L V G++AD+ R ++ S + F + Sbjct: 278 LESKVYNMGSKEAGFFGLVGIVGALAAPVVGKVADKKTPRFAVGFAIIFSTIAYVCFWGM 337 Query: 296 GLALVLGHPAAIAVALAVFDAGCFTAQVANQAGVVAIEPSRAGVLNSAYLFFYYVAGTIG 355 G + + + + + D G T QV+NQA V AI +N+ ++ Y++ G+IG Sbjct: 338 GYKI-----YGLVIGVILLDLGNQTGQVSNQARVQAISDQERSRINTVFMVSYFIGGSIG 392 Query: 356 AALAGVIVGSAGW 368 + +A V GW Sbjct: 393 SFVAAVFWQKFGW 405 >Z3982 [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 394 Score = 119 bits (297), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 118/386 (30%), Positives = 178/386 (46%), Gaps = 8/386 (2%) Query: 5 TDQHVRLSGRALAVLSVAAGSAIANNYAMQPALSLIAADFGVPVAPMTALASAAIIGYLL 64 T + LS + ++S+A G A+A+NY QP L IA +F + + + +AA +GY Sbjct: 2 TKPNHELSPALIVLMSIATGLAVASNYYAQPLLDTIARNFSLSASSAGFIVTAAQLGYAA 61 Query: 65 GLVLLVPLTDKLSPRVLIPGQLFALACALLLAAWAASPEVLIGCFVLIGATTTVAAQSSA 124 GL+ LVPL D R LI A +L+ A + S ++I L G + VA Sbjct: 62 GLLFLVPLGDMFERRRLIVSMTLLAAGGMLITASSQSLAMMILGTALTGLFSVVAQILVP 121 Query: 125 VVGKYAHAQHRALSMATISAGISAGILLSRFVGGVLAQWWGWRGALLAFAAFAAVSALCV 184 + A R + TI +G+ GILL+R V G+LA GWR + A+ AL + Sbjct: 122 LAATLASPDKRGKVVGTIMSGLLLGILLARTVAGLLANLGGWRTVFWVASVLMALMALAL 181 Query: 185 LPLLPTQGPDAQSGYFSNLRSMPILMKTSRELRLRIYAGMLWFFAFNLIWVGLVVRLAAP 244 LP + Y L S+ + +++ LR R G L F F++ W + LAAP Sbjct: 182 WRGLPQMKSETHLNYPQLLGSVFSMFISNKILRTRALLGCLTFANFSIXWTSMAFLLAAP 241 Query: 245 PFNLDAAHIGLYSLAGLMGLLMTRVAGRLADRFGHRRVVVSGLTSAFFAAIGLALVLGHP 304 PFN IGL+ LAG G L R AG AD+ GL + LA+ GH Sbjct: 242 PFNYSDGVIGLFGLAGAAGALGARPAGGFADKGKSHHTTTFGLLLLLLS--WLAIWFGHT 299 Query: 305 AAIA--VALAVFDAGCFTAQVANQAGVVAIEPSRAGVLNSAYLFFYYVAGTIGAALAGVI 362 + +A + + V D + NQ + I P L + Y+ Y++ G G+ ++ Sbjct: 300 SVLALIIGILVLDLTVQGVHITNQTVIYRIHPDARNRLTAGYMTSYFIGGAAGSLISASA 359 Query: 363 VGSAGWEALTLLAAVATASAAIISLL 388 GW + L A A+ A+++LL Sbjct: 360 WQHGGWAGVCL----AGATIALVNLL 381